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Aliases for GGA1 Gene

Aliases for GGA1 Gene

  • Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1 2 3
  • Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 1 4
  • Gamma-Adaptin-Related Protein 1 4

External Ids for GGA1 Gene

Previous GeneCards Identifiers for GGA1 Gene

  • GC22P034619
  • GC22P036247
  • GC22P036329
  • GC22P038004
  • GC22P020971

Summaries for GGA1 Gene

Entrez Gene Summary for GGA1 Gene

  • This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGA1 Gene

GGA1 (Golgi-Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and RNA Polymerase I Promoter Opening. An important paralog of this gene is GGA2.

UniProtKB/Swiss-Prot for GGA1 Gene

  • Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Gene Wiki entry for GGA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGA1 Gene

Genomics for GGA1 Gene

Regulatory Elements for GGA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GGA1 Gene

Chromosome:
22
Start:
37,607,235 bp from pter
End:
37,633,564 bp from pter
Size:
26,330 bases
Orientation:
Plus strand

Genomic View for GGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGA1 Gene

Proteins for GGA1 Gene

  • Protein details for GGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJY5-GGA1_HUMAN
    Recommended name:
    ADP-ribosylation factor-binding protein GGA1
    Protein Accession:
    Q9UJY5
    Secondary Accessions:
    • A8K3D3
    • B0QYR7
    • Q5R3N1
    • Q5TG07
    • Q6IC75
    • Q86YA9
    • Q8NCS6
    • Q9BW94
    • Q9UG00
    • Q9UGW0
    • Q9UGW1

    Protein attributes for GGA1 Gene

    Size:
    639 amino acids
    Molecular mass:
    70384 Da
    Quaternary structure:
    • Monomer. Interacts with NECAP1. Interacts with CNST (By similarity). Interacts with GGA2 and GGA3. Binds to clathrin and activated ARFs, including ARF1 and ARF6. Interacts with RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds CCDC91, P200, SYNRG, EPN4, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Interacts with RNF11.

    Three dimensional structures from OCA and Proteopedia for GGA1 Gene

    Alternative splice isoforms for GGA1 Gene

neXtProt entry for GGA1 Gene

Proteomics data for GGA1 Gene at MOPED

Post-translational modifications for GGA1 Gene

  • Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals.
  • Ubiquitinated.
  • Ubiquitination at Lys 23, Lys 101, Lys 165, Lys 198, and Lys 206
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GGA1 Gene

Domains & Families for GGA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJY5

UniProtKB/Swiss-Prot:

GGA1_HUMAN :
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif)
  • Belongs to the GGA protein family.
Domain:
  • The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif)
  • The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis
  • The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs
  • The GAE domain binds accessory proteins regulating GGAs function
  • Contains 1 GAE domain.
  • Contains 1 GAT domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the GGA protein family.
genes like me logo Genes that share domains with GGA1: view

Function for GGA1 Gene

Molecular function for GGA1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Gene Ontology (GO) - Molecular Function for GGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 11390366
genes like me logo Genes that share ontologies with GGA1: view
genes like me logo Genes that share phenotypes with GGA1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GGA1 Gene

Localization for GGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGA1 Gene

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GGA1 Gene COMPARTMENTS Subcellular localization image for GGA1 gene
Compartment Confidence
endosome 5
golgi apparatus 5
nucleus 4
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for GGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus TAS 20214818
GO:0010008 endosome membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GGA1: view

Pathways & Interactions for GGA1 Gene

genes like me logo Genes that share pathways with GGA1: view

Pathways by source for GGA1 Gene

2 Reactome pathways for GGA1 Gene
1 KEGG pathway for GGA1 Gene

Gene Ontology (GO) - Biological Process for GGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport TAS 20211637
GO:0016192 vesicle-mediated transport IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0045732 positive regulation of protein catabolic process IEA --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with GGA1: view

No data available for SIGNOR curated interactions for GGA1 Gene

Drugs & Compounds for GGA1 Gene

(2) Drugs for GGA1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
serine Nutra 420

(2) Additional Compounds for GGA1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
genes like me logo Genes that share compounds with GGA1: view

Transcripts for GGA1 Gene

Unigene Clusters for GGA1 Gene

Golgi-associated, gamma adaptin ear containing, ARF binding protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GGA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - -
SP17: - - - - - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - -
SP19: - - - - - - - - - - - - - -
SP20: - - - - - - - - -
SP21: - - -
SP22:
SP23:
SP24: - - - - - - - - - - - - - -
SP25: - - - - - - - - - - -
SP26: - - - - - - - -
SP27: - - - - - - - - -
SP28: - - - - -
SP29:
SP30:
SP31:

ExUns: 11 ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b · 21c ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: - - - - - - - - - - - - - - - - - - - - - -
SP9: -
SP10: - -
SP11: - -
SP12: - - - -
SP13:
SP14:
SP15: -
SP16: -
SP17: - - - - - - - - - - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:

ExUns: 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:

Relevant External Links for GGA1 Gene

GeneLoc Exon Structure for
GGA1
ECgene alternative splicing isoforms for
GGA1

Expression for GGA1 Gene

mRNA expression in normal human tissues for GGA1 Gene

mRNA differential expression in normal tissues according to GTEx for GGA1 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for GGA1 Gene

This gene is overexpressed in Brain (11.5) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GGA1 Gene



SOURCE GeneReport for Unigene cluster for GGA1 Gene Hs.499158

mRNA Expression by UniProt/SwissProt for GGA1 Gene

Q9UJY5-GGA1_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expression patterns with GGA1: view

Protein tissue co-expression partners for GGA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GGA1 Gene

Orthologs for GGA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GGA1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GGA1 35
  • 89.57 (n)
  • 93.55 (a)
GGA1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gga1 35
  • 88.45 (n)
  • 91.5 (a)
Gga1 16
Gga1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GGA1 35
  • 99.15 (n)
  • 98.73 (a)
rat
(Rattus norvegicus)
Mammalia Gga1 35
  • 87.66 (n)
  • 91.28 (a)
cow
(Bos Taurus)
Mammalia GGA1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GGA1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GGA1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857525 35
  • 76.8 (n)
  • 81.69 (a)
-- 36
  • 72 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia GGA1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gga1 35
  • 65.81 (n)
  • 70.85 (a)
zebrafish
(Danio rerio)
Actinopterygii gga1 35
  • 63.93 (n)
  • 65.43 (a)
gga1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3002 37
  • 26 (a)
Gga 36
  • 23 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011568 35
  • 50.75 (n)
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea apt-9 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GGA1 36
  • 17 (a)
ManyToMany
GGA2 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for GGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GGA1 Gene

ENSEMBL:
Gene Tree for GGA1 (if available)
TreeFam:
Gene Tree for GGA1 (if available)

Paralogs for GGA1 Gene

Paralogs for GGA1 Gene

genes like me logo Genes that share paralogs with GGA1: view

Variants for GGA1 Gene

Sequence variations from dbSNP and Humsavar for GGA1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7582 -- 37,633,288(-) AGGTT(C/T)CCCCA utr-variant-3-prime
rs751517 -- 37,624,970(-) ATCTC(C/T)GCTGG intron-variant, synonymous-codon, reference
rs761336 -- 37,613,234(+) TGCCT(A/C)GTGTG intron-variant
rs1065307 -- 37,632,464(+) CCCAT(C/T)GTCCA reference, synonymous-codon
rs1137759 -- 37,624,299(+) gcact(G/T)atcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GGA1 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834191 CNV Loss 17160897
dgv4964n71 CNV Loss 21882294
nsv471197 CNV Loss 18288195
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850

Variation tolerance for GGA1 Gene

Residual Variation Intolerance Score: 3.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GGA1 Gene

HapMap Linkage Disequilibrium report
GGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGA1 Gene

Disorders for GGA1 Gene

Relevant External Links for GGA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GGA1
genes like me logo Genes that share disorders with GGA1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGA1 Gene

Publications for GGA1 Gene

  1. Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. (PMID: 16407204) Xie L. … Mora S. (J. Biol. Chem. 2006) 2 23 67
  2. GGA autoinhibition revisited. (PMID: 20015111) Cramer J.F. … Thirup S.S. (Traffic 2010) 23 67
  3. Gyrating clathrin: highly dynamic clathrin structures involved in rapid receptor recycling. (PMID: 18817526) Zhao Y. … Keen J.H. (Traffic 2008) 23 67
  4. Molecular basis for autoregulatory interaction between GAE domain and hinge region of GGA1. (PMID: 17506864) Inoue M. … Wakatsuki S. (Traffic 2007) 23 67
  5. Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells. (PMID: 18431031) Hida T. … Waguri S. (Arch. Histol. Cytol. 2007) 23 67

Products for GGA1 Gene

Sources for GGA1 Gene

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