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Aliases for GFRAL Gene

Aliases for GFRAL Gene

  • GDNF Family Receptor Alpha Like 2 3 5
  • C6orf144 3 4
  • Chromosome 6 Open Reading Frame 144 2
  • BA360D14.1 3
  • IVFI9356 3
  • UNQ9356 3
  • GRAL 3

External Ids for GFRAL Gene

Previous HGNC Symbols for GFRAL Gene

  • C6orf144

Previous GeneCards Identifiers for GFRAL Gene

  • GC06P055192
  • GC06P055027

Summaries for GFRAL Gene

GeneCards Summary for GFRAL Gene

GFRAL (GDNF Family Receptor Alpha Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFRAL Gene

Genomics for GFRAL Gene

Regulatory Elements for GFRAL Gene

Enhancers for GFRAL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GFRAL on UCSC Golden Path with GeneCards custom track

Genomic Location for GFRAL Gene

55,327,469 bp from pter
55,402,493 bp from pter
75,025 bases
Plus strand

Genomic View for GFRAL Gene

Genes around GFRAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFRAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFRAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFRAL Gene

Proteins for GFRAL Gene

  • Protein details for GFRAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GDNF family receptor alpha-like
    Protein Accession:
    Secondary Accessions:
    • Q5VTF6

    Protein attributes for GFRAL Gene

    394 amino acids
    Molecular mass:
    44518 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GFRAL Gene

Proteomics data for GFRAL Gene at MOPED

Post-translational modifications for GFRAL Gene

  • Glycosylation at Asn 23, Asn 50, Asn 62, Asn 67, Asn 103, and Asn 116

Other Protein References for GFRAL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GFRAL Gene

Domains & Families for GFRAL Gene

Protein Domains for GFRAL Gene


Suggested Antigen Peptide Sequences for GFRAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDNFR family.
  • Belongs to the GDNFR family.
genes like me logo Genes that share domains with GFRAL: view

No data available for Gene Families for GFRAL Gene

Function for GFRAL Gene

Phenotypes for GFRAL Gene

genes like me logo Genes that share phenotypes with GFRAL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GFRAL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GFRAL Gene

Localization for GFRAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFRAL Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GFRAL Gene COMPARTMENTS Subcellular localization image for GFRAL gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GFRAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with GFRAL: view

Pathways & Interactions for GFRAL Gene

SuperPathways for GFRAL Gene

No Data Available

Interacting Proteins for GFRAL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000343636 for GFRAL Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GFRAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043524 negative regulation of neuron apoptotic process IEA --
genes like me logo Genes that share ontologies with GFRAL: view

No data available for Pathways by source and SIGNOR curated interactions for GFRAL Gene

Drugs & Compounds for GFRAL Gene

No Compound Related Data Available

Transcripts for GFRAL Gene

mRNA/cDNA for GFRAL Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GFRAL Gene

No ASD Table

Relevant External Links for GFRAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GFRAL Gene

mRNA expression in normal human tissues for GFRAL Gene

mRNA differential expression in normal tissues according to GTEx for GFRAL Gene

This gene is overexpressed in Adipose - Subcutaneous (x14.8), Testis (x6.1), Breast - Mammary Tissue (x5.7), and Brain - Cerebellar Hemisphere (x4.1).

SOURCE GeneReport for Unigene cluster for GFRAL Gene Hs.526967

genes like me logo Genes that share expression patterns with GFRAL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GFRAL Gene

Orthologs for GFRAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for GFRAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GFRAL 35
  • 83.02 (n)
  • 77.21 (a)
  • 75 (a)
(Canis familiaris)
Mammalia GFRAL 35
  • 88.18 (n)
  • 80.87 (a)
  • 81 (a)
(Mus musculus)
Mammalia Gfral 35
  • 81.17 (n)
  • 71.76 (a)
Gfral 16
Gfral 36
  • 70 (a)
(Pan troglodytes)
Mammalia GFRAL 35
  • 99.41 (n)
  • 98.98 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Gfral 35
  • 79.98 (n)
  • 70.88 (a)
(Monodelphis domestica)
Mammalia GFRAL 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia GFRAL 36
  • 58 (a)
(Gallus gallus)
Aves GFRAL 35
  • 61.33 (n)
  • 47.33 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia GFRAL 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gfral 35
  • 54.06 (n)
  • 43.12 (a)
(Danio rerio)
Actinopterygii GFRAL 36
  • 21 (a)
Species with no ortholog for GFRAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFRAL Gene

Gene Tree for GFRAL (if available)
Gene Tree for GFRAL (if available)

Paralogs for GFRAL Gene

No data available for Paralogs for GFRAL Gene

Variants for GFRAL Gene

Sequence variations from dbSNP and Humsavar for GFRAL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036234 A breast cancer sample
rs12199003 - 55,331,789(+) GCTTA(C/T)GTGAT reference, missense
rs9370418 - 55,401,827(+) CTTCA(C/T)CGATC reference, missense
rs1007968 -- 55,330,098(-) GTTAC(A/G)CAAGT intron-variant
rs1032767 -- 55,350,281(-) TTTTG(C/T)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GFRAL Gene

Variant ID Type Subtype PubMed ID
dgv6849n71 CNV Gain 21882294
nsv470819 CNV Gain 18288195
nsv462948 CNV Gain 19166990
nsv5311 CNV Loss 18451855

Variation tolerance for GFRAL Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GFRAL Gene

Disorders for GFRAL Gene

Relevant External Links for GFRAL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GFRAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFRAL Gene

Publications for GFRAL Gene

  1. Identification, expression and functional characterization of the GRAL gene. (PMID: 16086688) Li Z. … Zhou J. (J. Neurochem. 2005) 2 3 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3

Products for GFRAL Gene

Sources for GFRAL Gene