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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GFRA4 Gene

protein-coding   GIFtS: 51
GCID: GC20M003587

GDNF Family Receptor Alpha 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GDNF Family Receptor Alpha 41 2     GDNF Receptor Alpha-42 3
Persephin Receptor1 2 3     GDNF Family Receptor Alpha-42
GDNFR-alpha-42 3     GFR Receptor Alpha 42
GFR-alpha-42 3     

External Ids:    HGNC: 138211   Entrez Gene: 640962   Ensembl: ENSG000001258617   UniProtKB: Q9GZZ73   

Export aliases for GFRA4 gene to outside databases

Previous GC identifers: GC20M003627 GC20M003634


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GFRA4 Gene:
The protein encoded by this gene is a member of the GDNF receptor family. It is a
glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET
tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GFRA4 Gene: 
GFRA4 (GDNF family receptor alpha 4) is a protein-coding gene. Diseases associated with GFRA4 include multiple endocrine neoplasia, and hirschsprung's disease, and among its related super-pathways are Development EGFR signaling pathway and Axon guidance. GO annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA3.

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET
receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GFRA4 gene promoter:
         NRSF form 1   STAT5A   NRSF form 2   LCR-F1   Egr-4   E47   C/EBPalpha   CHOP-10   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGFRA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GFRA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFRA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13-p12   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13-p12

GFRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFRA4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003587:  view genomic region     (about GC identifiers)

Start:
3,639,939 bp from pter      End:
3,644,046 bp from pter
Size:
4,108 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7 (See protein sequence)
Recommended Name: GDNF family receptor alpha-4 precursor  
Size: 299 amino acids; 31670 Da
Subcellular location: Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor
Subcellular location: Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor
Subcellular location: Isoform GFRalpha4c: Secreted
Secondary accessions: Q5JT74 Q9H191 Q9H192
Alternative splicing: 3 isoforms:  Q9GZZ7-1   Q9GZZ7-2   Q9GZZ7-3   

Explore the universe of human proteins at neXtProt for GFRA4: NX_Q9GZZ7

Explore proteomics data for GFRA4 at MOPED 

GFRA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

GFRA4 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_071422.1  NP_665705.1  

ENSEMBL proteins: 
 ENSP00000290417   ENSP00000313423   ENSP00000435801  
Reactome Protein details: Q9GZZ7
Human Recombinant Protein Products for GFRA4: 
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Novus Biologicals GFRA4 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0005886plasma membrane IEA--
GO:0031225anchored to membrane IEA--

GFRA4 for ontologies           About GeneDecksing



GFRA4 Antibody Products: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IUPHAR Guide to PHARMACOLOGY protein family classification: GDNF family receptor α4 
GDNF receptor family

2 InterPro protein domains:
 IPR016017 GDNF/GAS1
 IPR003438 GDNF_rcpt

Graphical View of Domain Structure for InterPro Entry Q9GZZ7

ProtoNet protein and cluster: Q9GZZ7

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Similarity: Belongs to the GDNFR family


GFRA4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: GFRA4_HUMAN, Q9GZZ7
Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET
receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016167glial cell-derived neurotrophic factor receptor activity IEA--
     
GFRA4 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for GFRA4:
 Decreased Salmonella enterica   Increased cell number in G2M,   Increased gamma-H2AX phosphory 

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gfra4):
 endocrine/exocrine gland  skeleton 

GFRA4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Gfra4tm1Msa for GFRA4

   inGenious Targeting Laboratory - Custom generated mouse model solutions for GFRA4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GFRA4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GFRA4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GFRA4 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GFRA4
1 QIAGEN miScript miRNA Assays for microRNA that regulate GFRA4:
hsa-miR-4314
SwitchGear 3'UTR luciferase reporter plasmidGFRA4 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for GFRA4
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Gene Editing
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Clone
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OriGene clones in human, mouse for GFRA4 (see all 12)
OriGene ORF clones in mouse, rat for GFRA4
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GenScript: all cDNA clones in your preferred vector (see all 2): GFRA4 (NM_022139)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFRA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA4
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                     Customized lentivirus expression plasmids for stable overexpression of GFRA4 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GFRA4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Development EGFR signaling pathway
Development GDNF family signaling0.45
GDNF-Family Ligands and Receptor Interactions0.41
2Axon guidance
Axon guidance0.69
Developmental Biology0.69
3NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth0.62
NCAM1 interactions0.62

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for GFRA4
    Development GDNF family signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GFRA4
    GDNF-Family Ligands and Receptor Interactions

1 GeneGo (Thomson Reuters) Pathway for GFRA4
    Development GDNF family signaling

4        Reactome Pathways for GFRA4
    Developmental Biology
NCAM1 interactions
NCAM signaling for neurite out-growth
Axon guidance



GFRA4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GFRA4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for GFRA4 (Q9GZZ73 ENSP000003134234) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PSPNO605423, ENSP000002458104I2D: score=2 STRING: ENSP00000245810
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030279negative regulation of ossification IEA--
GO:0035860glial cell-derived neurotrophic factor receptor signaling pathway ----

GFRA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GFRA4

Search CenterWatch for drugs/clinical trials and news about GFRA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GFRA4 gene (3 alternative transcripts): 
NM_022139.3  NM_145762.2  NM_145763.1  

Unigene Cluster for GFRA4:

GDNF family receptor alpha 4
Hs.302025
Unigene Representative Sequence: NM_145762
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000290417(uc002win.3 uc002wio.3) ENST00000319242(uc002wip.1)
ENST00000477160
miRNA
Products:
     
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1 QIAGEN miScript miRNA Assays for microRNA that regulate GFRA4:
hsa-miR-4314
SwitchGear 3'UTR luciferase reporter plasmidGFRA4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for GFRA4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GFRA4
Clone
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OriGene clones in human, mouse for GFRA4 (see all 12)
OriGene ORF clones in mouse, rat for GFRA4
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GenScript: all cDNA clones in your preferred vector (see all 2): GFRA4 (NM_022139)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFRA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA4
Sirion Biotech Customized lentivirus for stable overexpression of GFRA4 
                     Customized lentivirus expression plasmids for stable overexpression of GFRA4 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for GFRA4
OriGene qSTAR qPCR primer pairs in human, mouse for GFRA4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GFRA4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GFRA4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFRA4

Additional mRNA sequence: 

AF253318.1 AJ291673.1 AJ291674.1 AJ291675.1 

2 DOTS entries:

DT.91653345  DT.91653343 

7 AceView cDNA sequences:

AJ291675 AJ291673 AJ291674 NM_022139 NM_145763 AF253318 NM_145762 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GFRA4    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1:              -                           
SP2:                                          
SP3:                                          


ECgene alternative splicing isoforms for GFRA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GFRA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGGCAGAGT
GFRA4 Expression
About this image


See GFRA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GFRA4

SOURCE GeneReport for Unigene cluster: Hs.302025

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Tissue specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and
thyroid glands

    SABiosciences Custom PCR Arrays for GFRA4
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for GFRA4 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gfra41 , 5 glial cell line derived neurotrophic factor family more1, 5 80(n)1
79.53(a)1
  2 (63.26 cM)5
145881  NM_020014.21  NP_064398.11 
 1310396325 


ENSEMBL Gene Tree for GFRA4 (if available)
TreeFam Gene Tree for GFRA4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GFRA4 gene
GFRA32  GFRA22  GFRA12  

GFRA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/172 SNPs in GFRA4 are shown (see all 172)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1395388971,2
--3639465(+) AGAAGA/GAGGCA 2 -- ds50010--------
rs61391761,2
C,F,A,H--3639595(+) AAAAAA/G/TTCAAT 2 -- ds500111NS EA WA NA 772
rs1819714901,2
--3639599(+) AATCAA/GTGCTC 2 -- ds50010--------
rs1435780331,2
C--3639688(+) TTATCC/TGAGTA 2 -- ds50010--------
rs1471903791,2
C--3639695(+) AGTACC/TAGTGG 2 -- ds50010--------
rs751458481,2
F--3639713(+) AGAGAC/TGAAAG 2 -- ds50011Minor allele frequency- T:0.01WA 118
rs169888241,2
C,F--3639725(+) AATGAG/AAATCC 2 -- ds50014Minor allele frequency- A:0.02NA EA 258
rs6761411,2
C,F,H--3639771(+) TTCCTT/AAGGTG 2 -- ds500112Minor allele frequency- A:0.06NS EA NA CSA WA 1078
rs1404643101,2
C--3639826(+) CAGGCC/TAGCAG 2 -- ds50010--------
rs1137912341,2
F--3639837(+) GGATAC/TACCCA 2 -- ds50011Minor allele frequency- T:0.50CSA 2

HapMap Linkage Disequilibrium report for GFRA4 (3639939 - 3644046 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for GFRA4:    About this table     
Variant IDTypeSubtypePubMed ID
dgv4521n71CNV Loss21882294
nsv520565CNV Loss19592680
nsv912615CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing GFRA4
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
4 diseases for GFRA4:    About MalaCards
multiple endocrine neoplasia    hirschsprung's disease    thyroiditis    neuronitis


GFRA4 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for GFRA4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
multiple endocrine neoplasia 77.3 1 15592530 (1)

Genetic Association Database (GAD): GFRA4
Human Genome Epidemiology (HuGE) Navigator: GFRA4 (1 document)

Export disorders for GFRA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for GFRA4 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with GFRA4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human glial cell line-derived neurotrophic factor receptor alpha4 is the receptor for persephin and is predomonantly expressed in normal and malignant thyroid medullary cells. (PubMed id 11116144)1, 2, 9 Lindahl M.... Saarma M. (2001)
  2. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (PubMed id 15225646)1, 3 Yang J....Saarma M. (2004)
  3. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. (PubMed id 12624147)1, 4 Borrego S....Eng C. (2003)
  4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  5. Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. (PubMed id 10958791)1, 3 Masure S....Gordon R.D. (2000)
  6. hGFRalpha-4: a new member of the GDNF receptor family and a candidate for NBIA. (PubMed id 11551746)1 Zhou B....Gitschier J.M. (2001)
  7. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. (PubMed id 9740802)1 Enokido Y....Davies A.M. (1998)
  8. A model for GFR alpha 4 function and a potential modifying role in multiple endocrine neoplasia 2. (PubMed id 15592530)9 Vanhorne J.B....Mulligan L.M. (2005)
  9. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. (PubMed id 9576965)9 Baloh R.H.... Milbrandt J. (1998)
  10. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. (PubMed id 15896320)9 Vourc'h P....Chesselet M.F. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 64096 HGNC: 13821 AceView: GFRA4 Ensembl:ENSG00000125861 euGenes: HUgn64096
ECgene: GFRA4 H-InvDB: GFRA4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for GFRA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for GFRA4 gene:
Search GeneIP for patents involving GFRA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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