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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GFRA4 Gene

protein-coding   GIFtS: 51
GCID: GC20M003587

GDNF family receptor alpha 4

 Explore 6 diseases affiliated with
GFRA4 via our new
 Human Malady Compendium 
Biological research products
for GFRA4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
GDNF Family Receptor Alpha 41 2     GDNF Receptor Alpha-42 3
Persephin Receptor2 3     GDNF Family Receptor Alpha-42
GDNFR-Alpha-41     GFR Receptor Alpha 42
GFR-Alpha-41     

External Ids:    HGNC: 138211   Entrez Gene: 640962   Ensembl: ENSG000001258617   UniProtKB: Q9GZZ73   

Export aliases for GFRA4 gene to outside databases

Previous GC identifers: GC20M003627 GC20M003634


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GFRA4:
The protein encoded by this gene is a member of the GDNF receptor family. It is a
glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET
tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May
be important in C-cell development and, in the postnatal development of the adrenal medulla




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GFRA4 gene promoter:
         NRSF form 1   STAT5A   NRSF form 2   LCR-F1   Egr-4   E47   C/EBPalpha   CHOP-10   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGFRA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GFRA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFRA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13-p12   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13-p12

GFRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFRA4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003587:  view genomic region     (about GC identifiers)

Start:
3,639,939 bp from pter      End:
3,644,046 bp from pter
Size:
4,108 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7 (See protein sequence)
Recommended Name: GDNF family receptor alpha-4 precursor  
Size: 299 amino acids; 31670 Da
Subcellular location: Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor
Subcellular location: Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor
Subcellular location: Isoform GFRalpha4c: Secreted
Secondary accessions: Q5JT74 Q9H191 Q9H192
Alternative splicing: 3 isoforms:  Q9GZZ7-1   Q9GZZ7-2   Q9GZZ7-3   

Explore the universe of human proteins at neXtProt for GFRA4: NX_Q9GZZ7

GFRA4 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_071422.1  NP_665705.1  

ENSEMBL proteins: 
 ENSP00000290417   ENSP00000313423   ENSP00000435801  
Reactome Protein details: Q9GZZ7
Human Recombinant Protein Products: 
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Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--
GO:0005886plasma membrane IEA--
GO:0031225anchored to membrane IEA--


GFRA4 for ontologies           About GeneDecksing



GFRA4 Antibody Products: 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GFRA4 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR016017 GDNF/GAS1
 IPR003438 GDNF_rcpt

Graphical View of Domain Structure for InterPro Entry Q9GZZ7

ProtoNet protein and cluster: Q9GZZ7

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Similarity: Belongs to the GDNFR family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May
be important in C-cell development and, in the postnatal development of the adrenal medulla

miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GFRA4
1 QIAGEN miScript miRNA Assays for microRNA that regulate GFRA4:
hsa-miR-4314
SwitchGear 3'UTR luciferase reporter plasmidGFRA4 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GFRA4 (see all 7)
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OriGene siRNA: GFRA4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GFRA4

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004872receptor activity ----
GO:0016167glial cell-derived neurotrophic factor receptor activity IEA--


GFRA4 for ontologies           About GeneDecksing


3 GenomeRNAi human phenotypes for GFRA4:
 Decreased Salmonella enterica   Increased cell number in G2M,   Increased gamma-H2AX phosphory 

Animal Models:
     Mouse knock-out Gfra4tm1Msa for GFRA4
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gfra4):
 endocrine/exocrine gland  skeleton 

GFRA4 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Development EGFR signaling pathway
Development GDNF family signaling0.45
GDNF-Family Ligands and Receptor Interactions0.21
Development_GDNF family signaling0.45
2NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth1.00
NCAM1 interactions0.62
3Axon guidance
Axon guidance1.00
Developmental Biology0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GFRA4
    Development GDNF family signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GFRA4
    GDNF-Family Ligands and Receptor Interactions

1 GeneGo (Thomson Reuters) Pathway for GFRA4
    Development GDNF family signaling

4        Reactome Pathways for GFRA4
    Developmental Biology
NCAM1 interactions
NCAM signaling for neurite out-growth
Axon guidance



GFRA4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GFRA4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for GFRA4 (Q9GZZ73 ENSP000003134234) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PSPNO605423, ENSP000002458104I2D: score=2 STRING: ENSP00000245810
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030279negative regulation of ossification IEA--


GFRA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GFRA4
Search CenterWatch for drugs/clinical trials and news about GFRA4 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GFRA4 gene (3 alternative transcripts): 
NM_022139.3  NM_145762.2  NM_145763.1  

Unigene Cluster for GFRA4:

GDNF family receptor alpha 4
Hs.302025
Unigene Representative Sequence: NM_145762
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000290417(uc002win.3 uc002wio.3) ENST00000319242(uc002wip.1)
ENST00000477160

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GFRA4
1 QIAGEN miScript miRNA Assays for microRNA that regulate GFRA4:
hsa-miR-4314
SwitchGear 3'UTR luciferase reporter plasmidGFRA4 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GFRA4 (see all 2)
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GenScript: all cDNA clones in your preferred vector (see all 2): GFRA4 (NM_022139)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFRA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA4 
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GFRA4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GFRA4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GFRA4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFRA4

Additional cDNA sequence: 

AF253318.1 AJ291673.1 AJ291674.1 AJ291675.1 

2 DOTS entries:

DT.91653345  DT.91653343 

7 AceView cDNA sequences:

AJ291675 AJ291673 AJ291674 NM_145763 AF253318 NM_145762 NM_022139 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GFRA4    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1:              -                           
SP2:                                          
SP3:                                          


ECgene alternative splicing isoforms for GFRA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GFRA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCAGAGT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See GFRA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GFRA4

SOURCE GeneReport for Unigene cluster: Hs.302025

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Tissue specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and
thyroid glands

    SABiosciences Custom PCR Arrays for GFRA4
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFRA4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for GFRA4 gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves GFRA46
GFR receptor alpha 4
25(a)
1 ↔ 1
4(92869509-92940953)
lizard
(Anolis carolinensis)
Reptilia GFRA46
--
29(a)
1 ↔ 1
GL343301.1(570761-651422)
zebrafish
(Danio rerio)
Actinopterygii BX247898.16
gfra46
GDNF family receptor alpha 4
25(a)
24(a)
1 ↔ many
1 ↔ many
14(23594934-23711736)
13(14052306-14348537)


ENSEMBL Gene Tree for GFRA4 (if available)
TreeFam Gene Tree for GFRA4 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for GFRA4 gene
GFRA32  GFRA22  GFRAL2  GFRA12  
1 SIMAP similar gene for GFRA4 using alignment to 1 protein entry:     GFRA4_HUMAN:
GFRA2

GFRA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/142 NCBI SNPs in GFRA4 are shown (see all 142    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1395388971,2
--3639465(+) AGAAGA/GAGGCA 2 -- ds50010--------
rs61391761,2
C,F,A,H,--3639595(+) AAAAAA/G/TTCAAT 2 -- ds500111NS EA WA NA 772
rs1819714901,2
--3639599(+) AATCAA/GTGCTC 2 -- ds50010--------
rs1435780331,2
--3639688(+) TTATCC/TGAGTA 2 -- ds50010--------
rs1471903791,2
--3639695(+) AGTACC/TAGTGG 2 -- ds50010--------
rs751458481,2
--3639713(+) AGAGAC/TGAAAG 2 -- ds50011Minor allele frequency- T:0.01WA 118
rs169888241,2
C,F,--3639725(+) AATGAG/AAATCC 2 -- ds50014Minor allele frequency- A:0.02NA EA 258
rs6761411,2
C,F,H,--3639771(+) TTCCTT/AAGGTG 2 -- ds500112Minor allele frequency- A:0.06NS EA NA CSA WA 1078
rs1404643101,2
--3639826(+) CAGGCC/TAGCAG 2 -- ds50010--------
rs1137912341,2
--3639837(+) GGATAC/TACCCA 2 -- ds50011Minor allele frequency- T:0.50CSA 2

HapMap Linkage Disequilibrium report for GFRA4 (3639939 - 3644046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for GFRA4: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GFRA4
DNA2.0 Custom Variant and Variant Library Synthesis for GFRA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GFRA4 for disorders           About GeneDecksing

6 diseases for GFRA4:    About MalaCards
multiple endocrine neoplasia    hirschsprung's disease    thyroid carcinoma    thyroiditis
carcinoma    neuronitis

1 Novoseek disease relationship for GFRA4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
multiple endocrine neoplasia 77.3 1 15592530 (1)

Genetic Association Database (GAD): GFRA4
Human Genome Epidemiology (HuGE) Navigator: GFRA4 (1 document)

Export disorders for GFRA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for GFRA4 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with GFRA4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human glial cell line-derived neurotrophic factor receptor alpha4 is the receptor for persephin and is predomonantly expressed in normal and malignant thyroid medullary cells. (PubMed id 11116144)1, 2, 9 Lindahl M.... Saarma M. (2001)
  2. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (PubMed id 15225646)1, 3 Yang J....Saarma M. (2004)
  3. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. (PubMed id 12624147)1, 4 Borrego S....Eng C. (2003)
  4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  5. Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. (PubMed id 10958791)1, 3 Masure S....Gordon R.D. (2000)
  6. hGFRalpha-4: a new member of the GDNF receptor family and a candidate for NBIA. (PubMed id 11551746)1 Zhou B....Gitschier J.M. (2001)
  7. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. (PubMed id 9740802)1 Enokido Y....Davies A.M. (1998)
  8. A model for GFR alpha 4 function and a potential modifying role in multiple endocrine neoplasia 2. (PubMed id 15592530)9 Vanhorne J.B....Mulligan L.M. (2005)
  9. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. (PubMed id 9576965)9 Baloh R.H.... Milbrandt J. (1998)
  10. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. (PubMed id 15896320)9 Vourc'h P....Chesselet M.F. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 64096 HGNC: 13821 AceView: GFRA4 Ensembl:ENSG00000125861 euGenes: HUgn64096
ECgene: GFRA4 H-InvDB: GFRA4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for GFRA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for GFRA4 gene:
Search GeneIP for patents involving GFRA4

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