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Aliases for GFRA4 Gene

Aliases for GFRA4 Gene

  • GDNF Family Receptor Alpha 4 2 3 5
  • Persephin Receptor 2 3 4
  • GDNF Receptor Alpha-4 3 4
  • GDNFR-Alpha-4 3 4
  • GFR-Alpha-4 3 4
  • GFR Receptor Alpha 4 3

External Ids for GFRA4 Gene

Previous GeneCards Identifiers for GFRA4 Gene

  • GC20M003627
  • GC20M003634

Summaries for GFRA4 Gene

Entrez Gene Summary for GFRA4 Gene

  • The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GFRA4 Gene

GFRA4 (GDNF Family Receptor Alpha 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA1.

UniProtKB/Swiss-Prot for GFRA4 Gene

  • Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFRA4 Gene

Genomics for GFRA4 Gene

Regulatory Elements for GFRA4 Gene

Genomic Location for GFRA4 Gene

3,659,292 bp from pter
3,663,399 bp from pter
4,108 bases
Minus strand

Genomic View for GFRA4 Gene

Genes around GFRA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFRA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFRA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFRA4 Gene

Proteins for GFRA4 Gene

  • Protein details for GFRA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GDNF family receptor alpha-4
    Protein Accession:
    Secondary Accessions:
    • Q5JT74
    • Q9H191
    • Q9H192

    Protein attributes for GFRA4 Gene

    299 amino acids
    Molecular mass:
    31670 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GFRA4 Gene


neXtProt entry for GFRA4 Gene

Proteomics data for GFRA4 Gene at MOPED

Post-translational modifications for GFRA4 Gene

Other Protein References for GFRA4 Gene

Antibody Products

  • R&D Systems Antibodies for GFRA4 (GFR alpha-4/GDNF R alpha-4)

No data available for DME Specific Peptides for GFRA4 Gene

Domains & Families for GFRA4 Gene

Gene Families for GFRA4 Gene

Protein Domains for GFRA4 Gene


Suggested Antigen Peptide Sequences for GFRA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDNFR family.
  • Belongs to the GDNFR family.
genes like me logo Genes that share domains with GFRA4: view

Function for GFRA4 Gene

Molecular function for GFRA4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

Gene Ontology (GO) - Molecular Function for GFRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016167 glial cell-derived neurotrophic factor receptor activity IEA --
genes like me logo Genes that share ontologies with GFRA4: view
genes like me logo Genes that share phenotypes with GFRA4: view

Animal Models for GFRA4 Gene

MGI Knock Outs for GFRA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for GFRA4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GFRA4 Gene

Localization for GFRA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFRA4 Gene

Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform GFRalpha4c: Secreted.

Subcellular locations from

Jensen Localization Image for GFRA4 Gene COMPARTMENTS Subcellular localization image for GFRA4 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GFRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005622 intracellular TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GFRA4: view

Pathways & Interactions for GFRA4 Gene

SuperPathways for GFRA4 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 GDNF-Family Ligands and Receptor Interactions
genes like me logo Genes that share pathways with GFRA4: view

Pathways by source for GFRA4 Gene

1 GeneGo (Thomson Reuters) pathway for GFRA4 Gene
1 Qiagen pathway for GFRA4 Gene

Interacting Proteins for GFRA4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9GZZ7-GFRA4_HUMAN ENSP00000313423 for GFRA4 Gene via I2D STRING

SIGNOR curated interactions for GFRA4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GFRA4 Gene


Drugs & Compounds for GFRA4 Gene

No Compound Related Data Available

Transcripts for GFRA4 Gene

mRNA/cDNA for GFRA4 Gene

(4) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFRA4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: -

Relevant External Links for GFRA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GFRA4 Gene

mRNA expression in normal human tissues for GFRA4 Gene

mRNA differential expression in normal tissues according to GTEx for GFRA4 Gene

This gene is overexpressed in Thyroid (x9.6), Brain - Amygdala (x7.7), Brain - Hippocampus (x7.5), and Testis (x4.9).

SOURCE GeneReport for Unigene cluster for GFRA4 Gene Hs.302025

mRNA Expression by UniProt/SwissProt for GFRA4 Gene

Tissue specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
genes like me logo Genes that share expression patterns with GFRA4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GFRA4 Gene

Orthologs for GFRA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GFRA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GFRA4 35
  • 83.55 (n)
  • 79.22 (a)
GFRA4 36
  • 70 (a)
(Canis familiaris)
Mammalia GFRA4 35
  • 86.88 (n)
  • 83.46 (a)
GFRA4 36
  • 69 (a)
(Mus musculus)
Mammalia Gfra4 35
  • 80 (n)
  • 79.53 (a)
Gfra4 16
Gfra4 36
  • 56 (a)
(Pan troglodytes)
Mammalia GFRA4 35
  • 97.04 (n)
  • 94.98 (a)
GFRA4 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Gfra4 35
  • 78.02 (n)
  • 75.55 (a)
(Monodelphis domestica)
Mammalia GFRA4 36
  • 34 (a)
(Gallus gallus)
Aves GFRA4 36
  • 27 (a)
(Anolis carolinensis)
Reptilia GFRA4 36
  • 26 (a)
(Danio rerio)
Actinopterygii BX247898.1 36
  • 26 (a)
gfra4 36
  • 25 (a)
Species with no ortholog for GFRA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFRA4 Gene

Gene Tree for GFRA4 (if available)
Gene Tree for GFRA4 (if available)

Paralogs for GFRA4 Gene

Paralogs for GFRA4 Gene

genes like me logo Genes that share paralogs with GFRA4: view

Variants for GFRA4 Gene

Sequence variations from dbSNP and Humsavar for GFRA4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs492370 -- 3,659,289(+) GTTAT(G/T)CCTAC downstream-variant-500B
rs492497 -- 3,659,333(+) GGCAA(A/T)TGCCA utr-variant-3-prime
rs601957 -- 3,663,466(+) TAGTG(C/T)CTCTG upstream-variant-2KB
rs616749 -- 3,661,999(+) GGATT(C/T)ATGCA intron-variant
rs618162 -- 3,662,322(+) CAAAA(A/C)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GFRA4 Gene

Variant ID Type Subtype PubMed ID
nsv520565 CNV Loss 19592680
dgv4521n71 CNV Loss 21882294
nsv912615 CNV Loss 21882294

Variation tolerance for GFRA4 Gene

Gene Damage Index Score: 2.20; 39.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GFRA4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFRA4 Gene

Disorders for GFRA4 Gene

Relevant External Links for GFRA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GFRA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFRA4 Gene

Publications for GFRA4 Gene

  1. Human glial cell line-derived neurotrophic factor receptor alpha4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. (PMID: 11116144) Lindahl M. … Saarma M. (J. Biol. Chem. 2001) 3 4 23 67
  2. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (PMID: 15225646) Yang J. … Saarma M. (FEBS Lett. 2004) 2 3
  3. Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. (PMID: 10958791) Masure S. … Gordon R.D. (J. Biol. Chem. 2000) 2 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. A model for GFR alpha 4 function and a potential modifying role in multiple endocrine neoplasia 2. (PMID: 15592530) Vanhorne J.B. … Mulligan L.M. (Oncogene 2005) 23

Products for GFRA4 Gene

Sources for GFRA4 Gene

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