Aliases for GFRA4 Gene
External Ids for GFRA4 Gene
Previous GeneCards Identifiers for GFRA4 Gene
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GFRA4 Gene
GFRA4 (GDNF Family Receptor Alpha 4) is a Protein Coding gene. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA2.
UniProtKB/Swiss-Prot for GFRA4 Gene
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.