Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GFRA4 Gene

protein-coding   GIFtS: 51
GCID: GC20M003587

GDNF Family Receptor Alpha 4

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
GDNF Family Receptor Alpha 41 2     GDNF Receptor Alpha-42 3
Persephin Receptor1 2 3     GDNF Family Receptor Alpha-42
GDNFR-alpha-42 3     GFR Receptor Alpha 42
GFR-alpha-42 3     

External Ids:    HGNC: 138211   Entrez Gene: 640962   Ensembl: ENSG000001258617   UniProtKB: Q9GZZ73   

Export aliases for GFRA4 gene to outside databases

Previous GC identifers: GC20M003627 GC20M003634


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GFRA4 Gene:
The protein encoded by this gene is a member of the GDNF receptor family. It is a
glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET
tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GFRA4 Gene:
GFRA4 (GDNF family receptor alpha 4) is a protein-coding gene. GO annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA3.

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET
receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GFRA4 gene promoter:
         NRSF form 1   STAT5A   NRSF form 2   LCR-F1   Egr-4   E47   C/EBPalpha   CHOP-10   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGFRA4 promoter sequence
   Search Chromatin IP Primers for GFRA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GFRA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13-p12   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13-p12

GFRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFRA4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003587:  view genomic region     (about GC identifiers)

Start:
3,639,939 bp from pter      End:
3,644,046 bp from pter
Size:
4,108 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7 (See protein sequence)
Recommended Name: GDNF family receptor alpha-4 precursor  
Size: 299 amino acids; 31670 Da
Secondary accessions: Q5JT74 Q9H191 Q9H192
Alternative splicing: 3 isoforms:  Q9GZZ7-1   Q9GZZ7-2   Q9GZZ7-3   

Explore the universe of human proteins at neXtProt for GFRA4: NX_Q9GZZ7

Explore proteomics data for GFRA4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn208

  • See GFRA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_071422.1  NP_665705.1  

    ENSEMBL proteins: 
     ENSP00000290417   ENSP00000313423   ENSP00000435801  
    Reactome Protein details: Q9GZZ7

    GFRA4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GFRA4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GFRA4
    GenScript Custom Purified and Recombinant Proteins Services for GFRA4
    Novus Biologicals GFRA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GFRA4 

     
    antibodies-online proteins for GFRA4 (3 products) 

     
    antibodies-online peptides for GFRA4

    GFRA4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GFRA4 (GFR alpha-4/GDNF R alpha-4)
    OriGene Antibodies for GFRA4
    OriGene Custom Antibody Services for GFRA4
    Novus Biologicals GFRA4 Antibodies
    Abcam antibodies for GFRA4
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for GFRA4
    LSBio Antibodies in human, mouse, rat for GFRA4
    antibodies-online antibodies for GFRA4 (41 products) 

    GFRA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GFRA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GFRA4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GFRA4 
    antibodies-online kits for GFRA4 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: GDNF family receptor alpha4
    GDNF receptor family

    2 InterPro protein domains:
     IPR016017 GDNF/GAS1
     IPR003438 GDNF_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9GZZ7

    ProtoNet protein and cluster: Q9GZZ7

    UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
    Similarity: Belongs to the GDNFR family


    Find genes that share domains with GFRA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GFRA4_HUMAN, Q9GZZ7
    Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET
    receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016167glial cell-derived neurotrophic factor receptor activity IEA--
         
    Find genes that share ontologies with GFRA4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GFRA4:
     Decreased Salmonella enterica   Increased cell number in G2M,   Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gfra4):
     endocrine/exocrine gland  skeleton 

    Find genes that share phenotypes with GFRA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gfra4tm1Msa for GFRA4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GFRA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GFRA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GFRA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GFRA4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GFRA4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GFRA4:
    hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidGFRA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GFRA4
    Predesigned siRNA for gene silencing in human, mouse, rat GFRA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GFRA4

    Clone
    Products:
         
    OriGene clones in human, mouse for GFRA4 (see all 11)
    OriGene ORF clones in mouse, rat for GFRA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GFRA4 (NM_022139)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFRA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GFRA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for GFRA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GFRA4_HUMAN, Q9GZZ7: Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GPI-anchor
    GFRA4_HUMAN, Q9GZZ7: Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor
    GFRA4_HUMAN, Q9GZZ7: Isoform GFRalpha4c: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with GFRA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GFRA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    Development GDNF family signaling0.45
    GDNF-Family Ligands and Receptor Interactions0.41
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3NCAM signaling for neurite out-growth
    NCAM1 interactions0.59
    NCAM signaling for neurite out-growth0.59


    Find genes that share SuperPaths with GFRA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GFRA4
        GDNF-Family Ligands and Receptor Interactions

    1 GeneGo (Thomson Reuters) Pathway for GFRA4
        Development GDNF family signaling

    1 Reactome Pathway for GFRA4
        NCAM1 interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GFRA4
    Interactions:

        Search GeneGlobe Interaction Network for GFRA4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for GFRA4 (Q9GZZ73 ENSP000003134234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSPNO605423, ENSP000002458104I2D: score=2 STRING: ENSP00000245810
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030279negative regulation of ossification IEA--
    GO:0035860glial cell-derived neurotrophic factor receptor signaling pathway ----

    Find genes that share ontologies with GFRA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GFRA4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GFRA4 gene (3 alternative transcripts): 
    NM_022139.3  NM_145762.2  NM_145763.1  

    Unigene Cluster for GFRA4:

    GDNF family receptor alpha 4
    Hs.302025
    Unigene Representative Sequence: NM_145762
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290417(uc002win.3 uc002wio.3) ENST00000319242(uc002wip.1)
    ENST00000477160
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GFRA4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GFRA4:
    hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidGFRA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GFRA4
    Predesigned siRNA for gene silencing in human, mouse, rat GFRA4
    Clone
    Products:
         
    OriGene clones in human, mouse for GFRA4 (see all 11)
    OriGene ORF clones in mouse, rat for GFRA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GFRA4 (NM_022139)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFRA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GFRA4
    OriGene qSTAR qPCR primer pairs in human, mouse for GFRA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GFRA4
      QuantiTect SYBR Green Assays in human, mouse, rat GFRA4
      QuantiFast Probe-based Assays in human, mouse, rat GFRA4

    Additional mRNA sequence: 

    AF253318.1 AJ291673.1 AJ291674.1 AJ291675.1 

    2 DOTS entries:

    DT.91653345  DT.91653343 

    7 AceView cDNA sequences:

    AJ291673 AJ291675 AJ291674 NM_145763 NM_145762 NM_022139 AF253318 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GFRA4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:              -                           
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for GFRA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GFRA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCAGAGT
    GFRA4 Expression
    About this image

    GFRA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GFRA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302025

    UniProtKB/Swiss-Prot: GFRA4_HUMAN, Q9GZZ7
    Tissue specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and
    thyroid glands

        Custom PCR Arrays for GFRA4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GFRA4
    OriGene qSTAR qPCR primer pairs in human, mouse for GFRA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GFRA4
    QuantiTect SYBR Green Assays in human, mouse, rat GFRA4
    QuantiFast Probe-based Assays in human, mouse, rat GFRA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GFRA4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gfra41 , 5 glial cell line derived neurotrophic factor family more1, 5 80(n)1
    79.53(a)1
      2 (63.26 cM)5
    145881  NM_020014.21  NP_064398.11 
     1310396325 
    chicken
    (Gallus gallus)
    Aves GFRA46
    Gallus gallus GDNF family receptor alpha 4 (GFRA4)...
    27(a)
    1 ↔ 1
    4(88844984-88914622)
    lizard
    (Anolis carolinensis)
    Reptilia GFRA46
    GDNF family receptor alpha 4
    26(a)
    1 ↔ 1
    GL343301.1(455492-663636)
    zebrafish
    (Danio rerio)
    Actinopterygii BX247898.16
    gfra46
    GDNF family receptor alpha 4
    26(a)
    25(a)
    1 ↔ many
    1 ↔ many
    14(23594934-23711736) ENSDARG00000074582
    13(14052306-14348537) ENSDARG00000056651


    ENSEMBL Gene Tree for GFRA4 (if available)
    TreeFam Gene Tree for GFRA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GFRA4 gene
    GFRA32  GFRA22  GFRA12  

    Find genes that share paralogs with GFRA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GFRA4 (see all 172)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395388971,2
    --3639465(+) AGAAGA/GAGGCA 2 -- ds50010--------
    rs61391761,2
    C,F,A,H--3639595(+) AAAAAA/G/TTCAAT 2 -- ds500111NS EA WA NA 772
    rs1819714901,2
    --3639599(+) AATCAA/GTGCTC 2 -- ds50010--------
    rs1435780331,2
    C--3639688(+) TTATCC/TGAGTA 2 -- ds50010--------
    rs1471903791,2
    C--3639695(+) AGTACC/TAGTGG 2 -- ds50010--------
    rs751458481,2
    F--3639713(+) AGAGAC/TGAAAG 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs169888241,2
    C,F--3639725(+) AATGAG/AAATCC 2 -- ds50014Minor allele frequency- A:0.02NA EA 258
    rs6761411,2
    C,F,H--3639771(+) TTCCTT/AAGGTG 2 -- ds500112Minor allele frequency- A:0.06NS EA NA CSA WA 1078
    rs1404643101,2
    C--3639826(+) CAGGCC/TAGCAG 2 -- ds50010--------
    rs1137912341,2
    F--3639837(+) GGATAC/TACCCA 2 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for GFRA4 (3639939 - 3644046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GFRA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4521n71CNV Loss21882294
    nsv520565CNV Loss19592680
    nsv912615CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GFRA4
    DNA2.0 Custom Variant and Variant Library Synthesis for GFRA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with GFRA4           About GenesLikeMe

    1 Novoseek inferred disease relationship for GFRA4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple endocrine neoplasia 77.3 1 15592530 (1)

    Genetic Association Database (GAD): GFRA4
    Human Genome Epidemiology (HuGE) Navigator: GFRA4 (1 document)

    Export disorders for GFRA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GFRA4 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with GFRA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human glial cell line-derived neurotrophic factor receptor alpha4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. (PubMed id 11116144)1, 2, 9 Lindahl M.... Saarma M. (J. Biol. Chem. 2001)
    2. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (PubMed id 15225646)1, 3 Yang J....Saarma M. (FEBS Lett. 2004)
    3. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. (PubMed id 12624147)1, 4 Borrego S....Eng C. (J. Med. Genet. 2003)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. (PubMed id 10958791)1, 3 Masure S....Gordon R.D. (J. Biol. Chem. 2000)
    6. hGFRalpha-4: a new member of the GDNF receptor family and a candidate for NBIA. (PubMed id 11551746)1 Zhou B....Gitschier J.M. (Pediatr. Neurol. 2001)
    7. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. (PubMed id 9740802)1 Enokido Y....Davies A.M. (Curr. Biol. 1998)
    8. A model for GFR alpha 4 function and a potential modifying role in multiple endocrine neoplasia 2. (PubMed id 15592530)9 Vanhorne J.B....Mulligan L.M. (Oncogene 2005)
    9. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. (PubMed id 9576965)9 Baloh R.H.... Milbrandt J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    10. Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. (PubMed id 15896320)9 Vourc'h P....Chesselet M.F. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64096 HGNC: 13821 AceView: GFRA4 Ensembl:ENSG00000125861 euGenes: HUgn64096
    ECgene: GFRA4 H-InvDB: GFRA4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GFRA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GFRA4 gene:
    Search GeneIP for patents involving GFRA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for GFRA4 (GFR alpha-4/GDNF R alpha-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GFRA4   OriGene RNAi products in human, mouse, rat for GFRA4  
     OriGene qPCR primer pairs and template standards for GFRA4   OriGene Protein Over-expression Lysate for GFRA4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GFRA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for GFRA4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GFRA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GFRA4   OriGene Custom Protein Services for GFRA4  

     
     
     Block miRNA regulation of human, mouse, rat GFRA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GFRA4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GFRA4 Predesigned siRNA for gene silencing in human, mouse, rat GFRA4
     QuantiFast Probe-based Assays in human, mouse, rat GFRA4 QuantiTect SYBR Green Assays in human, mouse, rat GFRA4
     Custom PCR Arrays for GFRA4 Search Chromatin IP Primers for GFRA4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GFRA4  Search GeneGlobe Interaction Network for GFRA4
     Regulatory tfbs in GFRA4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GFRA4 GenScript cDNA clones with any tag delivered in your preferred vector for GFRA4
     GenScript Custom Assay Services for GFRA4 GenScript Custom overexpressing Cell Line Services for GFRA4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GFRA4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GFRA4 antibodies
     GFRA4 lysates
     Antibodies for GFRA4
     See all of Abcam's Antibodies, Kits and Proteins for GFRA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GFRA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA4
     SwitchGear 3'UTR luciferase reporter plasmids for GFRA4
     SwitchGear Promoter luciferase reporter plasmids for GFRA4
     Search ThermoFisher Antibodies for GFRA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GFRA4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GFRA4
     LSBio Antibodies in human, mouse, rat for GFRA4
     Browse compounds at ApexBio
     Search Addgene for plasmids for GFRA4
      Search eBioscience for proteins for GFRA4
      Search eBioscience for elisas for GFRA4
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for GFRA4 (41 products)
     antibodies-online kits for GFRA4 (8 products)
     antibodies-online peptides for GFRA4
     antibodies-online proteins for GFRA4 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GFRA4 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4