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Aliases for GFRA3 Gene

Aliases for GFRA3 Gene

  • GDNF Family Receptor Alpha 3 2 3 5
  • GDNF Receptor Alpha-3 3 4
  • GDNFR-Alpha-3 3 4
  • GFR-Alpha-3 3 4
  • Glial Cell Line-Derived Neurotrophic Factor Receptor Alpha-3 3
  • GDNF Family Receptor Alpha-3 3
  • GPI-Linked Receptor 3
  • GDNFR3 3

External Ids for GFRA3 Gene

Previous GeneCards Identifiers for GFRA3 Gene

  • GC05M137463
  • GC05M137618
  • GC05M137665
  • GC05M137666
  • GC05M137615
  • GC05M137588
  • GC05M132780

Summaries for GFRA3 Gene

Entrez Gene Summary for GFRA3 Gene

  • The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

GeneCards Summary for GFRA3 Gene

GFRA3 (GDNF Family Receptor Alpha 3) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. GO annotations related to this gene include receptor binding and axon guidance receptor activity. An important paralog of this gene is GFRA1.

UniProtKB/Swiss-Prot for GFRA3 Gene

  • Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.

Gene Wiki entry for GFRA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFRA3 Gene

Genomics for GFRA3 Gene

Regulatory Elements for GFRA3 Gene

Enhancers for GFRA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G138222 1.2 Ensembl ENCODE 16.6 +51.7 51712 0.5 ELF3 TBP FOXA2 CBX3 ARNT ARID4B ZNF48 ZSCAN9 RAD21 RARA GFRA3 BRD8 KIF20A CDC23 GC05M138210
GH05G138350 1.4 ENCODE dbSUPER 9.2 -78.7 -78664 4.7 PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 KDM3B CDC23 FAM53C FAM13B KIF20A BRD8 GFRA3 REEP2 GC05P138377
GH05G138368 1.1 Ensembl ENCODE dbSUPER 9.2 -95.2 -95231 3.8 FOXA2 ATF2 NR2F2 ZNF121 ZNF316 EGR1 FOS EMSY MAFK WT1 FAM53C CDC25C ENSG00000249971 BRD8 KIF20A HSPA9 GFRA3 KDM3B REEP2 GC05P138377
GH05G138330 1.1 ENCODE 8.3 -56.9 -56886 2.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF143 HNRNPA0 KDM3B GFRA3 FAM53C LOC105379194 GC05P138279
GH05G138186 0.8 ENCODE 10.5 +88.4 88405 0.2 HDAC1 ATF1 TBL1XR1 RFX5 ZNF766 GATA2 POLR2A NFYB NR2F6 RELB GFRA3 NME5 BRD8 CDC23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GFRA3 on UCSC Golden Path with GeneCards custom track

Promoters for GFRA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187471 71 400 EGR1 SUZ12 ZBTB33 RBBP5 EZH2

Genomic Location for GFRA3 Gene

Chromosome:
5
Start:
138,252,379 bp from pter
End:
138,274,671 bp from pter
Size:
22,293 bases
Orientation:
Minus strand

Genomic View for GFRA3 Gene

Genes around GFRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFRA3 Gene

Proteins for GFRA3 Gene

  • Protein details for GFRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60609-GFRA3_HUMAN
    Recommended name:
    GDNF family receptor alpha-3
    Protein Accession:
    O60609
    Secondary Accessions:
    • B2RA36
    • B4DMY9
    • Q6UW20
    • Q8IUZ2

    Protein attributes for GFRA3 Gene

    Size:
    400 amino acids
    Molecular mass:
    44511 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GFRA3 Gene

    Alternative splice isoforms for GFRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GFRA3 Gene

Post-translational modifications for GFRA3 Gene

Other Protein References for GFRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GFRA3 (GFR alpha-3/GDNF R alpha-3)

Protein Products

No data available for DME Specific Peptides for GFRA3 Gene

Domains & Families for GFRA3 Gene

Gene Families for GFRA3 Gene

Suggested Antigen Peptide Sequences for GFRA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60609

UniProtKB/Swiss-Prot:

GFRA3_HUMAN :
  • Belongs to the GDNFR family.
Family:
  • Belongs to the GDNFR family.
genes like me logo Genes that share domains with GFRA3: view

Function for GFRA3 Gene

Molecular function for GFRA3 Gene

GENATLAS Biochemistry:
glial cell line-derived neurotrophic factor (GDNF) receptor alpha 3,43/62kDa,predominantly expressed in the cerebellum and spinal cord,also expressed in stomach,colon and several other tissues,not involved in RET signaling
UniProtKB/Swiss-Prot Function:
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.

Gene Ontology (GO) - Molecular Function for GFRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005102 receptor binding TAS 9407096
GO:0008046 axon guidance receptor activity IEA --
genes like me logo Genes that share ontologies with GFRA3: view
genes like me logo Genes that share phenotypes with GFRA3: view

Animal Models for GFRA3 Gene

MGI Knock Outs for GFRA3:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GFRA3 Gene

Localization for GFRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFRA3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFRA3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 3

Gene Ontology (GO) - Cellular Components for GFRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane TAS 9490034
genes like me logo Genes that share ontologies with GFRA3: view

Pathways & Interactions for GFRA3 Gene

SuperPathways for GFRA3 Gene

SuperPathway Contained pathways
1 RET signaling
2 GDNF-Family Ligands and Receptor Interactions
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with GFRA3: view

Pathways by source for GFRA3 Gene

1 GeneGo (Thomson Reuters) pathway for GFRA3 Gene
1 Qiagen pathway for GFRA3 Gene

SIGNOR curated interactions for GFRA3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GFRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001764 neuron migration IEA --
GO:0007165 signal transduction TAS 9490034
GO:0007399 nervous system development TAS 9490034
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with GFRA3: view

Drugs & Compounds for GFRA3 Gene

(1) Drugs for GFRA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GFRA3: view

Transcripts for GFRA3 Gene

mRNA/cDNA for GFRA3 Gene

Unigene Clusters for GFRA3 Gene

GDNF family receptor alpha 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFRA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: - -
SP3:

Relevant External Links for GFRA3 Gene

GeneLoc Exon Structure for
GFRA3
ECgene alternative splicing isoforms for
GFRA3

Expression for GFRA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GFRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GFRA3 Gene

This gene is overexpressed in Nerve - Tibial (x12.2) and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for GFRA3 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GFRA3 Gene



Protein tissue co-expression partners for GFRA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GFRA3 Gene:

GFRA3

SOURCE GeneReport for Unigene cluster for GFRA3 Gene:

Hs.58042

mRNA Expression by UniProt/SwissProt for GFRA3 Gene:

O60609-GFRA3_HUMAN
Tissue specificity: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.

Evidence on tissue expression from TISSUES for GFRA3 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with GFRA3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GFRA3 Gene

Orthologs for GFRA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GFRA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GFRA3 34 35
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia GFRA3 34 35
  • 87.61 (n)
cow
(Bos Taurus)
Mammalia GFRA3 34 35
  • 87.3 (n)
rat
(Rattus norvegicus)
Mammalia Gfra3 34
  • 84.08 (n)
mouse
(Mus musculus)
Mammalia Gfra3 34 16 35
  • 83.99 (n)
oppossum
(Monodelphis domestica)
Mammalia GFRA3 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GFRA3 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GFRA3 35
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gfra3 35
  • 28 (a)
OneToOne
Species where no ortholog for GFRA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFRA3 Gene

ENSEMBL:
Gene Tree for GFRA3 (if available)
TreeFam:
Gene Tree for GFRA3 (if available)

Paralogs for GFRA3 Gene

Paralogs for GFRA3 Gene

(2) SIMAP similar genes for GFRA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GFRA3: view

Variants for GFRA3 Gene

Sequence variations from dbSNP and Humsavar for GFRA3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs193921100 Uncertain significance 138,253,036(-) TGAGG(A/C)CACAG reference, missense
rs1000225033 -- 138,271,165(+) TTTTG(C/T)ATTTT intron-variant
rs1000243771 -- 138,263,428(+) TCACT(C/T)ATTGC intron-variant
rs1000403178 -- 138,267,164(+) ACAGC(C/G)AGCTT intron-variant
rs1000414290 -- 138,267,540(+) GCCAC(C/T)ACGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GFRA3 Gene

Variant ID Type Subtype PubMed ID
dgv3179n106 CNV deletion 24896259
esv2678510 CNV deletion 23128226
esv2730821 CNV deletion 23290073
esv3389910 CNV duplication 20981092
esv3566700 CNV deletion 23714750
nsv1152536 CNV deletion 26484159

Variation tolerance for GFRA3 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GFRA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GFRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFRA3 Gene

Disorders for GFRA3 Gene

Relevant External Links for GFRA3

Genetic Association Database (GAD)
GFRA3
Human Genome Epidemiology (HuGE) Navigator
GFRA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GFRA3

No disorders were found for GFRA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFRA3 Gene

Publications for GFRA3 Gene

  1. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. (PMID: 9576965) Baloh R.H. … Milbrandt J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 22 64
  2. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. (PMID: 9407096) Jing S. … Fox G.M. (J. Biol. Chem. 1997) 2 3 22 64
  3. [Artemin and GFRalpha3 expressions and their relevance to perineural invasiveness and metastasis of pancreatic carcinoma]. (PMID: 19304517) Zhu D.L. … Gao J.M. (Nan Fang Yi Ke Da Xue Xue Bao 2009) 3 22 64
  4. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PMID: 16765900) Wang X. … Garcia K.C. (Structure 2006) 3 4 64
  5. Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues. (PMID: 16773224) Yang C. … Sah D.W. (J. Mol. Histol. 2006) 3 22 64

Products for GFRA3 Gene

Sources for GFRA3 Gene

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