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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GFRA2 Gene

protein-coding   GIFtS: 62
GCID: GC08M021593

GDNF Family Receptor Alpha 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GDNF Family Receptor Alpha 21 2     NRTNR-ALPHA2
GDNFRB2 3 5     NTNRA2
Neurturin Receptor Alpha2 3     GDNF Family Receptor Alpha-22
GDNFR-alpha-22 3     GFR-Alpha 22
GDNFR-beta2 3     Glial Cell Line Derived Neurotrophic Factor Receptor, Beta2
NTNR-alpha2 3     PI-Linked Cell-Surface Accessory Protein2
RETL22 3     TRN Receptor, GPI-Anchored2
TRNR22 3     GFR-alpha-23
GDNF Receptor Beta2 3     NRTNR-alpha3
RET Ligand 22 3     GDNF Receptor Alpha-23
TGF-Beta-Related Neurotrophic Factor Receptor 22 3     

External Ids:    HGNC: 42441   Entrez Gene: 26752   Ensembl: ENSG000001685467   OMIM: 6019565   UniProtKB: O004513   

Export aliases for GFRA2 gene to outside databases

Previous GC identifers: GC08M021338 GC08M021863 GC08M021559 GC08M020092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GFRA2 Gene:
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent
neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein
encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked
cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This
encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family
receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for GFRA2 Gene: 
GFRA2 (GDNF family receptor alpha 2) is a protein-coding gene. Diseases associated with GFRA2 include geniculate ganglionitis, and hirschsprung's disease, and among its related super-pathways are Development EGFR signaling pathway and Axon guidance. GO annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA3.

UniProtKB/Swiss-Prot: GFRA2_HUMAN, O00451
Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET
receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor

Gene Wiki entry for GFRA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GFRA2 gene promoter:
         RP58   Tal-1   MAZR   Olf-1   CUTL1   E47   GATA-2   CREB   MZF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGFRA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GFRA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFRA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

GFRA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFRA2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M021593:  view genomic region     (about GC identifiers)

Start:
21,547,915 bp from pter      End:
21,669,869 bp from pter
Size:
121,955 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GFRA2_HUMAN, O00451 (See protein sequence)
Recommended Name: GDNF family receptor alpha-2 precursor  
Size: 464 amino acids; 51544 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
Secondary accessions: E9PD47 O15316 O15328 Q58J92 Q6GTR9 Q7Z5C2
Alternative splicing: 3 isoforms:  O00451-1   O00451-2   O00451-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GFRA2: NX_O00451

Explore proteomics data for GFRA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00451

  • GFRA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GFRA2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001158510.1  NP_001158511.1  NP_001486.4  

    ENSEMBL proteins: 
     ENSP00000428518   ENSP00000306654   ENSP00000429445   ENSP00000429206   ENSP00000429979  
     ENSP00000428721   ENSP00000430622   ENSP00000383592  
    Reactome Protein details: O00451
    Human Recombinant Protein Products for GFRA2: 
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    Sino Biological Cell Lysate for GFRA2 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0019898extrinsic to membrane TAS10829012
    GO:0031225anchored to membrane IEA--

    GFRA2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: GDNF family receptor α2 
    GDNF receptor family

    4 InterPro protein domains:
     IPR003504 GDNF_rcpt_a2
     IPR016017 GDNF/GAS1
     IPR003438 GDNF_rcpt
     IPR017372 Glial_neurotroph_fac_rcpt_a1/2

    Graphical View of Domain Structure for InterPro Entry O00451

    ProtoNet protein and cluster: O00451

    2 Blocks protein domains:
    IPB003438 Glial cell line-derived neurotrophic factor receptor family signature
    IPB003504 Glial cell line-derived neurotrophic factor receptor alpha 2 signature


    UniProtKB/Swiss-Prot: GFRA2_HUMAN, O00451
    Similarity: Belongs to the GDNFR family


    GFRA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GFRA2_HUMAN, O00451
    Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET
    receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor

         Genatlas biochemistry entry for GFRA2:
    glial cell line-derived neurotrophic factor (GDNF) receptor alpha 2,47kDa,mediating the autophosphorylation of
    RET,abundantly expressed in adult brain,intestine,placenta,fetal brain,lung,kidney,also receptor for neurturin
    and TGF-beta-related neurotrophic factor

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0016167glial cell-derived neurotrophic factor receptor activity TAS10829012
         
    GFRA2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gfra2):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size  homeostasis/metabolism 
     integument  nervous system  vision/eye 

    GFRA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gfra2tm1Msa for GFRA2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GFRA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GFRA2

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    SwitchGear 3'UTR luciferase reporter plasmidGFRA2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GFRA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    Development GDNF family signaling0.45
    GDNF-Family Ligands and Receptor Interactions0.41
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3NCAM signaling for neurite out-growth
    NCAM signaling for neurite out-growth0.62
    NCAM1 interactions0.62
    4TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GFRA2
        Development GDNF family signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GFRA2
        GDNF-Family Ligands and Receptor Interactions

    1 GeneGo (Thomson Reuters) Pathway for GFRA2
        Development GDNF family signaling

    1 Sino Biological Pathway for GFRA2 
        TGF-beta Signaling Pathway

    4        Reactome Pathways for GFRA2
        Developmental Biology
    NCAM1 interactions
    NCAM signaling for neurite out-growth
    Axon guidance



    GFRA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GFRA2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for GFRA2 (O004513 ENSP000003066544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GDNFP399053, ENSP000003171454I2D: score=2 STRING: ENSP00000317145
    NRTNQ997483, ENSP000003026484I2D: score=2 STRING: ENSP00000302648
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS9192898
    GO:0007399nervous system development IEA--
    GO:0035860glial cell-derived neurotrophic factor receptor signaling pathway TAS10829012

    GFRA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GFRA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GFRA2

    2 Novoseek inferred chemical compound relationships for GFRA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 50 12 9192898 (2), 9576965 (1), 10233362 (1), 9614243 (1) (see all 8)
    retinoic acid 8.67 1 15896320 (1)

    Search CenterWatch for drugs/clinical trials and news about GFRA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GFRA2 gene (3 alternative transcripts): 
    NM_001165038.1  NM_001165039.1  NM_001495.4  

    Unigene Cluster for GFRA2:

    GDNF family receptor alpha 2
    Hs.441202  [show with all ESTs]
    Unigene Representative Sequence: BC041688
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524240 ENST00000306793(uc003wzu.1) ENST00000517328 ENST00000518077
    ENST00000517892 ENST00000522071 ENST00000519195 ENST00000520676 ENST00000400782(uc003wzv.1 uc003wzw.1)


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    hsa-miR-765 hsa-miR-624 hsa-miR-766 hsa-miR-520a-5p hsa-miR-507 hsa-miR-374c hsa-miR-515-5p hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidGFRA2 3' UTR sequence
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    Additional mRNA sequence: 

    AF002700.1 AK299623.1 AY326396.1 AY941828.1 BC041688.1 U93703.1 U97145.1 

    5 DOTS entries:

    DT.454929  DT.121481372  DT.100663400  DT.100704878  DT.97823407 

    21 AceView cDNA sequences:

    BX426023 BX447443 CA392962 CB996522 AL530976 BX440579 CB994592 CA393138 
    BG718419 BM011391 BX425245 BM805557 BX485872 BU501708 AL545236 BQ889433 
    BX446824 AL552892 BM013065 BX333936 BQ068514 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GFRA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -     -                                             
    SP4:              -                                                         


    ECgene alternative splicing isoforms for GFRA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GFRA2 expression in normal human tissues (normalized intensities)      GFRA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTCACAG
    GFRA2 Expression
    About this image


    GFRA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Peripheral Nervous System (Nervous System)
             Human Perineurial Cells (HPC)   
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Tooth
             Dental pulp Stem Cells (DPSC)   

    See GFRA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GFRA2

    SOURCE GeneReport for Unigene cluster: Hs.441202

    UniProtKB/Swiss-Prot: GFRA2_HUMAN, O00451
    Tissue specificity: Isoform 1 is found in both brain and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including GFRA2: 
              Neurotrophins & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GFRA2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gfra21 , 5 glial cell line derived neurotrophic factor family more1, 5 90.86(n)1
    93.95(a)1
      14 (36.79 cM)5
    145861  NM_008115.21  NP_032141.21 
     708901305 
    chicken
    (Gallus gallus)
    Aves GFRA21 GDNF family receptor alpha 2 76.62(n)
    76.19(a)
      395993  NM_205101.1  NP_990432.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5649161 GDNF family receptor alpha-2-like 63.76(n)
    64.64(a)
      564916  XM_688234.4  XP_693326.4 


    ENSEMBL Gene Tree for GFRA2 (if available)
    TreeFam Gene Tree for GFRA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GFRA2 gene
    GFRA32  GFRA42  GFRA12  
    2 SIMAP similar genes for GFRA2 using alignment to 4 protein entries:     GFRA2_HUMAN (see all proteins):
    GFRA1    GFRA3

    GFRA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2402 SNPs in GFRA2 are shown (see all 2402)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385821181,2
    C--21554422(+) AGGAG-/AGGGGA 3 -- int10--------
    rs58899981,2
    C--21573820(+) AAAAA-/A/AA  
            
    GACAG
    3 -- int1 trp32NA CSA 4
    rs574275081,2
    C--21576968(+) AAAGAAT/-ATTAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs346462091,2
    C--21577667(+) ACATTT/-CCTGA 3 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1131025651,2
    C,F--21584412(+) AGCGCG/ACACCA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs344903461,2
    C--21585778(+) TTTTT-/TGAGAT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs113279721,2
    C,F--21587916(+) GTCTC-/AAAAAA 3 -- int1 trp33Minor allele frequency- A:0.33NA CSA 6
    rs351050001,2
    C--21592737(+) GTTCACA/-AAGGT 3 -- int11Minor allele frequency- -:0.50NA 2
    rs1138668391,2
    F--21599304(+) TGGTGC/TGTACC 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs717219111,2
    C--21602063(+) CACCA-/AC    
       
    /ACAC
    ACACA
    3 -- int10--------

    HapMap Linkage Disequilibrium report for GFRA2 (21547915 - 21669869 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GFRA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675982CNV Deletion23128226
    esv25058CNV Loss19812545
    essv19243CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601956    OMIM disorders: --

    13 diseases for GFRA2:    About MalaCards
    geniculate ganglionitis    hirschsprung's disease    tardive dyskinesia    paraganglioma
    retinal degeneration    teratocarcinoma    pheochromocytoma    thyroid cancer
    retinitis    thyroiditis    schizophrenia    neuronitis
    alzheimer's disease


    GFRA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for GFRA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirschsprung disease 40.6 1 11409869 (1)
    retinal degeneration 37.9 2 11239244 (2)
    tumors 0 2 10822229 (1)

    Genetic Association Database (GAD): GFRA2
    Human Genome Epidemiology (HuGE) Navigator: GFRA2 (8 documents)

    Export disorders for GFRA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GFRA2 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with GFRA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. (PubMed id 9177201)1, 2, 3, 9 Sanicola M.... Cate R.L. (1997)
    2. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. (PubMed id 9259272)1, 2, 9 Suvanto P....Saarma M. (1997)
    3. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. (PubMed id 9182803)1, 2, 9 Baloh R.H....Milbrandt J. (1997)
    4. Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. (PubMed id 20369355)1, 4, 9 Souza R.P....Wong A.H. (2010)
    5. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 4, 9 Lavedan C....Polymeropoulos M.H. (2008)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. Applicability of a genetic signature for enhanced ilo peridone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1, 4 Volpi S....Lavedan C. (2009)
    8. Genetic evidence for a role of IL33 in nasal polyposi s. (PubMed id 19860791)1, 4 Buysschaert I.D....Lambrechts D. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. (PubMed id 12624147)1, 4 Borrego S....Eng C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2675 HGNC: 4244 AceView: GFRA2 Ensembl:ENSG00000168546 euGenes: HUgn2675
    ECgene: GFRA2 H-InvDB: GFRA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GFRA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GFRA2 gene:
    Search GeneIP for patents involving GFRA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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