Aliases for GFRA2 Gene
External Ids for GFRA2 Gene
Previous GeneCards Identifiers for GFRA2 Gene
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for GFRA2 Gene
GFRA2 (GDNF Family Receptor Alpha 2) is a Protein Coding gene. Diseases associated with GFRA2 include Malignant Granular Cell Myoblastoma and Hirschsprung Disease 1. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA1.
UniProtKB/Swiss-Prot for GFRA2 Gene
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Isoform 2: participates in NRTN-induced Ser-727 phosphorylation of STAT3.