GFRA1 Gene

Aliases
for GFRA1 gene

Previous GC identifers: GC10M116742 GC10M117066 GC10M117954 GC10M117487 GC10M111444

Summaries
for GFRA1 gene

Genomic Views
for GFRA1 gene

RefSeq DNA sequence:

NC_000010.10  NC_018921.1  NT_030059.13  

SwitchGear Promoter luciferase reporter plasmids (see all 2): GFRA1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFRA1

GFRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M117813:  view genomic region     (about GC identifiers)

Proteins
for GFRA1 gene

Explore the universe of human proteins at neXtProt for GFRA1: NX_P56159

GFRA1 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for GFRA1 (GFR alpha-1/GDNF R alpha-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GFRA1 OriGene Protein Over-expression Lysate (see all 3): GFRA1 OriGene Custom Protein Services for GFRA1
	GenScript Custom Purified and Recombinant Proteins Services for GFRA1
	Novus Biologicals GFRA1 Proteins Novus Biologicals GFRA1 Lysates
	Sino Biological Recombinant Protein for GFRA1
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for GFRA1 (GFR alpha-1/GDNF R alpha-1)
	OriGene Antibodies: GFRA1 OriGene Custom Antibody Services for GFRA1
	GenScript Custom Superior Antibodies Services for GFRA1
	Novus Biologicals GFRA1 Antibodies
	Abcam antibodies for GFRA1
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for GFRA1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GFRA1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for GFRA1 gene

ProtoNet protein and cluster: P56159

Function
for GFRA1 gene

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 6 alleles) (MGI details for Gfra1)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GFRA1

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GFRA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GFRA1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate GFRA1 (see all 88):
		hsa-miR-194* hsa-miR-607 hsa-miR-300 hsa-miR-342-3p hsa-miR-519a hsa-miR-29a* hsa-miR-3148 hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: GFRA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GFRA1 (see all 7) OriGene shRNA RFP: GFRA1 OriGene siRNA: GFRA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GFRA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against GFRA1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for GFRA1
			Sirion Biotech Customized adenovirus for overexpression of GFRA1  Sirion Biotech Customized adenovirus for potent knockdown of GFRA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GFRA1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GFRA1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): GFRA1 (NM_005264)
		Sino Biological Human cDNA Clone for GFRA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFRA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFRA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GFRA1
		Search LifeMap BioReagents cell lines for GFRA1
		Sirion Biotech Customized stable knockdown cell line services for GFRA1  Sirion Biotech Customized inducible knockdown cell line services for GFRA1 Sirion Biotech Customized stable overexpressing cell line services for GFRA1 Sirion Biotech Customized inducible overexpressing cell line services for GFRA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA1

Pathways & Interactions
for GFRA1 gene

	Super-pathway	contained gene-specific pathways
1	Development EGFR signaling pathway	Development GDNF family signaling 0.45 GDNF-Family Ligands and Receptor Interactions 0.21 Development_GDNF family signaling 0.45
2	NCAM signaling for neurite out-growth	NCAM signaling for neurite out-growth 1.00 NCAM1 interactions 0.62
3	Axon guidance	Axon guidance 1.00 Developmental Biology 0.69
4	G-protein signaling K-RAS regulation pathway	G-protein signaling_H-RAS regulation pathway 0.27 G-protein signaling H-RAS regulation pathway 0.27
5	Diurnally regulated genes with circadian orthologs	Diurnally regulated genes with circadian orthologs 1.00

2 EMD Millipore Pathways for GFRA1

	Development GDNF family signaling
	G-protein signaling H-RAS regulation pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for GFRA1

GDNF-Family Ligands and Receptor Interactions

2 GeneGo (Thomson Reuters) Pathways for GFRA1

	G-protein signaling H-RAS regulation pathway
	Development GDNF family signaling

2 BioSystems Pathways for GFRA1

	Diurnally regulated genes with circadian orthologs
	Signaling events regulated by Ret tyrosine kinase

4        Reactome Pathways for GFRA1

	Developmental Biology
	NCAM1 interactions
	NCAM signaling for neurite out-growth
	Axon guidance

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for GFRA1 gene

Transcripts
for GFRA1 gene

Expression
for GFRA1 gene

GFRA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCCTCAC

About this image

GFRA1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyUreteric BudUreteric Bud Cells			Kidney
	TestisSeminiferous TubulesSpermatogonial Stem Cells			Germ Cells, Male Gametocytes
	Gut TubeMidgutMidgut Endoderm Cells			Endoderm
	Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor Cells			Spinal Cord
	Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor Cells			Motor Neurons
	BrainHypothalamus			Brain
	BrainMedulla Oblongata			Brain
	BrainThalamus			Brain
	Gut TubeMidgut			Gut Tube
	HeartDorsal Aorta			Heart
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 9 LifeMap Cells
	Name			Category
	ES-J1 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	PureStem™ progenitor E68 (Embryonic Progenitor Cell)
	PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)			Intermediate Mesoderm, Kidney
	PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)			Lateral Plate Mesoderm, Neural Crest
	PureStem™ progenitor E69 (Embryonic Progenitor Cell)
	PureStem™ progenitor U31 (Embryonic Progenitor Cell)
	Adult human kidney epithelial cells (Primary Cell)			Kidney
	Long-time differentiated EBs (Derivation of embryo...)
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GFRA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GFRA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GFRA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFRA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFRA1

Orthologs
for GFRA1 gene

Paralogs
for GFRA1 gene

Paralogs for GFRA1 gene

GFRA3²  GFRA2²  GFRAL²  GFRA4²  

2 SIMAP similar genes for GFRA1 using alignment to 3 protein entries:     GFRA1_HUMAN (see all proteins):

GFRA2    GFRA3

GFRA1 for paralogs           About GeneDecksing

Genomic Variants
for GFRA1 gene

10/4154 NCBI SNPs in GFRA1 are shown (see all 4154)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs354933941,2	C	--	111477778(+)	AAAAA-/AAAAAA	1	--	int1		2		NA	4
rs572225821,2	C,F	--	117816003(+)	CCAGTG/TCTGTC	3	--	ds5001		3		WA CSA	122
rs1498264841,2		--	117816084(+)	AAATAC/TTGGCT	3	--	ds5001		0	--	--	--	--
rs1887532831,2		--	117816158(+)	ACCACA/GAAGTG	3	--	ds5001		0	--	--	--	--
rs1913019061,2		--	117816183(+)	CCAAAG/TGATGC	3	--	ds5001		0	--	--	--	--
rs1834912961,2		--	117816269(+)	TAGTAC/GCAAGG	3	--	ds5001		0	--	--	--	--
rs1886157111,2		--	117816287(+)	GCCATA/GGTCTG	3	--	ds5001		0	--	--	--	--
rs2014510961,2		--	117816436(+)	AATGA-/TTTTTT	3	--	ut31		0	--	--	--	--
rs1805551,2	C,A,H	--	117816443(-)	TTTTTA/TAAAAA	3	--	ut31		4		NA WA EA	360
rs1159662051,2	C,F	--	117816456(+)	AAAACA/CATGTT	3	--	ut31		1		WA	118

HapMap Linkage Disequilibrium report for GFRA1 (117816436 - 118033126 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GFRA1
     2 CNVs: 48418 48004
Human Gene Mutation Database (HGMD): GFRA1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GFRA1

DNA2.0 Custom Variant and Variant Library Synthesis for GFRA1

Disorders / Diseases
for GFRA1 gene

20/46 diseases for GFRA1

10/16 Novoseek disease relationships for GFRA1 gene (see all 16)    About this table

Publications
for GFRA1 gene

PubMed articles for GFRA1 gene, integrated from 9 sources (see all 170): (articles sorted by number of sources associating them with GFRA1)

Utopia: connect your pdf to the dynamic world of online information

1. Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. (PubMed id 9545641)^{1, 2, 3, 9} Angrist M.... Chakravarti A. (1998)
2. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. (PubMed id 9177201)^{1, 2, 9} Sanicola M.... Cate R.L. (1997)
3. Molecular analysis of congenital central hypoventilation syndrome. (PubMed id 14566559)^{1, 2, 9} Sasaki A.... Hayasaka K. (2003)
4. Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer. (PubMed id 12490080)^{1, 4, 9} Borrego S....Antinolo G. (2002)
5. Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. (PubMed id 9465905)^{1, 3, 9} Gorodinsky A....Milbrandt J. (1997)
6. Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C. (PubMed id 16175604)^{1, 4} Kato N....Omata M. (2005)
7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
8. An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
10. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. (PubMed id 12624147)^{1, 4} Borrego S....Eng C. (2003)

External Searches for GFRA1 gene

Genome Databases showing GFRA1 gene

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Specialized Databases showing GFRA1 gene

Products
for GFRA1 gene