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GFRA1 Gene

protein-coding GIFtS: 60

GC10M117813

GDNF family receptor alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GDNFRA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp313E1012 ^²
DKFZp686J0156 ^²
FLJ10561 ^²
FLJ31546 ^²
GDNFR ^¹, ², ⁵
GDNFR-alpha ^³
GDNFRA ^², ³, ⁵
GFR-ALPHA-1 ^¹, ²
GFR-alpha-1 ^³
MGC23045 ^²
OTTHUMP00000020558 ^²
OTTHUMP00000020559 ^²
RET1L ^¹, ²
RETL1 ^¹, ², ³
TRNR1 ^¹, ², ³

Descriptions
GDNF family receptor alpha 1 ^²
GDNF receptor alpha ^³
GPI-linked anchor protein ^²
Glial cell line-derived neurotrophic factor receptor alpha ^²
PI-linked cell-surface accessory protein ^²
RET ligand 1 ^², ³
TGF-beta related neurotrophic factor receptor 1 ^²
TGF-beta-related neurotrophic factor receptor 1 ^³

External Ids
HGNC: 4243¹
Entrez Gene: 2674²
UniProtKB: P56159³
Ensembl: ENSG00000151892⁷

Search outside databases for aliases for GFRA1 gene

Previous GC identifers: GC10M116742 GC10M117066 GC10M117954 GC10M117487

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GFRA1:

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally

related, potent neurotrophic factors that play key roles in the control of neuron survival and

differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a

glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates

activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung

disease. Multiple alternatively spliced transcript variants have been described for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: GFRA1_HUMAN, P56159

Function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the

RET receptor (By similarity)

Gene Wiki entry for GFRA1 (GDNF_family_receptor_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GFRA1 gene

Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q25-q26

GFRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M117813: (about GC identifiers)

Start:	117,812,943 bp from pter
End:	118,022,966 bp from pter
Size:	210,024 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GFRA1_HUMAN, P56159 (See protein sequence)

Recommended Name: GDNF family receptor alpha-1 precursor

Size: 465 amino acids; 51456 Da

Subunit: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF

dimer and with 2 molecules of RET (By similarity)

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)

Secondary accessions: O15507 O43912

Alternative splicing: 2 isoforms: P56159-1 P56159-2

REFSEQ proteins (3 alternative transcripts):

NP_001138925.1 NP_005255.1 NP_665736.1

ENSEMBL proteins:

ENSP00000347591 ENSP00000358237 ENSP00000358239

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant GFRA1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for GFRA1 (GFR alpha-1/GDNF R alpha-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GDNF Receptor alpha 1)
	Human Recombinant Proteins from Abnova (GFRA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0019898	extrinsic to membrane	NAS	--
GO:0031225	anchored to membrane	IEA	--

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Antibodies for GFRA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GFRA1
	Sigma-Aldrich Antibodies for GFRA1
	R&D Systems Antibodies for GFRA1 (GFR alpha-1/GDNF R alpha-1)
	Antibodies from Abcam (GDNF Receptor alpha 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GFRA1)
	Novus Biologicals Antibodies for GFRA1

Assays for GFRA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P56159

ProtoNet protein and cluster: P56159

2 Blocks protein families:

IPB003438 Glial cell line-derived neurotrophic factor receptor family signature

IPB003503 Glial cell line-derived neurotrophic factor receptor alpha 1 signature

UniProtKB/Swiss-Prot: GFRA1_HUMAN, P56159

Similarity: Belongs to the GDNFR family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GFRA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GFRA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_145793

Applied Biosystems Silencer® siRNAs for GFRA1

Sigma-Aldrich siRNA for GFRA1

Sigma-Aldrich shRNA for GFRA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GFRA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001145453
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001145453
untagged cDNA clones in CMV expression vector (see all 3): NM_001145453

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005264

UniProtKB/Swiss-Prot: GFRA1_HUMAN, P56159

Function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the

RET receptor (By similarity)

Genatlas biochemistry entry for GFRA1:

glial cell line derived neurotrophic factor (GDNF) receptor alpha-1,also receptor for neurturin,not

(commonly) mutated in Hirschsprung disease,mediating the action of Ret protein receptor tyrosine

kinase

12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Gfra1):

behavior/neurological	cellular	digestive/alimentary	embryogenesis	immune system
lethality-prenatal/perinatal	muscle	nervous system	normal	renal/urinary system
reproductive system	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	NAS	--
GO:0005102	receptor binding	TAS	9545641
GO:0016167	glial cell line-derived neurotrophic factor receptor activity	TAS	10829012

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for GFRA1

5/47 Interacting proteins for GFRA1 (ENSP00000347591³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GDNF	ENSP00000317145³	STRING (score=.999)
NRTN	ENSP00000302648³	STRING (score=.999)
RET	ENSP00000344798³	STRING (score=.999)
NCAM1	ENSP00000318472³	STRING (score=.98)
SRC	ENSP00000362659³	STRING (score=.968)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor linked signal transduction	NAS	8674117

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GFRA1
5 Novoseek chemical compound relationships for GFRA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	67.59	40	9108413 (1), 9576965 (1), 11002419 (1), 18089803 (1) (see all 35)
heparan sulfate	25.11	1	12626395 (1)
phosphatidylinositol	21.66	1	11846482 (1)
bromodeoxyuridine	0.00	1	11079571 (1)
lipid	0.00	5	11182089 (2), 11476867 (1), 11106404 (1), 10774729 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GFRA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GFRA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_145793

Sigma-Aldrich siRNA for GFRA1

Sigma-Aldrich shRNA for GFRA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005264 NM_145793

REFSEQ mRNAs for GFRA1 gene (3 alternative transcripts):

NM_001145453.1 NM_005264.4 NM_145793.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005264 NM_145793

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001145453
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001145453
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001145453

Additional cDNA sequence:

AF038421.1 AF042080.1 AK001423.1 AK056108.1 AK292886.1 AK302914.1 AL832661.1 BC014962.1

BX648964.1 U97144.1

8 DOTS entries:

DT.444548 DT.95193991 DT.121301711 DT.99930465 DT.100744652 DT.121301702 DT.311101 DT.92429609

24/68 AceView cDNA sequences (see all 68 ):

BU860284 AI092346 BX953721 AF042080 BG696764 BX953798 BM669624 AI804110

AI049675 CA449277 BX106828 CB161940 CA487395 AW263087 BG750968 NM_005264

U95847 AI638398 U97144 BX427432 W37956 BU857306 BU935138 AI467912

highest scoring ESTs for GFRA1:

AF038421 AA312082 AA471183 AA505897 AA512935 AA573164 AF042080 AI049675 AI470774 AI638398

Unigene Cluster for GFRA1:

GDNF family receptor alpha 1

Hs.388347 [show with all ESTs]

Unigene Representative Sequence: NM_005264

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000355422 ENST00000369234 ENST00000369236

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GFRA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GFRA1

¹ / ² / ³

9 probe-sets matching GFRA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47564_at²	U95-B	1	1.00	1.00	0.94	0.99	--	--	--	--	--
37142_at²^{, 3}	U95-A	1	1.00	1.00	0.76	0.23	AF038421	1.00	1.00	1.00	1
73789_at²^{, 3}	U95-E	1	1.00	1.00	0.91	1.01	W37896	0.20	0.50	0.38	1
205696_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005264	0.40	1.00	0.76	1
227550_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
230163_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW263087	0.20	0.50	0.38	1
205696_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227550_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230163_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.388347

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GFRA1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GFRA1¹	--	GDNF family receptor alpha 1	92.64(n) 95.24(a)	609114 XM_846994.1 XP_852087.1
chimpanzee (Pan troglodytes)	GFRA1¹	--	GDNF family receptor alpha 1	99.78(n) 100(a)	450756 XM_001150668.1 XP_001150668.1
cow (Bos taurus)	GFRA1¹	--	GDNF family receptor alpha 1	91.85(n) 95.89(a)	534801 XM_614693.3 XP_614693.3
rat (Rattus norvegicus)	Gfra1¹	--	GDNF family receptor alpha 1	89.18(n) 93.33(a)	25454 NM_012959.1 NP_037091.1
mouse (Mus musculus)	Gfra1^{1, 5}	19 (29.00 cM)⁵	glial cell line derived neurotrophic factor family more^{1, 5}	88.96(n)¹ 93.55(a)¹	14585¹ NM_010279.2¹ NP_034409.1¹ AB000800⁵ AF012811⁵ (see all 19)

About this table Species with no ortholog for GFRA1

ENSEMBL Gene Tree for GFRA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GFRA1 gene

GFRA2² GFRA4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1411 NCBI SNPs in GFRA1 are shown (see all 1411 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 573)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1061413^1,2	A,C,F,H,O	117812953(-)	`AGCTTG/CTTTCC`	2	--	ut3¹ trp³		13	EA MN EU WA NA	2656
	rs2072277^1,2	C,F,H,O	117813194(-)	`GATTCA/GATACC`	2	--	ut3¹ ese³		7	NA EU EA WA	552
	rs1078080^1,2	C,F,H,O	117813729(+)	`GCCCCA/GAAGGA`	2	--	ut3¹		9	NA EU EA WA MN	746
	rs8192661^1,2	A,C,F,H	118021637(-)	`CCAGAG/ACAGCA`	2	--	ut5¹ ese³		4	EU EA WA	410
	rs8192662^1,2	C,F,H	118020405(-)	`CGCTCT/AACAAC`	2	N/Y	mis¹ ese³		5	EU EA WA	526
	rs2577361^1,2	A,C,F	118021781(+)	`ACCTGG/AAAGGG`	2	--	ut5¹ int¹ ese³ trp³		1	NA	854
	rs2072276^1,2	C,F,H	117839343(-)	`CTGCCA/GCTACC`	2	T/A	mis¹ ese³		15	NA EU EA WA	1338
	rs2577360^1,2	A,C,F	118021609(+)	`TCAGCA/GTGCAG`	2	--	ut5¹ ese³		1	NA	868
	rs3740573^1,2	A,C,F	118022615(+)	`GGGAAG/ACGGCA`	2	--	int¹ ng3¹		3	EA NA	1270
	rs886981^1,2	F,H	117813810(-)	`CCAGTT/CTAGGA`	2	--	ut3¹		5	MN EU EA WA	598

About this table

HapMap Linkage Disequilibrium images for GFRA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601496

10/16 Novoseek disease relationships for GFRA1 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hirschsprung disease	73.17	3	9545641 (1), 9465906 (1), 10812967 (1)
thyroid carcinoma medullary	67.59	1	12490080 (1)
men 2a	64.04	3	11979448 (2)
paroxysmal hemoglobinuria nocturnal	47.75	1	8890572 (1)
somatic mutations	43.62	1	8890572 (1)
pheochromocytoma	36.93	1	9000574 (1)
neuroendocrine tumors	33.35	1	9284737 (1)
prolactinoma	30.08	1	11932334 (1)
pituitary tumors	21.08	1	11932334 (1)
pancreatic cancer	18.83	6	19188437 (2), 16357163 (1), 16269310 (1)

About this table

Human Gene Mutation Database: GFRA1
Genetic Association Database: GFRA1
Human Genome Epidemiology Navigator: GFRA1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/156 PubMed articles for GFRA1 gene (see all 156 ):

Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. (PubMed id 9545641)^{1, 2, 3, 4} Angrist M....Chakravarti A. (1998)
Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. (PubMed id 9177201)^{1, 3, 4} Sanicola M.... Cate R.L. (1997)
Molecular analysis of congenital central hypoventilation syndrome. (PubMed id 14566559)^{1, 3, 4} Sasaki A.... Hayasaka K. (2003)
Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer. (PubMed id 12490080)^{1, 3, 6} Borrego S....Antinolo G. (2002)
Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. (PubMed id 9465905)^{1, 2, 3} Gorodinsky A....Milbrandt J. (1997)
Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C. (PubMed id 16175604)^{3, 6} Kato N....Omata M. (2005)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. (PubMed id 12624147)^{3, 6} Borrego S....Eng C. (2003)
Mutational analysis of the GDNF/RET-GDNFR-alpha signaling complex in a kindred with vesicoureteral reflux. (PubMed id 9600247)^{3, 4} Shefelbine S.E.... Gagel R.F. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2674	HGNC: 4243	AceView: GFRA1	Ensembl:ENSG00000151892	euGenes: HUgn2674
ECgene: GFRA1	H-InvDB: GFRA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GFRA1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GFRA1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GFRA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GFRA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GFRA1		Antibodies for GFRA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GFRA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GFRA1)
	Antibodies (GFRA1)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (GDNF Receptor alpha 1)

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Search Tocris compounds for GFRA1

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Antibodies for GFRA1

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GFRA1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for GFRA1

Summaries
for GFRA1

Genomic Location
for GFRA1

Proteins
for GFRA1

Protein Domains/
Families
for GFRA1

Gene Function
for GFRA1

Pathways & Interactions
for GFRA1

Drugs & Compounds
for GFRA1

Transcripts
for GFRA1

Expression
for GFRA1

Orthologs
for GFRA1

Paralogs
for GFRA1

SNPs/Variants
for GFRA1

Disorders & Mutations
for GFRA1

Medical News
for GFRA1

Publications
for GFRA1

Search for GFRA1

Genome Databases showing GFRA1

Other Databases showing GFRA1

Specialized Databases showing GFRA1

Licensable Technologies
for GFRA1

Services
for GFRA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GFRA1 (Gene Symbol)
DKFZp313E1012
DKFZp686J0156
FLJ10561
FLJ31546
GDNFR
GDNFR-alpha
GDNFRA
GFR-ALPHA-1
GFR-alpha-1
MGC23045
OTTHUMP00000020558
OTTHUMP00000020559
RET1L
RETL1
TRNR1
GDNF family receptor alpha 1
GDNF receptor alpha
GPI-linked anchor protein
Glial cell line-derived neurotrophic factor receptor alpha
PI-linked cell-surface accessory protein
RET ligand 1
TGF-beta related neurotrophic factor receptor 1
TGF-beta-related neurotrophic factor receptor 1

GFRA1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor GFRA1

Summariesfor GFRA1

Genomic Locationfor GFRA1

Proteinsfor GFRA1

Protein Domains/Familiesfor GFRA1

Gene Functionfor GFRA1

Pathways & Interactionsfor GFRA1

Drugs & Compoundsfor GFRA1

Transcriptsfor GFRA1

Expression for GFRA1

Orthologsfor GFRA1

Paralogsfor GFRA1

SNPs/Variantsfor GFRA1

Disorders & Mutationsfor GFRA1

Medical Newsfor GFRA1

Publicationsfor GFRA1

Search for GFRA1

Genome Databases showing GFRA1

Other Databases showing GFRA1

Specialized Databases showing GFRA1

Licensable Technologiesfor GFRA1

Servicesfor GFRA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GFRA1

Summaries
for GFRA1

Genomic Location
for GFRA1

Proteins
for GFRA1

Protein Domains/
Families
for GFRA1

Gene Function
for GFRA1

Pathways & Interactions
for GFRA1

Drugs & Compounds
for GFRA1

Transcripts
for GFRA1

Expression
for GFRA1

Orthologs
for GFRA1

Paralogs
for GFRA1

SNPs/Variants
for GFRA1

Disorders & Mutations
for GFRA1

Medical News
for GFRA1

Publications
for GFRA1

Licensable Technologies
for GFRA1

Services
for GFRA1