Aliases for GFRA1 Gene
External Ids for GFRA1 Gene
Previous HGNC Symbols for GFRA1 Gene
Previous GeneCards Identifiers for GFRA1 Gene
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for GFRA1 Gene
GFRA1 (GDNF Family Receptor Alpha 1) is a Protein Coding gene. Diseases associated with GFRA1 include jejunoileitis and medullary thyroid carcinoma, familial. Among its related pathways are Developmental Biology and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA2.
UniProtKB/Swiss-Prot for GFRA1 Gene
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).