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Aliases for GFPT2 Gene

Aliases for GFPT2 Gene

  • Glutamine-Fructose-6-Phosphate Transaminase 2 2 3
  • GFAT2 3 4 6
  • Glutamine: Fructose-6-Phosphate Aminotransferase 2 2 3
  • Glutamine:Fructose-6-Phosphate Amidotransferase 2 3 4
  • D-Fructose-6-Phosphate Amidotransferase 2 3 4
  • Hexosephosphate Aminotransferase 2 3 4
  • EC 2.6.1.16 4 64
  • GFAT 2 3 4
  • Glucosamine--Fructose-6-Phosphate Aminotransferase [Isomerizing] 2 3
  • Glutamine--Fructose-6-Phosphate Aminotransferase [Isomerizing] 2 3
  • Glutamine:Fructose 6 Phosphate Amidotransferase 2 3

External Ids for GFPT2 Gene

Summaries for GFPT2 Gene

GeneCards Summary for GFPT2 Gene

GFPT2 (Glutamine-Fructose-6-Phosphate Transaminase 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding and glutamine-fructose-6-phosphate transaminase (isomerizing) activity. An important paralog of this gene is GFPT1.

UniProtKB/Swiss-Prot for GFPT2 Gene

  • Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFPT2 Gene

Genomics for GFPT2 Gene

Genomic Location for GFPT2 Gene

Start:
180,300,690 bp from pter
End:
180,353,387 bp from pter
Size:
52,698 bases
Orientation:
Minus strand

Genomic View for GFPT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GFPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFPT2 Gene

Regulatory Elements for GFPT2 Gene

Proteins for GFPT2 Gene

  • Protein details for GFPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94808-GFPT2_HUMAN
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
    Protein Accession:
    O94808
    Secondary Accessions:
    • Q53XM2
    • Q9BWS4

    Protein attributes for GFPT2 Gene

    Size:
    682 amino acids
    Molecular mass:
    76931 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GFPT2 Gene

Proteomics data for GFPT2 Gene at MOPED

Post-translational modifications for GFPT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GFPT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GFPT2 Gene

UniProtKB/Swiss-Prot:

GFPT2_HUMAN
Domain:
  • Contains 1 glutamine amidotransferase type-2 domain.:
    • O94808
  • Contains 2 SIS domains.:
    • O94808
genes like me logo Genes that share domains with GFPT2: view

No data available for Gene Families for GFPT2 Gene

Function for GFPT2 Gene

Molecular function for GFPT2 Gene

GENATLAS Biochemistry: glutamine
UniProtKB/Swiss-Prot CatalyticActivity: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
UniProtKB/Swiss-Prot Function: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

Enzyme Numbers (IUBMB) for GFPT2 Gene

Gene Ontology (GO) - Molecular Function for GFPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GFPT2: view

Phenotypes for GFPT2 Gene

GenomeRNAi human phenotypes for GFPT2:
genes like me logo Genes that share phenotypes with GFPT2: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GFPT2 Gene

Localization for GFPT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GFPT2 Gene COMPARTMENTS Subcellular localization image for GFPT2 gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GFPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GFPT2: view

Pathways for GFPT2 Gene

genes like me logo Genes that share pathways with GFPT2: view

UniProtKB/Swiss-Prot O94808-GFPT2_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1

Gene Ontology (GO) - Biological Process for GFPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006002 fructose 6-phosphate metabolic process TAS 10198162
GO:0006048 UDP-N-acetylglucosamine biosynthetic process TAS --
GO:0006112 energy reserve metabolic process TAS 10198162
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
genes like me logo Genes that share ontologies with GFPT2: view

Compounds for GFPT2 Gene

(4) HMDB Compounds for GFPT2 Gene

Compound Synonyms Cas Number PubMed IDs
Famotidine
  • Amfamox
76824-35-6
Glucosamine 6-phosphate
  • 2-Amino-2-deoxy-D-glucose 6-phosphate
3616-42-0
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0
L-Glutamine
  • (2S)-2,5-diamino-5-oxopentanoic acid
56-85-9

(1) Drugbank Compounds for GFPT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamine
  • (S)-2,5-diamino-5-oxopentanoic acid
56-85-9 enzyme substrate
genes like me logo Genes that share compounds with GFPT2: view

Transcripts for GFPT2 Gene

Unigene Clusters for GFPT2 Gene

Glutamine-fructose-6-phosphate transaminase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GFPT2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for GFPT2 Gene

GeneLoc Exon Structure for
GFPT2
ECgene alternative splicing isoforms for
GFPT2

Expression for GFPT2 Gene

mRNA expression in normal human tissues for GFPT2 Gene

mRNA differential expression in normal tissues according to GTEx for GFPT2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GFPT2 Gene

SOURCE GeneReport for Unigene cluster for GFPT2 Gene Hs.696497

mRNA Expression by UniProt/SwissProt for GFPT2 Gene

O94808-GFPT2_HUMAN
Tissue specificity: Highest levels of expression in heart, placenta, and spinal cord
genes like me logo Genes that share expressions with GFPT2: view

Orthologs for GFPT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GFPT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GFPT2 36
  • 98.04 (n)
  • 97.79 (a)
GFPT2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GFPT2 36
  • 91.98 (n)
  • 97.8 (a)
GFPT2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GFPT2 36
  • 90.86 (n)
  • 97.65 (a)
GFPT2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gfpt2 36
  • 89.39 (n)
  • 97.8 (a)
Gfpt2 16
Gfpt2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GFPT2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gfpt2 36
  • 89.3 (n)
  • 97.65 (a)
chicken
(Gallus gallus)
Aves GFPT2 36
  • 79.03 (n)
  • 92.67 (a)
GFPT2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GFPT2 37
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12662 36
zebrafish
(Danio rerio)
Actinopterygii gfpt2 36
  • 73.73 (n)
  • 78.53 (a)
gfpt2 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011352 36
  • 65.67 (n)
  • 68.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gfat1 37
  • 64 (a)
ManyToMany
Gfat2 36
  • 65.44 (n)
  • 66.72 (a)
Gfat2 37
  • 66 (a)
ManyToMany
Gfat2 38
  • 66 (a)
Gfat1 38
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea F07A11.2 36
  • 60.47 (n)
  • 61.5 (a)
F07A11.2 37
  • 56 (a)
ManyToMany
F22B3.4 37
  • 57 (a)
ManyToMany
F07A11.2b 38
  • 58 (a)
F07A11.2a 38
  • 57 (a)
F22B3.4 38
  • 57 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL036C 36
  • 60.36 (n)
  • 59.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GFA1 36
  • 55.44 (n)
  • 59.23 (a)
GFA1 37
  • 55 (a)
OneToMany
GFA1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13596g 36
  • 56.28 (n)
  • 59.38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G24090 36
  • 54.74 (n)
  • 54.43 (a)
corn
(Zea mays)
Liliopsida Zm.11907 36
rice
(Oryza sativa)
Liliopsida Os12g0131100 36
  • 58.91 (n)
  • 59.43 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11350 36
  • 59.29 (n)
  • 57.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.11 36
  • 54.5 (n)
  • 56.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToMany
Species with no ortholog for GFPT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GFPT2 Gene

ENSEMBL:
Gene Tree for GFPT2 (if available)
TreeFam:
Gene Tree for GFPT2 (if available)

Paralogs for GFPT2 Gene

Paralogs for GFPT2 Gene

Selected SIMAP similar genes for GFPT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GFPT2: view

Variants for GFPT2 Gene

Sequence variations from dbSNP and Humsavar for GFPT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7725 -- 180,300,957(+) TTCAA(C/T)TGGAC utr-variant-3-prime
rs729568 -- 180,305,350(-) ATGCT(C/T)AATCA intron-variant
rs729652 -- 180,304,695(+) TGGTA(C/T)TGGCA intron-variant
rs734090 -- 180,350,869(-) TGATG(A/G)CACTG intron-variant
rs878705 -- 180,337,779(-) GATAG(A/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GFPT2 Gene

Variant ID Type Subtype PubMed ID
dgv1881e1 CNV Complex 17122850
nsv883290 CNV Loss 21882294
nsv830563 CNV Loss 17160897
nsv10787 CNV Gain 18304495
esv2731327 CNV Deletion 23290073
dgv1020e201 CNV Deletion 23290073
esv2731331 CNV Deletion 23290073
nsv883291 CNV Loss 21882294

Relevant External Links for GFPT2 Gene

HapMap Linkage Disequilibrium report
GFPT2
Human Gene Mutation Database (HGMD)
GFPT2

Disorders for GFPT2 Gene

Relevant External Links for GFPT2

Genetic Association Database (GAD)
GFPT2
Human Genome Epidemiology (HuGE) Navigator
GFPT2
genes like me logo Genes that share disorders with GFPT2: view

No data available for UniProtKB/Swiss-Prot for GFPT2 Gene

Publications for GFPT2 Gene

  1. cDNA cloning and mapping of a novel subtype of glutamine:fructose-6- phosphate amidotransferase (GFAT2) in human and mouse. (PMID: 10198162) Oki T. … Tanaka I. (Genomics 1999) 2 3 4 23
  2. Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels. (PMID: 14764791) Zhang H. … Elbein S.C. (J. Clin. Endocrinol. Metab. 2004) 3 23 49
  3. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. (PMID: 20353610) Prasad P. … Thelma B.K. (BMC Med. Genet. 2010) 3 23 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for GFPT2 Gene

Sources for GFPT2 Gene

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