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Aliases for GFPT2 Gene

Aliases for GFPT2 Gene

  • Glutamine-Fructose-6-Phosphate Transaminase 2 2 3 5
  • Glutamine: Fructose-6-Phosphate Aminotransferase 2 2 3
  • Glutamine:Fructose-6-Phosphate Amidotransferase 2 3 4
  • D-Fructose-6-Phosphate Amidotransferase 2 3 4
  • Hexosephosphate Aminotransferase 2 3 4
  • EC 2.6.1.16 4 63
  • GFAT 2 3 4
  • GFAT2 3 4
  • Glucosamine--Fructose-6-Phosphate Aminotransferase [Isomerizing] 2 3
  • Glutamine:Fructose 6 Phosphate Amidotransferase 2 3
  • GFAT 3

External Ids for GFPT2 Gene

Previous GeneCards Identifiers for GFPT2 Gene

  • GC05M179841
  • GC05M180705
  • GC05M179837
  • GC05M179660
  • GC05M174452
  • GC05M179727

Summaries for GFPT2 Gene

GeneCards Summary for GFPT2 Gene

GFPT2 (Glutamine-Fructose-6-Phosphate Transaminase 2) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include carbohydrate binding and glutamine-fructose-6-phosphate transaminase (isomerizing) activity. An important paralog of this gene is GFPT1.

UniProtKB/Swiss-Prot for GFPT2 Gene

  • Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFPT2 Gene

Genomics for GFPT2 Gene

Regulatory Elements for GFPT2 Gene

Enhancers for GFPT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GFPT2 on UCSC Golden Path with GeneCards custom track

Promoters for GFPT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GFPT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GFPT2 Gene

Chromosome:
5
Start:
180,300,690 bp from pter
End:
180,353,387 bp from pter
Size:
52,698 bases
Orientation:
Minus strand

Genomic View for GFPT2 Gene

Genes around GFPT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFPT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFPT2 Gene

Proteins for GFPT2 Gene

  • Protein details for GFPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94808-GFPT2_HUMAN
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
    Protein Accession:
    O94808
    Secondary Accessions:
    • Q53XM2
    • Q9BWS4

    Protein attributes for GFPT2 Gene

    Size:
    682 amino acids
    Molecular mass:
    76931 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GFPT2 Gene

Proteomics data for GFPT2 Gene at MOPED

Post-translational modifications for GFPT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GFPT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GFPT2 (GFAT2)

Domains & Families for GFPT2 Gene

Suggested Antigen Peptide Sequences for GFPT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94808

UniProtKB/Swiss-Prot:

GFPT2_HUMAN :
  • Contains 1 glutamine amidotransferase type-2 domain.
Domain:
  • Contains 1 glutamine amidotransferase type-2 domain.
  • Contains 2 SIS domains.
genes like me logo Genes that share domains with GFPT2: view

No data available for Gene Families for GFPT2 Gene

Function for GFPT2 Gene

Molecular function for GFPT2 Gene

GENATLAS Biochemistry:
glutamine
UniProtKB/Swiss-Prot CatalyticActivity:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
UniProtKB/Swiss-Prot Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

Enzyme Numbers (IUBMB) for GFPT2 Gene

genes like me logo Genes that share phenotypes with GFPT2: view

Animal Models for GFPT2 Gene

MGI Knock Outs for GFPT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GFPT2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GFPT2 Gene

Localization for GFPT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GFPT2 Gene COMPARTMENTS Subcellular localization image for GFPT2 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GFPT2 Gene

Pathways & Interactions for GFPT2 Gene

genes like me logo Genes that share pathways with GFPT2: view

UniProtKB/Swiss-Prot O94808-GFPT2_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.

Gene Ontology (GO) - Biological Process for GFPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006002 fructose 6-phosphate metabolic process TAS 10198162
GO:0006047 UDP-N-acetylglucosamine metabolic process IBA --
GO:0006487 protein N-linked glycosylation IBA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
genes like me logo Genes that share ontologies with GFPT2: view

No data available for SIGNOR curated interactions for GFPT2 Gene

Drugs & Compounds for GFPT2 Gene

(4) Drugs for GFPT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist, Enzyme, substrate 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
glucosamine 6-phosphate Experimental Pharma 0
L-Glutamic Acid Nutra Full agonist, Agonist 0

(1) Additional Compounds for GFPT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
643-13-0
genes like me logo Genes that share compounds with GFPT2: view

Transcripts for GFPT2 Gene

Unigene Clusters for GFPT2 Gene

Glutamine-fructose-6-phosphate transaminase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GFPT2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for GFPT2 Gene

GeneLoc Exon Structure for
GFPT2
ECgene alternative splicing isoforms for
GFPT2

Expression for GFPT2 Gene

mRNA expression in normal human tissues for GFPT2 Gene

mRNA differential expression in normal tissues according to GTEx for GFPT2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.5).

Protein differential expression in normal tissues from HIPED for GFPT2 Gene

This gene is overexpressed in Liver (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GFPT2 Gene



SOURCE GeneReport for Unigene cluster for GFPT2 Gene Hs.696497

mRNA Expression by UniProt/SwissProt for GFPT2 Gene

O94808-GFPT2_HUMAN
Tissue specificity: Highest levels of expression in heart, placenta, and spinal cord.
genes like me logo Genes that share expression patterns with GFPT2: view

Primer Products

No data available for Protein tissue co-expression partners for GFPT2 Gene

Orthologs for GFPT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GFPT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GFPT2 35
  • 91.98 (n)
  • 97.8 (a)
GFPT2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GFPT2 35
  • 90.86 (n)
  • 97.65 (a)
GFPT2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gfpt2 35
  • 89.39 (n)
  • 97.8 (a)
Gfpt2 16
Gfpt2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GFPT2 35
  • 98.04 (n)
  • 97.79 (a)
GFPT2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gfpt2 35
  • 89.3 (n)
  • 97.65 (a)
oppossum
(Monodelphis domestica)
Mammalia GFPT2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves GFPT2 35
  • 79.03 (n)
  • 92.67 (a)
GFPT2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GFPT2 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gfpt2 35
  • 73.73 (n)
  • 78.53 (a)
gfpt2 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12662 35
fruit fly
(Drosophila melanogaster)
Insecta Gfat1 37
  • 63 (a)
Gfat2 37
  • 66 (a)
Gfat2 35
  • 65.44 (n)
  • 66.72 (a)
Gfat1 36
  • 64 (a)
ManyToMany
Gfat2 36
  • 66 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011352 35
  • 65.67 (n)
  • 68.3 (a)
worm
(Caenorhabditis elegans)
Secernentea F07A11.2a 37
  • 57 (a)
F07A11.2b 37
  • 58 (a)
F22B3.4 37
  • 57 (a)
F07A11.2 35
  • 60.47 (n)
  • 61.5 (a)
F07A11.2 36
  • 56 (a)
ManyToMany
F22B3.4 36
  • 57 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL036C 35
  • 60.36 (n)
  • 59.38 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13596g 35
  • 56.28 (n)
  • 59.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GFA1 35
  • 55.44 (n)
  • 59.23 (a)
GFA1 36
  • 55 (a)
OneToMany
GFA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G24090 35
  • 54.74 (n)
  • 54.43 (a)
rice
(Oryza sativa)
Liliopsida Os12g0131100 35
  • 58.91 (n)
  • 59.43 (a)
corn
(Zea mays)
Liliopsida Zm.11907 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11350 35
  • 59.29 (n)
  • 57.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.11 35
  • 54.5 (n)
  • 56.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for GFPT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GFPT2 Gene

ENSEMBL:
Gene Tree for GFPT2 (if available)
TreeFam:
Gene Tree for GFPT2 (if available)

Paralogs for GFPT2 Gene

Paralogs for GFPT2 Gene

(1) SIMAP similar genes for GFPT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GFPT2: view

Variants for GFPT2 Gene

Sequence variations from dbSNP and Humsavar for GFPT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2303007 - 180,313,827(+) GCCGA(C/T)CTCCG downstream-variant-500B, reference, missense
rs729568 -- 180,305,350(-) ATGCT(C/T)AATCA intron-variant
rs729652 -- 180,304,695(+) TGGTA(C/T)TGGCA intron-variant
rs7725 -- 180,300,957(+) TTCAA(C/T)TGGAC utr-variant-3-prime
rs878705 -- 180,337,779(-) GATAG(A/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GFPT2 Gene

Variant ID Type Subtype PubMed ID
dgv1881e1 CNV Complex 17122850
nsv883290 CNV Loss 21882294
nsv830563 CNV Loss 17160897
nsv10787 CNV Gain 18304495
esv2731327 CNV Deletion 23290073
dgv1020e201 CNV Deletion 23290073
esv2731331 CNV Deletion 23290073
nsv883291 CNV Loss 21882294

Variation tolerance for GFPT2 Gene

Residual Variation Intolerance Score: 2.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GFPT2 Gene

Human Gene Mutation Database (HGMD)
GFPT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFPT2 Gene

Disorders for GFPT2 Gene

Relevant External Links for GFPT2

Genetic Association Database (GAD)
GFPT2
Human Genome Epidemiology (HuGE) Navigator
GFPT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GFPT2

No disorders were found for GFPT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFPT2 Gene

Publications for GFPT2 Gene

  1. cDNA cloning and mapping of a novel subtype of glutamine:fructose-6- phosphate amidotransferase (GFAT2) in human and mouse. (PMID: 10198162) Oki T. … Tanaka I. (Genomics 1999) 2 3 4 23 67
  2. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. (PMID: 20353610) Prasad P. … Thelma B.K. (BMC Med. Genet. 2010) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Common variants in glutamine:fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels. (PMID: 14764791) Zhang H. … Elbein S.C. (J. Clin. Endocrinol. Metab. 2004) 3 23

Products for GFPT2 Gene

Sources for GFPT2 Gene

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