Aliases for GFPT1 Gene
External Ids for GFPT1 Gene
Previous HGNC Symbols for GFPT1 Gene
Previous GeneCards Identifiers for GFPT1 Gene
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
GeneCards Summary for GFPT1 Gene
GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1) is a Protein Coding gene. Diseases associated with GFPT1 include Myasthenia, Congenital, 12, With Tubular Aggregates and Congenital Myasthenic Syndromes With Glycosylation Defect. Among its related pathways are Glucose / Energy Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include carbohydrate binding and glutamine-fructose-6-phosphate transaminase (isomerizing) activity. An important paralog of this gene is GFPT2.
UniProtKB/Swiss-Prot for GFPT1 Gene
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.