Aliases for GFPT1 Gene
External Ids for GFPT1 Gene
Previous HGNC Symbols for GFPT1 Gene
Previous GeneCards Identifiers for GFPT1 Gene
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
GeneCards Summary for GFPT1 Gene
GFPT1 (Glutamine--Fructose-6-Phosphate Transaminase 1) is a Protein Coding gene. Diseases associated with GFPT1 include myasthenia, congenital, 12, with tubular aggregates and congenital myasthenic syndromes with glycosylation defect. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include carbohydrate binding and glutamine-fructose-6-phosphate transaminase (isomerizing) activity. An important paralog of this gene is GFPT2.
UniProtKB/Swiss-Prot for GFPT1 Gene
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.