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Aliases for GFOD1 Gene

Aliases for GFOD1 Gene

  • Glucose-Fructose Oxidoreductase Domain Containing 1 2 3 5
  • C6orf114 3 4
  • Glucose-Fructose Oxidoreductase Domain-Containing Protein 1 3
  • Chromosome 6 Open Reading Frame 114 2
  • EC 1.-.-.- 4
  • ADG-90 3

External Ids for GFOD1 Gene

Previous HGNC Symbols for GFOD1 Gene

  • C6orf114

Previous GeneCards Identifiers for GFOD1 Gene

  • GC06M013426
  • GC06M013471

Summaries for GFOD1 Gene

GeneCards Summary for GFOD1 Gene

GFOD1 (Glucose-Fructose Oxidoreductase Domain Containing 1) is a Protein Coding gene. Diseases associated with GFOD1 include Attention Deficit-Hyperactivity Disorder. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is GFOD2.

Additional gene information for GFOD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFOD1 Gene

Genomics for GFOD1 Gene

Regulatory Elements for GFOD1 Gene

Enhancers for GFOD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H013394 2 FANTOM5 Ensembl ENCODE dbSUPER 30 +90.8 90825 4.1 PKNOX1 ARNT FEZF1 ZNF766 SMARCB1 MEF2D ZNF610 SMARCA4 ZSCAN16 GLIS1 GFOD1 GFOD1-AS1 SIRT5 TBC1D7 PIR51588 GC06M013385
GH06H013403 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.3 +81.3 81335 4.9 FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 ZNF143 FOS DEK GFOD1 GFOD1-AS1 SIRT5 RANBP9 PIR51588 GC06M013385
GH06H013424 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.7 +57.1 57080 11.2 HDGF PKNOX1 ATF1 SIN3A FEZF1 ZNF121 ZNF143 ZNF207 FOS ATF7 GFOD1 TBC1D7 GFOD1-AS1 SIRT5 RANBP9 GC06M013385 PIR51588
GH06H013411 1.5 Ensembl ENCODE dbSUPER 26.6 +74.5 74475 4.4 FOXA2 MLX ARID4B DMAP1 ZNF548 SP5 MIER2 PPARG NFIL3 MIER3 GFOD1 GFOD1-AS1 SIRT5 TBC1D7 GC06M013385 PIR51588
GH06H013461 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.6 +25.1 25092 2.3 KLF1 HLF MAX MNT REST ZIC2 RAD21 JUND ATF3 POLR2A GFOD1 GFOD1-AS1 SIRT5 TBC1D7 GC06M013422 GC06M013385
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GFOD1 on UCSC Golden Path with GeneCards custom track

Promoters for GFOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000193466 862 3201 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF121 ZNF766 GLIS2 ZNF207

Genomic Locations for GFOD1 Gene

Genomic Locations for GFOD1 Gene
chr6:13,357,830-13,487,662
(GRCh38/hg38)
Size:
129,833 bases
Orientation:
Minus strand
chr6:13,358,062-13,487,894
(GRCh37/hg19)

Genomic View for GFOD1 Gene

Genes around GFOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFOD1 Gene

Proteins for GFOD1 Gene

  • Protein details for GFOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXC2-GFOD1_HUMAN
    Recommended name:
    Glucose-fructose oxidoreductase domain-containing protein 1
    Protein Accession:
    Q9NXC2
    Secondary Accessions:
    • A8E4L6
    • Q5T058
    • Q96JD4
    • Q9H5K2

    Protein attributes for GFOD1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43158 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GFOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GFOD1 Gene

Post-translational modifications for GFOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GFOD1 Gene

No data available for DME Specific Peptides for GFOD1 Gene

Domains & Families for GFOD1 Gene

Gene Families for GFOD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GFOD1 Gene

Suggested Antigen Peptide Sequences for GFOD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXC2

UniProtKB/Swiss-Prot:

GFOD1_HUMAN :
  • Belongs to the Gfo/Idh/MocA family.
Family:
  • Belongs to the Gfo/Idh/MocA family.
genes like me logo Genes that share domains with GFOD1: view

Function for GFOD1 Gene

Enzyme Numbers (IUBMB) for GFOD1 Gene

Gene Ontology (GO) - Molecular Function for GFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GFOD1: view
genes like me logo Genes that share phenotypes with GFOD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GFOD1 Gene

Localization for GFOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFOD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFOD1 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GFOD1: view

Pathways & Interactions for GFOD1 Gene

SuperPathways for GFOD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GFOD1: view

No data available for Pathways by source and SIGNOR curated interactions for GFOD1 Gene

Drugs & Compounds for GFOD1 Gene

No Compound Related Data Available

Transcripts for GFOD1 Gene

Unigene Clusters for GFOD1 Gene

Glucose-fructose oxidoreductase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFOD1 Gene

No ASD Table

Relevant External Links for GFOD1 Gene

GeneLoc Exon Structure for
GFOD1
ECgene alternative splicing isoforms for
GFOD1

Expression for GFOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GFOD1 Gene

Protein differential expression in normal tissues from HIPED for GFOD1 Gene

This gene is overexpressed in Fetal gut (33.3), Placenta (6.9), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GFOD1 Gene



Protein tissue co-expression partners for GFOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GFOD1 Gene:

GFOD1

SOURCE GeneReport for Unigene cluster for GFOD1 Gene:

Hs.484686

Evidence on tissue expression from TISSUES for GFOD1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with GFOD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GFOD1 Gene

Orthologs for GFOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GFOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GFOD1 34 33
  • 99.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GFOD1 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GFOD1 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GFOD1 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gfod1 33
  • 90.77 (n)
mouse
(Mus musculus)
Mammalia Gfod1 34 16 33
  • 90.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GFOD1 33
  • 86.15 (n)
chicken
(Gallus gallus)
Aves GFOD1 34 33
  • 82.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GFOD1 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gfod1 33
  • 75.81 (n)
zebrafish
(Danio rerio)
Actinopterygii GFOD1 34
  • 85 (a)
OneToOne
si:ch211-276f18.2 33
  • 75.3 (n)
Dr.12253 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008097 33
  • 58.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17712 33 34
  • 56.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.291 34
  • 41 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14263 33
Species where no ortholog for GFOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFOD1 Gene

ENSEMBL:
Gene Tree for GFOD1 (if available)
TreeFam:
Gene Tree for GFOD1 (if available)

Paralogs for GFOD1 Gene

Paralogs for GFOD1 Gene

(1) SIMAP similar genes for GFOD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GFOD1: view

Variants for GFOD1 Gene

Sequence variations from dbSNP and Humsavar for GFOD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000030448 -- 13,473,718(+) CCTTT(C/T)CAATT intron-variant, upstream-variant-2KB
rs1000067604 -- 13,388,516(+) GAAAG(A/G)ATTCC intron-variant
rs1000069105 -- 13,489,531(+) TGGTG(C/T)ATAGT upstream-variant-2KB
rs1000077429 -- 13,388,701(+) GACAT(A/G)GGCAA intron-variant
rs1000091541 -- 13,370,669(+) AAGTA(C/T)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GFOD1 Gene

Variant ID Type Subtype PubMed ID
nsv600994 CNV gain 21841781
nsv520921 CNV loss 19592680
nsv470802 CNV gain 18288195
nsv462640 CNV gain 19166990
nsv1074381 CNV deletion 25765185
nsv1033620 CNV gain 25217958
esv3608126 CNV loss 21293372
esv3390454 CNV insertion 20981092
esv3354997 CNV duplication 20981092
esv3308926 CNV mobile element insertion 20981092
esv2731605 CNV deletion 23290073
esv1029682 CNV insertion 17803354

Variation tolerance for GFOD1 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GFOD1 Gene

Human Gene Mutation Database (HGMD)
GFOD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GFOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFOD1 Gene

Disorders for GFOD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GFOD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search GFOD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GFOD1

Genetic Association Database (GAD)
GFOD1
Human Genome Epidemiology (HuGE) Navigator
GFOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GFOD1
genes like me logo Genes that share disorders with GFOD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GFOD1 Gene

Publications for GFOD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60

Products for GFOD1 Gene

Sources for GFOD1 Gene

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