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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GFM2 Gene

protein-coding   GIFtS: 54
GCID: GC05M074018

G Elongation Factor, Mitochondrial 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Elongation Factor, Mitochondrial 21 2     MST0272
EFG22 3 5     RRF22
EF-G2mt2 3     Mitochondrial Elongation Factor G22
RRF2mt2 3     Mitochondrial Ribosome Recycling Factor 22
hEFG22 3     Ribosome-Releasing Factor 2, Mitochondrial2
MEF-G 22 3     Elongation Factor G 2, Mitochondrial3
MRRF22     Elongation Factor G23

External Ids:    HGNC: 296821   Entrez Gene: 843402   Ensembl: ENSG000001643477   OMIM: 6065445   UniProtKB: Q969S93   

Export aliases for GFM2 gene to outside databases

Previous GC identifers: GC05M074052 GC05M069221


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GFM2 Gene:
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria.
Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to
a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of
mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase
that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from
messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to
mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding
distinct isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for GFM2 Gene: 
GFM2 (G elongation factor, mitochondrial 2) is a protein-coding gene. Diseases associated with GFM2 include pneumonia, and tuberculosis. GO annotations related to this gene include GTP binding and translation elongation factor activity.

UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9
Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of
mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome
disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal
translocation step during translation elongation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GFM2 gene promoter:
         LHX3b/Lhx3b   Pbx1a   NF-AT   CREB   NF-AT4   NF-AT2   LHX3a/Lhx3a   Chx10   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGFM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GFM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13

GFM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFM2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M074018:  view genomic region     (about GC identifiers)

Start:
74,017,029 bp from pter      End:
74,063,196 bp from pter
Size:
46,168 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9 (See protein sequence)
Recommended Name: Ribosome-releasing factor 2, mitochondrial precursor  
Size: 779 amino acids; 86601 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: A0AR28 Q8N6D8 Q8WYI0 Q9H6Z1
Alternative splicing: 5 isoforms:  Q969S9-1   Q969S9-2   Q969S9-3   Q969S9-4   Q969S9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GFM2: NX_Q969S9

Explore proteomics data for GFM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969S9

  • GFM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GFM2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001268231.1  NP_115756.2  NP_733781.1  NP_733792.1  

    ENSEMBL proteins: 
     ENSP00000296805   ENSP00000296804   ENSP00000427004   ENSP00000405808   ENSP00000421717  
     ENSP00000424877  

    Human Recombinant Protein Products for GFM2: 
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    Novus Biologicals GFM2 Proteins
    Novus Biologicals GFM2 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GFM2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    GFM2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for GFM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR000795 EF_GTP-bd_dom
     IPR005517 Transl_elong_EFG/EF2_IV
     IPR005225 Small_GTP-bd_dom
     IPR004161 Transl_elong_EFTu/EF1A_2
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry Q969S9

    ProtoNet protein and cluster: Q969S9

    2 Blocks protein domains:
    IPB000640 Elongation factor G
    IPB005517 Elongation factor G


    UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9
    Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily


    GFM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRF2M_HUMAN, Q969S9
    Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of
    mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome
    disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal
    translocation step during translation elongation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003746NOT translation elongation factor activity IDA19716793
    GO:0003924GTPase activity IDA19716793
    GO:0005525GTP binding IEA--
         
    GFM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GFM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GFM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GFM2 
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    hsa-miR-96* hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidGFM2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GFM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for GFM2 (Q969S93 ENSP000002968054) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    RBX1P628773I2D: score=2 
    DNAJA1P316893I2D: score=1 
    SMAD2Q157963I2D: score=1 
    RPS20ENSP000000095894STRING: ENSP00000009589
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA19716793
    GO:0032543mitochondrial translation IDA19716793
    GO:0032790ribosome disassembly IDA19716793
    GO:0070125NOT mitochondrial translational elongation IDA19716793

    GFM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GFM2 (RRF2M)

    4 HMDB Compounds for GFM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about GFM2 / RRF2M

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GFM2 gene (4 alternative transcripts): 
    NM_001281302.1  NM_032380.4  NM_170681.2  NM_170691.2  

    Unigene Cluster for GFM2:

    G elongation factor, mitochondrial 2
    Hs.277154  [show with all ESTs]
    Unigene Representative Sequence: NM_032380
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296805(uc003kdh.1 uc003kdi.1 uc010izj.1 uc010izk.1 uc010izl.1)
    ENST00000345239 ENST00000509430 ENST00000515125 ENST00000514734 ENST00000506263
    ENST00000427854(uc003kdj.1) ENST00000513331 ENST00000509097 ENST00000506778

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate GFM2:
    hsa-miR-96* hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidGFM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector (see all 3): GFM2 (NM_170681)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFM2
    Sirion Biotech Customized lentivirus for stable overexpression of GFM2 
                         Customized lentivirus expression plasmids for stable overexpression of GFM2 
    Primer
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    OriGene qPCR primer pairs and template standards for GFM2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GFM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFM2

    Additional mRNA sequence: 

    AF111808.1 AF367997.1 AK025314.1 AK126251.1 AK307839.1 AK308422.1 AK315705.1 AY453587.1 
    BC015712.1 BC030612.1 

    24/25 DOTS entries (see all 25):

    DT.92460306  DT.100059726  DT.100868799  DT.97862484  DT.120814589  DT.100776785  DT.100059733  DT.100798975 
    DT.92460289  DT.100848492  DT.95301878  DT.92460310  DT.100776780  DT.92460296  DT.97788223  DT.101976061 
    DT.120814536  DT.402852  DT.75129626  DT.91641767  DT.95173447  DT.95173454  DT.100664535  DT.121211263 

    24/210 AceView cDNA sequences (see all 210):

    BX422090 AA418187 BX436120 CR592399 NM_170691 AI565292 NM_032380 AI279694 
    BX441855 CR607096 BQ067943 BM745868 BM479840 AI393493 AF367997 CB143756 
    CB305632 AF074660 AV709414 AF111808 BM787714 BM771778 BG743022 BF438751 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for GFM2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ·
    SP1:                                                  -                                   -                                                                     
    SP2:                                                                                      -                                                     -     -         
    SP3:                                                                                                                                            -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                                                                                                                            -     -         

    ExUns: 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23
    SP1:                                                            
    SP2:        -                                                   
    SP3:        -                                                   
    SP4:        -                                                   
    SP5:                                                            


    ECgene alternative splicing isoforms for GFM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GFM2 expression in normal human tissues (normalized intensities)      GFM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTCATCT
    GFM2 Expression
    About this image


    GFM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius   

    See GFM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GFM2

    SOURCE GeneReport for Unigene cluster: Hs.277154

    UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for GFM2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GFM2 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gfm21 , 5 G elongation factor, mitochondrial 21, 5 82.75(n)1
    84.77(a)1
      13 (50.66 cM)5
    3208061  NM_177266.41  NP_796240.31 
     971379375 
    chicken
    (Gallus gallus)
    Aves GFM21 G elongation factor, mitochondrial 2 73.31(n)
    73.05(a)
      427205  XM_424792.2  XP_424792.2 
    lizard
    (Anolis carolinensis)
    Reptilia GFM26
    G elongation factor, mitochondrial 2
    71(a)
    1 ↔ 1
    2(15126931-15150910)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU911836.12   -- 77.98(n)    BU911836.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570470712   -- 69.21(n)    57047071 
    fruit fly
    (Drosophila melanogaster)
    Insecta EF-G21 Elongation Factor G2 50.66(n)
    42.88(a)
      42670  NM_170028.2  NP_732771.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y119D3B.141 Protein Y119D3B.14 47.32(n)
    39.09(a)
      191043  NM_064944.3  NP_497345.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEF2(YJL102W)4
    MEF21
    Mitochondrial elongation factor involved in translational more4
    Mef2p1
    49.32(n)1
    41.11(a)1
      10(231301-233760)4
    8533421, 4  NP_012433.11, 4 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CB344954.22   -- 79.47(n)    CB344954.2 


    ENSEMBL Gene Tree for GFM2 (if available)
    TreeFam Gene Tree for GFM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GFM2 gene
    2 SIMAP similar genes for GFM2 using alignment to 3 protein entries:     RRF2M_HUMAN (see all proteins):
    GFM1    EEF1A1

    GFM2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GFM2
    PGOHUM00000251316


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/934 SNPs in GFM2 are shown (see all 934)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs361167751,2
    C--69243025(+) TTGGT-/AAAAAA 3 -- int10--------
    rs1859587441,2
    C--69243035(+) AAAAAA/C/GAAAAC 3 -- int10--------
    rs2019147701,2
    --69257104(+) ACCAC-/ATTTTCT 3 -- int10--------
    rs716004381,2
    C--74018077(+) AACGAAACTT/
            
    AACTT
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs600777451,2
    C--74024174(+) ATCGT-/TAAGAG 2 -- int10--------
    rs673608411,2
    C--74028753(+) TTTAG-/ACAC  
            
    ACACA
    2 -- int11Minor allele frequency- ACAC:0.00NA 2
    rs3676558071,2
    C--74028753(+) TTTAG-/ACACAC
            
    ACACA
    2 -- int10--------
    rs595714821,2
    C--74029160(+) AAAAA-/A/AA  
            
    GACAA
    2 -- int10--------
    rs1456542361,2
    C--74049782(+) TGGGG-/GAAAAA 3 -- int10--------
    rs30312081,2
    C--74050131(+) CAATG-/A/AA  
            
    AAAAA
    3 -- int11CSA 2

    HapMap Linkage Disequilibrium report for GFM2 (74017029 - 74063196 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GFM2: --

    Human Gene Mutation Database (HGMD): GFM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GFM2
    DNA2.0 Custom Variant and Variant Library Synthesis for GFM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606544    OMIM disorders: --

    2 diseases for GFM2:    About MalaCards
    pneumonia    tuberculosis


    GFM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GFM2
    Human Genome Epidemiology (HuGE) Navigator: GFM2 (1 document)

    Export disorders for GFM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GFM2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with GFM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution. (PubMed id 11735030)1, 2, 3, 9 Hammarsund M.... Sangfelt O. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. (PubMed id 19716793)1, 2 Tsuboi M.... Takeuchi N. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastat in toxicity. (PubMed id 22719265)1 Callegari S....de Barros Lopes M.A. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2. (PubMed id 18753147)1 Sasarman F....Shoubridge E.A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84340 HGNC: 29682 AceView: GFM2 Ensembl:ENSG00000164347 euGenes: HUgn84340
    ECgene: GFM2 H-InvDB: GFM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GFM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GFM2 gene:
    Search GeneIP for patents involving GFM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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