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Aliases for GFM2 Gene

Aliases for GFM2 Gene

  • G Elongation Factor, Mitochondrial 2 2 3
  • EFG2 3 4 6
  • MEF-G 2 3 4
  • EF-G2mt 3 4
  • RRF2mt 3 4
  • HEFG2 3 4
  • Ribosome-Releasing Factor 2, Mitochondrial 3
  • Mitochondrial Ribosome Recycling Factor 2 3
  • Elongation Factor G 2, Mitochondrial 4
  • Mitochondrial Elongation Factor G2 3
  • Elongation Factor G2 4
  • MSTP027 3
  • MST027 3
  • MRRF2 3
  • RRF2 3

External Ids for GFM2 Gene

Summaries for GFM2 Gene

Entrez Gene Summary for GFM2 Gene

  • Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for GFM2 Gene

GFM2 (G Elongation Factor, Mitochondrial 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and translation elongation factor activity.

UniProtKB/Swiss-Prot for GFM2 Gene

  • Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFM2 Gene

Genomics for GFM2 Gene

Genomic Location for GFM2 Gene

Start:
74,721,204 bp from pter
End:
74,767,371 bp from pter
Size:
46,168 bases
Orientation:
Minus strand

Genomic View for GFM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GFM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFM2 Gene

Regulatory Elements for GFM2 Gene

Proteins for GFM2 Gene

  • Protein details for GFM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S9-RRF2M_HUMAN
    Recommended name:
    Ribosome-releasing factor 2, mitochondrial
    Protein Accession:
    Q969S9
    Secondary Accessions:
    • A0AR28
    • Q8N6D8
    • Q8WYI0
    • Q9H6Z1

    Protein attributes for GFM2 Gene

    Size:
    779 amino acids
    Molecular mass:
    86601 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GFM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GFM2 Gene

Proteomics data for GFM2 Gene at MOPED

Post-translational modifications for GFM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GFM2 Gene

Domains for GFM2 Gene

Suggested Antigen Peptide Sequences for GFM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969S9

UniProtKB/Swiss-Prot:

RRF2M_HUMAN
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.:
    • Q969S9
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.:
    • Q969S9
genes like me logo Genes that share domains with GFM2: view

No data available for Gene Families for GFM2 Gene

Function for GFM2 Gene

Molecular function for GFM2 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.

Gene Ontology (GO) - Molecular Function for GFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 NOT translation elongation factor activity IDA 19716793
GO:0003924 GTPase activity IDA 19716793
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GFM2: view

miRNA for GFM2 Gene

miRTarBase miRNAs that target GFM2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GFM2 Gene

Localization for GFM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFM2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GFM2 Gene COMPARTMENTS Subcellular localization image for GFM2 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for GFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with GFM2: view

Pathways for GFM2 Gene

SuperPathways for GFM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0032790 ribosome disassembly IDA 19716793
GO:0070125 NOT mitochondrial translational elongation IDA 19716793
genes like me logo Genes that share ontologies with GFM2: view

No data available for Pathways by source for GFM2 Gene

Compounds for GFM2 Gene

(4) HMDB Compounds for GFM2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with GFM2: view

Transcripts for GFM2 Gene

Unigene Clusters for GFM2 Gene

G elongation factor, mitochondrial 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GFM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9: - -
SP10:
SP11:

ExUns: 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23
SP1:
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for GFM2 Gene

GeneLoc Exon Structure for
GFM2
ECgene alternative splicing isoforms for
GFM2

Expression for GFM2 Gene

mRNA expression in normal human tissues for GFM2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GFM2 Gene

SOURCE GeneReport for Unigene cluster for GFM2 Gene Hs.277154

mRNA Expression by UniProt/SwissProt for GFM2 Gene

Q969S9-RRF2M_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with GFM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GFM2 Gene

Orthologs for GFM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GFM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GFM2 35
  • 99.61 (n)
  • 99.49 (a)
GFM2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GFM2 35
  • 90.08 (n)
  • 89.43 (a)
GFM2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GFM2 35
  • 90.35 (n)
  • 89.96 (a)
GFM2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gfm2 35
  • 81.51 (n)
  • 83.61 (a)
Gfm2 16
Gfm2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GFM2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GFM2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gfm2 35
  • 82.92 (n)
  • 84.26 (a)
chicken
(Gallus gallus)
Aves GFM2 35
  • 73.27 (n)
  • 72.93 (a)
GFM2 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GFM2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gfm2 35
  • 70.6 (n)
  • 70.85 (a)
zebrafish
(Danio rerio)
Actinopterygii gfm2 35
  • 66.11 (n)
  • 69.99 (a)
gfm2 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RRF2M_ANOGA 35
  • 49.7 (n)
  • 45.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta EF-G2 35
  • 51.15 (n)
  • 43.08 (a)
EF-G2 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y119D3B.14 35
  • 47.6 (n)
  • 39.37 (a)
Y119D3B.14 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR085W 35
  • 48.05 (n)
  • 44.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEF2 35
  • 49.5 (n)
  • 41.74 (a)
MEF2 36
  • 34 (a)
OneToOne
MEF2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13992g 35
  • 49.55 (n)
  • 39.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07021 35
  • 43.49 (n)
  • 35.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC660.10 35
  • 50.91 (n)
  • 42.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for GFM2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GFM2 Gene

ENSEMBL:
Gene Tree for GFM2 (if available)
TreeFam:
Gene Tree for GFM2 (if available)

Paralogs for GFM2 Gene

Selected SIMAP similar genes for GFM2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GFM2 Gene

genes like me logo Genes that share paralogs with GFM2: view

No data available for Paralogs for GFM2 Gene

Variants for GFM2 Gene

Sequence variations from dbSNP and Humsavar for GFM2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs957680 Benign, - 74,759,384(-) CATCA(A/G)TCCTC reference, missense, nc-transcript-variant
rs1374694 -- 74,735,097(-) AGCTG(A/G)TTGTA intron-variant
rs1447452 -- 74,740,423(-) agaaa(C/T)atttt intron-variant
rs2314936 -- 74,754,384(+) gaatg(G/T)aaatg intron-variant
rs2314937 -- 74,754,490(+) actca(A/C)ataaa intron-variant

Relevant External Links for GFM2 Gene

HapMap Linkage Disequilibrium report
GFM2
Human Gene Mutation Database (HGMD)
GFM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GFM2 Gene

Disorders for GFM2 Gene

Relevant External Links for GFM2

Genetic Association Database (GAD)
GFM2
Human Genome Epidemiology (HuGE) Navigator
GFM2
genes like me logo Genes that share disorders with GFM2: view

No data available for UniProtKB/Swiss-Prot for GFM2 Gene

Publications for GFM2 Gene

  1. Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution. (PMID: 11735030) Hammarsund M. … Sangfelt O. (Hum. Genet. 2001) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. (PMID: 19716793) Tsuboi M. … Takeuchi N. (Mol. Cell 2009) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for GFM2 Gene

Sources for GFM2 Gene

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