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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GFM2 Gene

protein-coding GIFtS: 51
GCID: GC05M074052

G elongation factor, mitochondrial 2

Explore 4 diseases affiliated with
GFM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
G Elongation Factor, Mitochondrial 2¹ ²		MRRF2²
EFG2¹ ² ³ ⁵		MST027²
Elongation Factor G 2, Mitochondrial² ³		MSTP027²
EF-G2mt² ³		RRF2²
RRF2mt² ³		Mitochondrial Elongation Factor G2²
HEFG2¹		Mitochondrial Ribosome Recycling Factor 2²
MEF-G 2² ³		Ribosome-Releasing Factor 2, Mitochondrial²
FLJ21661¹		Elongation Factor G2³

External Ids:	HGNC: 29682¹	Entrez Gene: 84340²	Ensembl: ENSG00000164347⁷	OMIM: 606544⁵	UniProtKB: Q969S9³

Export aliases for GFM2 gene to outside databases

Previous GC identifer: GC05M069221

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GFM2:

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial

translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the

respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes

one of mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and

in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at

least three transcript variants encoding distinct isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9

Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of

mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly

and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step

during translation elongation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GFM2 gene promoter:
LHX3b/Lhx3b Pbx1a NF-AT CREB NF-AT4 NF-AT2 LHX3a/Lhx3a Chx10 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GFM2 promoter sequence

Search SABiosciences Chromatin IP Primers for GFM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13

GFM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFM2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M074052: view genomic region (about GC identifiers)

Start:	74,017,029 bp from pter	End:	74,063,196 bp from pter
Size:	46,168 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9 (See protein sequence)

Recommended Name: Ribosome-releasing factor 2, mitochondrial precursor

Size: 779 amino acids; 86601 Da

Subcellular location: Mitochondrion (By similarity)

Secondary accessions: A0AR28 Q8N6D8 Q8WYI0 Q9H6Z1

Alternative splicing: 5 isoforms: Q969S9-1 Q969S9-2 Q969S9-3 Q969S9-4 Q969S9-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GFM2: NX_Q969S9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q969S9

GFM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_115756.2 NP_733781.1 NP_733792.1

ENSEMBL proteins:

ENSP00000296805 ENSP00000296804 ENSP00000427004 ENSP00000405808 ENSP00000421717

ENSP00000424877

Human Recombinant Protein Products for GFM2:

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	Uscn Proteins for GFM2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

GFM2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GFM2 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR000795 EF_GTP-bd_dom

IPR005517 Transl_elong_EFG/EF2_IV

IPR005225 Small_GTP-bd_dom

IPR004161 Transl_elong_EFTu/EF1A_2

IPR020568 Ribosomal_S5_D2-typ_fold

Graphical View of Domain Structure for InterPro Entry Q969S9

ProtoNet protein and cluster: Q969S9

2 Blocks protein families:

IPB000640 Elongation factor G

IPB005517 Elongation factor G

UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RRF2M_HUMAN, Q969S9

Function: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of

mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly

and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step

during translation elongation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003746	NOT translation elongation factor activity	IDA	19716793
GO:0003924	GTPase activity	IDA	19716793
GO:0005525	GTP binding	IEA	--

GFM2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GFM2

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GFM2 Browse MicroRNA Expression Plasmids
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		hsa-miR-96* hsa-miR-2116
		SwitchGear 3'UTR luciferase reporter plasmid: GFM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GFM2 (see all 4) OriGene shRNA RFP: GFM2 OriGene siRNA: GFM2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GFM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for GFM2 (Q969S9³ ENSP00000296805⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLX4	Q8IY92³, ENSP00000294008⁴	I2D: score=1 STRING: ENSP00000294008
RBX1	P62877³	I2D: score=2
DNAJA1	P31689³	I2D: score=1
SMAD2	Q15796³	I2D: score=1
RPS20	ENSP00000009589⁴	STRING: ENSP00000009589

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	IDA	19716793
GO:0032543	mitochondrial translation	IDA	19716793
GO:0032790	ribosome disassembly	IDA	19716793
GO:0070125	NOT mitochondrial translational elongation	IDA	19716793

GFM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GFM2

4 HMDB Compounds for GFM2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about GFM2 / RRF2M

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GFM2 gene (3 alternative transcripts):

NM_032380.3 NM_170681.1 NM_170691.1

Unigene Cluster for GFM2:

G elongation factor, mitochondrial 2

Hs.277154 [show with all ESTs]

Unigene Representative Sequence: NM_032380

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296805(uc003kdh.1 uc003kdi.1 uc010izj.1 uc010izk.1 uc010izl.1)

ENST00000345239 ENST00000509430 ENST00000515125 ENST00000514734 ENST00000506263

ENST00000427854(uc003kdj.1) ENST00000513331 ENST00000509097 ENST00000510540

ENST00000506778

miRNA Products:		OriGene 3'-UTR Clone (see all 3): GFM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GFM2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GFM2:
		hsa-miR-96* hsa-miR-2116
		SwitchGear 3'UTR luciferase reporter plasmid: GFM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GFM2 (see all 4) OriGene shRNA RFP: GFM2 OriGene siRNA: GFM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GFM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against GFM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GFM2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GFM2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): GFM2 (NM_170681)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFM2

Additional cDNA sequence:

AF111808.1 AF367997.1 AK025314.1 AK126251.1 AK307839.1 AK308422.1 AK315705.1 AY453587.1

BC015712.1 BC030612.1

24/25 DOTS entries (see all 25):

DT.92460306 DT.100059726 DT.100868799 DT.97862484 DT.120814589 DT.100776785 DT.100059733 DT.100798975

DT.92460289 DT.100848492 DT.95301878 DT.92460310 DT.100776780 DT.92460296 DT.97788223 DT.101976061

DT.120814536 DT.402852 DT.75129626 DT.91641767 DT.95173447 DT.95173454 DT.100664535 DT.121211263

24/210 AceView cDNA sequences (see all 210):

BG743022 BX436120 AI393493 H92828 AF074660 BX098025 NM_170681 AL043965

BQ067943 AA418187 AI684062 AF367997 BC015712 BX422090 AI521928 AF111808

BM787714 AI886226 BM479840 AA452589 AL039297 BM772056 BU622328 BM745868

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for GFM2 (see all 11) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17a	·	17b	·
SP1:																	-												-
SP2:																													-																		-		-
SP3:																																															-		-
SP4:																																															-		-
SP5:																																															-		-

ExUns:	17c	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·	22b	^	23
SP1:
SP2:			-
SP3:			-
SP4:			-
SP5:

ECgene alternative splicing isoforms for GFM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GFM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTTCATCT

About this image

GFM2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GFM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GFM2

SOURCE GeneReport for Unigene cluster: Hs.277154

UniProtKB/Swiss-Prot: RRF2M_HUMAN, Q969S9

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for GFM2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for GFM2 gene from 11/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gfm2^{1 , 5}	G elongation factor, mitochondrial 2^{1, 5}	82.75(n)¹ 84.77(a)¹		13 (50.66 cM)⁵ 320806¹ NM_177266.4¹ NP_796240.3¹ 97137937⁵
chicken (Gallus gallus)	Aves	GFM2¹	G elongation factor, mitochondrial 2	73.31(n) 73.05(a)		427205 XM_424792.2 XP_424792.2
lizard (Anolis carolinensis)	Reptilia	GFM2⁶ GFM1⁶	--	75(a) 33(a)	1 ↔ 1 possible ortholog	2(15132714-15150910) 3(14113841-14146250)
African clawed frog (Xenopus laevis)	Amphibia	BU911836.1²	--	77.98(n)		BU911836.1
zebrafish (Danio rerio)	Actinopterygii	57047071²	--	69.21(n)		57047071
fruit fly (Drosophila melanogaster)	Insecta	EF-G2¹	Elongation Factor G2	50.66(n) 42.88(a)		42670 NM_170028.2 NP_732771.2
worm (Caenorhabditis elegans)	Secernentea	Y119D3B.14¹	Protein Y119D3B.14	47.32(n) 39.09(a)		191043 NM_064944.3 NP_497345.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	MEF2(YJL102W)⁴ MEF2¹	Mitochondrial elongation factor involved in translational more⁴ Mef2p¹	49.32(n)¹ 41.11(a)¹		10(231301-233760)⁴ 853342^{1, 4} NP_012433.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSCO1⁶ AT1G45332⁶ (see all 3)	Elongation factor G (see all 3)	35(a) 32(a) (see all 3)	possible ortholog possible ortholog (see all 3)	1(23233434-23236447) 1(17172322-17176821)
rice (Oryza sativa)	Liliopsida	-- --	elongation factor, putative, expressed	33(a) 32(a)	possible ortholog possible ortholog	4(26732755-26735520) 3(20401513-20416037)

ENSEMBL Gene Tree for GFM2 (if available)
TreeFam Gene Tree for GFM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GFM2 gene

2 SIMAP similar genes for GFM2 using alignment to 3 protein entries: RRF2M_HUMAN (see all proteins):

GFM1 EEF1A1

GFM2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for GFM2
PGOHUM00000251316

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs16872219^1,2	C	--	69222749(+)	`AGTAGT/CGCAAG`	2	--	int¹		4	NA WA	260
rs113923552^1,2		--	69223065(+)	`TTTCTC/TTCAGG`	2	--	int¹		2	CSA	3
rs17856871^1,2	H	--	69223157(+)	`TAATTT/CCTGCT`	4	/E /G	mis¹		5	NS EA NA	422
rs16872220^1,2	C,F,H	--	69223720(+)	`GAAAAA/CTTTAG`	2	--	int¹ trp³		10	NA NS EA CSA WA	794
rs111573658^1,2	C	--	69223806(+)	`ATGCAC/TAAAGA`	2	--	int¹		1	NA	2
rs79449088^1,2		--	69224224(+)	`TTGACT/CTCCTT`	2	--	int¹		1	NA	120
rs16872221^1,2	C	--	69224333(+)	`CCCTAT/CTCAAA`	2	--	int¹		3	NA	142
rs72764642^1,2	C,F	--	69225181(+)	`AGGTTG/AGCAGA`	2	--	int¹		1	NA	120
rs62366372^1,2		--	69226147(+)	`AGAAAT/CGTCAC`	2	--	int¹		2	NA	122
rs17856872^1,2	H	--	69226843(+)	`TTGCTT/CCCACT`	4	/E /G	mis¹		5	NS EA NA	422

HapMap Linkage Disequilibrium report for GFM2 (74017029 - 74063196 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GFM2: --
Human Gene Mutation Database (HGMD): GFM2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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GFM2 for disorders           About GeneDecksing

OMIM gene information: 606544    OMIM disorders: --

4 diseases for GFM2:    About MalaCards

pneumonia tuberculosis malaria mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: GFM2 (1 document)

Export disorders for GFM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GFM2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with GFM2)

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world of online information

Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution. (PubMed id 11735030)^{1, 2, 3, 9} Hammarsund M.... Sangfelt O. (2001)
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. (PubMed id 19716793)^{1, 2} Tsuboi M.... Takeuchi N. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastat in toxicity. (PubMed id 22719265)¹ Callegari S....de Barros Lopes M.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2. (PubMed id 18753147)¹ Sasarman F....Shoubridge E.A. (2008)
The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1. (PubMed id 16632485)¹ Antonicka H....Shoubridge E.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84340	HGNC: 29682	AceView: GFM2	Ensembl:ENSG00000164347	euGenes: HUgn84340
ECgene: GFM2	H-InvDB: GFM2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GFM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GFM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GFM2 gene:
Search GeneIP for patents involving GFM2

GeneCards and IP:
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G elongation factor, mitochondrial 2

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G elongation factor, mitochondrial 2

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