GFM1 Gene
protein-coding GIFtS: 59
GCID: GC03P158362
|
|
G elongation factor, mitochondrial 1(Previous names: G translation elongation factor, mitochondrial )
| |
Aliases
for GFM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Elongation Factor, Mitochondrial 11 2 | | EF-Gmt2 3 | | GFM1 2 3 5 | | EFG2 3 | | EFG12 3 5 | | HEFG11 | | EFGM1 2 | | MEF-G 12 3 | | EGF11 2 | | COXPD12 5 | | G Translation Elongation Factor, Mitochondrial1 2 | | Elongation Factor G, Mitochondrial2 | | Elongation Factor G 1, Mitochondrial2 3 | | Mitochondrial Elongation Factor G2 | | Elongation Factor G12 3 | | Mitochondrial Elongation Factor G12 |
Export aliases for GFM1 gene to outside databasesPrevious GC identifers: GC03P159846 GC03P155758 |
Summaries
for GFM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GFM1:
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrialtranslation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in therespiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodesone of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial functionand in different disease states attributed to mitochondrial dysfunction is not known. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: EFGM_HUMAN, Q96RP9Function: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translationelongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational(POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changesin the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrialprotein biosynthesis
Gene Wiki entry for GFM1
|
Genomic Views
for GFM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GFM1 gene promoter:
PPAR-alpha RFX1 AP-1 ATF-2 STAT3 Sox9 Nkx2-5 c-Jun c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GFM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25 Ensembl cytogenetic band: 3q25.32 HGNC cytogenetic band: 3q25GFM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P158362: view genomic region
(about GC identifiers)
Start:
|
158,362,067 bp from pter |
End:
|
158,410,364 bp from pter |
Size:
|
48,298 bases |
Orientation:
|
plus strand |
|
Proteins
for GFM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EFGM_HUMAN, Q96RP9 (See
protein sequence)Recommended Name: Elongation factor G, mitochondrial precursor Size: 751 amino acids; 83471 Da
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=EAW78682.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NCI9 B2RCB9 B3KRW1 Q6GTN2 Q96T39Alternative splicing: 2 isoforms: Q96RP9-1 Q96RP9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GFM1: NX_Q96RP9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RP9
GFM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079272.4
ENSEMBL proteins: ENSP00000419038 ENSP00000418755 ENSP00000417225 ENSP00000264263 ENSP00000417532 ENSP00000420272 ENSP00000327081
Human Recombinant Protein Products for GFM1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GFM1 for ontologies About GeneDecksing
GFM1 Antibody Products:
Assay Products for GFM1: |
Protein
Domains /
Families
for GFM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GFM1 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q96RP9ProtoNet protein and cluster: Q96RP9 2 Blocks protein families: IPB000640 Elongation factor G IPB005517 Elongation factor G
UniProtKB/Swiss-Prot: EFGM_HUMAN, Q96RP9Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily |
Function
for GFM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EFGM_HUMAN, Q96RP9Function: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translationelongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational(POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changesin the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrialprotein biosynthesis Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
GFM1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for GFM1:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Gfm1):
GFM1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GFM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GFM1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GFM1 (NM_024996) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GFM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM1 |
|
Pathways & Interactions
for GFM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: EFGM_HUMAN, Q96RP9Pathway: Protein biosynthesis; polypeptide chain elongationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GFM1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/80 Interacting proteins for GFM1 (Q96RP92, 3 ENSP000004190384) via UniProtKB, MINT, STRING, and/or I2D (see all 80) About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
GFM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GFM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GFM1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for GFM1 |
 Browse Tocris compounds for GFM1
4 HMDB Compounds for GFM1 About this table
10/22 Novoseek chemical compound relationships for GFM1 gene (see all 22) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| viomycin |
85.2 |
1 |
17515906 (1) |
| gtp |
84.2 |
122 |
18836081 (6), 16940356 (5), 17630323 (5), 15985150 (4) (see all 50) |
| thiostrepton |
82.7 |
8 |
15492007 (2), 10449736 (2), 9628883 (1), 9696754 (1) (see all 6) |
| trna |
79.4 |
28 |
17630323 (4), 18538656 (2), 11980724 (2), 17349960 (2) (see all 19) |
| fusidic acid |
79.4 |
22 |
8642600 (3), 17980694 (3), 11980724 (1), 16489743 (1) (see all 11) |
| aminoacyl-trna |
77.4 |
6 |
12370017 (1), 17194938 (1), 16240709 (1), 2207151 (1) (see all 6) |
| gamma-carboxyglutamic acid |
76.6 |
25 |
17387172 (2), 14579355 (1), 11566805 (1), 20156644 (1) (see all 9) |
| fe(ii)-edta |
73.4 |
1 |
11780642 (1) |
| gdp |
71.9 |
26 |
18836081 (4), 16940356 (3), 9678602 (2), 17630323 (2) (see all 13) |
| puromycin |
59.4 |
2 |
1733779 (1), 1322179 (1) |
Search CenterWatch for drugs/clinical trials and news about GFM1 / EFGM
|
Transcripts
for GFM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GFM1 gene: NM_024996.5 Unigene Cluster for GFM1: G elongation factor, mitochondrial 1 Hs.518355 [show with all ESTs]Unigene Representative Sequence: AF30977712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486715(uc003fce.3) ENST00000478576(uc003fcd.3) ENST00000478254
ENST00000264263(uc003fcg.3) ENST00000464732 ENST00000478251 ENST00000486008
ENST00000490261 ENST00000477721 ENST00000481468 ENST00000472383 ENST00000312756
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GFM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GFM1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GFM1 (NM_024996) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GFM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFM1 |
Additional cDNA sequence: AF309777.1 AF367998.1 AK000780.1 AK092293.1 AK315031.1 BC049210.1 18 DOTS entries: DT.97771529 DT.101959083 DT.446628 DT.91935820 DT.120924610 DT.100819161 DT.100819164 DT.86852999 DT.100819162 DT.92418949 DT.95359469 DT.99934549 DT.40285341 DT.80100117 DT.91966683 DT.92418950 DT.95331287 DT.97822777 24/249 AceView cDNA sequences (see all 249): AA768294 AA649021 BP365297 BQ430445 BP346010 CD513040 AW612101 CR623235 BX329287 CD109494 BI825994 BQ691628 BM980706 AF367998 BM480336 BF941819 NM_024996 BQ772778 BM856912 BU194886 BX102879 AV651198 CB159253 CK819842
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GFM1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for GFM1
|
Expression
for GFM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GFM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTTCTTG
About this image
See GFM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GFM1
SOURCE GeneReport for Unigene cluster: Hs.518355
SABiosciences Custom PCR Arrays for GFM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GFM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GFM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GFM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM1 |
Orthologs
for GFM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GFM1 gene from 10/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GFM11 |
G elongation factor, mitochondrial 1 |
75.68(n)
82.24(a) |
|
425018 XM_001233638.2 XP_001233639.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GFM16GFM26 |
-- |
83(a)34(a) |
1 ↔ 1possible ortholog |
3(14113841-14146250) 2(15132714-15150910) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ617382.12 |
-- |
80.26(n) |
|
BJ617382.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570544002 |
-- |
68.92(n) |
|
57054400 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ico1 |
iconoclast |
62.9(n)
67.66(a) |
|
34004 NM_135261.1 NP_609105.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_F29C12.41 |
Protein F29C12.4 |
57.54(n)
56.5(a) |
|
174956 NM_064386.3 NP_496787.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MEF1(YLR069C)4
MEF11 |
Mitochondrial elongation factor involved in translational more4
Mef1p1 |
58.88(n)1
58.44(a)1 |
|
12(273915-271630)4
8507581, 4 NP_013170.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G453321 |
Elongation factor G |
58.73(n)
56.64(a) |
|
841097 NM_103595.3 NP_175135.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.39212 |
Oryza sativa (japonica cultivar-group) mEF-G mRNA for more |
73.31(n) |
|
AB040051.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
fusA6 |
protein chain elongation factor EF-G, GTP-binding |
43(a) |
1 ↔ 1 |
Chromosome(3469422-3471536) |
ENSEMBL Gene Tree for GFM1 (if available)
TreeFam Gene Tree for GFM1 (if available) |
Paralogs
for GFM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GFM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GFM1 (158362067 - 158410364 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GFM1: --
Human Gene Mutation Database (HGMD): GFM1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GFM1 |
|
Disorders
/ Diseases
for GFM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GFM1 for disorders About GeneDecksing
OMIM gene information: 606639
OMIM disorders: 609060
UniProtKB/Swiss-Prot: EFGM_HUMAN, Q96RP9
Defects in GFM1 are the cause of combined oxidative phosphorylation deficiency type 1 (COXPD1) [MIM:609060].It leads to early fatal progressive hepatoencephalopathy
12  diseases for GFM1: About MalaCardscombined oxidative phosphorylation deficiency combined oxidative phosphorylation deficiency 1 factor vii deficiency hemophilia
hemophilia b heart aneurysm candidiasis chondrosarcoma
pneumonia tuberculosis malaria mycobacterium tuberculosis
2 diseases from the University of Copenhagen DISEASES database for GFM1:Heart aneurysm Pearson syndrome 1 Novoseek disease relationship for GFM1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: GFM1 (2 documents)
Export disorders for GFM1 gene to outside databases
|
Publications
for GFM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GFM1 gene, integrated from 9 sources (see all 167):
(articles sorted by number of sources associating them with GFM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and gfm, and mapping of GFM to human chromosome 3q25.1-q26.2. (PubMed id 11374907)1, 2, 3, 9 Gao J.... Zhao S. (2001)
- Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution. (PubMed id 11735030)1, 2, 3, 9 Hammarsund M.... Sangfelt O. (2001)
- Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency. (PubMed id 15537906)1, 2, 9 Coenen M.J.H.... Smeitink J.A.M. (2004)
- Expression and characterization of isoform 1 of human mitochondrial elongation factor G. (PubMed id 15358359)1, 2, 9 Bhargava K....Spremulli L.L. (2004)
- EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. (PubMed id 19716793)1, 2, 9 Tsuboi M.... Takeuchi N. (2009)
- Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. (PubMed id 17160893)1, 2, 9 Valente L....Zeviani M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Toward genotype phenotype correlations in GFM1 mutatio ns. (PubMed id 21986555)1 Galmiche L....Rotig A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for GFM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GFM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GFM1 gene
(According to HUGE)
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Specialized Databases showing GFM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for GFM1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GFM1 |
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| Patent Information for GFM1 gene:
Search GeneIP for patents involving GFM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GFM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for GFM1 | | OriGene shRNA RFP for GFM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GFM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GFM1 | | | OriGene Protein Over-expression Lysate for GFM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for GFM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GFM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GFM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GFM1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GFM1 | | OriGene Custom Protein Services for GFM1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GFM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GFM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GFM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GFM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GFM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GFM1 |
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| | | | Search Tocris compounds for GFM1 |
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 | | | GFM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFM1 |
|  |  |  |  | | | | ThermoFisher Antibody for GFM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFM1 |
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