Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GFER Gene

protein-coding   GIFtS: 66
GCID: GC16P002116

Growth Factor, Augmenter Of Liver Regeneration

(Previous names: growth factor, erv1 (S. cerevisiae)-like (augmenter of liver...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Growth Factor, Augmenter Of Liver Regeneration1 2     ERV1 Homolog2
ALR2 3 5     Erv1-Like Growth Factor2
HERV12 3     FAD-Linked Sulfhydryl Oxidase ALR2
HPO2 3     Hepatic Regenerative Stimulation Substance2
ERV12 5     Hepatopoietin Protein2
ERV1 Homolog (S. Cerevisiae)1     EC 1.8.3.23
Growth Factor, Erv1 (S. Cerevisiae)-Like (Augmenter Of Liver Regeneration)1     Hepatopoietin3
HPO12     Augmenter Of Liver Regeneration3
HPO22     hERV13
HSS2     

External Ids:    HGNC: 42361   Entrez Gene: 26712   Ensembl: ENSG000001275547   OMIM: 6009245   UniProtKB: P557893   

Export aliases for GFER gene to outside databases

Previous GC identifers: GC16P002051 GC16P002061 GC16P001974 GC16P002036 GC16P001965 GC16P002043 GC16P002045 GC16P002049 GC16P002056 GC16P002083 GC16P002095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GFER Gene:
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors
responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic
regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus
for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast.
The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of
mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog
of the yeast scERV1 gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GFER Gene:
GFER (growth factor, augmenter of liver regeneration) is a protein-coding gene. Diseases associated with GFER include nodular regenerative hyperplasia, and myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay. GO annotations related to this gene include growth factor activity and protein disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot: ALR_HUMAN, P55789
Function: Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in
CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial
intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with
GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes
re-oxidized by donating electrons to cytochrome c or molecular oxygen
Function: Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration

Gene Wiki entry for GFER Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GFER gene promoter:
         ER-alpha   p53   ATF-2   AP-4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGFER promoter sequence
   Search Chromatin IP Primers for GFER

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GFER


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3-p13.12   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3-p13.12

GFER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GFER gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002116:  view genomic region     (about GC identifiers)

Start:
2,034,150 bp from pter      End:
2,037,750 bp from pter
Size:
3,601 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ALR_HUMAN, P55789 (See protein sequence)
Recommended Name: FAD-linked sulfhydryl oxidase ALR  
Size: 205 amino acids; 23449 Da
Cofactor: FAD
Subunit: Homodimer; disulfide-linked. May form heterodimers of isoform 1 and isoform 2
Sequence caution: Sequence=AAA96390.2; Type=Frameshift; Positions=70; Sequence=AAD36986.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAD56538.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAH02429.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=AAH28348.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
6 PDB 3D structures from and Proteopedia for GFER:
3MBG (3D)        3O55 (3D)        3TK0 (3D)        3U2L (3D)        3U2M (3D)        3U5S (3D)    
Secondary accessions: Q53YM6 Q8TAH6 Q9H290 Q9UK40
Alternative splicing: 2 isoforms:  P55789-1   P55789-2   

Explore the universe of human proteins at neXtProt for GFER: NX_P55789

Explore proteomics data for GFER at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys78
  • Modification sites at PhosphoSitePlus

  • See GFER Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005253.3  
    ENSEMBL proteins: 
     ENSP00000456432   ENSP00000248114   ENSP00000456189   ENSP00000455885  
    Reactome Protein details: P55789

    GFER Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GFER
    OriGene Protein Over-expression Lysate for GFER
    OriGene MassSpec for GFER
    OriGene Custom Protein Services for GFER
    GenScript Custom Purified and Recombinant Proteins Services for GFER
    Novus Biologicals GFER Proteins
    Sino Biological Recombinant Protein for GFER
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GFER
    Cloud-Clone Corp. Proteins for GFER

    GFER Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GFER
    R&D Systems Antibodies for GFER (GFER/ALR)
    OriGene Antibodies for GFER
    OriGene Custom Antibody Services for GFER
    Novus Biologicals GFER Antibody
    Abcam antibodies for GFER
    Cloud-Clone Corp. Antibodies for GFER
    Search ThermoFisher Antibodies for GFER
    LSBio Antibodies in human, mouse, rat for GFER

    GFER Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GFER
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GFER
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GFER
    Cloud-Clone Corp. CLIAs for GFER


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR017905 ERV/ALR_sulphydryl_oxidase

    Graphical View of Domain Structure for InterPro Entry P55789

    ProtoNet protein and cluster: P55789

    1 Blocks protein domain: IPB006863 Erv1/Alr

    UniProtKB/Swiss-Prot: ALR_HUMAN, P55789
    Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain


    GFER for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALR_HUMAN, P55789
    Function: Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in
    CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial
    intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with
    GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes
    re-oxidized by donating electrons to cytochrome c or molecular oxygen
    Function: Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration
    Catalytic activity: 2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)

         Genatlas biochemistry entry for GFER:
    growth factor homolog of yeast ERV1 gene,15.1kDa, (?involved in oxidative phosphorylation),identical to SazB/C
    locus (see D16S530E)

         Enzyme Number (IUBMB): EC 1.8.3.21

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12681488
    GO:0008083growth factor activity IEA--
    GO:0015035protein disulfide oxidoreductase activity IDA--
    GO:0016972thiol oxidase activity IEA--
    GO:0050660flavin adenine dinucleotide binding IDA--
         
    GFER for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GFER:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GFER
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GFER

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GFER
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GFER

    miRNA
    Products:
        
    miRTarBase miRNAs that target GFER:
    hsa-mir-18a-3p (MIRT040937), hsa-mir-744-5p (MIRT037615)

    Block miRNA regulation of human, mouse, rat GFER using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GFER:
    hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidGFER 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GFER
    Predesigned siRNA for gene silencing in human, mouse, rat GFER

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GFER

    Clone
    Products:
         
    OriGene clones in human, mouse for GFER (see all 6)
    OriGene ORF clones in mouse, rat for GFER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GFER (NM_005262)
    Sino Biological Human cDNA Clone for GFER
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFER

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GFER
    Browse ESI BIO Cell Lines and PureStem Progenitors for GFER 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFER


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ALR_HUMAN, P55789: Isoform 1: Mitochondrion intermembrane space
    ALR_HUMAN, P55789: Isoform 2: Cytoplasm. Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion5
    cytosol3
    plasma membrane2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005758mitochondrial intermembrane space IEA--

    GFER for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GFER About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GFER (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    1 Reactome Pathway for GFER
        Mitochondrial protein import



    GFER for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GFER
    Interactions:

        GeneGlobe Interaction Network for GFER

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GFER (P557892, 3 ENSP000002481144) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS8Q996272, 3, ENSP000003463404MINT-50638 MINT-50731 MINT-50628 MINT-50635 MINT-50627 I2D: score=1 STRING: ENSP00000346340
    COPS5Q929052, 3, ENSP000003505124MINT-50626 MINT-50637 MINT-50636 MINT-50625 I2D: score=3 STRING: ENSP00000350512
    COPS2P612012, 3, ENSP000002992594MINT-50629 MINT-50729 MINT-50639 MINT-50630 MINT-50634 I2D: score=2 STRING: ENSP00000299259
    GPS1Q130982, 3, ENSP000003472514MINT-50633 MINT-50640 MINT-50631 MINT-50730 MINT-50632 I2D: score=1 STRING: ENSP00000347251
    BNIPLQ7Z4653, ENSP000003579274I2D: score=3 STRING: ENSP00000357927
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0007283spermatogenesis ----
    GO:0008283cell proliferation ----
    GO:0044267cellular protein metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    GFER for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GFER (ALR)

    1 HMDB Compound for GFER    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    1 DrugBank Compound for GFER    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Flavin-Adenine Dinucleotide-- 146-14-5target--10592235

    1 Novoseek inferred chemical compound relationship for GFER gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 3.8 2 15683237 (1), 14500725 (1)



    GFER for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GFER gene: 
    NM_005262.2  

    Unigene Cluster for GFER:

    Growth factor, augmenter of liver regeneration
    Hs.27184  [show with all ESTs]
    Unigene Representative Sequence: NM_005262
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569451 ENST00000248114(uc002cob.3 uc002coc.3) ENST00000561710
    ENST00000565658 ENST00000567719
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GFER using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GFER:
    hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidGFER 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GFER
    Predesigned siRNA for gene silencing in human, mouse, rat GFER
    Clone
    Products:
         
    OriGene clones in human, mouse for GFER (see all 6)
    OriGene ORF clones in mouse, rat for GFER
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GFER (NM_005262)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GFER
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFER
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GFER
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GFER
      QuantiTect SYBR Green Assays in human, mouse, rat GFER
      QuantiFast Probe-based Assays in human, mouse, rat GFER

    Additional mRNA sequence: 

    AF124603.1 AF124604.1 AF208342.1 AF306863.1 AY550027.1 BC002429.1 BC028348.2 U31176.1 

    6 DOTS entries:

    DT.446584  DT.75111124  DT.120657401  DT.100667953  DT.95320427  DT.95273315 

    Selected AceView cDNA sequences (see all 96):

    AI951959 CA425087 BM664375 BU634006 CA440890 BM712141 BM669425 AW024944 
    BU734265 BM142157 BM699603 BU622978 BU625465 CK819931 BM696090 AY550027 
    CR616739 BX283260 Z42613 BC028348 BM141862 AF124603 BU624003 BM823891 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GFER expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGATAGG
    GFER Expression
    About this image

    GFER Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GFER Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.27184

    UniProtKB/Swiss-Prot: ALR_HUMAN, P55789
    Tissue specificity: Ubiquitously expressed. Highest expression in the testis and liver and low expression in the
    muscle

        Custom PCR Arrays for GFER
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GFER
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GFER
    QuantiTect SYBR Green Assays in human, mouse, rat GFER
    QuantiFast Probe-based Assays in human, mouse, rat GFER
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFER

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GFER gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gfer1 , 5 growth factor, erv1 (S. cerevisiae)-like (augmenter more1, 5 81.56(n)1
    78.17(a)1
      17 (12.48 cM)5
    116921  NM_023040.31  NP_075527.21 
     246931915 
    chicken
    (Gallus gallus)
    Aves GFER1 growth factor, augmenter of liver regeneration 63.92(n)
    60(a)
      416547  XM_414848.4  XP_414848.2 
    lizard
    (Anolis carolinensis)
    Reptilia GFER6
    growth factor, augmenter of liver regeneration
    53(a)
    1 ↔ 1
    GL343650.1(143221-146882)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.110362 Xenopus laevis transcribed sequence with moderate similarity more 75.6(n)    CA981864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gfer1 growth factor, augmenter of liver regeneration (ERV1 more 62.24(n)
    58.86(a)
      560433  NM_001089386.1  NP_001082855.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG125343 flavin-linked sulfhydryl oxidase 52(a)   18F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea F56C11.31 , 3 F56C11.31 52(a)3
    52.55(n)1
    48.18(a)1
      I(182139-182771)3
    1716111  NM_058289.31  NP_490690.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERV16
    Flavin-linked sulfhydryl oxidase of the mitochondr...
    32(a)
    1 ↔ 1
    VII(543553-544205) YGR029W


    ENSEMBL Gene Tree for GFER (if available)
    TreeFam Gene Tree for GFER (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GFER gene
    1 SIMAP similar gene for GFER using alignment to 4 protein entries:     ALR_HUMAN (see all proteins):
    ALR

    GFER for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GFER (see all 170)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219081921,2,,4
    CMyopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay (MPMCHD)4 pathogenic11971001(+) TGAGCA/GCTGGC 2 H R mis10--------
    rs129184171,2
    C,F--1956977(+) aaaaaC/Aaaaaa 1 -- us2k1 trp32Minor allele frequency- A:0.50NA 4
    rs1859868461,2
    C--1967189(+) TCAGCA/CTCTAA 1 -- us2k10--------
    rs1150281261,2
    F--1967246(+) GTGTCT/CGTCCC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs668742001,2
    C,F--1967269(+) TCTCAT/GGCCCT 1 -- us2k16Minor allele frequency- G:0.09NA CSA WA 246
    rs734960381,2
    C--1967316(+) CTGCTC/TACATA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs37852731,2
    C,F,H--1967338(-) GGGGAA/GCCCTG 1 -- us2k1 tfbs321Minor allele frequency- G:0.26EA NS NA WA CSA 3826
    rs37852721,2
    C,F,H--1967419(-) GTCTCC/TCCTGG 1 -- us2k119Minor allele frequency- T:0.14NS EA NA CSA WA 2344
    rs1446527581,2
    --1967473(+) ACAAGC/TAGAGG 1 -- us2k10--------
    rs778442791,2
    C,F--1967593(+) CTGAAT/GAGTAC 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for GFER (2034150 - 2037750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GFER (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv336n27CNV Loss19166990
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905082CNV Loss21882294
    nsv905048CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2540n71CNV Loss21882294
    nsv523037CNV Loss19592680
    nsv905091CNV Loss21882294

    Human Gene Mutation Database (HGMD): GFER
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GFER
    DNA2.0 Custom Variant and Variant Library Synthesis for GFER

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600924   
    OMIM disorders: 613076  
    UniProtKB/Swiss-Prot: ALR_HUMAN, P55789
  • Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay
    (MPMCHD) [MIM:613076]: A disease characterized by progressive myopathy and partial combined respiratory-chain
    deficiency, congenital cataract, sensorineural hearing loss, and developmental delay. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • Selected diseases for GFER (see all 24):    About MalaCards
    nodular regenerative hyperplasia    myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay    polycystic kidney disease    hepatitis
    myopathy congenital    kidney disease    viral hepatitis    myopathy
    cataract    hepatoblastoma    liver cirrhosis    neuroblastoma
    tuberculosis    t-cell leukemia    hepatocellular carcinoma    insulin resistance
    malaria    multiple myeloma    endotheliitis    myeloma


    GFER for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for GFER gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12713870 (1)

    Genetic Association Database (GAD): GFER
    Human Genome Epidemiology (HuGE) Navigator: GFER (1 document)

    Export disorders for GFER gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GFER gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with GFER)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast. (PubMed id 8575761)1, 2, 3 Lisowsky T....Schneider M.C. (Genomics 1995)
    2. Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription. (PubMed id 12180965)1, 2, 9 Li Y.... He F. (Eur. J. Biochem. 2002)
    3. The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory- chain deficiency. (PubMed id 19409522)1, 2, 9 Di Fonzo A.... Comi G.P. (Am. J. Hum. Genet. 2009)
    4. An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR. (PubMed id 22224850)1, 2 Banci L.... Tokatlidis K. (J. Am. Chem. Soc. 2012)
    5. Molecular recognition and substrate mimicry drive the electron- transfer process between MIA40 and ALR. (PubMed id 21383138)1, 2 Banci L.... Tokatlidis K. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    6. Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy. (PubMed id 20593814)1, 2 Daithankar V.N.... Thorpe C. (Biochemistry 2010)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Augmenter of liver regeneration: substrate specificity of a flavin- dependent oxidoreductase from the mitochondrial intermembrane space. (PubMed id 19397338)1, 2 Daithankar V.N.... Thorpe C. (Biochemistry 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin. (PubMed id 10982794)1, 9 Li Y....He F. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2671 HGNC: 4236 AceView: GFER Ensembl:ENSG00000127554 euGenes: HUgn2671
    ECgene: GFER H-InvDB: GFER

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GFER Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GFER gene:
    Search GeneIP for patents involving GFER

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GFER
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for GFER (GFER/ALR)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GFER   OriGene RNAi products in human, mouse, rat for GFER  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GFER  
     OriGene MassSpec something-or-other for GFER   OriGene clones in human, mouse for GFER  
     OriGene qSTAR qPCR primer pairs in human, mouse for GFER   OriGene Purified Protein for GFER  
     OriGene ORF clones in mouse, rat for GFER   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GFER   OriGene Custom Protein Services for GFER  

     
     
     Block miRNA regulation of human, mouse, rat GFER using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GFER
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GFER Predesigned siRNA for gene silencing in human, mouse, rat GFER
     QuantiFast Probe-based Assays in human, mouse, rat GFER QuantiTect SYBR Green Assays in human, mouse, rat GFER
     Custom PCR Arrays for GFER Search Chromatin IP Primers for GFER
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GFER  GeneGlobe Interaction Network for GFER
     Regulatory tfbs in GFER promoter
     GenScript Custom Purified and Recombinant Proteins Services for GFER GenScript cDNA clones with any tag delivered in your preferred vector for GFER
     GenScript Custom Assay Services for GFER GenScript Custom overexpressing Cell Line Services for GFER
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GFER (ALR)
     Proteins for GFER
     Browse Sino Biological Cell Lysates
     cDNA Clones for GFER
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GFER antibodies
     GFER proteins
     Antibodies for GFER
     See all of Abcam's Antibodies, Kits and Proteins for GFER
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GFER
     Proteins for GFER
     Antibodies for GFER
     ELISAs for GFER
     CLIAs for GFER



     Browse ESI BIO Cell Lines and PureStem Progenitors for GFER
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GFER
     SwitchGear 3'UTR luciferase reporter plasmids for GFER
     SwitchGear Promoter luciferase reporter plasmids for GFER
     Search ThermoFisher Antibodies for GFER
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GFER
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GFER
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GFER
     LSBio Antibodies in human, mouse, rat for GFER
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GFER gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4