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Aliases for GET4 Gene

Aliases for GET4 Gene

  • Golgi To ER Traffic Protein 4 Homolog (S. Cerevisiae) 2 3
  • C7orf20 3 4 6
  • CEE 3 4 6
  • Transmembrane Domain Recognition Complex 35 KDa Subunit 3 4
  • Conserved Edge-Expressed Protein 3 4
  • Conserved Edge Protein 2 3
  • TRC35 3 4
  • Transmembrane Domain Recognition Complex, 35kDa 3
  • Transmembrane Domain Recognition Complex 2
  • Golgi To ER Traffic Protein 4 Homolog 3
  • Chromosome 7 Open Reading Frame 20 2
  • Conserved Edge Expressed Protein 3
  • CGI-20 Protein 2
  • H_NH1244M04.5 3
  • CGI-20 3
  • 35kDa 2

External Ids for GET4 Gene

Previous HGNC Symbols for GET4 Gene

  • C7orf20

Previous GeneCards Identifiers for GET4 Gene

  • GC07P000916

Summaries for GET4 Gene

GeneCards Summary for GET4 Gene

GET4 (Golgi To ER Traffic Protein 4 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with GET4 include louping ill and erysipeloid.

UniProtKB/Swiss-Prot for GET4 Gene

  • Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.

Gene Wiki entry for GET4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GET4 Gene

Genomics for GET4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GET4 Gene

Start:
876,552 bp from pter
End:
896,436 bp from pter
Size:
19,885 bases
Orientation:
Plus strand

Genomic View for GET4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GET4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GET4 Gene

No data available for Regulatory Elements for GET4 Gene

Proteins for GET4 Gene

  • Protein details for GET4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5D6-GET4_HUMAN
    Recommended name:
    Golgi to ER traffic protein 4 homolog
    Protein Accession:
    Q7L5D6
    Secondary Accessions:
    • A4D2Q1
    • B3KNC7
    • Q9UFC9
    • Q9Y309

    Protein attributes for GET4 Gene

    Size:
    327 amino acids
    Molecular mass:
    36504 Da
    Quaternary structure:
    • Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35.

    Alternative splice isoforms for GET4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GET4 Gene

Proteomics data for GET4 Gene at MOPED

Post-translational modifications for GET4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GET4 Gene

Antibody Products

No data available for DME Specific Peptides for GET4 Gene

Domains for GET4 Gene

Protein Domains for GET4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GET4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L5D6

UniProtKB/Swiss-Prot:

GET4_HUMAN :
  • Q7L5D6
Family:
  • Belongs to the GET4 family.
genes like me logo Genes that share domains with GET4: view

No data available for Gene Families for GET4 Gene

Function for GET4 Gene

Molecular function for GET4 Gene

UniProtKB/Swiss-Prot Function:
Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.

Gene Ontology (GO) - Molecular Function for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with GET4: view

Phenotypes for GET4 Gene

GenomeRNAi human phenotypes for GET4:
genes like me logo Genes that share phenotypes with GET4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GET4 Gene

Localization for GET4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GET4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GET4 Gene COMPARTMENTS Subcellular localization image for GET4 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 2
extracellular 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 20676083
GO:0071818 BAT3 complex IDA 20676083
genes like me logo Genes that share ontologies with GET4: view

Pathways for GET4 Gene

SuperPathways for GET4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0071816 tail-anchored membrane protein insertion into ER membrane IMP 20676083
genes like me logo Genes that share ontologies with GET4: view

No data available for Pathways by source for GET4 Gene

Transcripts for GET4 Gene

Unigene Clusters for GET4 Gene

Golgi to ER traffic protein 4 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GET4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GET4 Gene

No ASD Table

Relevant External Links for GET4 Gene

GeneLoc Exon Structure for
GET4
ECgene alternative splicing isoforms for
GET4

Expression for GET4 Gene

mRNA expression in normal human tissues for GET4 Gene

Protein differential expression in normal tissues for GET4 Gene

This gene is overexpressed in Bone (24.0) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GET4 Gene

SOURCE GeneReport for Unigene cluster for GET4 Gene Hs.107387

genes like me logo Genes that share expressions with GET4: view

Expression partners for GET4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GET4 Gene

Orthologs for GET4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GET4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GET4 35
  • 89.83 (n)
  • 94.97 (a)
GET4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GET4 35
  • 87.74 (n)
  • 95.58 (a)
GET4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Get4 35
  • 86.21 (n)
  • 94.98 (a)
Get4 16
Get4 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GET4 35
  • 99.59 (n)
  • 99.39 (a)
GET4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Get4 35
  • 86.83 (n)
  • 94.98 (a)
oppossum
(Monodelphis domestica)
Mammalia GET4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GET4 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GET4 35
  • 75.66 (n)
  • 88.82 (a)
GET4 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GET4 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia get4 35
  • 74.71 (n)
  • 87.46 (a)
Str.1674 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.26196 35
zebrafish
(Danio rerio)
Actinopterygii get4 35
  • 75.13 (n)
  • 85.58 (a)
wufd15h01 35
get4 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000119 35
  • 57.82 (n)
  • 47.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9853 35
  • 52.43 (n)
  • 40 (a)
CG9853 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cee-1 36
  • 25 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20295g 35
  • 39.32 (n)
  • 28.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GET4 35
  • 40.79 (n)
  • 32.49 (a)
GET4 36
  • 29 (a)
OneToOne
GET4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63220 35
  • 44.08 (n)
  • 34.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01190 35
  • 43.5 (n)
  • 25.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes get4 35
  • 43.07 (n)
  • 34.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2033 36
  • 38 (a)
OneToOne
Species with no ortholog for GET4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GET4 Gene

ENSEMBL:
Gene Tree for GET4 (if available)
TreeFam:
Gene Tree for GET4 (if available)

Paralogs for GET4 Gene

No data available for Paralogs for GET4 Gene

Variants for GET4 Gene

Sequence variations from dbSNP and Humsavar for GET4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6820 -- 896,168(-) CAATC(A/G)TCACC utr-variant-3-prime
rs13171 -- 891,052(-) GCCTG(A/G)GCCAC reference, synonymous-codon
rs689549 -- 879,417(+) GTGTC(A/G)GTAGT intron-variant
rs1053310 -- 896,277(-) CCCTT(C/T)TGTCA utr-variant-3-prime
rs1063819 -- 896,269(-) TCATC(G/T)TTCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GET4 Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
nsv887134 CNV Loss 21882294
nsv887135 CNV Loss 21882294
dgv7080n71 CNV Loss 21882294
nsv464244 CNV Loss 19166990
esv25170 CNV Loss 19812545
nsv509182 CNV Insertion 20534489
nsv5611 CNV Insertion 18451855
nsv464245 CNV Gain 19166990
esv24184 CNV Gain+Loss 19812545
esv2733671 CNV Deletion 23290073
esv2733673 CNV Deletion 23290073
esv1624512 CNV Deletion 17803354
esv1790011 CNV Deletion 17803354
nsv887137 CNV Gain 21882294
esv2733674 CNV Deletion 23290073
esv2733675 CNV Deletion 23290073

Relevant External Links for GET4 Gene

HapMap Linkage Disequilibrium report
GET4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GET4 Gene

Disorders for GET4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GET4 Gene in MalaCards »

(2) Diseases for GET4 Gene including...

(4) University of Copenhagen DISEASES for GET4 Gene

genes like me logo Genes that share disorders with GET4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for GET4 Gene

Publications for GET4 Gene

  1. A ribosome-associating factor chaperones tail-anchored membrane proteins. (PMID: 20676083) Mariappan M. … Hegde R.S. (Nature 2010) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. (PMID: 20106980) Chang Y.W. … Wang C. (J. Biol. Chem. 2010) 2 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for GET4 Gene

Sources for GET4 Gene

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