Aliases for GEN1 Gene
External Ids for GEN1 Gene
Previous GeneCards Identifiers for GEN1 Gene
GeneCards Summary for GEN1 Gene
GEN1 (GEN1, Holliday Junction 5' Flap Endonuclease) is a Protein Coding gene. Diseases associated with GEN1 include xeroderma pigmentosum, group g and nasopharyngeal disease. Among its related pathways are DNA Double-Strand Break Repair and Homologous DNA Pairing and Strand Exchange. GO annotations related to this gene include nuclease activity and crossover junction endodeoxyribonuclease activity. An important paralog of this gene is FEN1.
UniProtKB/Swiss-Prot for GEN1 Gene
Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.