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GEMIN6 Gene

protein-coding   GIFtS: 57
GCID: GC02P038916

Gem (Nuclear Organelle) Associated Protein 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gem (Nuclear Organelle) Associated Protein 61 2
SIP22 3
Gem-Associated Protein 62
Gemin 62
gemin-62
Gemin-63

External Ids:    HGNC: 200441   Entrez Gene: 798332   Ensembl: ENSG000001521477   OMIM: 6070065   UniProtKB: Q8WXD53   

Export aliases for GEMIN6 gene to outside databases

Previous GC identifers: GC02P038970 GC02P039152 GC02P038936 GC02P038979 GC02P038832 GC02P038859 GC02P038744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GEMIN6 Gene:
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a
role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex
include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5
(MIM 607005).(supplied by OMIM, Jul 2002)

GeneCards Summary for GEMIN6 Gene:
GEMIN6 (gem (nuclear organelle) associated protein 6) is a protein-coding gene. Diseases associated with GEMIN6 include spinal muscular atrophy, and muscular atrophy.

UniProtKB/Swiss-Prot: GEMI6_HUMAN, Q8WXD5
Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
transport to the nucleus

Gene Wiki entry for GEMIN6 (Gem-associated protein 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GEMIN6 gene promoter:
         HFH-3   Pax-2   Pax-2a   POU3F2   Nkx5-1   Evi-1   FOXI1   HSF2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGEMIN6 promoter sequence
   Search Chromatin IP Primers for GEMIN6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GEMIN6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

GEMIN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GEMIN6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P038916:  view genomic region     (about GC identifiers)

Start:
38,978,676 bp from pter      End:
39,012,142 bp from pter
Size:
33,467 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GEMI6_HUMAN, Q8WXD5 (See protein sequence)
Recommended Name: Gem-associated protein 6  
Size: 167 amino acids; 18824 Da
Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6,
GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4,
GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and
SNRPG. Interacts directly with GEMIN7, SNRPB, SNRPD2, SNRPD3 and SNRPE
Sequence caution: Sequence=BAB15660.1; Type=Frameshift; Positions=142;
1 PDB 3D structure from and Proteopedia for GEMIN6:
1Y96 (3D)    
Secondary accessions: B2RDP8 Q53SI5 Q8WVB4 Q9H5G6

Explore the universe of human proteins at neXtProt for GEMIN6: NX_Q8WXD5

Explore proteomics data for GEMIN6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys108, Lys112
  • Modification sites at PhosphoSitePlus

  • See GEMIN6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079051.9  
    ENSEMBL proteins: 
     ENSP00000387191   ENSP00000281950   ENSP00000386613  
    Reactome Protein details: Q8WXD5

    GEMIN6 Human Recombinant Protein Products:

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    GEMIN6 Antibody Products:

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    GEMIN6 Assay Products:

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    Cloud-Clone Corp. CLIAs for GEMIN6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009422 Gemin6

    Graphical View of Domain Structure for InterPro Entry Q8WXD5

    ProtoNet protein and cluster: Q8WXD5


    GEMIN6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GEMI6_HUMAN, Q8WXD5
    Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
    cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
    the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
    the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
    transport to the nucleus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11748230
         
    GEMIN6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GEMIN6:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GEMIN6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GEMIN6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GEMIN6

    miRNA
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    miRTarBase miRNAs that target GEMIN6:
    hsa-mir-92a-3p (MIRT049420)

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    GenScript: all cDNA clones in your preferred vector: GEMIN6 (NM_024775)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GEMIN6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GEMIN6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GEMIN6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GEMI6_HUMAN, Q8WXD5: Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in
    nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also
    found in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex ----
    GO:0005737cytoplasm IDA11748230
    GO:0005829cytosol TAS--

    GEMIN6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GEMIN6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    2Gene Expression
    Gene Expression0.40
    3RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GEMIN6
        snRNP Assembly


    1 Kegg Pathway  (Kegg details for GEMIN6):
        RNA transport


    GEMIN6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GEMIN6
    Interactions:

        GeneGlobe Interaction Network for GEMIN6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GEMIN6 (Q8WXD51, 2, 3 ENSP000002819504) via UniProtKB, MINT, STRING, and/or I2D (see all 592)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    SNRPD3P623182, 3, ENSP000002158294MINT-7947479 I2D: score=2 STRING: ENSP00000215829
    SNRPEP623042, 3, ENSP000004005914MINT-7947479 I2D: score=2 STRING: ENSP00000400591
    GEMIN4P576782, 3, ENSP000003217064MINT-7947479 I2D: score=1 STRING: ENSP00000321706
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly IEA--
    GO:0000387spliceosomal snRNP assembly TAS11748230
    GO:0000398mRNA splicing, via spliceosome TAS11748230
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    GEMIN6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GEMIN6 (GEMI6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GEMIN6 gene: 
    NM_024775.9  

    Unigene Cluster for GEMIN6:

    Gem (nuclear organelle) associated protein 6
    Hs.143818  [show with all ESTs]
    Unigene Representative Sequence: BQ057876
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409011(uc002rrb.3 uc002rrc.3) ENST00000281950 ENST00000409566

    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GEMIN6
      QuantiTect SYBR Green Assays in human, mouse, rat GEMIN6
      QuantiFast Probe-based Assays in human, mouse, rat GEMIN6

    Additional mRNA sequence: 

    AF453443.1 AK027112.1 AK315627.1 BC018195.1 BC029584.1 

    6 DOTS entries:

    DT.423316  DT.100016046  DT.95356005  DT.101968694  DT.40200138  DT.99937420 

    Selected AceView cDNA sequences (see all 65):

    BM126774 BG332807 BU619707 AA535725 CA843444 BI601764 BM703986 AF453443 
    NM_024775 BQ420639 AA316006 BU729886 BM852830 BX281172 D11654 BM471707 
    BU618547 BG026296 BM798016 BG944981 BG033250 D11594 BC029584 BG941774 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GEMIN6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                                -                     
    SP2:                                                      
    SP3:                          -     -                     


    ECgene alternative splicing isoforms for GEMIN6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GEMIN6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGCAGAC
    GEMIN6 Expression
    About this image

    GEMIN6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GEMIN6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143818
        Custom PCR Arrays for GEMIN6
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GEMIN6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gemin61 , 5 gem (nuclear organelle) associated protein 61, 5 86.75(n)1
    86.14(a)1
      17 (50.63 cM)5
    672421  NM_026053.31  NP_080329.11 
     802244415 
    chicken
    (Gallus gallus)
    Aves GEMIN61 gem (nuclear organelle) associated protein 6 63.67(n)
    59.88(a)
      426266  NM_001277722.1  NP_001264651.1 
    lizard
    (Anolis carolinensis)
    Reptilia GEMIN66
    gem (nuclear organelle) associated protein 6
    62(a)
    1 ↔ 1
    1(254025539-254027710)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW643427.12   -- 74.47(n)    AW643427.1 
    zebrafish
    (Danio rerio)
    Actinopterygii GEMIN66
    gem (nuclear organelle) associated protein 6
    37(a)
    1 ↔ 1
    11(46268722-46269111) ENSDARG00000090806


    ENSEMBL Gene Tree for GEMIN6 (if available)
    TreeFam Gene Tree for GEMIN6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GEMIN6 gene
    Selected SIMAP similar genes for GEMIN6 using alignment to 3 protein entries:     GEMI6_HUMAN (see all proteins) (see all similar genes):
    X-linked retinopathy protein    EIF3G    ZNF211    pp12301    C12orf76    COQ5
    NDC80    UTY    ARL6IP5    ZNF85    ADCK1    C3orf64
    CALCOCO2    KIAA1651    AGBL3    DPP9    ELP4    FP6778

    GEMIN6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GEMIN6 (see all 188)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1179257301,2
    C,F--39003349(+) TGCAAC/TGAATA 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1921927881,2
    --39003557(+) TGTACC/TGTTTT 1 -- us2k10--------
    rs1438000911,2
    --39003624(+) AATCCA/GTAGCA 1 -- us2k10--------
    rs788111301,2
    C--39003814(+) ATACCA/TTGGCC 1 -- us2k10--------
    rs752542201,2
    C--39003816(+) ACCTTG/TGCCGT 1 -- us2k10--------
    rs1387566461,2
    --39003820(+) TGGCCG/TTGTCA 1 -- us2k10--------
    rs1493758071,2
    --39003951(+) GGAAGA/GCATTA 1 -- us2k10--------
    rs596396711,2
    C,F--39003961(+) AATAAC/TGTTTA 1 -- us2k14Minor allele frequency- T:0.11NA EA 244
    rs1447527881,2
    C--39003997(+) GTAATC/TCCAGC 1 -- us2k10--------
    rs133908451,2
    C--39004021(+) gaggcA/Gggcgg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GEMIN6 (38978676 - 39012142 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GEMIN6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv9646CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GEMIN6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607006    OMIM disorders: --

    3 diseases for GEMIN6:    About MalaCards
    spinal muscular atrophy    muscular atrophy    neuronitis

    1 disease from the University of Copenhagen DISEASES database for GEMIN6:
    Muscular atrophy

    GEMIN6 for disorders           About GeneDecksing


    Export disorders for GEMIN6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GEMIN6 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with GEMIN6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. (PubMed id 11748230)1, 2, 3 Pellizzoni L.... Dreyfuss G. (J. Biol. Chem. 2002)
    2. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    3. The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure. (PubMed id 15939020)1, 2 Ma Y.... Van Duyne G.D. (Structure 2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. (PubMed id 12065586)1, 2 Baccon J.... Dreyfuss G. (J. Biol. Chem. 2002)
    8. Gemin8 is required for the architecture and function of the survival motor neuron complex. (PubMed id 17023415)1, 9 Carissimi C.... Pellizzoni L. (J. Biol. Chem. 2006)
    9. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (Nucleic Acids Res. 2013)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79833 HGNC: 20044 AceView: GEMIN6 Ensembl:ENSG00000152147 euGenes: HUgn79833
    ECgene: GEMIN6 Kegg: 79833 H-InvDB: GEMIN6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GEMIN6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GEMIN6 gene:
    Search GeneIP for patents involving GEMIN6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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