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GEMIN4 Gene

protein-coding   GIFtS: 58
GCID: GC17M000705

Gem (Nuclear Organelle) Associated Protein 4

  Search for GEMIN4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gem (Nuclear Organelle) Associated Protein 41 2     HCAP12
Component Of Gems 41 2 3     HHRF-12
HCC-Associated Protein 11 2     Gem-Associated Protein 42
p972 3     gemin-42
HC562     Gemin-43

External Ids:    HGNC: 157171   Entrez Gene: 506282   Ensembl: ENSG000001794097   OMIM: 6069695   UniProtKB: P576783   

Export aliases for GEMIN4 gene to outside databases

Previous GC identifers: GC17U990191 GC17M000851 GC17M000601 GC17M000632 GC17M000594 GC17M000558 GC17M000650 GC17M000651 GC17M000652 GC17M000660 GC17M000677 GC17M000693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GEMIN4 Gene:
The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear
bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and
regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts
with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have
been described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for GEMIN4 Gene:
GEMIN4 (gem (nuclear organelle) associated protein 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: GEMI4_HUMAN, P57678
Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
transport to the nucleus

Gene Wiki entry for GEMIN4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GEMIN4 gene promoter:
         RP58   ISGF-3   AML1a   AP-4   XBP-1   RelA   NF-kappaB   E47   FOXL1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGEMIN4 promoter sequence
   Search Chromatin IP Primers for GEMIN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GEMIN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

GEMIN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GEMIN4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000705:  view genomic region     (about GC identifiers)

Start:
647,654 bp from pter      End:
657,239 bp from pter
Size:
9,586 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GEMI4_HUMAN, P57678 (See protein sequence)
Recommended Name: Gem-associated protein 4  
Size: 1058 amino acids; 120037 Da
Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6,
GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4,
GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and
SNRPG. Interacts directly with GEMIN3 and with several snRNP SM core proteins, including SNRPB, SNRPD1, SNRPD2,
SNRPD3 and SNRPE. Interacts with PPP4R2
Secondary accessions: Q9NZS7 Q9UG32 Q9Y4Q2

Explore the universe of human proteins at neXtProt for GEMIN4: NX_P57678

Explore proteomics data for GEMIN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys201, Lys1054
  • Modification sites at PhosphoSitePlus

  • See GEMIN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056536.2  
    ENSEMBL proteins: 
     ENSP00000321706   ENSP00000459565   ENSP00000392460   ENSP00000460286   ENSP00000461103  
     ENSP00000461368   ENSP00000458896  
    Reactome Protein details: P57678

    GEMIN4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: P57678


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GEMI4_HUMAN, P57678
    Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
    cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
    the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
    the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
    transport to the nucleus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11714716
         
    Find genes that share ontologies with GEMIN4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GEMIN4
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    miRNA
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    miRTarBase miRNAs that target GEMIN4:
    hsa-mir-342-3p (MIRT005881), hsa-mir-193b-3p (MIRT041307), hsa-mir-16-5p (MIRT032030), hsa-mir-331-3p (MIRT043366), hsa-mir-28-5p (MIRT049997), hsa-mir-484 (MIRT041966)

    Block miRNA regulation of human, mouse, rat GEMIN4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate GEMIN4:
    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidGEMIN4 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GEMI4_HUMAN, P57678: Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note=Localized in subnuclear
    structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the
    nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex ----
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm TAS10725331
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GEMIN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GEMIN4 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    2Gene Expression
    Gene Expression0.40
    3RNA transport
    RNA transport


    Find genes that share SuperPaths with GEMIN4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GEMIN4
        snRNP Assembly


    1 Kegg Pathway  (Kegg details for GEMIN4):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GEMIN4
    Interactions:

        GeneGlobe Interaction Network for GEMIN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GEMIN4 (P576782, 3 ENSP000003217064) via UniProtKB, MINT, STRING, and/or I2D (see all 973)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791 I2D: score=3 STRING: ENSP00000356520
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    FBLP220872, 3, ENSP000002218014MINT-6489539 MINT-6489355 I2D: score=1 STRING: ENSP00000221801
    GEMIN6Q8WXD52, 3, ENSP000002819504MINT-7947479 I2D: score=1 STRING: ENSP00000281950
    SNRPD1P623142, 3, ENSP000003004134MINT-7947479 I2D: score=1 STRING: ENSP00000300413
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0006364rRNA processing TAS10725331
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0034660ncRNA metabolic process TAS--

    Find genes that share ontologies with GEMIN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GEMIN4 (GEMI4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GEMIN4 gene: 
    NM_015721.2  

    Unigene Cluster for GEMIN4:

    Gem (nuclear organelle) associated protein 4
    Hs.499620  [show with all ESTs]
    Unigene Representative Sequence: AF177341
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319004(uc002frs.1 uc010vqa.1) ENST00000576778 ENST00000437269
    ENST00000573482 ENST00000570364 ENST00000576383 ENST00000574958
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate GEMIN4:
    hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidGEMIN4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: GEMIN4 (NM_015721)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GEMIN4
      QuantiTect SYBR Green Assays in human, mouse, rat GEMIN4
      QuantiFast Probe-based Assays in human, mouse, rat GEMIN4

    Additional mRNA sequence: 

    AF173856.1 AF177341.2 AK302722.1 AL080150.1 AL080167.1 BC020062.1 BC032084.1 BC036024.1 

    8 DOTS entries:

    DT.214844  DT.100755019  DT.86856156  DT.439873  DT.100654099  DT.100697152  DT.100755020  DT.405784 

    Selected AceView cDNA sequences (see all 220):

    W02084 AA417871 BE257360 AI863662 BQ214337 BQ065529 BQ223741 BE208612 
    AI738467 BG413343 BU165407 BE780403 AA577437 AA830928 BM480173 CD558056 
    AA921699 R06075 CN483779 BQ652561 AW419190 AW016516 BQ648905 BI826565 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GEMIN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATAATGG
    GEMIN4 Expression
    About this image

    GEMIN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GEMIN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499620
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GEMIN4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gemin41 , 5 gem (nuclear organelle) associated protein 41, 5 82.04(n)1
    81.66(a)1
      11 (45.92 cM)5
    2769191  NM_177367.31  NP_796341.21 
     762105715 
    chicken
    (Gallus gallus)
    Aves GEMIN41 gem (nuclear organelle) associated protein 4 61.53(n)
    52.54(a)
      427835  NM_001012610.1  NP_001012628.1 
    lizard
    (Anolis carolinensis)
    Reptilia GEMIN46
    gem (nuclear organelle) associated protein 4
    46(a)
    1 ↔ 1
    GL344108.1(61497-71478)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gemin41 gem (nuclear organelle) associated protein 4 52.12(n)
    44.78(a)
      100379790  XM_004911679.1  XP_004911736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gemin41 gem (nuclear organelle) associated protein 4 48.3(n)
    36.05(a)
      324754  NM_001018144.2  NP_001018154.1 


    ENSEMBL Gene Tree for GEMIN4 (if available)
    TreeFam Gene Tree for GEMIN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GEMIN4 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838628091,2
    --568390(+) TTAATA/GATCAC 1 -- us2k10--------
    rs1477862221,2
    C--568466(+) AGGCAG/TGTCTA 1 -- us2k10--------
    rs345323941,2
    C--647144(+) AGACT-/GTACACA 1 -- ds50010--------
    rs1920539281,2
    --647181(+) AAACCA/GTTCAT 1 -- ds50010--------
    rs681528401,2
    C,F--647188(+) TCATTC/AATCCA 1 -- ds50016Minor allele frequency- A:0.17NA WA EA 364
    rs1497932281,2
    --647249(+) GCACAC/TCTCTG 1 -- ds50010--------
    rs1844394681,2
    --647297(+) TGGGGA/GTGACT 1 -- ds50010--------
    rs1892001271,2
    --647326(+) CTGTAG/TGGGAA 1 -- ds50010--------
    rs350570001,2
    C--647424(+) AAGAC-/TGTACAC 1 -- ds50010--------
    rs1457865811,2
    --647529(+) GAATTA/GTGCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GEMIN4 (647654 - 657239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GEMIN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422420CNV Duplication17116639
    nsv457631CNV Gain19166990
    esv673CNV CNV17122850
    dgv925e1CNV Complex17122850
    nsv469891CNV Complex16826518

    Human Gene Mutation Database (HGMD): GEMIN4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GEMIN4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606969    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for GEMIN4:
    Muscular atrophy     Spinal muscular atrophy

    Find genes that share disorders with GEMIN4           About GenesLikeMe

    Genetic Association Database (GAD): GEMIN4
    Human Genome Epidemiology (HuGE) Navigator: GEMIN4 (9 documents)

    Export disorders for GEMIN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GEMIN4 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with GEMIN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gemin4: a novel component of the SMN complex that is found in both gems and nucleoli. (PubMed id 10725331)1, 2, 3, 9 Charroux B.... Dreyfuss G. (J. Cell Biol. 2000)
    2. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4, 9 Horikawa Y....Wu X. (Clin. Cancer Res. 2008)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    4. Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study. (PubMed id 20721975)1, 4 Kim J.S....Park J.Y. (Mol. Carcinog. 2010)
    5. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PubMed id 19851984)1, 4 Clague J....Wu X. (Mol. Carcinog. 2010)
    6. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1, 4 Lin J....Wu X. (Carcinogenesis 2010)
    7. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    8. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PubMed id 19138993)1, 4 Ye Y....Wu X. (Cancer Prev Res (Phila) 2008)
    9. Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs. (PubMed id 12668731)1, 2 Carnegie G.K.... Cohen P.T.W. (J. Cell Sci. 2003)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50628 HGNC: 15717 AceView: GEMIN4 Ensembl:ENSG00000179409 euGenes: HUgn50628
    ECgene: GEMIN4 Kegg: 50628 H-InvDB: GEMIN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GEMIN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GEMIN4 gene:
    Search GeneIP for patents involving GEMIN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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