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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GEMIN2 Gene

protein-coding GIFtS: 56
GCID: GC14P039584

gem (nuclear organelle) associated protein 2

(Previous name: survival of motor neuron protein interacting protein 1...)
(Previous symbol: SIP1)

Explore 12 diseases affiliated with
GEMIN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gem (Nuclear Organelle) Associated Protein 2¹ ²		Gemin-2³
SIP1¹ ² ³ ⁵		SMN Interacting Protein 1-Delta²
Survival Of Motor Neuron Protein Interacting Protein 1¹ ²		Gemin-2³
Component Of Gems 2² ³		SMN-Interacting Protein 1³
SIP1-Delta¹		Survival Of Motor Neuron Protein-Interacting Protein 1³
Gem-Associated Protein 2²

External Ids:	HGNC: 10884¹	Entrez Gene: 8487²	Ensembl: ENSG00000092208⁷	OMIM: 602595⁵	UniProtKB: O14893³

Export aliases for GEMIN2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GEMIN2:

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the

protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called

gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This

protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN

complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron

degeneration. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: GEMI2_HUMAN, O14893

Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for

pre-mRNA splicing in the nucleus

Gene Wiki entry for GEMIN2 (Survival of motor neuron protein-interacting protein 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for GEMIN2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GEMIN2 promoter sequence

Search SABiosciences Chromatin IP Primers for GEMIN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GEMIN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13 Ensembl cytogenetic band: 14q21.1 HGNC cytogenetic band: 14q21.1

GEMIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GEMIN2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P039584: view genomic region (about GC identifiers)

Start:	39,583,427 bp from pter	End:	39,606,177 bp from pter
Size:	22,751 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GEMI2_HUMAN, O14893 (See protein sequence)

Recommended Name: Gem-associated protein 2

Size: 280 amino acids; 31585 Da

Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7,

GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN5

Subcellular location: Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called

gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm

Caution: It is uncertain whether Met-1 or Met-12 is the initiator

Sequence caution: Sequence=CAC16117.2; Type=Erroneous initiation; Note=Translation N-terminally extended;

2 PDB 3D structures from and Proteopedia for GEMIN2:

2LEH (3D)

3S6N (3D)

Secondary accessions: B2R9W8 Q2M3B3 Q9H4F5 Q9NS77 Q9NS78 Q9NS79

Alternative splicing: 4 isoforms: O14893-1 O14893-2 O14893-3 O14893-4

Explore the universe of human proteins at neXtProt for GEMIN2: NX_O14893

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14893

GEMIN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001009182.1 NP_001009183.1 NP_003607.1

ENSEMBL proteins:

ENSP00000308533 ENSP00000436854 ENSP00000379548 ENSP00000416827 ENSP00000250379

ENSP00000431500 ENSP00000436065 ENSP00000434048

Reactome Protein details: O14893
Human Recombinant Protein Products for GEMIN2:

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	Novus Biologicals GEMIN2 Proteins Novus Biologicals GEMIN2 Lysates
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	Uscn Proteins for GEMIN2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	TAS	9323130
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	IEA	--
GO:0005737	cytoplasm	TAS	9323130

GEMIN2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for GEMIN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GEMIN2 for domains About GeneDecksing

2 InterPro domains/families:

IPR007022 SIP1

IPR017364 Survival_motor_neuron_Gemin2

Graphical View of Domain Structure for InterPro Entry O14893

ProtoNet protein and cluster: O14893

1 Blocks protein family: IPB007022 Survival motor neuron interacting protein 1

UniProtKB/Swiss-Prot: GEMI2_HUMAN, O14893

Similarity: Belongs to the gemin-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GEMI2_HUMAN, O14893

Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for

pre-mRNA splicing in the nucleus

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

GEMIN2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for GEMIN2:

Decreased p24 protein expressi

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gemin2):

mortality/aging

nervous system

GEMIN2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GEMIN2

miRNA Products:		miRTarBase miRNAs that target GEMIN2: hsa-mir-141 (MIRT000318), hsa-mir-200b (MIRT002482), hsa-mir-200a (MIRT002481), hsa-mir-429 (MIRT003719), hsa-mir-205 (MIRT002479)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GEMIN2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLBP independent Processing of Histone Pre-mRNAs

Metabolism of non-coding RNA

0.28

snRNP Assembly

0.28

RNA transport

RNA transport

1.00

Metabolism of mRNA

Metabolism of RNA

0.92

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for GEMIN2

	snRNP Assembly
	Metabolism of RNA
	Gene Expression
	Metabolism of non-coding RNA

1 Kegg Pathway (Kegg details for GEMIN2):

RNA transport

GEMIN2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GEMIN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/149 Interacting proteins for GEMIN2 (O14893^{1, 2, 3} ENSP00000308533⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 149)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637¹^,²^,³, ENSP00000370083⁴	EBI-443648,EBI-395421 MINT-16652 MINT-16651 MINT-16653 MINT-8271520 MINT-16654 I2D: score=5 STRING: ENSP00000370083
SMN2	Q16637¹^,²^,³, ENSP00000370119⁴	EBI-443648,EBI-395421 MINT-16652 MINT-16651 MINT-16653 MINT-8271520 MINT-16654 I2D: score=5 STRING: ENSP00000370119
DHX9	Q08211²^,³, ENSP00000356520⁴	MINT-6488791 I2D: score=3 STRING: ENSP00000356520
SNRPD2	P62316³, ENSP00000342374⁴	I2D: score=3 STRING: ENSP00000342374
LGALS1	P09382³, ENSP00000215909⁴	I2D: score=2 STRING: ENSP00000215909

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000245	spliceosomal complex assembly	IEA	--
GO:0000375	RNA splicing, via transesterification reactions	TAS	9323129
GO:0000387	spliceosomal snRNP assembly	TAS	--
GO:0006397	mRNA processing	TAS	9323130
GO:0008380	RNA splicing	TAS	9323129

GEMIN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GEMIN2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GEMIN2
2 Novoseek chemical compound relationships for GEMIN2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	30	3	20428734 (1), 12714599 (1), 17958891 (1)
gtp	19.5	1	10631144 (1)

Search CenterWatch for drugs/clinical trials and news about GEMIN2 / GEMI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GEMIN2 gene (3 alternative transcripts):

NM_001009182.1 NM_001009183.1 NM_003616.2

Unigene Cluster for GEMIN2:

Gem (nuclear organelle) associated protein 2

Hs.652307 [show with all ESTs]

Unigene Representative Sequence: BC028095

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000308317(uc001wuq.3 uc001wur.3 uc001wus.3) ENST00000525153(uc010amx.3)

ENST00000396249 ENST00000412033 ENST00000250379 ENST00000531684 ENST00000534684

ENST00000525430 ENST00000527381 ENST00000524980 ENST00000529365 ENST00000524781

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Additional cDNA sequence:

AB037701.1 AB037702.1 AB037703.1 AF027150.1 AK313947.1 BC028095.1 BC104968.1

12 DOTS entries:

DT.444658 DT.95242746 DT.97838356 DT.100741084 DT.95370316 DT.100741085 DT.92425855 DT.95370317

DT.100739022 DT.120757517 DT.75137735 DT.75115595

24/75 AceView cDNA sequences (see all 75):

AA252493 BX109093 BQ277743 BC028095 AA314485 AA261912 AW403560 AF027150

AB037702 AB037701 BM680163 CN484054 BM987457 CA436038 NM_003616 BE043922

AI539159 AA828244 AA455655 BP357198 AB037703 AI052503 BE888768 AA765723

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for GEMIN2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	·	11c
SP1:													-
SP2:													-										-
SP3:													-				-
SP4:													-		-				-
SP5:

ECgene alternative splicing isoforms for GEMIN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GEMIN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGCAGCCT

About this image

GEMIN2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Selective marker (cell-identifying gene)

Neural Crest

Head Mesenchyme

Branchial Arch 2

Cranial Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GEMIN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GEMIN2

SOURCE GeneReport for Unigene cluster: Hs.652307

SABiosciences Custom PCR Arrays for GEMIN2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GEMIN2 gene from 9/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gemin2⁵ Sip1¹	survival of motor neuron protein interacting protein more^{1, 5}	88.98(n)¹ 94.49(a)¹		12 (25.99 cM)⁵ 66603¹ NM_025656.4¹ NP_079932.2¹ 59013393⁵
chicken (Gallus gallus)	Aves	GEMIN2¹	gem (nuclear organelle) associated protein 2	75.17(n) 79.35(a)		423336 NM_001039302.1 NP_001034391.1
lizard (Anolis carolinensis)	Reptilia	GEMIN2⁶	--	81(a)	1 ↔ 1	1(23975346-23987490)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3305²	Xenopus laevis survival of motor neuron protein interacting more	76.26(n)		AF027151.1
zebrafish (Danio rerio)	Actinopterygii	wufc52a05²	Transcribed sequence with weak similarity to protein more	76.93(n)		57050797
fruit fly (Drosophila melanogaster)	Insecta	Gem2¹	Gemin2	40.86(n) 30.97(a)		40087 NM_140835.3 NP_649092.1
worm (Caenorhabditis elegans)	Secernentea	smi-1⁶	SMN (survival of motor neuron) protein Interactor ...	22(a)	1 ↔ 1	III(1878356-1880830)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G42510⁶ AT1G54380⁶	uncharacterized protein survival of motor neuron protein-interacting prote...	6(a) 13(a)	many → 1 many → 1	2(17701662-17704618) 1(20297965-20300908)
rice (Oryza sativa)	Liliopsida	--	survival motor neuron containing protein, expresse...	16(a)	1 ↔ 1	11(10686485-10692910)

ENSEMBL Gene Tree for GEMIN2 (if available)
TreeFam Gene Tree for GEMIN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GEMIN2 gene

GEMIN2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GEMIN2
PGOHUM00000244273 PGOHUM00000238007

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112035139^1,2		--	39581538(+)	`TGCAAC/TGGCAC`	3	--	us2k¹		2		CSA	3
rs187151363^1,2		--	39581549(+)	`AATCTC/GGGCTC`	3	--	us2k¹		0	--	--	--	--
rs115736842^1,2	F	--	39581783(+)	`GGCCAA/GGATTC`	3	--	us2k¹		1		WA	118
rs10140656^1,2	C	--	39581870(+)	`GGGGTA/CAAATA`	3	--	us2k¹ tfbs³		4		NA WA CSA	7
rs192065054^1,2		--	39581990(+)	`GGGCAA/TGACTC`	3	--	us2k¹		0	--	--	--	--
rs2415531^1,2	C,A,H	--	39582043(+)	`AGGCCA/GGGCGC`	3	--	us2k¹		4		NA WA CSA	125
rs2415532^1,2	C,A,H	--	39582295(+)	`TCCAGC/ACTGGG`	3	--	us2k¹		7		NA WA	14
rs11410356^1,2	C	--	39582323(+)	`AAAAAA/-TTCAG`	3	--	us2k¹ trp³		1		NA	2
rs142259255^1,2		--	39582361(+)	`CACGTC/GACTAC`	3	--	us2k¹		0	--	--	--	--
rs147878616^1,2		--	39582517(+)	`GTGTCC/TCAATT`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GEMIN2 (39583427 - 39606177 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GEMIN2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GEMIN2 for disorders           About GeneDecksing

OMIM gene information: 602595    OMIM disorders: --

12 diseases for GEMIN2:    About MalaCards

neuronitis mowat-wilson syndrome spinal muscular atrophy benign hereditary chorea

muscular atrophy chorea spindle cell carcinoma motor neuron disease

hirschsprung's disease colorectal cancer immunodeficiency carcinoma

2 Novoseek disease relationships for GEMIN2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
muscular atrophy spinal	91.3	2	10909848 (1), 11092763 (1)
breast cancer	0	2	16314317 (1), 16568083 (1)

Export disorders for GEMIN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GEMIN2 gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with GEMIN2)

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The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. (PubMed id 9323129)^{1, 2, 3, 9} Liu Q.... Dreyfuss G. (1997)
An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA). (PubMed id 10909848)^{1, 2, 9} Helmken C....Wirth B. (2000)
Increased expression level of the splicing variant of SIP1 in motor neuron diseases. (PubMed id 11943600)^{1, 2, 9} Aerbajinai W.... Tsukahara T. (2002)
A cell system with targeted disruption of the SMN gene: functional conservation of the SMN protein and dependence of Gemin2 on SMN. (PubMed id 11121410)^{1, 3, 9} Wang J. and Dreyfuss G. (2001)
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. (PubMed id 9323130)^{1, 3, 9} Fischer U....Dreyfuss G. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. (PubMed id 11714716)^{1, 2} Gubitz A.K....Dreyfuss G. (2002)
Identification of the role of Smad interacting protei n 1 (SIP1) in glioma. (PubMed id 19806322)^{1, 9} Xia M....Su L. (2010)
Gemin2 plays an important role in stabilizing the survival of motor neuron complex. (PubMed id 17308308)^{1, 9} Ogawa C....Suzuki H. (2007)
Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo. (PubMed id 16731905)^{1, 9} Hamamoto S....Masuda T. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8487	HGNC: 10884	AceView: SIP1	Ensembl:ENSG00000092208	euGenes: HUgn8487
ECgene: GEMIN2	Kegg: 8487	H-InvDB: GEMIN2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GEMIN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GEMIN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GEMIN2 gene:
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GeneCards and IP:
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gem (nuclear organelle) associated protein 2

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gem (nuclear organelle) associated protein 2

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