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Aliases for GEM Gene

Aliases for GEM Gene

  • GTP Binding Protein Overexpressed In Skeletal Muscle 2 3 5
  • GTP-Binding Mitogen-Induced T-Cell Protein 3 4
  • Kinase-Inducible Ras-Like Protein 2 3
  • RAS-Like Protein KIR 3 4
  • KIR 3 4
  • GTP-Binding Protein Overexpressed In Skeletal Muscle 2
  • GTP-Binding Protein GEM 3

External Ids for GEM Gene

Previous GeneCards Identifiers for GEM Gene

  • GC08M094007
  • GC08M095107
  • GC08M094930
  • GC08M095218
  • GC08M095330
  • GC08M090470

Summaries for GEM Gene

Entrez Gene Summary for GEM Gene

  • The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GEM Gene

GEM (GTP Binding Protein Overexpressed In Skeletal Muscle) is a Protein Coding gene. GO annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is RRAD.

UniProtKB/Swiss-Prot for GEM Gene

  • Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Gene Wiki entry for GEM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GEM Gene

Genomics for GEM Gene

Regulatory Elements for GEM Gene

Enhancers for GEM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G094239 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22 +20.7 20708 3.5 PKNOX1 FOXA2 SIN3A ZNF2 GLIS2 GATA2 ZNF207 FOS JUNB TSHZ1 GEM CDH17 LOC105375648
GH08G094258 1.6 FANTOM5 ENCODE dbSUPER 24.5 +1.4 1367 5.9 HDGF ATF1 WRNIP1 SIN3A GLIS2 ZNF766 GATA2 ZNF143 ZNF207 FOS GEM LOC105375648
GH08G094233 1.6 FANTOM5 Ensembl ENCODE dbSUPER 23.6 +27.7 27690 1.5 GTF2F1 CTCF ESRRA JUN RBBP5 E2F1 GATA3 EGR1 SCRT2 FOS GEM MYL12AP1 LOC105375648
GH08G094218 1.1 Ensembl ENCODE 17 +42.7 42676 1.4 TBL1XR1 RFX5 CBX5 RCOR1 FOS RELB IKZF2 CREM CBFB CEBPB GEM CDH17 LOC105375648
GH08G094205 1.3 FANTOM5 ENCODE dbSUPER 10.8 +54.8 54811 4.7 CTCF ZSCAN4 ZNF384 CEBPG RAD21 ARID3A ZNF207 MCM3 MTA2 BHLHE40 GEM CDH17 RPL6P23 GC08P094206
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GEM on UCSC Golden Path with GeneCards custom track

Promoters for GEM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227171 550 1601 HDGF ATF1 WRNIP1 SIN3A FEZF1 GLIS2 ZNF143 ZNF207 FOS REST

Genomic Location for GEM Gene

Chromosome:
8
Start:
94,249,253 bp from pter
End:
94,262,350 bp from pter
Size:
13,098 bases
Orientation:
Minus strand

Genomic View for GEM Gene

Genes around GEM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GEM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GEM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GEM Gene

Proteins for GEM Gene

  • Protein details for GEM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55040-GEM_HUMAN
    Recommended name:
    GTP-binding protein GEM
    Protein Accession:
    P55040
    Secondary Accessions:
    • B2RA31

    Protein attributes for GEM Gene

    Size:
    296 amino acids
    Molecular mass:
    33949 Da
    Quaternary structure:
    • Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.

    Three dimensional structures from OCA and Proteopedia for GEM Gene

neXtProt entry for GEM Gene

Post-translational modifications for GEM Gene

Other Protein References for GEM Gene

No data available for DME Specific Peptides for GEM Gene

Domains & Families for GEM Gene

Gene Families for GEM Gene

Suggested Antigen Peptide Sequences for GEM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55040

UniProtKB/Swiss-Prot:

GEM_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with GEM: view

Function for GEM Gene

Molecular function for GEM Gene

GENATLAS Biochemistry:
mitogen-induced gene,35kDa,expressed in G1 phase of the cell cycle,GTP binding protein (G protein),with high homology to RAD1,Ras superfamily
UniProtKB/Swiss-Prot Function:
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
UniProtKB/Swiss-Prot Induction:
By mitogens.

Gene Ontology (GO) - Molecular Function for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 17107948
GO:0003924 GTPase activity IDA 17107948
GO:0005515 protein binding IPI 12093360
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IDA,IEA 17107948
genes like me logo Genes that share ontologies with GEM: view
genes like me logo Genes that share phenotypes with GEM: view

Animal Models for GEM Gene

MGI Knock Outs for GEM:
  • Gem tm1.1Jgun

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GEM

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GEM Gene

Localization for GEM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GEM Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GEM gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0009898 cytoplasmic side of plasma membrane IDA 7912851
GO:0016020 membrane IEA --
GO:0030496 midbody IDA 22964304
genes like me logo Genes that share ontologies with GEM: view

Pathways & Interactions for GEM Gene

No Data Available

Gene Ontology (GO) - Biological Process for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 22964304
GO:0006955 immune response TAS 7912851
GO:0007067 mitotic nuclear division IMP --
GO:0007165 signal transduction IEA,TAS 7912851
GO:0007166 cell surface receptor signaling pathway TAS 7912851
genes like me logo Genes that share ontologies with GEM: view

No data available for Pathways by source and SIGNOR curated interactions for GEM Gene

Drugs & Compounds for GEM Gene

(6) Drugs for GEM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for GEM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GEM: view

Transcripts for GEM Gene

Unigene Clusters for GEM Gene

GTP binding protein overexpressed in skeletal muscle:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GEM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GEM Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for GEM Gene

GeneLoc Exon Structure for
GEM
ECgene alternative splicing isoforms for
GEM

Expression for GEM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GEM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GEM Gene

This gene is overexpressed in Artery - Aorta (x5.3).

Protein differential expression in normal tissues from HIPED for GEM Gene

This gene is overexpressed in Gallbladder (37.0) and Uterus (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GEM Gene



Protein tissue co-expression partners for GEM Gene

NURSA nuclear receptor signaling pathways regulating expression of GEM Gene:

GEM

SOURCE GeneReport for Unigene cluster for GEM Gene:

Hs.654463

mRNA Expression by UniProt/SwissProt for GEM Gene:

P55040-GEM_HUMAN
Tissue specificity: Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for GEM Gene

  • Nervous system(4.5)
  • Blood(4)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with GEM: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GEM Gene

Orthologs for GEM Gene

This gene was present in the common ancestor of animals.

Orthologs for GEM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GEM 34 35
  • 99.55 (n)
oppossum
(Monodelphis domestica)
Mammalia GEM 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GEM 34 35
  • 90.99 (n)
mouse
(Mus musculus)
Mammalia Gem 34 16 35
  • 90.28 (n)
cow
(Bos Taurus)
Mammalia GEM 34 35
  • 89.64 (n)
rat
(Rattus norvegicus)
Mammalia Gem 34
  • 89.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GEM 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GEM 34 35
  • 79.28 (n)
lizard
(Anolis carolinensis)
Reptilia GEM 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gem 34
  • 75.96 (n)
zebrafish
(Danio rerio)
Actinopterygii gem 34 35
  • 60.37 (n)
zgc56144 34
fruit fly
(Drosophila melanogaster)
Insecta Rgk1 35
  • 18 (a)
ManyToMany
Rgk3 35
  • 17 (a)
ManyToMany
Rgk2 35
  • 13 (a)
ManyToMany
CG42541 35
  • 7 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 35
  • 14 (a)
OneToMany
Species where no ortholog for GEM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GEM Gene

ENSEMBL:
Gene Tree for GEM (if available)
TreeFam:
Gene Tree for GEM (if available)

Paralogs for GEM Gene

Paralogs for GEM Gene

(12) SIMAP similar genes for GEM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GEM: view

Variants for GEM Gene

Sequence variations from dbSNP and Humsavar for GEM Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000203951 -- 94,250,109(+) TCAGG(A/C)TTTTC utr-variant-3-prime
rs1000230939 -- 94,249,230(+) TTGGG(A/G)AGGAA downstream-variant-500B
rs1000328112 -- 94,256,294(+) CCCCT(-/C)CCACC intron-variant
rs1000328441 -- 94,262,964(+) ATTGT(G/T)CTAAA upstream-variant-2KB
rs1000382830 -- 94,262,363(+) CGACC(C/T)GCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GEM Gene

Variant ID Type Subtype PubMed ID
dgv7270n100 CNV gain 25217958
nsv1022473 CNV loss 25217958
nsv831401 CNV loss 17160897

Variation tolerance for GEM Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GEM Gene

Human Gene Mutation Database (HGMD)
GEM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GEM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GEM Gene

Disorders for GEM Gene

Relevant External Links for GEM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GEM

No disorders were found for GEM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GEM Gene

Publications for GEM Gene

  1. The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. (PMID: 11956230) Ward Y. … Kelly K. (J. Cell Biol. 2002) 2 3 4 22 64
  2. Gem: an induced, immediate early protein belonging to the Ras family. (PMID: 7912851) Maguire J. … Kelly K. (Science 1994) 2 3 4 22 64
  3. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PMID: 9115241) Moyers J.S. … Kahn C.R. (J. Biol. Chem. 1997) 3 4 22 64
  4. Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. (PMID: 7809057) Cohen L. … Witte O. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GEM Gene

Sources for GEM Gene

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