Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GEM Gene

Aliases for GEM Gene

  • GTP Binding Protein Overexpressed In Skeletal Muscle 2 3
  • GTP-Binding Protein Overexpressed In Skeletal Muscle 2 3
  • GTP-Binding Mitogen-Induced T-Cell Protein 3 4
  • Kinase-Inducible Ras-Like Protein 2 3
  • RAS-Like Protein KIR 3 4
  • KIR 3 4
  • GTP-Binding Protein GEM 3

External Ids for GEM Gene

Previous GeneCards Identifiers for GEM Gene

  • GC08M094007
  • GC08M095107
  • GC08M094930
  • GC08M095218
  • GC08M095330
  • GC08M090470

Summaries for GEM Gene

Entrez Gene Summary for GEM Gene

  • The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GEM Gene

GEM (GTP Binding Protein Overexpressed In Skeletal Muscle) is a Protein Coding gene. GO annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for GEM Gene

  • Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity

Gene Wiki entry for GEM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GEM Gene

Genomics for GEM Gene

Genomic Location for GEM Gene

94,249,253 bp from pter
94,262,350 bp from pter
13,098 bases
Minus strand

Genomic View for GEM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GEM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GEM Gene

Proteins for GEM Gene

  • Protein details for GEM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein GEM
    Protein Accession:
    Secondary Accessions:
    • B2RA31

    Protein attributes for GEM Gene

    296 amino acids
    Molecular mass:
    33949 Da
    Quaternary structure:
    • Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.

    Three dimensional structures from OCA and Proteopedia for GEM Gene

neXtProt entry for GEM Gene

Proteomics data for GEM Gene at MOPED

Post-translational modifications for GEM Gene

Other Protein References for GEM Gene

No data available for DME Specific Peptides for GEM Gene

Domains for GEM Gene

Suggested Antigen Peptide Sequences for GEM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P55040
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with GEM: view

No data available for Gene Families for GEM Gene

Function for GEM Gene

Molecular function for GEM Gene

GENATLAS Biochemistry: mitogen-induced gene,35kDa,expressed in G1 phase of the cell cycle,GTP binding protein (G protein),with high homology to RAD1,Ras superfamily
UniProtKB/Swiss-Prot Function: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity
UniProtKB/Swiss-Prot Induction: By mitogens

Gene Ontology (GO) - Molecular Function for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 17107948
GO:0003924 GTPase activity IDA 17107948
GO:0005515 protein binding IPI 12093360
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IDA 17107948
genes like me logo Genes that share ontologies with GEM: view
genes like me logo Genes that share phenotypes with GEM: view

Animal Models for GEM Gene

MGI Knock Outs for GEM:
  • Gem tm1.1Jgun

Animal Model Products

CRISPR Products

miRNA for GEM Gene

miRTarBase miRNAs that target GEM

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GEM Gene

Localization for GEM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GEM Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for GEM Gene COMPARTMENTS Subcellular localization image for GEM gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0009898 cytoplasmic side of plasma membrane IDA 7912851
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GEM: view

Pathways for GEM Gene

SuperPathways for GEM Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat

Gene Ontology (GO) - Biological Process for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006955 immune response TAS 7912851
GO:0007067 mitotic nuclear division IMP 22964304
GO:0007165 signal transduction TAS 7912851
GO:0007166 cell surface receptor signaling pathway TAS 7912851
genes like me logo Genes that share ontologies with GEM: view

No data available for Pathways by source for GEM Gene

Compounds for GEM Gene

(3) HMDB Compounds for GEM Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP

(5) Novoseek inferred chemical compound relationships for GEM Gene

Compound -log(P) Hits PubMed IDs
gtp 58.3 5
katp 53 2
serine 41.6 2
calcium 38.6 12
tyrosine 20.3 3
genes like me logo Genes that share compounds with GEM: view

Transcripts for GEM Gene

Unigene Clusters for GEM Gene

GTP binding protein overexpressed in skeletal muscle:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GEM

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GEM Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for GEM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GEM Gene

mRNA expression in normal human tissues for GEM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GEM Gene

This gene is overexpressed in Artery - Aorta (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GEM Gene

SOURCE GeneReport for Unigene cluster for GEM Gene Hs.654463

mRNA Expression by UniProt/SwissProt for GEM Gene

Tissue specificity: Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle
genes like me logo Genes that share expressions with GEM: view

In Situ Assay Products

Orthologs for GEM Gene

This gene was present in the common ancestor of animals.

Orthologs for GEM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GEM 35
  • 99.55 (n)
  • 99.66 (a)
GEM 36
  • 100 (a)
(Bos Taurus)
Mammalia GEM 35
  • 89.64 (n)
  • 94.59 (a)
GEM 36
  • 95 (a)
(Canis familiaris)
Mammalia GEM 35
  • 90.99 (n)
  • 94.93 (a)
GEM 36
  • 95 (a)
(Mus musculus)
Mammalia Gem 35
  • 90.28 (n)
  • 95.93 (a)
Gem 16
Gem 36
  • 96 (a)
(Monodelphis domestica)
Mammalia GEM 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia GEM 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Gem 35
  • 89.38 (n)
  • 95.25 (a)
(Gallus gallus)
Aves GEM 35
  • 79.28 (n)
  • 82.77 (a)
GEM 36
  • 84 (a)
(Anolis carolinensis)
Reptilia GEM 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gem 35
  • 75.96 (n)
  • 81.97 (a)
(Danio rerio)
Actinopterygii gem 35
  • 60.37 (n)
  • 56.64 (a)
gem 36
  • 54 (a)
zgc56144 35
fruit fly
(Drosophila melanogaster)
Insecta CG42541 36
  • 7 (a)
Rgk1 36
  • 18 (a)
Rgk2 36
  • 13 (a)
Rgk3 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 14 (a)
Species with no ortholog for GEM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GEM Gene

Gene Tree for GEM (if available)
Gene Tree for GEM (if available)

Paralogs for GEM Gene

Paralogs for GEM Gene

Selected SIMAP similar genes for GEM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GEM: view

Variants for GEM Gene

Sequence variations from dbSNP and Humsavar for GEM Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs11985 -- 94,249,488(-) ATTTT(C/T)ATAAA utr-variant-3-prime
rs17036 -- 94,249,727(-) CCACC(A/G)AGACA utr-variant-3-prime
rs981678 -- 94,264,233(+) CGCCT(G/T)TAATC upstream-variant-2KB
rs1050616 -- 94,250,025(-) AGTAG(A/G)GAAGT utr-variant-3-prime
rs1050627 -- 94,249,465(-) AAAAC(C/T)TCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GEM Gene

Variant ID Type Subtype PubMed ID
nsv831401 CNV Loss 17160897

Relevant External Links for GEM Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GEM Gene

Disorders for GEM Gene

No disorders were found for GEM Gene.

No data available for UniProtKB/Swiss-Prot for GEM Gene

Publications for GEM Gene

  1. Gem: an induced, immediate early protein belonging to the Ras family. (PMID: 7912851) Maguire J. … Kelly K. (Science 1994) 2 3 4 23
  2. The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. (PMID: 11956230) Ward Y. … Kelly K. (J. Cell Biol. 2002) 2 3 4 23
  3. Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. (PMID: 7809057) Cohen L. … Witte O. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  4. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PMID: 9115241) Moyers J.S. … Kahn C.R. (J. Biol. Chem. 1997) 3 4 23
  5. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. (PMID: 14701738) Ward Y. … Kelly K. (Mol. Cell. Biol. 2004) 3 23

Products for GEM Gene

  • Addgene plasmids for GEM

Sources for GEM Gene

Back to Top