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GEM Gene

protein-coding   GIFtS: 58
GCID: GC08M095330

GTP Binding Protein Overexpressed In Skeletal Muscle

(Previous name: GTP-binding protein overexpressed in skeletal muscle)
  Search for GEM
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GTP Binding Protein Overexpressed In Skeletal Muscle1 2     GTP-Binding Mitogen-Induced T-Cell Protein2 3
GTP-Binding Protein Overexpressed In Skeletal Muscle1 2     RAS-Like Protein KIR2 3
Kinase-Inducible Ras-Like Protein1 2     GTP-Binding Protein GEM2
KIR2 3     

External Ids:    HGNC: 42341   Entrez Gene: 26692   Ensembl: ENSG000001649497   OMIM: 6001645   UniProtKB: P550403   

Export aliases for GEM gene to outside databases

Previous GC identifers: GC08M094007 GC08M095107 GC08M094930 GC08M095218 GC08M090470


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GEM Gene:
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the
inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal
transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein
have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for GEM Gene:
GEM (GTP binding protein overexpressed in skeletal muscle) is a protein-coding gene. GO annotations related to this gene include magnesium ion binding and GTP binding. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: GEM_HUMAN, P55040
Function: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the
plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity

Gene Wiki entry for GEM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GEM gene promoter:
         NF-1/L   p300   Cdc5   LCR-F1   NF-kappaB   Egr-4   NF-kappaB2   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGEM promoter sequence
   Search Chromatin IP Primers for GEM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GEM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13-q21   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q13-q21

GEM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GEM gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095330:  view genomic region     (about GC identifiers)

Start:
95,261,481 bp from pter      End:
95,274,578 bp from pter
Size:
13,098 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GEM_HUMAN, P55040 (See protein sequence)
Recommended Name: GTP-binding protein GEM  
Size: 296 amino acids; 33949 Da
Subunit: Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1
3 PDB 3D structures from and Proteopedia for GEM:
2CJW (3D)        2G3Y (3D)        2HT6 (3D)    
Secondary accessions: B2RA31

Explore the universe of human proteins at neXtProt for GEM: NX_P55040

Explore proteomics data for GEM at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GEM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005252.1  NP_859053.1  

    ENSEMBL proteins: 
     ENSP00000379497   ENSP00000297596   ENSP00000428258  

    GEM Human Recombinant Protein Products:

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    Novus Biologicals GEM Protein
    Novus Biologicals GEM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GEM

     
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    GEM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for GEM

    GEM Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GEM
    Cloud-Clone Corp. CLIAs for GEM
    Search eBioscience for ELISAs for GEM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR017358 Small_GTPase_GEM/REM/Rad
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P55040

    ProtoNet protein and cluster: P55040

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: GEM_HUMAN, P55040
    Similarity: Belongs to the small GTPase superfamily. RGK family


    Find genes that share domains with GEM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GEM_HUMAN, P55040
    Function: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the
    plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity
    Induction: By mitogens

         Genatlas biochemistry entry for GEM:
    mitogen-induced gene,35kDa,expressed in G1 phase of the cell cycle,GTP binding protein (G protein),with high
    homology to RAD1,Ras superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA17107948
    GO:0003924GTPase activity IDA17107948
    GO:0005515protein binding IPI12093360
    GO:0005516calmodulin binding IEA--
    GO:0005525GTP binding IDA17107948
         
    Find genes that share ontologies with GEM           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for GEM:
     Decreased cilium length after   Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gem):
     endocrine/exocrine gland  homeostasis/metabolism  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with GEM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gemtm1.1Jgun for GEM

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GEM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GEM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GEM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GEM

    miRNA
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    miRTarBase miRNAs that target GEM:
    hsa-mir-335-5p (MIRT017623), hsa-mir-26b-5p (MIRT029336)

    Block miRNA regulation of human, mouse, rat GEM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GEM (see all 19):
    hsa-miR-448 hsa-miR-429 hsa-miR-507 hsa-miR-888* hsa-miR-641 hsa-miR-3658 hsa-miR-548x hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidGEM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GEM
    Predesigned siRNA for gene silencing in human, mouse, rat GEM

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for GEM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GEM (NM_005261)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GEM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GEM
    Addgene plasmids for GEM 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GEM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GEM_HUMAN, P55040: Cell membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0009898cytoplasmic side of plasma membrane IDA7912851
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with GEM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including GEM: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GEM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for GEM (P550401, 2, 3 ENSP000002975964) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319461, 2, 3, ENSP000003001614EBI-744104,EBI-359815 MINT-8006625 MINT-8006618 MINT-8006644 I2D: score=2 STRING: ENSP00000300161
    TRIM23P364061, 2, 3, ENSP000002315244EBI-744104,EBI-740098 MINT-66445 I2D: score=5 STRING: ENSP00000231524
    CACNB1Q026412, 3, ENSP000003778404MINT-3388383 I2D: score=1 STRING: ENSP00000377840
    PDLIM7Q9NR122, 3, ENSP000003480994MINT-68066 I2D: score=5 STRING: ENSP00000348099
    BMP1P134973, ENSP000003057144I2D: score=2 STRING: ENSP00000305714
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006955immune response TAS7912851
    GO:0007067mitosis IMP--
    GO:0007165signal transduction TAS7912851
    GO:0007166cell surface receptor signaling pathway TAS7912851

    Find genes that share ontologies with GEM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GEM

    3 HMDB Compounds for GEM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 Novoseek inferred chemical compound relationships for GEM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 58.3 7 11956230 (2), 8810259 (1), 14701738 (1), 9115241 (1)
    katp 53 2 12448791 (1), 7733230 (1)
    serine 41.6 2 10372548 (1), 14701738 (1)
    calcium 38.6 14 11395774 (5), 14701738 (3), 17303572 (1), 16298391 (1) (see all 6)
    tyrosine 20.3 9 9059895 (2), 8810259 (1)



    Find genes that share compounds with GEM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GEM gene (2 alternative transcripts): 
    NM_005261.3  NM_181702.2  

    Unigene Cluster for GEM:

    GTP binding protein overexpressed in skeletal muscle
    Hs.654463  [show with all ESTs]
    Unigene Representative Sequence: NM_005261
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396194(uc003ygi.3) ENST00000297596(uc003ygj.3) ENST00000523660
    ENST00000521817 ENST00000523433
    miRNA
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    Block miRNA regulation of human, mouse, rat GEM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GEM (see all 19):
    hsa-miR-448 hsa-miR-429 hsa-miR-507 hsa-miR-888* hsa-miR-641 hsa-miR-3658 hsa-miR-548x hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidGEM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GEM
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GEM (NM_005261)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GEM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GEM
    Addgene plasmids for GEM 
    Primer
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    OriGene qPCR primer pairs and template standards for GEM
    OriGene qSTAR qPCR primer pairs in human, mouse for GEM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GEM
      QuantiTect SYBR Green Assays in human, mouse, rat GEM
      QuantiFast Probe-based Assays in human, mouse, rat GEM

    Additional mRNA sequence: 

    AK314017.1 BC022010.2 U10550.1 U13052.1 

    7 DOTS entries:

    DT.115926  DT.100754360  DT.40208780  DT.40116767  DT.100754359  DT.92064488  DT.121482803 

    Selected AceView cDNA sequences (see all 138):

    BM716263 BQ006034 NM_181702 AA165379 NM_005261 BQ188866 Z39309 T10773 
    CK300237 AV725269 AA418223 BQ003096 BE856187 BC022010 BM702975 BQ880549 
    CA413887 BQ003131 CR603445 BU631713 AW263572 BX389685 CD242637 CD677074 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GEM    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
    SP1:                    -           -     -                     
    SP2:                                -     -                     
    SP3:                    -                                       
    SP4:                                                            


    ECgene alternative splicing isoforms for GEM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GEM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCATCAT
    GEM Expression
    About this image


    GEM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Neural Tube (Nervous System)
             Spinal Dorsal Columns
    GEM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GEM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654463

    UniProtKB/Swiss-Prot: GEM_HUMAN, P55040
    Tissue specificity: Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain,
    liver and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including GEM: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GEM
    OriGene qSTAR qPCR primer pairs in human, mouse for GEM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GEM
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    QuantiFast Probe-based Assays in human, mouse, rat GEM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GEM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GEM gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gem1 , 5 GTP binding protein (gene overexpressed in skeletal more1, 5 90.28(n)1
    95.93(a)1
      4 (5.34 cM)5
    145791  NM_010276.41  NP_034406.21 
     117044575 
    chicken
    (Gallus gallus)
    Aves GEM1 GTP binding protein overexpressed in skeletal muscle 79.28(n)
    82.77(a)
      404771  NM_213579.1  NP_998744.1 
    lizard
    (Anolis carolinensis)
    Reptilia GEM6
    GTP binding protein overexpressed in skeletal musc...
    85(a)
    1 ↔ 1
    4(18943399-18955846)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gem1 GTP binding protein overexpressed in skeletal muscle 75.96(n)
    81.97(a)
      100038040  NM_001097353.1  NP_001090822.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561442 similar to RAS (RAD and GEM)-like GTP-binding 76.63(n)   394149  BC045943.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425416
    Rgk16
    (see all 4)
    Rgk1
    (see all 4)
    7(a)
    18(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(3785530-3824611)
    2R(15199898-15212994)
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.46
    Protein Y52B11A.4 (Y52B11A.4) mRNA, complete cds
    14(a)
    1 → many
    I(10979607-11004283) WBGene00013124


    ENSEMBL Gene Tree for GEM (if available)
    TreeFam Gene Tree for GEM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GEM gene
    REM12  RALA2  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  REM22  
    KRAS2  RRAS22  HRAS2  MRAS2  
    12 SIMAP similar genes for GEM using alignment to 2 protein entries:     GEM_HUMAN (see all proteins):
    RRAD    REM1    REM2    RAB6B    RALA    RALB
    MRAS    NRAS    RIT2    RAP2B    RIT1    RAP1A

    Find genes that share paralogs with GEM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GEM (see all 311)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24468551,2
    C,F,A,H--95261076(-) AGGAAG/TCTAGT 2 -- ds500113Minor allele frequency- T:0.50NS EA NA WA CSA 787
    rs1873190601,2
    --95261123(+) TAATGC/TCTTAG 2 -- ds50010--------
    rs1475750461,2
    C--95261155(+) TCCAGA/GGAGCA 2 -- ds50010--------
    rs746699351,2
    C,F--95261263(+) CCCAAC/TGGTAT 2 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs1904811861,2
    C--95261293(+) ATTACC/G/TGTGAA 2 -- ds50010--------
    rs1419510571,2
    --95261361(+) TATTGC/TTAGTG 2 -- ds50010--------
    rs1459003541,2
    --95261608(+) ATGCTC/TTATCA 2 -- ut310--------
    rs1830267601,2
    --95261613(+) TTATCA/GAATGT 2 -- ut310--------
    rs26231671,2
    C,F,O,H--95261682(-) TACTTT/GGGTTG 2 -- ut3123Minor allele frequency- G:0.04NS NA EA 1852
    rs10506271,2
    C,F,O,A--95261693(-) AAAACT/CTCCAG 2 -- ut3113Minor allele frequency- C:0.37NA MN WA EA 696

    HapMap Linkage Disequilibrium report for GEM (95261481 - 95274578 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GEM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831401CNV Loss17160897

    Human Gene Mutation Database (HGMD): GEM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GEM
    DNA2.0 Custom Variant and Variant Library Synthesis for GEM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600164    OMIM disorders: --


    Find genes that share disorders with GEM           About GenesLikeMe


    Export disorders for GEM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GEM gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with GEM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. (PubMed id 11956230)1, 2, 3, 9 Ward Y.... Kelly K. (J. Cell Biol. 2002)
    2. Gem: an induced, immediate early protein belonging to the Ras family. (PubMed id 7912851)1, 2, 3, 9 Maguire J....Kelly K. (Science 1994)
    3. Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. (PubMed id 7809057)1, 2, 9 Cohen L.... Witte O. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    4. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PubMed id 9115241)1, 2, 9 Moyers J.S.... Kahn C.R. (J. Biol. Chem. 1997)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein. (PubMed id 8825643)1, 9 Santoro T....Kelly K. (Genomics 1995)
    7. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. (PubMed id 14701738)1, 9 Ward Y....Kelly K. (Mol. Cell. Biol. 2004)
    8. Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. (PubMed id 11395774)1, 9 BAcguin P....Seino S. (Nature 2001)
    9. The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression. (PubMed id 22964304)1 Andrieu G....Hatzoglou A. (FASEB J. 2012)
    10. Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels. (PubMed id 22589533)1 Fan M....Yang J. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2669 HGNC: 4234 AceView: GEM Ensembl:ENSG00000164949 euGenes: HUgn2669
    ECgene: GEM H-InvDB: GEM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GEM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GEM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GEM gene:
    Search GeneIP for patents involving GEM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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