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Aliases for GEM Gene

Aliases for GEM Gene

  • GTP Binding Protein Overexpressed In Skeletal Muscle 2 3 5
  • GTP-Binding Protein Overexpressed In Skeletal Muscle 2 3
  • GTP-Binding Mitogen-Induced T-Cell Protein 3 4
  • Kinase-Inducible Ras-Like Protein 2 3
  • RAS-Like Protein KIR 3 4
  • KIR 3 4

External Ids for GEM Gene

Previous GeneCards Identifiers for GEM Gene

  • GC08M094007
  • GC08M095107
  • GC08M094930
  • GC08M095218
  • GC08M095330
  • GC08M090470

Summaries for GEM Gene

Entrez Gene Summary for GEM Gene

  • The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GEM Gene

GEM (GTP Binding Protein Overexpressed In Skeletal Muscle) is a Protein Coding gene. GO annotations related to this gene include GTP binding and magnesium ion binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for GEM Gene

  • Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Gene Wiki entry for GEM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GEM Gene

Genomics for GEM Gene

Regulatory Elements for GEM Gene

Promoters for GEM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GEM on UCSC Golden Path with GeneCards custom track

Genomic Location for GEM Gene

Chromosome:
8
Start:
94,249,253 bp from pter
End:
94,262,350 bp from pter
Size:
13,098 bases
Orientation:
Minus strand

Genomic View for GEM Gene

Genes around GEM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GEM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GEM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GEM Gene

Proteins for GEM Gene

  • Protein details for GEM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55040-GEM_HUMAN
    Recommended name:
    GTP-binding protein GEM
    Protein Accession:
    P55040
    Secondary Accessions:
    • B2RA31

    Protein attributes for GEM Gene

    Size:
    296 amino acids
    Molecular mass:
    33949 Da
    Quaternary structure:
    • Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.

    Three dimensional structures from OCA and Proteopedia for GEM Gene

neXtProt entry for GEM Gene

Proteomics data for GEM Gene at MOPED

Post-translational modifications for GEM Gene

Other Protein References for GEM Gene

Antibody Products

No data available for DME Specific Peptides for GEM Gene

Domains & Families for GEM Gene

Gene Families for GEM Gene

Suggested Antigen Peptide Sequences for GEM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55040

UniProtKB/Swiss-Prot:

GEM_HUMAN :
  • Belongs to the small GTPase superfamily. RGK family.
Family:
  • Belongs to the small GTPase superfamily. RGK family.
genes like me logo Genes that share domains with GEM: view

Function for GEM Gene

Molecular function for GEM Gene

GENATLAS Biochemistry:
mitogen-induced gene,35kDa,expressed in G1 phase of the cell cycle,GTP binding protein (G protein),with high homology to RAD1,Ras superfamily
UniProtKB/Swiss-Prot Function:
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
UniProtKB/Swiss-Prot Induction:
By mitogens.

Gene Ontology (GO) - Molecular Function for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17107948
genes like me logo Genes that share ontologies with GEM: view
genes like me logo Genes that share phenotypes with GEM: view

Animal Models for GEM Gene

MGI Knock Outs for GEM:
  • Gem tm1.1Jgun

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GEM Gene

Localization for GEM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GEM Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GEM Gene COMPARTMENTS Subcellular localization image for GEM gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GEM: view

Pathways & Interactions for GEM Gene

SuperPathways for GEM Gene

No Data Available

Gene Ontology (GO) - Biological Process for GEM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 7912851
GO:0051276 chromosome organization IMP 22964304
genes like me logo Genes that share ontologies with GEM: view

No data available for Pathways by source and SIGNOR curated interactions for GEM Gene

Drugs & Compounds for GEM Gene

(6) Drugs for GEM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for GEM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GEM: view

Transcripts for GEM Gene

Unigene Clusters for GEM Gene

GTP binding protein overexpressed in skeletal muscle:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GEM Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for GEM Gene

GeneLoc Exon Structure for
GEM
ECgene alternative splicing isoforms for
GEM

Expression for GEM Gene

mRNA expression in normal human tissues for GEM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GEM Gene

This gene is overexpressed in Artery - Aorta (x5.3).

Protein differential expression in normal tissues from HIPED for GEM Gene

This gene is overexpressed in Gallbladder (37.0) and Uterus (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GEM Gene



SOURCE GeneReport for Unigene cluster for GEM Gene Hs.654463

mRNA Expression by UniProt/SwissProt for GEM Gene

P55040-GEM_HUMAN
Tissue specificity: Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.
genes like me logo Genes that share expression patterns with GEM: view

Protein tissue co-expression partners for GEM Gene

Primer Products

In Situ Assay Products

Orthologs for GEM Gene

This gene was present in the common ancestor of animals.

Orthologs for GEM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GEM 35
  • 99.55 (n)
  • 99.66 (a)
GEM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GEM 36
  • 95 (a)
OneToOne
GEM 35
  • 89.64 (n)
  • 94.59 (a)
dog
(Canis familiaris)
Mammalia GEM 35
  • 90.99 (n)
  • 94.93 (a)
GEM 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gem 16
Gem 36
  • 96 (a)
OneToOne
Gem 35
  • 90.28 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia GEM 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GEM 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gem 35
  • 89.38 (n)
  • 95.25 (a)
chicken
(Gallus gallus)
Aves GEM 36
  • 84 (a)
OneToOne
GEM 35
  • 79.28 (n)
  • 82.77 (a)
lizard
(Anolis carolinensis)
Reptilia GEM 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gem 35
  • 75.96 (n)
  • 81.97 (a)
zebrafish
(Danio rerio)
Actinopterygii gem 36
  • 54 (a)
OneToOne
zgc56144 35
gem 35
  • 60.37 (n)
  • 56.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rgk3 36
  • 17 (a)
ManyToMany
Rgk2 36
  • 13 (a)
ManyToMany
Rgk1 36
  • 18 (a)
ManyToMany
CG42541 36
  • 7 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y52B11A.4 36
  • 14 (a)
OneToMany
Species with no ortholog for GEM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GEM Gene

ENSEMBL:
Gene Tree for GEM (if available)
TreeFam:
Gene Tree for GEM (if available)

Paralogs for GEM Gene

Paralogs for GEM Gene

(12) SIMAP similar genes for GEM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GEM: view

Variants for GEM Gene

Sequence variations from dbSNP and Humsavar for GEM Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17036 -- 94,249,727(-) CCACC(A/G)AGACA utr-variant-3-prime
rs981678 -- 94,264,233(+) CGCCT(G/T)TAATC upstream-variant-2KB
rs1050616 -- 94,250,025(-) AGTAG(A/G)GAAGT utr-variant-3-prime
rs1050627 -- 94,249,465(-) AAAAC(C/T)TCCAG utr-variant-3-prime
rs2445711 -- 94,251,414(+) GGGCC(C/T)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GEM Gene

Variant ID Type Subtype PubMed ID
nsv831401 CNV Loss 17160897

Variation tolerance for GEM Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GEM Gene

HapMap Linkage Disequilibrium report
GEM
Human Gene Mutation Database (HGMD)
GEM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GEM Gene

Disorders for GEM Gene

Relevant External Links for GEM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GEM

No disorders were found for GEM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GEM Gene

Publications for GEM Gene

  1. The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. (PMID: 11956230) Ward Y. … Kelly K. (J. Cell Biol. 2002) 2 3 4 23 67
  2. Gem: an induced, immediate early protein belonging to the Ras family. (PMID: 7912851) Maguire J. … Kelly K. (Science 1994) 2 3 23
  3. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. (PMID: 14701738) Ward Y. … Kelly K. (Mol. Cell. Biol. 2004) 3 23
  4. Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. (PMID: 11395774) BAcguin P. … Seino S. (Nature 2001) 3 23
  5. Rad and Rad-related GTPases interact with calmodulin and calmodulin- dependent protein kinase II. (PMID: 9115241) Moyers J.S. … Kahn C.R. (J. Biol. Chem. 1997) 3 23

Products for GEM Gene

Sources for GEM Gene

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