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Aliases for GDPGP1 Gene

Aliases for GDPGP1 Gene

  • GDP-D-Glucose Phosphorylase 1 2 3
  • C15orf58 3 4
  • GDP-D-Glucose Phosphorylase C15orf58 3
  • Chromosome 15 Open Reading Frame 58 2
  • EC 2.7.7.78 4
  • VTC2 3

External Ids for GDPGP1 Gene

Previous HGNC Symbols for GDPGP1 Gene

  • C15orf58

Previous GeneCards Identifiers for GDPGP1 Gene

  • GC15P090778

Summaries for GDPGP1 Gene

GeneCards Summary for GDPGP1 Gene

GDPGP1 (GDP-D-Glucose Phosphorylase 1) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for GDPGP1 Gene

  • Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDPGP1 Gene

Genomics for GDPGP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GDPGP1 Gene

Start:
90,233,808 bp from pter
End:
90,245,811 bp from pter
Size:
12,004 bases
Orientation:
Plus strand

Genomic View for GDPGP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GDPGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPGP1 Gene

No data available for Regulatory Elements for GDPGP1 Gene

Proteins for GDPGP1 Gene

  • Protein details for GDPGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNW5-GDPP1_HUMAN
    Recommended name:
    GDP-D-glucose phosphorylase 1
    Protein Accession:
    Q6ZNW5
    Secondary Accessions:

    Protein attributes for GDPGP1 Gene

    Size:
    385 amino acids
    Molecular mass:
    42362 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants

neXtProt entry for GDPGP1 Gene

Proteomics data for GDPGP1 Gene at MOPED

Post-translational modifications for GDPGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GDPGP1 Gene

No data available for DME Specific Peptides for GDPGP1 Gene

Domains for GDPGP1 Gene

Protein Domains for GDPGP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ZNW5

UniProtKB/Swiss-Prot:

GDPP1_HUMAN :
  • Q6ZNW5
Family:
  • Belongs to the GDPGP1 family.
genes like me logo Genes that share domains with GDPGP1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GDPGP1 Gene

Function for GDPGP1 Gene

Molecular function for GDPGP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2 uM for GDP-D-glucose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=12 uM for GDP-L-galactose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=42 uM for GDP-D-mannose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=2.9 mM for inorganic phosphate (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; Note=kcat is 26 s(-1) at 31 degrees Celsius. The catalytic efficiency for GDP-D-glucose is 35-fold higher than for GDP-L- galactose.;
UniProtKB/Swiss-Prot CatalyticActivity: GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.
UniProtKB/Swiss-Prot Function: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

Enzyme Numbers (IUBMB) for GDPGP1 Gene

Gene Ontology (GO) - Molecular Function for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0080048 GDP-D-glucose phosphorylase activity IDA 21507950
genes like me logo Genes that share ontologies with GDPGP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDPGP1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GDPGP1 Gene

Localization for GDPGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPGP1 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with GDPGP1: view

No data available for Subcellular locations from COMPARTMENTS for GDPGP1 Gene

Pathways for GDPGP1 Gene

SuperPathways for GDPGP1 Gene

No Data Available

Interacting Proteins for GDPGP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368405%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000368405 for GDPGP1 Gene via STRING

Gene Ontology (GO) - Biological Process for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IMP 21507950
GO:0008152 metabolic process --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with GDPGP1: view

No data available for Pathways by source for GDPGP1 Gene

Transcripts for GDPGP1 Gene

mRNA/cDNA for GDPGP1 Gene

(6) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDPGP1 Gene

GDP-D-glucose phosphorylase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDPGP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GDPGP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDPGP1 Gene

No ASD Table

Relevant External Links for GDPGP1 Gene

GeneLoc Exon Structure for
GDPGP1
ECgene alternative splicing isoforms for
GDPGP1

Expression for GDPGP1 Gene

mRNA expression in normal human tissues for GDPGP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GDPGP1 Gene

SOURCE GeneReport for Unigene cluster for GDPGP1 Gene Hs.304673

genes like me logo Genes that share expressions with GDPGP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GDPGP1 Gene

Orthologs for GDPGP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GDPGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDPGP1 35
  • 99.13 (n)
  • 98.96 (a)
GDPGP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GDPGP1 35
  • 84.16 (n)
  • 81.82 (a)
GDPGP1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDPGP1 35
  • 85.19 (n)
  • 81.82 (a)
GDPGP1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdpgp1 35
  • 79.43 (n)
  • 79.17 (a)
Gdpgp1 16
Gdpgp1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GDPGP1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdpgp1 35
  • 80.64 (n)
  • 80.73 (a)
chicken
(Gallus gallus)
Aves GDPGP1 36
  • 52 (a)
OneToOne
LOC100858151 35
  • 59.88 (n)
  • 55.23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gdpgp1 35
  • 54.42 (n)
  • 51.57 (a)
zebrafish
(Danio rerio)
Actinopterygii GDPGP1 36
  • 53 (a)
OneToOne
zgc:153343 35
  • 55.16 (n)
  • 55.06 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000740 35
  • 48.63 (n)
  • 37.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3552 35
  • 45.3 (n)
  • 32.75 (a)
CG3552 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mcp-1 35
  • 41.75 (n)
  • 32.08 (a)
mcp-1 36
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons VTC5 35
  • 44.37 (n)
  • 33.44 (a)
rice
(Oryza sativa)
Liliopsida Os12g0190000 35
  • 47.1 (n)
  • 36.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToOne
Species with no ortholog for GDPGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GDPGP1 Gene

ENSEMBL:
Gene Tree for GDPGP1 (if available)
TreeFam:
Gene Tree for GDPGP1 (if available)

Paralogs for GDPGP1 Gene

Selected SIMAP similar genes for GDPGP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GDPGP1: view

No data available for Paralogs for GDPGP1 Gene

Variants for GDPGP1 Gene

Sequence variations from dbSNP and Humsavar for GDPGP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_043555 -
VAR_043556 -
VAR_043557 -

Relevant External Links for GDPGP1 Gene

HapMap Linkage Disequilibrium report
GDPGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GDPGP1 Gene

Disorders for GDPGP1 Gene

No disorders were found for GDPGP1 Gene.

No data available for UniProtKB/Swiss-Prot for GDPGP1 Gene

Publications for GDPGP1 Gene

  1. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. (PMID: 21507950) Adler L.N. … Linster C.L. (J. Biol. Chem. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for GDPGP1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GDPGP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for GDPGP1
    • Block miRNA regulation of GDPGP1 using miScript Target Protectors

    Sources for GDPGP1 Gene

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