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Aliases for GDPGP1 Gene

Aliases for GDPGP1 Gene

  • GDP-D-Glucose Phosphorylase 1 2 3 5
  • C15orf58 3 4
  • GDP-D-Glucose Phosphorylase C15orf58 3
  • Chromosome 15 Open Reading Frame 58 2
  • EC 2.7.7.78 4
  • VTC2 3

External Ids for GDPGP1 Gene

Previous HGNC Symbols for GDPGP1 Gene

  • C15orf58

Previous GeneCards Identifiers for GDPGP1 Gene

  • GC15P090778

Summaries for GDPGP1 Gene

GeneCards Summary for GDPGP1 Gene

GDPGP1 (GDP-D-Glucose Phosphorylase 1) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for GDPGP1 Gene

  • Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDPGP1 Gene

Genomics for GDPGP1 Gene

Regulatory Elements for GDPGP1 Gene

Enhancers for GDPGP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GDPGP1 on UCSC Golden Path with GeneCards custom track

Promoters for GDPGP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GDPGP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GDPGP1 Gene

Chromosome:
15
Start:
90,233,808 bp from pter
End:
90,245,811 bp from pter
Size:
12,004 bases
Orientation:
Plus strand

Genomic View for GDPGP1 Gene

Genes around GDPGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDPGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDPGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPGP1 Gene

Proteins for GDPGP1 Gene

  • Protein details for GDPGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNW5-GDPP1_HUMAN
    Recommended name:
    GDP-D-glucose phosphorylase 1
    Protein Accession:
    Q6ZNW5

    Protein attributes for GDPGP1 Gene

    Size:
    385 amino acids
    Molecular mass:
    42362 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

neXtProt entry for GDPGP1 Gene

Proteomics data for GDPGP1 Gene at MOPED

Post-translational modifications for GDPGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GDPGP1 Gene

No data available for DME Specific Peptides for GDPGP1 Gene

Domains & Families for GDPGP1 Gene

Protein Domains for GDPGP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GDPGP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNW5

UniProtKB/Swiss-Prot:

GDPP1_HUMAN :
  • Belongs to the GDPGP1 family.
Family:
  • Belongs to the GDPGP1 family.
genes like me logo Genes that share domains with GDPGP1: view

No data available for Gene Families for GDPGP1 Gene

Function for GDPGP1 Gene

Molecular function for GDPGP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2 uM for GDP-D-glucose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=12 uM for GDP-L-galactose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=42 uM for GDP-D-mannose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=2.9 mM for inorganic phosphate (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; Note=kcat is 26 s(-1) at 31 degrees Celsius. The catalytic efficiency for GDP-D-glucose is 35-fold higher than for GDP-L- galactose.;
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.
UniProtKB/Swiss-Prot Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

Enzyme Numbers (IUBMB) for GDPGP1 Gene

Gene Ontology (GO) - Molecular Function for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0080048 GDP-D-glucose phosphorylase activity IDA 21507950
genes like me logo Genes that share ontologies with GDPGP1: view

Phenotypes for GDPGP1 Gene

genes like me logo Genes that share phenotypes with GDPGP1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GDPGP1 Gene

Localization for GDPGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPGP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GDPGP1 Gene COMPARTMENTS Subcellular localization image for GDPGP1 gene
Compartment Confidence
cytosol 3
chloroplast 2
nucleus 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for GDPGP1 Gene

Pathways & Interactions for GDPGP1 Gene

SuperPathways for GDPGP1 Gene

No Data Available

Interacting Proteins for GDPGP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368405%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000368405 for GDPGP1 Gene via STRING

Gene Ontology (GO) - Biological Process for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IMP 21507950
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GDPGP1: view

No data available for Pathways by source and SIGNOR curated interactions for GDPGP1 Gene

Drugs & Compounds for GDPGP1 Gene

(2) Drugs for GDPGP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glucose 1-phosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for GDPGP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-glucose
  • GDP-alpha-D-Glucose
  • GDP-alpha-delta-Glucose
  • GDPG
  • Guanosine 5-pyrophosphate
  • Guanosine diphosphoglucose
5750-57-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with GDPGP1: view

Transcripts for GDPGP1 Gene

mRNA/cDNA for GDPGP1 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDPGP1 Gene

GDP-D-glucose phosphorylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDPGP1 Gene

No ASD Table

Relevant External Links for GDPGP1 Gene

GeneLoc Exon Structure for
GDPGP1
ECgene alternative splicing isoforms for
GDPGP1

Expression for GDPGP1 Gene

mRNA expression in normal human tissues for GDPGP1 Gene

Protein differential expression in normal tissues from HIPED for GDPGP1 Gene

This gene is overexpressed in Spleen (11.8), Salivary gland (9.0), Stomach (7.9), and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GDPGP1 Gene



SOURCE GeneReport for Unigene cluster for GDPGP1 Gene Hs.304673

genes like me logo Genes that share expression patterns with GDPGP1: view

Protein tissue co-expression partners for GDPGP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GDPGP1 Gene

Orthologs for GDPGP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GDPGP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GDPGP1 35
  • 84.16 (n)
  • 81.82 (a)
GDPGP1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDPGP1 35
  • 85.19 (n)
  • 81.82 (a)
GDPGP1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdpgp1 35
  • 79.43 (n)
  • 79.17 (a)
Gdpgp1 16
Gdpgp1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GDPGP1 35
  • 99.13 (n)
  • 98.96 (a)
GDPGP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdpgp1 35
  • 80.64 (n)
  • 80.73 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GDPGP1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858151 35
  • 59.88 (n)
  • 55.23 (a)
GDPGP1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gdpgp1 35
  • 54.42 (n)
  • 51.57 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153343 35
  • 55.16 (n)
  • 55.06 (a)
GDPGP1 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000740 35
  • 48.63 (n)
  • 37.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3552 35
  • 45.3 (n)
  • 32.75 (a)
CG3552 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mcp-1 35
  • 41.75 (n)
  • 32.08 (a)
mcp-1 36
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons VTC5 35
  • 44.37 (n)
  • 33.44 (a)
rice
(Oryza sativa)
Liliopsida Os12g0190000 35
  • 47.1 (n)
  • 36.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToOne
Species with no ortholog for GDPGP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GDPGP1 Gene

ENSEMBL:
Gene Tree for GDPGP1 (if available)
TreeFam:
Gene Tree for GDPGP1 (if available)

Paralogs for GDPGP1 Gene

(1) SIMAP similar genes for GDPGP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GDPGP1: view

No data available for Paralogs for GDPGP1 Gene

Variants for GDPGP1 Gene

Sequence variations from dbSNP and Humsavar for GDPGP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_043555 -
VAR_043556 -
VAR_043557 -

Variation tolerance for GDPGP1 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDPGP1 Gene

HapMap Linkage Disequilibrium report
GDPGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GDPGP1 Gene

Disorders for GDPGP1 Gene

Relevant External Links for GDPGP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDPGP1

No disorders were found for GDPGP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDPGP1 Gene

Publications for GDPGP1 Gene

  1. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. (PMID: 21507950) Adler L.N. … Linster C.L. (J. Biol. Chem. 2011) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for GDPGP1 Gene

Sources for GDPGP1 Gene

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