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Aliases for GDPGP1 Gene

Aliases for GDPGP1 Gene

  • GDP-D-Glucose Phosphorylase 1 2 3 5
  • C15orf58 3 4
  • GDP-D-Glucose Phosphorylase C15orf58 3
  • Chromosome 15 Open Reading Frame 58 2
  • EC 2.7.7.78 4
  • VTC2 3

External Ids for GDPGP1 Gene

Previous HGNC Symbols for GDPGP1 Gene

  • C15orf58

Previous GeneCards Identifiers for GDPGP1 Gene

  • GC15P090778

Summaries for GDPGP1 Gene

GeneCards Summary for GDPGP1 Gene

GDPGP1 (GDP-D-Glucose Phosphorylase 1) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for GDPGP1 Gene

  • Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDPGP1 Gene

Genomics for GDPGP1 Gene

Regulatory Elements for GDPGP1 Gene

Enhancers for GDPGP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F090157 1.7 FANTOM5 Ensembl ENCODE 11.6 -70.3 -70276 12.3 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 CIB1 ENSG00000228998 LOC100631255 ENSG00000259314 POLG SEMA4B GDPGP1 NGRN NIFKP5 ENSG00000259212
GH15F090361 1.2 Ensembl ENCODE 15.1 +129.5 129527 4.1 CBX3 SIN3A BRCA1 RAD21 RFX5 GATA2 RCOR1 FOS CREM MIXL1 IQGAP1 GDPGP1 NGRN CRTC3 ZNF774 CIB1 PEX11A GC15M090347 GC15P090381
GH15F090209 1.5 FANTOM5 Ensembl ENCODE 11.8 -21.3 -21322 5.9 TBP FEZF1 RAD21 ZNF121 GATA2 SCRT2 ZNF143 ETV6 FOS CREM SEMA4B CIB1 GDPGP1 IDH2 NGRN IQGAP1 ENSG00000228998 TTLL13P RPS12P26 PIR48569
GH15F090153 1.3 Ensembl ENCODE 11.6 -78.9 -78885 1.9 PKNOX1 ZNF133 ARID4B SIN3A FEZF1 ZNF2 YY1 GLIS2 FOS ZHX2 CIB1 GDPGP1 NGRN GABARAPL3 ZNF774 SEMA4B IDH2 GC15M090124
GH15F090293 1.3 Ensembl ENCODE 11.1 +59.9 59853 0.9 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 ZNF2 GLIS2 ZNF143 FOS NGRN GDPGP1 ZNF774 GABARAPL3 GOLGA2P8 RN7SL736P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GDPGP1 on UCSC Golden Path with GeneCards custom track

Promoters for GDPGP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000413357 -8 2401 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS

Genomic Location for GDPGP1 Gene

Chromosome:
15
Start:
90,233,808 bp from pter
End:
90,245,811 bp from pter
Size:
12,004 bases
Orientation:
Plus strand

Genomic View for GDPGP1 Gene

Genes around GDPGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDPGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDPGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPGP1 Gene

Proteins for GDPGP1 Gene

  • Protein details for GDPGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNW5-GDPP1_HUMAN
    Recommended name:
    GDP-D-glucose phosphorylase 1
    Protein Accession:
    Q6ZNW5

    Protein attributes for GDPGP1 Gene

    Size:
    385 amino acids
    Molecular mass:
    42362 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

neXtProt entry for GDPGP1 Gene

Post-translational modifications for GDPGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GDPGP1 Gene

No data available for DME Specific Peptides for GDPGP1 Gene

Domains & Families for GDPGP1 Gene

Protein Domains for GDPGP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GDPGP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNW5

UniProtKB/Swiss-Prot:

GDPP1_HUMAN :
  • Belongs to the GDPGP1 family.
Family:
  • Belongs to the GDPGP1 family.
genes like me logo Genes that share domains with GDPGP1: view

No data available for Gene Families for GDPGP1 Gene

Function for GDPGP1 Gene

Molecular function for GDPGP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2 uM for GDP-D-glucose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=12 uM for GDP-L-galactose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=42 uM for GDP-D-mannose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=2.9 mM for inorganic phosphate (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; Note=kcat is 26 s(-1) at 31 degrees Celsius. The catalytic efficiency for GDP-D-glucose is 35-fold higher than for GDP-L- galactose.;
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.
UniProtKB/Swiss-Prot Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

Enzyme Numbers (IUBMB) for GDPGP1 Gene

Gene Ontology (GO) - Molecular Function for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GDPGP1: view
genes like me logo Genes that share phenotypes with GDPGP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GDPGP1 Gene

Localization for GDPGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPGP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDPGP1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
genes like me logo Genes that share ontologies with GDPGP1: view

Pathways & Interactions for GDPGP1 Gene

SuperPathways for GDPGP1 Gene

No Data Available

Interacting Proteins for GDPGP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368405%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000368405 Q6ZNW5-GDPP1_HUMAN for GDPGP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IMP 21507950
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with GDPGP1: view

No data available for Pathways by source and SIGNOR curated interactions for GDPGP1 Gene

Drugs & Compounds for GDPGP1 Gene

(3) Drugs for GDPGP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Glucose 1-phosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(1) Additional Compounds for GDPGP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-glucose
  • GDP-alpha-D-Glucose
  • GDP-alpha-delta-Glucose
  • GDPG
  • Guanosine 5-pyrophosphate
  • Guanosine diphosphoglucose
5750-57-2
genes like me logo Genes that share compounds with GDPGP1: view

Transcripts for GDPGP1 Gene

mRNA/cDNA for GDPGP1 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDPGP1 Gene

GDP-D-glucose phosphorylase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDPGP1 Gene

No ASD Table

Relevant External Links for GDPGP1 Gene

GeneLoc Exon Structure for
GDPGP1
ECgene alternative splicing isoforms for
GDPGP1

Expression for GDPGP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GDPGP1 Gene

Protein differential expression in normal tissues from HIPED for GDPGP1 Gene

This gene is overexpressed in Spleen (11.8), Salivary gland (9.0), Stomach (7.9), and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GDPGP1 Gene



Protein tissue co-expression partners for GDPGP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GDPGP1 Gene:

GDPGP1

SOURCE GeneReport for Unigene cluster for GDPGP1 Gene:

Hs.304673
genes like me logo Genes that share expression patterns with GDPGP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GDPGP1 Gene

Orthologs for GDPGP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GDPGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDPGP1 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia GDPGP1 34 35
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia GDPGP1 34 35
  • 84.16 (n)
rat
(Rattus norvegicus)
Mammalia Gdpgp1 34
  • 80.64 (n)
mouse
(Mus musculus)
Mammalia Gdpgp1 34 16 35
  • 79.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GDPGP1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858151 34
  • 59.88 (n)
GDPGP1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gdpgp1 34
  • 54.42 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153343 34
  • 55.16 (n)
GDPGP1 35
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000740 34
  • 48.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3552 34 35
  • 45.3 (n)
worm
(Caenorhabditis elegans)
Secernentea mcp-1 34 35
  • 41.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons VTC5 34
  • 44.37 (n)
rice
(Oryza sativa)
Liliopsida Os12g0190000 34
  • 47.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToOne
Species where no ortholog for GDPGP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GDPGP1 Gene

ENSEMBL:
Gene Tree for GDPGP1 (if available)
TreeFam:
Gene Tree for GDPGP1 (if available)

Paralogs for GDPGP1 Gene

(1) SIMAP similar genes for GDPGP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GDPGP1: view

No data available for Paralogs for GDPGP1 Gene

Variants for GDPGP1 Gene

Sequence variations from dbSNP and Humsavar for GDPGP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152994 -- 90,241,698(+) CAGGG(A/C)CTGAC intron-variant, reference, missense
rs10153004 -- 90,241,828(+) CCTCA(C/T)AGGGG intron-variant, reference, missense
rs111423541 -- 90,233,529(+) CGCAG(A/C)CCGGG intron-variant, upstream-variant-2KB
rs111646134 -- 90,239,710(+) TATCT(A/G)TCTAT intron-variant
rs111849502 -- 90,241,854(+) GGGCC(C/T)GGAAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GDPGP1 Gene

Variant ID Type Subtype PubMed ID
nsv833087 CNV loss 17160897
nsv817707 CNV gain 17921354
nsv442384 CNV gain 18776908
nsv1052652 CNV gain 25217958
esv3637214 CNV gain 21293372
esv2760054 CNV gain 17122850
dgv112e55 CNV gain 17911159

Variation tolerance for GDPGP1 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDPGP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GDPGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDPGP1 Gene

Disorders for GDPGP1 Gene

Relevant External Links for GDPGP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDPGP1

No disorders were found for GDPGP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDPGP1 Gene

Publications for GDPGP1 Gene

  1. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. (PMID: 21507950) Adler L.N. … Linster C.L. (J. Biol. Chem. 2011) 2 3 4 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for GDPGP1 Gene

Sources for GDPGP1 Gene

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