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Aliases for GDPD4 Gene

Aliases for GDPD4 Gene

  • Glycerophosphodiester Phosphodiesterase Domain Containing 4 2 3 5
  • Glycerophosphodiester Phosphodiesterase 6 3 4
  • UgpQ 3 4
  • GDE6 3 4
  • GDPD Domain Containing Protein 3
  • EC 3.1.-.- 4

External Ids for GDPD4 Gene

Previous GeneCards Identifiers for GDPD4 Gene

  • GC11M076606
  • GC11M076927
  • GC11M073225

Summaries for GDPD4 Gene

GeneCards Summary for GDPD4 Gene

GDPD4 (Glycerophosphodiester Phosphodiesterase Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphodiester phosphodiesterase activity. An important paralog of this gene is GDPD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDPD4 Gene

Genomics for GDPD4 Gene

Regulatory Elements for GDPD4 Gene

Enhancers for GDPD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GDPD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GDPD4 Gene

77,216,558 bp from pter
77,301,699 bp from pter
85,142 bases
Minus strand

Genomic View for GDPD4 Gene

Genes around GDPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPD4 Gene

Proteins for GDPD4 Gene

  • Protein details for GDPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycerophosphodiester phosphodiesterase domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q7Z5B0

    Protein attributes for GDPD4 Gene

    623 amino acids
    Molecular mass:
    71996 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GDPD4 Gene


neXtProt entry for GDPD4 Gene

Proteomics data for GDPD4 Gene at MOPED

Post-translational modifications for GDPD4 Gene

  • Glycosylation at Asn 308 and Asn 397
  • Modification sites at PhosphoSitePlus

Other Protein References for GDPD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GDPD4 Gene

Domains & Families for GDPD4 Gene

Suggested Antigen Peptide Sequences for GDPD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GP-PDE domain.
  • Belongs to the glycerophosphoryl diester phosphodiesterase family.
  • Contains 1 GP-PDE domain.
  • Belongs to the glycerophosphoryl diester phosphodiesterase family.
genes like me logo Genes that share domains with GDPD4: view

No data available for Gene Families for GDPD4 Gene

Function for GDPD4 Gene

Enzyme Numbers (IUBMB) for GDPD4 Gene

Gene Ontology (GO) - Molecular Function for GDPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with GDPD4: view

Phenotypes for GDPD4 Gene

genes like me logo Genes that share phenotypes with GDPD4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GDPD4 Gene

Localization for GDPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPD4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GDPD4 Gene COMPARTMENTS Subcellular localization image for GDPD4 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for GDPD4 Gene

Pathways & Interactions for GDPD4 Gene

SuperPathways for GDPD4 Gene

No Data Available

Interacting Proteins for GDPD4 Gene

Gene Ontology (GO) - Biological Process for GDPD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for GDPD4 Gene

Drugs & Compounds for GDPD4 Gene

No Compound Related Data Available

Transcripts for GDPD4 Gene

mRNA/cDNA for GDPD4 Gene

(10) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDPD4 Gene

Glycerophosphodiester phosphodiesterase domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDPD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: -

Relevant External Links for GDPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GDPD4 Gene

mRNA expression in normal human tissues for GDPD4 Gene

mRNA differential expression in normal tissues according to GTEx for GDPD4 Gene

This gene is overexpressed in Testis (x32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GDPD4 Gene

SOURCE GeneReport for Unigene cluster for GDPD4 Gene Hs.249795

genes like me logo Genes that share expression patterns with GDPD4: view

Protein tissue co-expression partners for GDPD4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GDPD4 Gene

Orthologs for GDPD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC524642 35
  • 75.68 (n)
  • 61.2 (a)
-- 36
  • 62 (a)
-- 36
  • 54 (a)
(Canis familiaris)
Mammalia GDPD4 35
  • 81.18 (n)
  • 68.4 (a)
GDPD4 36
  • 52 (a)
(Mus musculus)
Mammalia Gdpd4 35
  • 76.79 (n)
  • 66.67 (a)
Gdpd4 16
Gdpd4 36
  • 53 (a)
(Pan troglodytes)
Mammalia GDPD4 35
  • 96.6 (n)
  • 95.18 (a)
GDPD4 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Gdpd4 35
  • 76.34 (n)
  • 66.4 (a)
(Monodelphis domestica)
Mammalia GDPD4 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia GDPD4 36
  • 33 (a)
(Gallus gallus)
Aves GDPD4 35
  • 59.44 (n)
  • 50.64 (a)
GDPD4 36
  • 40 (a)
(Anolis carolinensis)
Reptilia GDPD4 36
  • 38 (a)
(Danio rerio)
Actinopterygii GDPD4 (1 of 3) 36
  • 38 (a)
GDPD4 (3 of 3) 36
  • 34 (a)
gdpd4a 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for GDPD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDPD4 Gene

Gene Tree for GDPD4 (if available)
Gene Tree for GDPD4 (if available)

Paralogs for GDPD4 Gene

Paralogs for GDPD4 Gene

(2) SIMAP similar genes for GDPD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDPD4: view

Variants for GDPD4 Gene

Sequence variations from dbSNP and Humsavar for GDPD4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2729772 - 77,268,505(+) CAGCT(C/T)TCTCA reference, missense
rs11237146 - 77,243,788(+) CACAT(A/G)CTGAA intron-variant, reference, missense
rs11237145 - 77,243,767(+) TTCAA(C/T)GGATA intron-variant, reference, missense
VAR_064764 -
rs883680 -- 77,225,518(+) ATGCA(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDPD4 Gene

Variant ID Type Subtype PubMed ID
nsv509434 CNV Insertion 20534489
nsv897936 CNV Loss 21882294
esv273524 CNV Insertion 20981092
esv270224 CNV Insertion 20981092

Variation tolerance for GDPD4 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.39; 97.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GDPD4 Gene

Disorders for GDPD4 Gene

Relevant External Links for GDPD4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GDPD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDPD4 Gene

Publications for GDPD4 Gene

  1. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4 67

Products for GDPD4 Gene

Sources for GDPD4 Gene