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Aliases for GDPD3 Gene

Aliases for GDPD3 Gene

  • Glycerophosphodiester Phosphodiesterase Domain Containing 3 2 3
  • EC 3.1.-.- 4

External Ids for GDPD3 Gene

Previous GeneCards Identifiers for GDPD3 Gene

  • GC16M030024
  • GC16M027777

Summaries for GDPD3 Gene

GeneCards Summary for GDPD3 Gene

GDPD3 (Glycerophosphodiester Phosphodiesterase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include glycerophosphodiester phosphodiesterase activity. An important paralog of this gene is GDPD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDPD3 Gene

Genomics for GDPD3 Gene

Regulatory Elements for GDPD3 Gene

Genomic Location for GDPD3 Gene

Start:
30,104,810 bp from pter
End:
30,113,943 bp from pter
Size:
9,134 bases
Orientation:
Minus strand

Genomic View for GDPD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GDPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPD3 Gene

Proteins for GDPD3 Gene

  • Protein details for GDPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5L3-GDPD3_HUMAN
    Recommended name:
    Glycerophosphodiester phosphodiesterase domain-containing protein 3
    Protein Accession:
    Q7L5L3
    Secondary Accessions:
    • Q9H652

    Protein attributes for GDPD3 Gene

    Size:
    318 amino acids
    Molecular mass:
    36596 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02714.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GDPD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GDPD3 Gene

Proteomics data for GDPD3 Gene at MOPED

Post-translational modifications for GDPD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GDPD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GDPD3 Gene

Domains for GDPD3 Gene

Suggested Antigen Peptide Sequences for GDPD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L5L3

UniProtKB/Swiss-Prot:

GDPD3_HUMAN :
  • Q7L5L3
Domain:
  • Contains 1 GP-PDE domain.
Family:
  • Belongs to the glycerophosphoryl diester phosphodiesterase family.
genes like me logo Genes that share domains with GDPD3: view

No data available for Gene Families for GDPD3 Gene

Function for GDPD3 Gene

Enzyme Numbers (IUBMB) for GDPD3 Gene

Gene Ontology (GO) - Molecular Function for GDPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity --
GO:0008889 glycerophosphodiester phosphodiesterase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GDPD3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDPD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GDPD3 Gene

Localization for GDPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GDPD3 Gene COMPARTMENTS Subcellular localization image for GDPD3 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GDPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GDPD3: view

Pathways for GDPD3 Gene

SuperPathways for GDPD3 Gene

No Data Available

Interacting Proteins for GDPD3 Gene

Gene Ontology (GO) - Biological Process for GDPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with GDPD3: view

No data available for Pathways by source for GDPD3 Gene

Transcripts for GDPD3 Gene

mRNA/cDNA for GDPD3 Gene

Unigene Clusters for GDPD3 Gene

Glycerophosphodiester phosphodiesterase domain containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDPD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDPD3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for GDPD3 Gene

GeneLoc Exon Structure for
GDPD3
ECgene alternative splicing isoforms for
GDPD3

Expression for GDPD3 Gene

mRNA expression in normal human tissues for GDPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDPD3 Gene

This gene is overexpressed in Esophagus - Mucosa (5.9).

Protein differential expression in normal tissues for GDPD3 Gene

This gene is overexpressed in Urine (27.7), Cervix (22.2), and Lung (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GDPD3 Gene

SOURCE GeneReport for Unigene cluster for GDPD3 Gene Hs.289015

genes like me logo Genes that share expressions with GDPD3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for GDPD3 Gene

Orthologs for GDPD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDPD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GDPD3 35
  • 84.7 (n)
  • 83.02 (a)
GDPD3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDPD3 35
  • 83.86 (n)
  • 80.5 (a)
GDPD3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdpd3 35
  • 81.49 (n)
  • 78.93 (a)
Gdpd3 16
Gdpd3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GDPD3 35
  • 99.48 (n)
  • 99.06 (a)
GDPD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdpd3 35
  • 80.71 (n)
  • 76.92 (a)
oppossum
(Monodelphis domestica)
Mammalia GDPD3 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GDPD3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100125107 35
  • 56.32 (n)
  • 50.33 (a)
zebrafish
(Danio rerio)
Actinopterygii gdpd3b 35
  • 55.18 (n)
  • 49.83 (a)
gdpd3a 36
  • 47 (a)
OneToMany
gdpd3b 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for GDPD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDPD3 Gene

ENSEMBL:
Gene Tree for GDPD3 (if available)
TreeFam:
Gene Tree for GDPD3 (if available)

Paralogs for GDPD3 Gene

Paralogs for GDPD3 Gene

Selected SIMAP similar genes for GDPD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GDPD3: view

Variants for GDPD3 Gene

Sequence variations from dbSNP and Humsavar for GDPD3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1561414 -- 30,113,189(+) CCAGG(C/T)TGCGC intron-variant
rs1985680 -- 30,111,895(+) ACCAC(C/T)GCACT intron-variant
rs2014510 -- 30,110,448(-) TATAC(A/C)GGAtt intron-variant
rs8061772 -- 30,108,204(+) GGTCA(A/C)GGCCT intron-variant
rs10523466 -- 30,110,876(+) AAAAA(-/AAAAAAAAAAAAAA/AAAAAAAAAAAAAAAA)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDPD3 Gene

Variant ID Type Subtype PubMed ID
dgv2668n71 CNV Loss 21882294
nsv833187 CNV Loss 17160897
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850

Relevant External Links for GDPD3 Gene

HapMap Linkage Disequilibrium report
GDPD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDPD3 Gene

Disorders for GDPD3 Gene

No disorders were found for GDPD3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GDPD3 Gene

Publications for GDPD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4

Products for GDPD3 Gene

Sources for GDPD3 Gene

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