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Aliases for GDI2 Gene

Aliases for GDI2 Gene

  • GDP Dissociation Inhibitor 2 2 3 5
  • Guanosine Diphosphate Dissociation Inhibitor 2 3 4
  • Rab GDI Beta 3 4
  • RABGDIB 3 4
  • GDI-2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 46e 3
  • Rab GDP-Dissociation Inhibitor, Beta 3
  • Rab GDP-Dissociation 2
  • HEL-S-46e 3

External Ids for GDI2 Gene

Previous GeneCards Identifiers for GDI2 Gene

  • GC10M005751
  • GC10M005957
  • GC10M005811
  • GC10M005848
  • GC10M005737

Summaries for GDI2 Gene

Entrez Gene Summary for GDI2 Gene

  • GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for GDI2 Gene

GDI2 (GDP Dissociation Inhibitor 2) is a Protein Coding gene. Diseases associated with GDI2 include tumor of exocrine pancreas. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include poly(A) RNA binding and small GTPase binding. An important paralog of this gene is CHML.

UniProtKB/Swiss-Prot for GDI2 Gene

  • Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Gene Wiki entry for GDI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDI2 Gene

Genomics for GDI2 Gene

Regulatory Elements for GDI2 Gene

Genomic Location for GDI2 Gene

Chromosome:
10
Start:
5,765,223 bp from pter
End:
5,842,132 bp from pter
Size:
76,910 bases
Orientation:
Minus strand

Genomic View for GDI2 Gene

Genes around GDI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDI2 Gene

Proteins for GDI2 Gene

  • Protein details for GDI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50395-GDIB_HUMAN
    Recommended name:
    Rab GDP dissociation inhibitor beta
    Protein Accession:
    P50395
    Secondary Accessions:
    • O43928
    • Q5SX88
    • Q9UQM6

    Protein attributes for GDI2 Gene

    Size:
    445 amino acids
    Molecular mass:
    50663 Da
    Quaternary structure:
    • Interacts with RHOH.

    Alternative splice isoforms for GDI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GDI2 Gene

Proteomics data for GDI2 Gene at MOPED

Post-translational modifications for GDI2 Gene

  • Ubiquitination at Lys 142, Lys 309, Lys 418, Lys 422, and Lys 435
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GDI2 Gene

Domains & Families for GDI2 Gene

Protein Domains for GDI2 Gene

Graphical View of Domain Structure for InterPro Entry

P50395

UniProtKB/Swiss-Prot:

GDIB_HUMAN :
  • Belongs to the Rab GDI family.
Family:
  • Belongs to the Rab GDI family.
genes like me logo Genes that share domains with GDI2: view

No data available for Gene Families for GDI2 Gene

Function for GDI2 Gene

Molecular function for GDI2 Gene

GENATLAS Biochemistry:
RAB GDP-dissociation inhibitor beta,ubiquitously expressed,involved in the regulation of vesicle-mediated cellular transport between endoplasmic reticulum and Golgi
UniProtKB/Swiss-Prot Function:
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Gene Ontology (GO) - Molecular Function for GDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11809807
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GDI2: view
genes like me logo Genes that share phenotypes with GDI2: view

Animal Models for GDI2 Gene

MGI Knock Outs for GDI2:
  • Gdi2 tm1b(EUCOMM)Hmgu

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDI2 Gene

Localization for GDI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDI2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GDI2 Gene COMPARTMENTS Subcellular localization image for GDI2 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 3
endoplasmic reticulum 2
cytoskeleton 1
endosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with GDI2: view

Pathways & Interactions for GDI2 Gene

genes like me logo Genes that share pathways with GDI2: view

Pathways by source for GDI2 Gene

1 GeneGo (Thomson Reuters) pathway for GDI2 Gene

Gene Ontology (GO) - Biological Process for GDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA,TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with GDI2: view

No data available for SIGNOR curated interactions for GDI2 Gene

Drugs & Compounds for GDI2 Gene

(2) Drugs for GDI2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GDI2: view

Transcripts for GDI2 Gene

Unigene Clusters for GDI2 Gene

GDP dissociation inhibitor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDI2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: - - - - - -

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for GDI2 Gene

GeneLoc Exon Structure for
GDI2
ECgene alternative splicing isoforms for
GDI2

Expression for GDI2 Gene

mRNA expression in normal human tissues for GDI2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GDI2 Gene



SOURCE GeneReport for Unigene cluster for GDI2 Gene Hs.299055

mRNA Expression by UniProt/SwissProt for GDI2 Gene

P50395-GDIB_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with GDI2: view

Protein tissue co-expression partners for GDI2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for GDI2 Gene

Orthologs for GDI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GDI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDI2 35
  • 99.4 (n)
  • 99.78 (a)
GDI2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GDI2 36
  • 97 (a)
OneToOne
GDI2 35
  • 91.24 (n)
  • 97.08 (a)
dog
(Canis familiaris)
Mammalia GDI2 35
  • 89.36 (n)
  • 97.3 (a)
GDI2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdi2 36
  • 96 (a)
OneToOne
Gdi2 16
Gdi2 35
  • 89.29 (n)
  • 96.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GDI2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdi2 35
  • 89.06 (n)
  • 96.4 (a)
chicken
(Gallus gallus)
Aves GDI2 36
  • 93 (a)
OneToOne
GDI2 35
  • 82.02 (n)
  • 93.71 (a)
lizard
(Anolis carolinensis)
Reptilia GDI2 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia gdi2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gdi2 35
  • 79.4 (n)
  • 90.11 (a)
Str.6286 35
zebrafish
(Danio rerio)
Actinopterygii gdi2 36
  • 89 (a)
OneToOne
gdi2 35
  • 76.13 (n)
  • 89.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gdi 36
  • 67 (a)
OneToMany
Gdi 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea gdi-1 37
  • 66 (a)
gdi-1 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GDI1 36
  • 54 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1570 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09550 35
  • 60.28 (n)
  • 61.21 (a)
rice
(Oryza sativa)
Liliopsida Os03g0277000 35
  • 60 (n)
  • 57.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4705 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for GDI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GDI2 Gene

ENSEMBL:
Gene Tree for GDI2 (if available)
TreeFam:
Gene Tree for GDI2 (if available)

Paralogs for GDI2 Gene

Paralogs for GDI2 Gene

(2) SIMAP similar genes for GDI2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for GDI2 Gene

genes like me logo Genes that share paralogs with GDI2: view

Variants for GDI2 Gene

Sequence variations from dbSNP and Humsavar for GDI2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1567706 -- 5,811,804(+) TTCTC(C/T)AATAA intron-variant
rs1473838 -- 5,807,169(+) AATAA(A/G)CTTTG intron-variant
rs1512695 -- 5,814,246(+) TCTCT(A/G)GCTTC upstream-variant-2KB
rs2386664 -- 5,805,534(-) GCGTG(G/T)TGGCA intron-variant
rs2175629 -- 5,800,393(-) TTAGC(A/G)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDI2 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv831775 CNV Loss 17160897
esv2731840 CNV Deletion 23290073
nsv515935 CNV Gain 19592680

Variation tolerance for GDI2 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDI2 Gene

HapMap Linkage Disequilibrium report
GDI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDI2 Gene

Disorders for GDI2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GDI2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tumor of exocrine pancreas
  • malignant neoplasm of the exocrine pancreas
- elite association - COSMIC cancer census association via MalaCards
Search GDI2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GDI2

Genetic Association Database (GAD)
GDI2
Human Genome Epidemiology (HuGE) Navigator
GDI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDI2
genes like me logo Genes that share disorders with GDI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GDI2 Gene

Publications for GDI2 Gene

  1. The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13. (PMID: 9434952) Sedlacek Z. … Poutska A. (Mamm. Genome 1998) 2 3 4 67
  2. Pericentriolar targeting of GDP-dissociation inhibitor isoform 2. (PMID: 8575461) Shisheva A. … Czech M.P. (Eur. J. Cell Biol. 1995) 3 23
  3. Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. (PMID: 7585614) Nishimura N. … Sano K. (Cancer Res. 1995) 3 23
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GDI2 Gene

Sources for GDI2 Gene

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