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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GDI1 Gene

protein-coding   GIFtS: 62
GCID: GC0XP153665

GDP dissociation inhibitor 1


(Previous symbols: MRX48, MRX41, GDIL)
 Explore 19 diseases affiliated with
GDI1 via our new
 Human Malady Compendium 
Biological research products
for GDI1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
GDP Dissociation Inhibitor 11 2     GDI-12 3
GDIL1 2 3     RABGD1A2 5
OPHN21 2 3     FLJ414111
RABGDIA1 2 3     1A2
MRX411 2 5     Mental Retardation, X-Linked 482
MRX481 2 5     Oligophrenin-23
XAP-41 2     Rab GDP Dissociation Inhibitor Alpha2
Guanosine Diphosphate Dissociation Inhibitor 12 3     Rab GDP-Dissociation Inhibitor, Alpha2
Protein XAP-42 3     Oligophrenin-23
Rab GDI Alpha2 3     XAP43

External Ids:    HGNC: 42261   Entrez Gene: 26642   Ensembl: ENSG000002038797   OMIM: 3001045   UniProtKB: P311503   

Export aliases for GDI1 gene to outside databases

Previous GC identifers: GC0XP147728 GC0XP150046 GC0XP151251 GC0XP152133 GC0XP153234 GC0XP153318 GC0XP142218


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GDI1:
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family,
small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between
cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound
rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked
nonspecific mental retardation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GDIA_HUMAN, P31150
Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them,
and the subsequent binding of GTP to them

Gene Wiki entry for GDI1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GDI1 gene promoter:
         CREB   deltaCREB   Nkx2-5   YY1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GDI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GDI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

GDI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDI1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153665:  view genomic region     (about GC identifiers)

Start:
153,665,259 bp from pter      End:
153,671,814 bp from pter
Size:
6,556 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GDIA_HUMAN, P31150 (See protein sequence)
Recommended Name: Rab GDP dissociation inhibitor alpha  
Size: 447 amino acids; 50583 Da
Subunit: Interacts with RHOH. Interacts with RAB10; negatively regulates RAB10 association with membranes and
activation
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: P50394 Q6FG50 Q7Z2G6 Q7Z2G9 Q7Z2H5 Q7Z2I6

Explore the universe of human proteins at neXtProt for GDI1: NX_P31150

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31150

  • GDI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001484.1  
    ENSEMBL proteins: 
     ENSP00000394071   ENSP00000394752   ENSP00000416195   ENSP00000396215  
    Reactome Protein details: P31150
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    Uscn Proteins for GDI1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030496midbody IDA15166316
    GO:0043005neuron projection IEA--
    GO:0043234protein complex IEA--


    GDI1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GDI1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GDI1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000806 RabGDI
     IPR018203 GDP_dissociation_inhibitor

    Graphical View of Domain Structure for InterPro Entry P31150

    ProtoNet protein and cluster: P31150

    1 Blocks protein family: IPB000806 Rab GDI protein signature

    UniProtKB/Swiss-Prot: GDIA_HUMAN, P31150
    Similarity: Belongs to the Rab GDI family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GDIA_HUMAN, P31150
    Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them,
    and the subsequent binding of GTP to them

         Genatlas biochemistry entry for GDI1:
    RhoA/Rab GDI (GDP-dissociation inhibitor) p155,23kDa,ligand for presenilin 1 (PSEN1),also expressed predominantly in
    neural and sensory tissues,involved in the regulation of vesicle-mediated cellular transport,also in neuronal
    differentiation and brain development (signal transduction)

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005092GDP-dissociation inhibitor activity TAS7849400
    GO:0005093Rab GDP-dissociation inhibitor activity IEA--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI19570034
    GO:0017137Rab GTPase binding IEA--


    GDI1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GDI1:
     Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-out Gdi1tm1Ytk for GDI1
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gdi1):
     behavior/neurological  homeostasis/metabolism  nervous system  taste/olfaction 

    GDI1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic1.00
    Transport_Clathrin-coated vesicle cycle0.66
    2Cell death signalling via NRAGE, NRIF and NADE
    Rho GTPase cycle0.25
    Signaling by Rho GTPases0.25
    3Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway1.00
    4Signaling mediated by p38-alpha and p38-beta
    Signaling mediated by p38-alpha and p38-beta1.00
    5Signaling by GPCR
    Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GDI1
        Clathrin-dependent protein traffic


    1 GeneGo (Thomson Reuters) Pathway for GDI1
        Transport Clathrin-coated vesicle cycle

    2 BioSystems Pathways for GDI1 
        Integrated Breast Cancer Pathway
    Signaling mediated by p38-alpha and p38-beta

    3        Reactome Pathways for GDI1
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    GDI1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GDI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/92 Interacting proteins for GDI1 (P311501, 2, 3 ENSP000003940714) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8273488 I2D: score=2 
    RAB1AP628202, 3, ENSP000003872864MINT-7720823 I2D: score=1 STRING: ENSP00000387286
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2859276 I2D: score=3 STRING: ENSP00000357292
    YWHAZP631042, 3, ENSP000003095034MINT-3308599 I2D: score=1 STRING: ENSP00000309503
    RAB9AP511513, ENSP000004201274I2D: score=3 STRING: ENSP00000420127
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7543319
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport IEA--
    GO:0050771negative regulation of axonogenesis ISS--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--


    GDI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GDI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GDI1

    2 HMDB Compounds for GDI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for GDI1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Geran-8-Yl Geran-- --target--17139284 17016423 10592235

    4 Novoseek chemical compound relationships for GDI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 83.9 9 8141770 (3), 7512369 (1), 7513052 (1), 11967128 (1) (see all 7)
    gtp 67.1 4 10676816 (1), 8356058 (1), 8141770 (1), 11967128 (1)
    nadph 26.4 2 8141770 (2)
    superoxide 0 1 8141770 (1)

    Search CenterWatch for drugs/clinical trials and news about GDI1 / GDIA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GDI1 gene: 
    NM_001493.2  

    Unigene Clusters for GDI1:

    GDP dissociation inhibitor 1
    Hs.74576  [show with all ESTs], Hs.595950  [show with all ESTs]
    Unigene Representative Sequences: NM_001493, BE797584
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447750(uc004fli.4 uc004flj.3) ENST00000445564 ENST00000475976
    ENST00000434049 ENST00000415109 ENST00000481304 ENST00000485143 ENST00000491154(uc011mzo.1)
    ENST00000489589 ENST00000471972 ENST00000468483 ENST00000476540 ENST00000465640
    ENST00000460984

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    hsa-miR-1224-3p hsa-miR-1260b hsa-miR-486-3p hsa-miR-218 hsa-miR-298 hsa-miR-133a hsa-miR-296-5p hsa-miR-642b
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    Additional cDNA sequence: 

    EF212247.1 EF212248.1 

    24/53 DOTS entries (see all 53):

    DT.100888319  DT.100888307  DT.92458110  DT.100888312  DT.99952231  DT.121294752  DT.121293932  DT.121294624 
    DT.92458119  DT.95212016  DT.121294025  DT.121294343  DT.121294311  DT.121294643  DT.100038377  DT.92458121 
    DT.95212057  DT.121293638  DT.121293862  DT.121294067  DT.95212067  DT.121293958  DT.95212070  DT.121293633 

    24/442 AceView cDNA sequences (see all 442):

    AI304892 BX110973 BM894228 BQ009297 AI986428 BM699954 BU726358 BF224249 
    BM712118 CN479636 AI373005 BQ433166 AI564750 AI183344 AI301197 AW264885 
    X74608 AI536996 AW516808 AI873939 BE327367 CR604675 F35368 CB305983 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GDI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTTCCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GDI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GDI1

    SOURCE GeneReport for Unigene clusters: Hs.74576 Hs.595950

    UniProtKB/Swiss-Prot: GDIA_HUMAN, P31150
    Tissue specificity: Brain; predominant in neural and sensory tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GDI1 gene from 7/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia GDI16
    --
    90(a)
    1 ↔ 1
    GL344369.1(15037-32410)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc09e022 wufc09e02 79.3(n)   323765  AY391428.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gdi1 , 3 neurotransmitter secretion GDP-dissociation
    inhibitor3
    GDP dissociation inhibitor1
    68(a)3
    66.74(n)1
    68.11(a)1
      30B83
    342641  NM_078800.31  NP_523524.21 
    worm
    (Caenorhabditis elegans)
    Secernentea gdi-11 , 3 GDI-1 GDP dissociation inhibitor3
    Protein GDI-11
    65(a)3
    63.67(n)1
    66.36(a)1
      IV(14791300-14793012)3
    1784021  NM_001047579.21  NP_001041044.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GDI11 Gdi1p 56.08(n)
    56.47(a)
      856876   NP_011062.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GDI21 RAB GDP dissociation inhibitor 2 59.29(n)
    57.81(a)
      825162  NM_115855.3  NP_191551.1 
    rice
    (Oryza sativa)
    Liliopsida AK066648.12   -- 71.27(n)    AK066648.1 


    ENSEMBL Gene Tree for GDI1 (if available)
    TreeFam Gene Tree for GDI1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GDI1 gene
    CHML2  GDI22  CHM2  
    1 SIMAP similar gene for GDI1 using alignment to 5 protein entries:     GDIA_HUMAN (see all proteins):
    GDI2

    GDI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/101 NCBI SNPs in GDI1 are shown (see all 101    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921158451,2
    --153665539(+) GGCGGC/GGGCGA 1 -- ut510--------
    rs2014633671,2
    --153665571(+) AGGAGC/TCGAGC 1 -- ut510--------
    rs1839531771,2
    --153665579(+) AGCGGA/GCGCTG 1 -- ut510--------
    rs2006453581,2
    --153665589(+) GGCACC/TGAGGC 1 -- ut510--------
    rs1877047981,2
    --153665789(+) CTGCTC/TCCCCA 1 -- int10--------
    rs1895780671,2
    --153665794(+) CCCCCA/CGCGAC 1 -- int10--------
    rs1826069751,2
    --153665860(+) CGCCTC/TCTGGG 1 -- int10--------
    rs1868353021,2
    --153666022(+) CCGCCC/TAGCGT 1 -- int10--------
    rs1921298071,2
    --153666065(+) ATCCCG/TGTGGG 1 -- int10--------
    rs1853591671,2
    --153666125(+) CAGCCC/TGCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for GDI1 (153665259 - 153671814 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GDI1: --
    Human Gene Mutation Database (HGMD): GDI1

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GDI1 for disorders           About GeneDecksing

    OMIM gene information: 300104   
    OMIM disorders: 309541  
    UniProtKB/Swiss-Prot: GDIA_HUMAN, P31150
  • Defects in GDI1 are the cause of mental retardation X-linked type 41 (MRX41) [MIM:300849]. Mental retardation
  • is characterized by significantly sub-average general intellectual functioning associated with impairments in
    adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not
    manifest other clinical signs

    19 diseases for GDI1:    About MalaCards
    mental retardation, x-linked    mental retardation, x-linked, nonspecific    tumor of exocrine pancreas    intellectual disability
    choroideremia    rett syndrome    keratitis    hematopoiesis
    alzheimer's disease    ovarian cancer    pharyngitis    t cell deficiency
    colorectal cancer    ataxia    neuroblastoma    schizophrenia
    malaria    neuronitis    choroiditis

    2 diseases from the University of Copenhagen DISEASES database for GDI1:
    Intellectual disability     Tumor of exocrine pancreas

    2 Novoseek disease relationships for GDI1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 62.2 6 9620768 (2), 12810981 (1), 18829665 (1), 12624134 (1) (see all 5)
    tumors 0 3 18651761 (3)

    Human Genome Epidemiology (HuGE) Navigator: GDI1 (1 document)

    Export disorders for GDI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GDI1 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with GDI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression patterns of two human genes coding for different rab GDP- dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport. (PubMed id 7543319)1, 2, 3 Bachner D.... Poustka A. (1995)
    2. Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI). (PubMed id 7849400)1, 2, 3 Sedlacek Z.... Poustka A. (1994)
    3. Mutations in GDI1 are responsible for X-linked non-specific mental retardation. (PubMed id 9620768)1, 2, 9 D'Adamo P.... Toniolo D. (1998)
    4. Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. (PubMed id 7585614)1, 2, 9 Nishimura N.... Sano K. (1995)
    5. GDI-1 preferably interacts with Rab10 in insulin-stim ulated GLUT4 translocation. (PubMed id 19570034)1, 2 Chen Y....Xu T. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. (PubMed id 12777533)1, 2 Kitano T.... Paeaebo S. (2003)
    8. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. (PubMed id 11809807)1, 2 Li X.... Lim B. (2002)
    9. Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor. (PubMed id 9668174)1, 2 Bienvenu T....Chelly J. (1998)
    10. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2664 HGNC: 4226 AceView: GDI1 Ensembl:ENSG00000203879 euGenes: HUgn2664
    ECgene: GDI1 H-InvDB: GDI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GDI1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MRX3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GDI1 gene:
    Search GeneIP for patents involving GDI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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