GDF9 Gene

Aliases
for GDF9 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC05M131719 GC05M132644 GC05M132228 GC05M132273 GC05M132225 GC05M132224 GC05M127389

Summaries
for GDF9 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for GDF9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NT_034772.7  NC_018916.2  

SwitchGear Promoter luciferase reporter plasmid: GDF9 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GDF9

GDF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M132196:  view genomic region     (about GC identifiers)

Proteins
for GDF9 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for GDF9: NX_O60383

Explore proteomics data for GDF9 at MOPED

Post-translational modifications: 

GDF9 Human Recombinant Protein Products:

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	GeneTex Proteins for GDF9:                       GDF9 recombinant protein (GTX65104)
	antibodies-online proteins for GDF9 (9 products)
	antibodies-online peptides for GDF9

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	antibodies-online kits for GDF9 (31 products)

Domains /
Families
for GDF9 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: O60383

Find genes that share domains with GDF9           About GenesLikeMe

Function
for GDF9 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Gdf9)

genOway: Develop your customized and physiologically relevant rodent model for GDF9

miRNA Products:		miRTarBase miRNAs that target GDF9: hsa-mir-335-5p (MIRT017790), hsa-mir-148b-3p (MIRT019338)
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		Predesigned siRNA for gene silencing in human, mouse, rat GDF9

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GDF9

Clone Products:		OriGene clones in human, mouse for GDF9 (see all 6) OriGene ORF clones in mouse, rat for GDF9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GDF9 (NM_005260)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF9

Localization
for GDF9 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	3
golgi apparatus	2
nucleus	2
plasma membrane	2
endoplasmic reticulum	1
lysosome	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for GDF9 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for GDF9 About   (see all 15)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	Apoptotic Pathways in Synovial Fibroblasts	Mitochondrial Apoptosis 0.85 Rac1 Pathway 0.65 Cellular Apoptosis Pathway 0.85 Glioma Invasiveness 0.64 Apoptotic Pathways in Synovial Fibroblasts 0.84 Actin-Based Motility by Rho Family GTPases 0.62 p53 Mediated Apoptosis 0.84 ERK5 Signaling 0.61
2	GPCR Pathway	Ras Pathway 0.73 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.73 NFAT in Immune Response 0.58 GPCR Pathway 0.62 Estrogen Pathway 0.55 Pancreatic Adenocarcinoma 0.59
3	ERK Signaling	ERK Signaling 0.61 Molecular Mechanisms of Cancer 0.51 Rho Family GTPases 0.61 ILK Signaling 0.49 MAPK Signaling 0.58
4	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 0.61 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48
5	TGF-Beta Pathway	TGF-Beta Pathway 0.60 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.51

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GDF9

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 BioSystems Pathway for GDF9

Ovarian Infertility Genes

1 Sino Biological Pathway for GDF9

TGF-beta Signaling Pathway

1 Kegg Pathway  (Kegg details for GDF9)

Ovarian steroidogenesis

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for GDF9 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for GDF9 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for GDF9 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GDF9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTACCTGCC

About this image

Ovary (Reproductive System)    fully expand to see all 8 entries
Primary Oocyte Primary Follicle
Ovarian tissue-dissociated cells (human)
Oocytes
Gonad
Primary Oocyte Primary Follicle
Human oogonial stem cells
Germ Cells (Reproductive System)
Human oogonial stem cells
Testis (Reproductive System)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF9

Orthologs
for GDF9 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for GDF9 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for GDF9 gene

GDF15²  NODAL²  BMP3²  GDF10²  BMP15²  

Find genes that share paralogs with GDF9           About GenesLikeMe

Genomic Variants
for GDF9 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GDF9 (see all 132)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs104912801,2	C,F,H	--	132196383(-)	ATTTAT/GAACTG	1	--	ds5001		26		NS NA EA WA CSA	2452
rs1825466021,2		--	132196389(+)	TAAATA/CTATCT	1	--	ds5001		0	--	--	--	--
rs1381027311,2		--	132196508(+)	ATATAG/TAAAGA	1	--	ds5001		0	--	--	--	--
rs1495447831,2		--	132196638(+)	TGCTAC/GTTAAC	1	--	ds5001		0	--	--	--	--
rs175166731,2	C,F,H	--	132196711(+)	GCTCTC/TTAGTC	1	--	ds5001		20		NA NS EA WA	2358
rs596825921,2	C,F	--	132196800(+)	ATGGCC/TAGCTT	1	--	ds5001		4		WA NA EA	244
rs1880638701,2		--	132196868(+)	ACACAA/CAAAAT	1	--	ds5001		0	--	--	--	--
rs1926422311,2		--	132196904(+)	TTCTAA/TTAAGA	1	--	ut31		0	--	--	--	--
rs1441169221,2		--	132197185(+)	ACATTC/TAGAGA	1	--	ut31		0	--	--	--	--
rs1486831201,2	C	--	132197237(+)	ACAGTA/CGTTAC	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for GDF9 (132196873 - 132202576 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for GDF9:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv5004	CNV	Insertion	18451855
nsv830489	CNV	Loss	17160897
nsv5003	CNV	Loss	18451855
nsv882919	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): GDF9

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GDF9

DNA2.0 Custom Variant and Variant Library Synthesis for GDF9

Disorders / Diseases
for GDF9 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in

patients with premature ovarian failure and mothers of dizygotic twins

3 diseases for GDF9:    
About MalaCards

5 Novoseek inferred disease relationships for GDF9 gene    About this table

Publications
for GDF9 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GDF9 gene, integrated from 10 sources (see all 123): (articles sorted by number of sources associating them with GDF9)

Utopia: connect your pdf to the dynamic world of online information

1. Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure. (PubMed id 17482612)^{1, 2, 4, 9} Zhao H.... Rajkovic A. (Fertil. Steril. 2007)
2. Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure. (PubMed id 16278619)^{1, 2, 4, 9} Dixit H.... Singh L. (Menopause 2005)
3. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. (PubMed id 16645022)^{1, 2, 4, 9} Laissue P.... Veitia R.A. (Eur. J. Endocrinol. 2006)
4. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. (PubMed id 10443672)^{1, 2, 9} Aaltonen J.... Ritvos O. (J. Clin. Endocrinol. Metab. 1999)
5. Oocyte-specific expression of growth/differentiation factor-9. (PubMed id 7760846)^{1, 3, 9} McGrath S.A....Lee S.J. (Mol. Endocrinol. 1995)
6. Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation. (PubMed id 19366876)^{1, 2, 9} Huang Q.... Leung P.C. (Am. J. Physiol. 2009)
7. Growth differentiating factor-9 mutations may be associated with premature ovarian failure. (PubMed id 17156781)^{1, 2, 9} Kovanci E....Carson S.A. (Fertil. Steril. 2007)
8. Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure. (PubMed id 19438907)^{1, 2, 9} Wang B.... Ma X. (Clin. Endocrinol. (Oxf.) 2010)
9. Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions. (PubMed id 18006624)^{1, 2, 9} McMahon H.E.... Shimasaki S. (Endocrinology 2008)
10. Novel variants in growth differentiation factor 9 in mothers of dizygotic twins. (PubMed id 16954162)^{1, 2, 9} Palmer J.S.... Montgomery G.W. (J. Clin. Endocrinol. Metab. 2006)

External Searches for GDF9 gene

Genome Databases showing GDF9 gene

Other Databases showing GDF9 gene

Specialized Databases showing GDF9 gene

Products
for GDF9 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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