Aliases for GDF7 Gene
External Ids for GDF7 Gene
Previous GeneCards Identifiers for GDF7 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]
GeneCards Summary for GDF7 Gene
GDF7 (Growth Differentiation Factor 7) is a Protein Coding gene. Among its related pathways are TGF-beta signaling pathway (KEGG) and Hippo signaling pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is GDF6.
UniProtKB/Swiss-Prot for GDF7 Gene
May play an active role in the motor area of the primate neocortex.