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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GDF3 Gene

protein-coding   GIFtS: 58
GCID: GC12M007842

Growth Differentiation Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Differentiation Factor 31 2
GDF-32 3
KFS32 5
MCOP72 5
MCOPCB62 5
Growth/Differentiation Factor 32

External Ids:    HGNC: 42181   Entrez Gene: 95732   Ensembl: ENSG000001843447   OMIM: 6065225   UniProtKB: Q9NR233   

Export aliases for GDF3 gene to outside databases

Previous GC identifers: GC12P007400 GC12M007892 GC12M007742 GC12M007733 GC12M007656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GDF3 Gene:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta
superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved
to produce a mature protein containing seven conserved cysteine residues. The members of this family are
regulators of cell growth and differentiation in both embryonic and adult tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for GDF3 Gene: 
GDF3 (growth differentiation factor 3) is a protein-coding gene. Diseases associated with GDF3 include microphthalmia with coloboma 6, and microphthalmia, isolated 7. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

Gene Wiki entry for GDF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GDF3 gene promoter:
         HOXA3   SREBP-1c   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   AP-4   LUN-1   LCR-F1   SREBP-1b   SREBP-1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGDF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GDF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GDF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.1

GDF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDF3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007842:  view genomic region     (about GC identifiers)

Start:
7,842,378 bp from pter      End:
7,848,372 bp from pter
Size:
5,995 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GDF3_HUMAN, Q9NR23 (See protein sequence)
Recommended Name: Growth/differentiation factor 3 precursor  
Size: 364 amino acids; 41387 Da
Subunit: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be
disulfide-linked
Subcellular location: Secreted (Probable)
Secondary accessions: Q8NEJ4

Explore the universe of human proteins at neXtProt for GDF3: NX_Q9NR23

Explore proteomics data for GDF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NR23

  • GDF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GDF3 Protein Expression
    REFSEQ proteins: NP_065685.1  
    ENSEMBL proteins: 
     ENSP00000331745  

    Human Recombinant Protein Products for GDF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GDF3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GDF3
    GenScript Custom Purified and Recombinant Proteins Services for GDF3
    Novus Biologicals GDF3 Proteins
    Novus Biologicals GDF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for GDF3
    Cloud-Clone Corp. Proteins for GDF3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    GDF3 for ontologies           About GeneDecksing



    GDF3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GDF3
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    Novus Biologicals GDF3 Antibodies
    Abcam antibodies for GDF3
    Cloud-Clone Corp. Antibodies for GDF3 
    ThermoFisher Antibodies for GDF3
    LSBio Antibodies in human, mouse, rat for GDF3 

    Assay Products for GDF3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for GDF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GDF3 
    Cloud-Clone Corp. CLIAs for GDF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry Q9NR23

    ProtoNet protein and cluster: Q9NR23

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: GDF3_HUMAN, Q9NR23
    Similarity: Belongs to the TGF-beta family


    GDF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for GDF3:
    growth differentiation factor 3,TGF beta superfamily member,expressed in human embryonal carcinoma cell lines in a
    stem cell-specific fashion

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    GDF3 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gdf3):
     adipose tissue  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     normal 

    GDF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gdf3tm1Zuk for GDF3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GDF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GDF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GDF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GDF3 

    miRNA
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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of GDF3

    Clone
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    OriGene clones in human, mouse for GDF3 (see all 6)
    OriGene ORF clones in mouse, rat for GDF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GDF3 (NM_020634)
    Sino Biological Human cDNA Clone for GDF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDF3
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                         Customized lentivirus expression plasmids for stable overexpression of GDF3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GDF3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway


    1 Sino Biological Pathway for GDF3 
        TGF-beta Signaling Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GDF3

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IMP19864492
    GO:0001654eye development IMP19864492
    GO:0001701in utero embryonic development IEA--
    GO:0002021response to dietary excess IEA--
    GO:0007165signal transduction IEA--

    GDF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GDF3

    Search CenterWatch for drugs/clinical trials and news about GDF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GDF3 gene: 
    NM_020634.1  

    Unigene Cluster for GDF3:

    Growth differentiation factor 3
    Hs.86232  [show with all ESTs]
    Unigene Representative Sequence: BC030959
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329913(uc001qte.3)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GDF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GDF3
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDF3
    Sirion Biotech Customized lentivirus for stable overexpression of GDF3 
                         Customized lentivirus expression plasmids for stable overexpression of GDF3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GDF3
    OriGene qSTAR qPCR primer pairs in human, mouse for GDF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GDF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GDF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GDF3

    Additional mRNA sequence: 

    AF110641.1 AF263538.1 AY358875.1 BC030959.1 

    2 DOTS entries:

    DT.310451  DT.75102159 

    24/36 AceView cDNA sequences (see all 36):

    AI962654 BF056259 AA902779 AY358875 NM_020634 AA902285 AI652879 AF263538 
    AA737950 AW003483 BG432736 AW590671 AW025944 BC030959 AF110641 AA926805 
    AW274953 BE466237 AI655507 AA206112 AW236102 AA906740 BF772164 BE046991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GDF3 expression in normal human tissues (normalized intensities)      GDF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGTGTCC
    GDF3 Expression
    About this image


    GDF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 17 entries
             VUB03_DM1
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 3 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocalyxin+, CD24+, GCTM2 (low) ( Derivation and sorting of renal cells from human...
     
     Testis (Reproductive System)

    See GDF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GDF3

    SOURCE GeneReport for Unigene cluster: Hs.86232
        SABiosciences Expression via Pathway-Focused PCR Arrays including GDF3: 
              Cell Lineage Identification in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GDF3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gdf31 , 5 growth differentiation factor 31, 5 77.5(n)1
    71.15(a)1
      6 (57.70 cM)5
    145621  NM_008108.41  NP_032134.21 
     1226054035 
    chicken
    (Gallus gallus)
    Aves GDF31 growth differentiation factor 3 58.62(n)
    48.85(a)
      396132  NM_205211.1  NP_990542.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia gdf3-A-prov2 derriere (posterior determination, TGFb family member) 77.91(n)    AF065135.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_130948.12   -- 73.4(n)   30125  NM_130948.1 


    ENSEMBL Gene Tree for GDF3 (if available)
    TreeFam Gene Tree for GDF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GDF3 gene
    GDF52  BMP52  BMP8B2  GDF62  BMP42  GDF72  GDF22  BMP22  
    BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    3 SIMAP similar genes for GDF3 using alignment to 1 protein entry:     GDF3_HUMAN:
    GDF3A    GDF1    BMP2

    GDF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/233 SNPs in GDF3 are shown (see all 233)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0651474
    Microphthalmia, isolated, 7 (MCOP7)4--see VAR_0651472 R Q mis40--------
    VAR_0651494
    Microphthalmia, isolated, with coloboma, 6 (MCOPCB6)4--see VAR_0651492 R W mis40--------
    VAR_0651504
    Microphthalmia, isolated, 7 (MCOP7)4--see VAR_0651502 L P mis40--------
    rs1409264121,2,4
    C,FMicrophthalmia, isolated, with coloboma, 6 (MCOPCB6)4 --7725821(+) GTGACG/AGTGGC 2 /R /C mis12Minor allele frequency- A:0.00NA EU 5855
    rs1495912781,2
    C--7657854(+) GTCTC-/AAAAAA 1 -- int10--------
    rs1138991861,2
    C--7725037(+) ACAGGC/TGTGAG 1 -- ds50010--------
    rs1414797631,2
    --7725209(+) ACAGTC/GAAATG 1 -- ds50010--------
    rs1843495541,2
    C--7725522(+) ACATCC/TTACCC 2 * syn10--------
    rs23025161,2,4
    C,F,H--7725635(+) ACACAC/GAGCCT 2 L V mis1 ese311Minor allele frequency- G:0.02EA NS NA EU 7270
    rs1461970891,2
    C,F--7725741(+) TGGCAG/ATAATT 2 /Y syn11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for GDF3 (7842378 - 7848372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GDF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666104CNV Deletion23128226
    esv2422393CNV Duplication17116639
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639


    Human Gene Mutation Database (HGMD): GDF3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GDF3
    DNA2.0 Custom Variant and Variant Library Synthesis for GDF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606522   
    OMIM disorders: 613702  613703  613704  
    UniProtKB/Swiss-Prot: GDF3_HUMAN, Q9NR23
  • Klippel-Feil syndrome 3 (KFS3) [MIM:613702]: A skeletal disorder characterized by congenital fusion of
    cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of
    fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Microphthalmia, isolated, with coloboma, 6 (MCOPCB6) [MIM:613703]: A disorder of eye formation, ranging
    from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like
    opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
    Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and
    the fusion of the fetal fissure (optic fissure). Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Microphthalmia, isolated, 7 (MCOP7) [MIM:613704]: A disorder of eye formation, ranging from small size of
    a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea
    and lens, scaring of the retina and choroid, and other abnormalities may also be present. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 19 diseases for GDF3:    About MalaCards
    microphthalmia with coloboma 6    microphthalmia, isolated 7    klippel-feil syndrome 3, autosomal dominant    klippel-feil syndrome
    mixed germ cell tumor    hypoplastic left heart syndrome    coloboma    microphthalmia
    seminoma    teratocarcinoma    choroiditis    germ cell tumors
    cataract    hepatitis b    obesity    cerebritis
    hepatitis    cervicitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for GDF3:
    Klippel-Feil syndrome     Embryonal carcinoma

    GDF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GDF3
    Human Genome Epidemiology (HuGE) Navigator: GDF3 (3 documents)

    Export disorders for GDF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GDF3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with GDF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. (PubMed id 9467948)1, 3, 9 Caricasole A.A....van den Eijnden-van Raaij A.J. (1998)
    2. Mutation of the bone morphogenetic protein GDF3 cause s ocular and skeletal anomalies. (PubMed id 19864492)1, 2, 9 Ye M....Lehmann O.J. (2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Expression pattern of growth/differentiation factor 3 in human and murine cerebral cortex, hippocampus as well as cerebellum. (PubMed id 16126341)1, 9 Hexige S....Yu L. (2005)
    8. Testicular mixed germ cell tumors: a morphological an d immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, wit h emphasis on morphologically difficult-to-classify areas. (PubMed id 19396148)1, 9 Gopalan A....Tickoo S.K. (2009)
    9. GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. (PubMed id 8429021)1, 9 McPherron A.C. and Lee S.J. (1993)
    10. Genome-wide association analyses suggest NELL1 influen ces adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9573 HGNC: 4218 AceView: GDF3 Ensembl:ENSG00000184344 euGenes: HUgn9573
    ECgene: GDF3 H-InvDB: GDF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GDF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GDF3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/GDF3

    (Patent information from GeneIP,
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    Patent Information for GDF3 gene:
    Search GeneIP for patents involving GDF3

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