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GDF3 Gene

protein-coding   GIFtS: 58
GCID: GC12M007842

Growth Differentiation Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Growth Differentiation Factor 31 2
GDF-32 3
KFS32 5
MCOP72 5
MCOPCB62 5
Growth/Differentiation Factor 32

External Ids:    HGNC: 42181   Entrez Gene: 95732   Ensembl: ENSG000001843447   OMIM: 6065225   UniProtKB: Q9NR233   

Export aliases for GDF3 gene to outside databases

Previous GC identifers: GC12P007400 GC12M007892 GC12M007742 GC12M007733 GC12M007656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GDF3 Gene:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta
superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved
to produce a mature protein containing seven conserved cysteine residues. The members of this family are
regulators of cell growth and differentiation in both embryonic and adult tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for GDF3 Gene:
GDF3 (growth differentiation factor 3) is a protein-coding gene. Diseases associated with GDF3 include microphthalmia with coloboma 6, and microphthalmia, isolated 7. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

Gene Wiki entry for GDF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the GDF3 gene promoter:
         HOXA3   SREBP-1c   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   AP-4   LUN-1   LCR-F1   SREBP-1b   SREBP-1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGDF3 promoter sequence
   Search Chromatin IP Primers for GDF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GDF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.1

GDF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDF3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007842:  view genomic region     (about GC identifiers)

Start:
7,842,378 bp from pter      End:
7,848,372 bp from pter
Size:
5,995 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GDF3_HUMAN, Q9NR23 (See protein sequence)
Recommended Name: Growth/differentiation factor 3 precursor  
Size: 364 amino acids; 41387 Da
Subunit: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be
disulfide-linked
Secondary accessions: Q8NEJ4

Explore the universe of human proteins at neXtProt for GDF3: NX_Q9NR23

Explore proteomics data for GDF3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn112, Asn306

  • See GDF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065685.1  
    ENSEMBL proteins: 
     ENSP00000331745  

    GDF3 Human Recombinant Protein Products:

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    Novus Biologicals GDF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GDF3
    Cloud-Clone Corp. Proteins for GDF3

    GDF3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GDF3
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    Novus Biologicals GDF3 Antibodies
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    LSBio Antibodies in human, mouse, rat for GDF3

    GDF3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GDF3
    Cloud-Clone Corp. CLIAs for GDF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry Q9NR23

    ProtoNet protein and cluster: Q9NR23

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: GDF3_HUMAN, Q9NR23
    Similarity: Belongs to the TGF-beta family


    GDF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for GDF3:
    growth differentiation factor 3,TGF beta superfamily member,expressed in human embryonal carcinoma cell lines in a
    stem cell-specific fashion

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0019901protein kinase binding IPI--
         
    GDF3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gdf3):
     adipose tissue  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  normal 

    GDF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gdf3tm1Zuk for GDF3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GDF3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GDF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GDF3

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GDF3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GDF3 (NM_020634)
    Sino Biological Human cDNA Clone for GDF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDF3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GDF3_HUMAN, Q9NR23: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IDA--

    GDF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GDF3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway


    1 Sino Biological Pathway for GDF3
        TGF-beta Signaling Pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including GDF3: 
              Cell Lineage Identification in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GDF3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for GDF3 (ENSP000003317454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NANOGENSP000002293074STRING: ENSP00000229307
    SHHENSP000002972614STRING: ENSP00000297261
    --ENSP000003237774STRING: ENSP00000323777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IMP19864492
    GO:0001654eye development IMP19864492
    GO:0001701in utero embryonic development IEA--
    GO:0002021response to dietary excess IEA--
    GO:0007165signal transduction IEA--

    GDF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GDF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GDF3 gene: 
    NM_020634.1  

    Unigene Cluster for GDF3:

    Growth differentiation factor 3
    Hs.86232  [show with all ESTs]
    Unigene Representative Sequence: BC030959
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329913(uc001qte.3)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GDF3
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    OriGene ORF clones in mouse, rat for GDF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GDF3 (NM_020634)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDF3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GDF3
    OriGene qSTAR qPCR primer pairs in human, mouse for GDF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GDF3
      QuantiTect SYBR Green Assays in human, mouse, rat GDF3
      QuantiFast Probe-based Assays in human, mouse, rat GDF3

    Additional mRNA sequence: 

    AF110641.1 AF263538.1 AY358875.1 BC030959.1 

    2 DOTS entries:

    DT.310451  DT.75102159 

    Selected AceView cDNA sequences (see all 36):

    AF263538 AI962654 NM_020634 BF056259 AA902779 AA902285 AY358875 AI652879 
    AA926805 AF110641 AW003483 AA737950 BC030959 BE466237 AW274953 AW025944 
    AW590671 BG432736 AI655507 AW236102 AA906740 BF772164 AA206112 AA968722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GDF3 expression in normal human tissues (normalized intensities)      GDF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGTGTCC
    GDF3 Expression
    About this image


    GDF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 17 entries
             VUB03_DM1
     
     Epiblast (Early Embryo)    fully expand to see all 4 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive Streak Cells Anterior Primitive Streak
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocalyxin+, CD24+, GCTM2-
     
     Testis (Reproductive System)
    GDF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GDF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.86232
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GDF3: 
              Cell Lineage Identification in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GDF3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gdf31 , 5 growth differentiation factor 31, 5 77.5(n)1
    71.15(a)1
      6 (57.70 cM)5
    145621  NM_008108.41  NP_032134.21 
     1226054035 
    chicken
    (Gallus gallus)
    Aves GDF31 growth differentiation factor 3 57.95(n)
    48.85(a)
      396132  NM_205211.1  NP_990542.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia gdf3-A-prov2 derriere (posterior determination, TGFb family member) 77.91(n)    AF065135.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_130948.12   -- 73.4(n)   30125  NM_130948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dpp6
    decapentaplegic
    15(a)
    1 → many
    2L(2428372-2459823)


    ENSEMBL Gene Tree for GDF3 (if available)
    TreeFam Gene Tree for GDF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GDF3 gene
    GDF52  BMP52  BMP8B2  GDF62  BMP42  GDF72  GDF22  BMP22  
    BMP102  BMP72  GDF12  BMP8A2  BMP62  
    3 SIMAP similar genes for GDF3 using alignment to 1 protein entry:     GDF3_HUMAN:
    GDF3A    GDF1    BMP2

    GDF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GDF3 (see all 233)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409264121,2,,4
    C,FMicrophthalmia, isolated, with coloboma, 6 (MCOPCB6)4 --7725821(+) GTGACG/AGTGGC 2 /R /C mis12Minor allele frequency- A:0.00NA EU 5855
    VAR_0651474
    Microphthalmia, isolated, 7 (MCOP7)4--see VAR_0651472 R Q mis40--------
    VAR_0651494
    Microphthalmia, isolated, with coloboma, 6 (MCOPCB6)4--see VAR_0651492 R W mis40--------
    VAR_0651504
    Microphthalmia, isolated, 7 (MCOP7)4--see VAR_0651502 L P mis40--------
    rs1495912781,2
    C--7657854(+) GTCTC-/AAAAAA 1 -- int10--------
    rs1138991861,2
    C--7725037(+) ACAGGC/TGTGAG 1 -- ds50010--------
    rs1414797631,2
    --7725209(+) ACAGTC/GAAATG 1 -- ds50010--------
    rs1843495541,2
    C--7725522(+) ACATCC/TTACCC 2 * syn10--------
    rs23025161,2,,4
    C,F,H--7725635(+) ACACAC/GAGCCT 2 L V mis1 ese311Minor allele frequency- G:0.02EA NS NA EU 7270
    rs1461970891,2
    C,F--7725741(+) TGGCAG/ATAATT 2 /Y syn11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for GDF3 (7842378 - 7848372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GDF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666104CNV Deletion23128226
    esv2422393CNV Duplication17116639
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639

    Human Gene Mutation Database (HGMD): GDF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GDF3
    DNA2.0 Custom Variant and Variant Library Synthesis for GDF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606522   
    OMIM disorders: 613702  613703  613704  
    UniProtKB/Swiss-Prot: GDF3_HUMAN, Q9NR23
  • Klippel-Feil syndrome 3, autosomal dominant (KFS3) [MIM:613702]: A skeletal disorder characterized by
    congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during
    the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and
    limited neck movement. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Microphthalmia, isolated, with coloboma, 6 (MCOPCB6) [MIM:613703]: A disorder of eye formation, ranging
    from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like
    opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
    Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and
    the fusion of the fetal fissure (optic fissure). Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Microphthalmia, isolated, 7 (MCOP7) [MIM:613704]: A disorder of eye formation, ranging from small size of
    a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea
    and lens, scaring of the retina and choroid, and other abnormalities may also be present. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for GDF3 (see all 24):    About MalaCards
    microphthalmia with coloboma 6    microphthalmia, isolated 7    klippel-feil syndrome 3, autosomal dominant    klippel-feil syndrome
    klippel-feil syndrome 1, autosomal dominant    mixed germ cell tumor    microphthalmia, isolated 2    hypoplastic left heart syndrome
    matthew-wood syndrome    coloboma    germ cell tumors    microphthalmia
    seminoma    teratocarcinoma    choroiditis    cataract
    hepatitis b    obesity    cerebritis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for GDF3:
    Klippel-Feil syndrome     Embryonal carcinoma

    GDF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GDF3
    Human Genome Epidemiology (HuGE) Navigator: GDF3 (3 documents)

    Export disorders for GDF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GDF3 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with GDF3)
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    1. Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours. (PubMed id 9467948)1, 3, 9 Caricasole A.A....van den Eijnden-van Raaij A.J. (Oncogene 1998)
    2. Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies. (PubMed id 19864492)1, 2, 9 Ye M....Lehmann O.J. (Hum. Mol. Genet. 2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Expression pattern of growth/differentiation factor 3 in human and murine cerebral cortex, hippocampus as well as cerebellum. (PubMed id 16126341)1, 9 Hexige S....Yu L. (Neurosci. Lett. 2005)
    8. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. (PubMed id 19396148)1, 9 Gopalan A....Tickoo S.K. (Mod. Pathol. 2009)
    9. GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. (PubMed id 8429021)1, 9 McPherron A.C. and Lee S.J. (J. Biol. Chem. 1993)
    10. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9573 HGNC: 4218 AceView: GDF3 Ensembl:ENSG00000184344 euGenes: HUgn9573
    ECgene: GDF3 H-InvDB: GDF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GDF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GDF3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/GDF3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GDF3 gene:
    Search GeneIP for patents involving GDF3

    GeneCards and IP:
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