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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GDF2 Gene

protein-coding   GIFtS: 54
GCID: GC10M048413

Growth Differentiation Factor 2

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Growth Differentiation Factor 21 2
BMP92 3 5
Bone Morphogenetic Protein 92 3
BMP-92 3
GDF-22 3
Growth/Differentiation Factor 22

External Ids:    HGNC: 42171   Entrez Gene: 26582   Ensembl: ENSG000001288027   OMIM: 6051205   UniProtKB: Q9UK053   

Export aliases for GDF2 gene to outside databases

Previous GC identifers: GC10P047523 GC10P047653 GC10M048349 GC10M047807 GC10M048033 GC10M043166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GDF2 Gene:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta
superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved
to produce a mature protein containing seven conserved cysteine residues. The members of this family are
regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest
that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system
neurons. (provided by RefSeq, Jul 2008)

GeneCards Summary for GDF2 Gene: 
GDF2 (growth differentiation factor 2) is a protein-coding gene. Diseases associated with GDF2 include hepatopulmonary syndrome, and hereditary hemorrhagic telangiectasia, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: GDF2_HUMAN, Q9UK05
Function: Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the
type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta
coreceptor endoglin/ENG

Gene Wiki entry for GDF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030772.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GDF2 gene promoter:
         GR-beta   Lmo2   HNF-4alpha1   Ik-2   POU2F1   HOXA5   POU2F1a   POU2F1b   POU2F1c   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGDF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GDF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GDF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.22

GDF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDF2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M048413:  view genomic region     (about GC identifiers)

Start:
48,413,092 bp from pter      End:
48,416,853 bp from pter
Size:
3,762 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GDF2_HUMAN, Q9UK05 (See protein sequence)
Recommended Name: Growth/differentiation factor 2 precursor  
Size: 429 amino acids; 47320 Da
Subunit: Homodimer; disulfide-linked. Interacts with ENG
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for GDF2:
1ZKZ (3D)        4FAO (3D)    
Secondary accessions: Q5VSQ9 Q9Y571

Explore the universe of human proteins at neXtProt for GDF2: NX_Q9UK05

Explore proteomics data for GDF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK05

  • GDF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GDF2 Protein Expression
    REFSEQ proteins: NP_057288.1  
    ENSEMBL proteins: 
     ENSP00000249598  

    Human Recombinant Protein Products for GDF2: 
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    Novus Biologicals GDF2 Proteins
    Novus Biologicals GDF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GDF2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    GDF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry Q9UK05

    ProtoNet protein and cluster: Q9UK05

    4 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature
    IPB002405 Inhibin alpha chain signature


    UniProtKB/Swiss-Prot: GDF2_HUMAN, Q9UK05
    Similarity: Belongs to the TGF-beta family


    GDF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDF2_HUMAN, Q9UK05
    Function: Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the
    type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta
    coreceptor endoglin/ENG

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI17068149
    GO:0008083growth factor activity IEA--
         
    GDF2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Gdf2):
     cardiovascular system  skeleton  vision/eye 

    GDF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Gdf2tm1Sjl for GDF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GDF2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GDF2 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GDF2 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for GDF2
        ALK1 signaling events



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GDF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for GDF2 (ENSP000002495984) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR2AENSP000002414164STRING: ENSP00000241416
    ACVR2BENSP000003403614STRING: ENSP00000340361
    BMPR2ENSP000003637084STRING: ENSP00000363708
    SMAD9ENSP000003691544STRING: ENSP00000369154
    TGFBR3ENSP000002123554STRING: ENSP00000212355
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification TAS--
    GO:0001569patterning of blood vessels IDA--
    GO:0001570vasculogenesis IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0001937negative regulation of endothelial cell proliferation IDA--

    GDF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GDF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GDF2

    1 Novoseek inferred chemical compound relationship for GDF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 0 5 12598908 (3), 15851468 (1)

    Search CenterWatch for drugs/clinical trials and news about GDF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GDF2 gene: 
    NM_016204.1  

    Unigene Cluster for GDF2:

    Growth differentiation factor 2
    Hs.279463  [show with all ESTs]
    Unigene Representative Sequence: NM_016204
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000249598(uc001jfa.1)

    miRNA
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    Additional mRNA sequence: 

    AF156891.1 AF188285.1 AK314956.1 BC069643.1 BC074921.2 

    1 DOTS entry:

    DT.91741484 

    6 AceView cDNA sequences:

    BC074921 AF156891 BC069643 BX494908 AF188285 NM_016204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GDF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCCAATT
    GDF2 Expression
    About this image


    See GDF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GDF2

    SOURCE GeneReport for Unigene cluster: Hs.279463
        SABiosciences Expression via Pathway-Focused PCR Arrays including GDF2: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stem Cells in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GDF2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gdf21 , 5 growth differentiation factor 21, 5 82.09(n)1
    80.37(a)1
      14 (20.80 cM)5
    121651  NM_019506.41  NP_062379.31 
     339410395 
    chicken
    (Gallus gallus)
    Aves GDF21 growth differentiation factor 2 63.94(n)
    61.78(a)
      396412  NM_205432.1  NP_990763.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gdf21 growth differentiation factor 2 54.18(n)
    45.43(a)
      563287  NM_001171586.1  NP_001165057.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dbl-16
    Protein DBL-1
    21(a)
    1 → many
    V(6758135-6760409)


    ENSEMBL Gene Tree for GDF2 (if available)
    TreeFam Gene Tree for GDF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GDF2 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  BMP22  
    BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    1 SIMAP similar gene for GDF2 using alignment to 1 protein entry:     GDF2_HUMAN:
    BMP10

    GDF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 SNPs in GDF2 are shown (see all 186)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94217991,2
    C,F,A,H--48412830(+) AGCATT/GTGGCC 1 -- int116Minor allele frequency- G:0.40NS EA NA WA CSA 788
    rs1925540971,2
    --48412942(+) CACTCC/TTGGGC 1 -- int10--------
    rs727920431,2
    C--48413125(+) AACTGG/AGTTGT 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs343791001,2
    C,F--48413181(+) CCCTCT/GACTCC 1 -- ut315Minor allele frequency- G:0.24NA WA 244
    rs1841925491,2
    C--48413257(+) TGCCCA/GCCTGT 1 -- ut310--------
    rs37402971,2
    C,F,H--48413273(+) TCTGGC/TTCACT 1 -- ut3117Minor allele frequency- T:0.14EA NA NS 3316
    rs611066751,2
    C,F--48413362(+) CCAGGC/ATTTCC 1 -- ut311Minor allele frequency- A:0.07WA 118
    rs70999631,2
    H--48413422(+) AGCGGT/AGTATG 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1889430171,2
    C--48413433(+) CTTTGA/GGTGGG 1 -- ut310--------
    rs1922926141,2
    --48413443(+) GGTGTG/TGGGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GDF2 (48413092 - 48416853 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for GDF2 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436102CNV Deletion17901297
    esv2736163CNV Deletion23290073
    nsv831861CNV Loss17160897
    nsv528799CNV Loss19592680
    nsv895342CNV Loss21882294
    nsv895344CNV Loss21882294
    dgv696n71CNV Gain21882294
    nsv895343CNV Gain21882294
    nsv467059CNV Gain19166990
    nsv8636CNV Gain+Loss18304495

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605120    OMIM disorders: --

    14 diseases for GDF2:    About MalaCards
    hepatopulmonary syndrome    hereditary hemorrhagic telangiectasia    endotheliitis    hepatitis b
    liver disease    alzheimer's disease    neuronitis    ovarian cancer
    hepatitis    prostate cancer    prostatitis    adenocarcinoma
    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for GDF2:
    Hereditary hemorrhagic telangiectasia

    GDF2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): GDF2
    Human Genome Epidemiology (HuGE) Navigator: GDF2 (6 documents)

    Export disorders for GDF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GDF2 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with GDF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of BMP-9 and functional interactions with pro-region and receptors. (PubMed id 15851468)1, 2, 9 Brown M.A....Choe S. (2005)
    2. Bone morphogenetic protein-9 is a circulating vascular quiescence factor. (PubMed id 18309101)1, 2, 9 David L....Bailly S. (2008)
    3. Soluble endoglin specifically binds bone morphogeneti c proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. (PubMed id 21737454)1, 2 Castonguay R....Grinberg A.V. (2011)
    4. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    6. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Bone morphogenetic protein-9. An autocrine/paracrine cytokine in the liver. (PubMed id 10849432)1, 3 Miller A.F....Olson M.S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2658 HGNC: 4217 AceView: GDF2 Ensembl:ENSG00000128802 euGenes: HUgn2658
    ECgene: GDF2 H-InvDB: GDF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GDF2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/GDF2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GDF2 gene:
    Search GeneIP for patents involving GDF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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