Aliases for GDF15 Gene
External Ids for GDF15 Gene
Previous GeneCards Identifiers for GDF15 Gene
The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015]
GeneCards Summary for GDF15 Gene
GDF15 (Growth Differentiation Factor 15) is a Protein Coding gene. Diseases associated with GDF15 include pulmonary systemic sclerosis and transitional papilloma. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is NODAL.