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Aliases for GDF11 Gene

Aliases for GDF11 Gene

  • Growth Differentiation Factor 11 2 3 5
  • Bone Morphogenetic Protein 11 3 4
  • BMP-11 3 4
  • GDF-11 3 4
  • BMP11 3 4

External Ids for GDF11 Gene

Previous GeneCards Identifiers for GDF11 Gene

  • GC12P056061
  • GC12P056210
  • GC12P055853
  • GC12P054423
  • GC12P056137
  • GC12P053175

Summaries for GDF11 Gene

Entrez Gene Summary for GDF11 Gene

  • The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

GeneCards Summary for GDF11 Gene

GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include currarino syndrome. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot for GDF11 Gene

  • Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

Gene Wiki entry for GDF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF11 Gene

Genomics for GDF11 Gene

Regulatory Elements for GDF11 Gene

Promoters for GDF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GDF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for GDF11 Gene

Chromosome:
12
Start:
55,743,278 bp from pter
End:
55,757,466 bp from pter
Size:
14,189 bases
Orientation:
Plus strand

Genomic View for GDF11 Gene

Genes around GDF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF11 Gene

Proteins for GDF11 Gene

  • Protein details for GDF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95390-GDF11_HUMAN
    Recommended name:
    Growth/differentiation factor 11
    Protein Accession:
    O95390
    Secondary Accessions:
    • Q9UID1
    • Q9UID2

    Protein attributes for GDF11 Gene

    Size:
    407 amino acids
    Molecular mass:
    45091 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for GDF11 Gene

Proteomics data for GDF11 Gene at MOPED

Post-translational modifications for GDF11 Gene

  • Glycosylation at Asn 94
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GDF11 Gene

Domains & Families for GDF11 Gene

Suggested Antigen Peptide Sequences for GDF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95390

UniProtKB/Swiss-Prot:

GDF11_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF11: view

No data available for Gene Families for GDF11 Gene

Function for GDF11 Gene

Molecular function for GDF11 Gene

UniProtKB/Swiss-Prot Function:
Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

LifeMap Function Summary for GDF11 Gene

During embryonic development, GDF11 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for GDF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005160 transforming growth factor beta receptor binding IBA --
genes like me logo Genes that share ontologies with GDF11: view
genes like me logo Genes that share phenotypes with GDF11: view

Animal Models for GDF11 Gene

MGI Knock Outs for GDF11:

Animal Model Products

miRNA for GDF11 Gene

miRTarBase miRNAs that target GDF11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF11 Gene

Localization for GDF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GDF11 Gene COMPARTMENTS Subcellular localization image for GDF11 gene
Compartment Confidence
extracellular 5
nucleus 4
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GDF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with GDF11: view

Pathways & Interactions for GDF11 Gene

SuperPathways for GDF11 Gene

No Data Available

SIGNOR curated interactions for GDF11 Gene

Activates:

Gene Ontology (GO) - Biological Process for GDF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0007399 nervous system development TAS 10075854
GO:0007498 mesoderm development TAS 10075854
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with GDF11: view

No data available for Pathways by source for GDF11 Gene

Drugs & Compounds for GDF11 Gene

No Compound Related Data Available

Transcripts for GDF11 Gene

mRNA/cDNA for GDF11 Gene

Unigene Clusters for GDF11 Gene

Growth differentiation factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDF11 Gene

No ASD Table

Relevant External Links for GDF11 Gene

GeneLoc Exon Structure for
GDF11
ECgene alternative splicing isoforms for
GDF11

Expression for GDF11 Gene

mRNA expression in normal human tissues for GDF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GDF11 Gene

This gene is overexpressed in Bone (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GDF11 Gene



SOURCE GeneReport for Unigene cluster for GDF11 Gene Hs.600883

genes like me logo Genes that share expression patterns with GDF11: view

Protein tissue co-expression partners for GDF11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GDF11 Gene

Orthologs for GDF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for GDF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GDF11 35
  • 94.22 (n)
  • 99.47 (a)
GDF11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdf11 35
  • 94 (n)
  • 99.45 (a)
Gdf11 16
Gdf11 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GDF11 35
  • 100 (n)
  • 100 (a)
GDF11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdf11 35
  • 93.26 (n)
  • 99.72 (a)
dog
(Canis familiaris)
Mammalia GDF11 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GDF11 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GDF11 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gdf11 35
  • 76.8 (n)
  • 86.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13638 35
zebrafish
(Danio rerio)
Actinopterygii gdf11 35
  • 73.98 (n)
  • 80.99 (a)
gdf8 35
gdf11 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.119 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005289 35
  • 64.26 (n)
  • 61.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta myo 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-7 35
  • 43.3 (n)
  • 29.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for GDF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GDF11 Gene

ENSEMBL:
Gene Tree for GDF11 (if available)
TreeFam:
Gene Tree for GDF11 (if available)

Paralogs for GDF11 Gene

Paralogs for GDF11 Gene

(2) SIMAP similar genes for GDF11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GDF11: view

Variants for GDF11 Gene

Sequence variations from dbSNP and Humsavar for GDF11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs772250 -- 55,747,719(+) TAAAG(C/T)TGGGA intron-variant
rs772251 -- 55,750,560(+) AACCC(C/T)GCTCT intron-variant, utr-variant-3-prime
rs1681083 -- 55,743,181(+) CCCCC(C/G)GGTCC upstream-variant-2KB
rs3843621 -- 55,744,646(+) ACCCC(C/T)CCTTT intron-variant
rs3782241 -- 55,745,983(-) CCCCC(C/G)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDF11 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897
nsv469410 CNV Loss 19166990

Variation tolerance for GDF11 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDF11 Gene

HapMap Linkage Disequilibrium report
GDF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF11 Gene

Disorders for GDF11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GDF11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
currarino syndrome
  • currarino triad
- elite association - COSMIC cancer census association via MalaCards
Search GDF11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GDF11

Genetic Association Database (GAD)
GDF11
Human Genome Epidemiology (HuGE) Navigator
GDF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDF11
genes like me logo Genes that share disorders with GDF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GDF11 Gene

Publications for GDF11 Gene

  1. GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. (PMID: 15988002) Ge G. … Greenspan D.S. (Mol. Cell. Biol. 2005) 2 3 23 67
  2. Clinical significance of growth differentiation factor 11 in colorectal cancer. (PMID: 17912435) Yokoe T. … Mori M. (Int. J. Oncol. 2007) 3 23
  3. Growth differentiation factor 11 is a protective factor for osteoblastogenesis by targeting PPARgamma. (PMID: 25534870) Zhang Y. … Ye W. (Gene 2015) 3
  4. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. (PMID: 26001423) Egerman M.A. … Glass D.J. (Cell Metab. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for GDF11 Gene

Sources for GDF11 Gene

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