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Aliases for GDF10 Gene

Aliases for GDF10 Gene

  • Growth Differentiation Factor 10 2 3
  • Bone Morphogenetic Protein 3B 3 4
  • Bone-Inducing Protein 3 4
  • BMP-3b 3 4
  • GDF-10 3 4
  • BMP3B 3 4
  • BIP 3 4

External Ids for GDF10 Gene

Previous GeneCards Identifiers for GDF10 Gene

  • GC10P047501
  • GC10P047630
  • GC10M048361
  • GC10M047820
  • GC10M048045
  • GC10M048425
  • GC10M043178

Summaries for GDF10 Gene

Entrez Gene Summary for GDF10 Gene

  • The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GDF10 Gene

GDF10 (Growth Differentiation Factor 10) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding.

UniProtKB/Swiss-Prot for GDF10 Gene

  • Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Gene Wiki entry for GDF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF10 Gene

Genomics for GDF10 Gene

Regulatory Elements for GDF10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GDF10 Gene

Chromosome:
10
Start:
47,300,224 bp from pter
End:
47,313,583 bp from pter
Size:
13,360 bases
Orientation:
Plus strand

Genomic View for GDF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GDF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF10 Gene

Proteins for GDF10 Gene

  • Protein details for GDF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55107-GDF10_HUMAN
    Recommended name:
    Growth/differentiation factor 10
    Protein Accession:
    P55107
    Secondary Accessions:
    • Q5VSQ8
    • Q9UCX6

    Protein attributes for GDF10 Gene

    Size:
    478 amino acids
    Molecular mass:
    53122 Da
    Quaternary structure:
    • Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.

neXtProt entry for GDF10 Gene

Proteomics data for GDF10 Gene at MOPED

Post-translational modifications for GDF10 Gene

  • Glycosylation at Asn 118, Asn 156, Asn 281, and Asn 469
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GDF10 (BMP-3b/GDF-10)

No data available for DME Specific Peptides for GDF10 Gene

Domains & Families for GDF10 Gene

Gene Families for GDF10 Gene

Suggested Antigen Peptide Sequences for GDF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55107

UniProtKB/Swiss-Prot:

GDF10_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF10: view

Function for GDF10 Gene

Molecular function for GDF10 Gene

UniProtKB/Swiss-Prot Function:
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Gene Ontology (GO) - Molecular Function for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with GDF10: view
genes like me logo Genes that share phenotypes with GDF10: view

Animal Models for GDF10 Gene

MGI Knock Outs for GDF10:

Animal Model Products

miRNA for GDF10 Gene

miRTarBase miRNAs that target GDF10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDF10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GDF10 Gene

Localization for GDF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF10 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with GDF10: view

No data available for Subcellular locations from COMPARTMENTS for GDF10 Gene

Pathways & Interactions for GDF10 Gene

genes like me logo Genes that share pathways with GDF10: view

Pathways by source for GDF10 Gene

PCR Array Products

Interacting Proteins for GDF10 Gene

Selected Interacting proteins: P55107-GDF10_HUMAN for GDF10 Gene via I2D

Symbol External ID(s) Details
IGHA1

Gene Ontology (GO) - Biological Process for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8670277
GO:0001649 osteoblast differentiation IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8679252
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISS --
GO:0040007 growth --
genes like me logo Genes that share ontologies with GDF10: view

No data available for SIGNOR curated interactions for GDF10 Gene

Drugs & Compounds for GDF10 Gene

No Compound Related Data Available

Transcripts for GDF10 Gene

mRNA/cDNA for GDF10 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF10 Gene

Growth differentiation factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDF10 Gene

No ASD Table

Relevant External Links for GDF10 Gene

GeneLoc Exon Structure for
GDF10
ECgene alternative splicing isoforms for
GDF10

Expression for GDF10 Gene

mRNA expression in normal human tissues for GDF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF10 Gene

This gene is overexpressed in Lung (x4.1).

Protein differential expression in normal tissues from HIPED for GDF10 Gene

This gene is overexpressed in Testis (40.0) and Retina (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GDF10 Gene



SOURCE GeneReport for Unigene cluster for GDF10 Gene Hs.2171

mRNA Expression by UniProt/SwissProt for GDF10 Gene

P55107-GDF10_HUMAN
Tissue specificity: Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
genes like me logo Genes that share expression patterns with GDF10: view

Protein tissue co-expression partners for GDF10 Gene

Primer Products

In Situ Assay Products

Orthologs for GDF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDF10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GDF10 35
  • 85.81 (n)
  • 85.95 (a)
dog
(Canis familiaris)
Mammalia GDF10 35
  • 80.53 (n)
  • 76.2 (a)
mouse
(Mus musculus)
Mammalia Gdf10 35
  • 82.81 (n)
  • 85.33 (a)
Gdf10 16
chimpanzee
(Pan troglodytes)
Mammalia GDF10 35
  • 98.67 (n)
  • 98.32 (a)
rat
(Rattus norvegicus)
Mammalia Gdf10 35
  • 82.44 (n)
  • 85.56 (a)
chicken
(Gallus gallus)
Aves GDF10 35
  • 66.67 (n)
  • 67.41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gdf10 35
  • 56.32 (n)
  • 53.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia xBMP-3b 35
zebrafish
(Danio rerio)
Actinopterygii gdf10a 35
  • 62.41 (n)
  • 60.71 (a)
Species with no ortholog for GDF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDF10 Gene

ENSEMBL:
Gene Tree for GDF10 (if available)
TreeFam:
Gene Tree for GDF10 (if available)

Paralogs for GDF10 Gene

(1) SIMAP similar genes for GDF10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDF10: view

No data available for Paralogs for GDF10 Gene

Variants for GDF10 Gene

Sequence variations from dbSNP and Humsavar for GDF10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3007 -- 47,313,015(+) GAATT(A/T)GCCCT utr-variant-3-prime
rs9860 -- 47,313,369(+) AGGGC(A/G)TTGAC utr-variant-3-prime
rs743508 -- 47,312,471(-) GGCAT(A/C)CACCT intron-variant
rs743509 -- 47,312,564(-) AGCTC(C/T)GCCCT intron-variant
rs762454 -- 47,312,116(+) TGTCA(A/G)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDF10 Gene

Variant ID Type Subtype PubMed ID
dgv252e1 CNV Complex 17122850
nsv510991 OTHER Complex 20534489
nsv8636 CNV Gain+Loss 18304495
nsv436102 CNV Deletion 17901297
nsv7203 OTHER Inversion 18451855
esv2736163 CNV Deletion 23290073
nsv467059 CNV Gain 19166990
esv21870 CNV Gain+Loss 19812545
dgv696n71 CNV Gain 21882294
nsv895342 CNV Loss 21882294
nsv895343 CNV Gain 21882294
nsv895344 CNV Loss 21882294
nsv831861 CNV Loss 17160897
essv16333 CNV CNV 17122850
esv1010922 CNV Deletion 20482838

Variation tolerance for GDF10 Gene

Residual Variation Intolerance Score: 30.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDF10 Gene

HapMap Linkage Disequilibrium report
GDF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF10 Gene

Disorders for GDF10 Gene

Relevant External Links for GDF10

Genetic Association Database (GAD)
GDF10
Human Genome Epidemiology (HuGE) Navigator
GDF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDF10
genes like me logo Genes that share disorders with GDF10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDF10 Gene

Publications for GDF10 Gene

  1. The role of endogenous bone morphogenetic proteins in normal skeletal repair. (PMID: 20082790) Marsell R. … Einhorn T.A. (Injury 2009) 23 67
  2. The effect of calcium phosphate microstructure on bone-related cells in vitro. (PMID: 18485476) Li X. … Watari F. (Biomaterials 2008) 23 67
  3. Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein. (PMID: 17899080) Srour M.A. … Schwaab R. (Ann. Hematol. 2008) 23 67
  4. Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation, and apoptosis, and ERK1/2 phosphorylation. (PMID: 16847058) Wang Z. … Yarema K.J. (J. Biol. Chem. 2006) 23 67
  5. Optimization of tetracycline-responsive recombinant protein production and effect on cell growth and ER stress in mammalian cells. (PMID: 15981277) Jones J. … Betenbaugh M.J. (Biotechnol. Bioeng. 2005) 23 67

Products for GDF10 Gene

Sources for GDF10 Gene

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