Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GDF10 Gene

Aliases for GDF10 Gene

  • Growth Differentiation Factor 10 2 3 5
  • Bone Morphogenetic Protein 3B 3 4
  • Bone-Inducing Protein 3 4
  • BMP-3b 3 4
  • GDF-10 3 4
  • BMP3B 3 4
  • BIP 3 4

External Ids for GDF10 Gene

Previous GeneCards Identifiers for GDF10 Gene

  • GC10P047501
  • GC10P047630
  • GC10M048361
  • GC10M047820
  • GC10M048045
  • GC10M048425
  • GC10M043178

Summaries for GDF10 Gene

Entrez Gene Summary for GDF10 Gene

  • The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GDF10 Gene

GDF10 (Growth Differentiation Factor 10) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is NODAL.

UniProtKB/Swiss-Prot for GDF10 Gene

  • Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Gene Wiki entry for GDF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF10 Gene

Genomics for GDF10 Gene

Regulatory Elements for GDF10 Gene

Enhancers for GDF10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GDF10 on UCSC Golden Path with GeneCards custom track

Promoters for GDF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GDF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for GDF10 Gene

47,300,224 bp from pter
47,313,583 bp from pter
13,360 bases
Plus strand

Genomic View for GDF10 Gene

Genes around GDF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF10 Gene

Proteins for GDF10 Gene

  • Protein details for GDF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Growth/differentiation factor 10
    Protein Accession:
    Secondary Accessions:
    • Q5VSQ8
    • Q9UCX6

    Protein attributes for GDF10 Gene

    478 amino acids
    Molecular mass:
    53122 Da
    Quaternary structure:
    • Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.

neXtProt entry for GDF10 Gene

Proteomics data for GDF10 Gene at MOPED

Post-translational modifications for GDF10 Gene

  • Glycosylation at Asn 118, Asn 156, Asn 281, and Asn 469
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GDF10 (BMP-3b/GDF-10)

No data available for DME Specific Peptides for GDF10 Gene

Domains & Families for GDF10 Gene

Gene Families for GDF10 Gene

Suggested Antigen Peptide Sequences for GDF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TGF-beta family.
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF10: view

Function for GDF10 Gene

Molecular function for GDF10 Gene

UniProtKB/Swiss-Prot Function:
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
genes like me logo Genes that share phenotypes with GDF10: view

Animal Models for GDF10 Gene

MGI Knock Outs for GDF10:

Animal Model Products

miRNA for GDF10 Gene

miRTarBase miRNAs that target GDF10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF10 Gene

Localization for GDF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF10 Gene


Subcellular locations from

Jensen Localization Image for GDF10 Gene COMPARTMENTS Subcellular localization image for GDF10 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GDF10 Gene

Pathways & Interactions for GDF10 Gene

genes like me logo Genes that share pathways with GDF10: view

Pathways by source for GDF10 Gene

Interacting Proteins for GDF10 Gene

Selected Interacting proteins: P55107-GDF10_HUMAN for GDF10 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8679252
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA,ISS --
GO:0030509 BMP signaling pathway IBA --
GO:0040007 growth IEA --
genes like me logo Genes that share ontologies with GDF10: view

No data available for SIGNOR curated interactions for GDF10 Gene

Drugs & Compounds for GDF10 Gene

No Compound Related Data Available

Transcripts for GDF10 Gene

mRNA/cDNA for GDF10 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF10 Gene

Growth differentiation factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDF10 Gene

No ASD Table

Relevant External Links for GDF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GDF10 Gene

mRNA expression in normal human tissues for GDF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF10 Gene

This gene is overexpressed in Lung (x4.1).

Protein differential expression in normal tissues from HIPED for GDF10 Gene

This gene is overexpressed in Testis (40.0) and Retina (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GDF10 Gene

SOURCE GeneReport for Unigene cluster for GDF10 Gene Hs.2171

mRNA Expression by UniProt/SwissProt for GDF10 Gene

Tissue specificity: Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
genes like me logo Genes that share expression patterns with GDF10: view

Protein tissue co-expression partners for GDF10 Gene

Primer Products

Orthologs for GDF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GDF10 35
  • 85.81 (n)
  • 85.95 (a)
(Canis familiaris)
Mammalia GDF10 35
  • 80.53 (n)
  • 76.2 (a)
(Mus musculus)
Mammalia Gdf10 35
  • 82.81 (n)
  • 85.33 (a)
Gdf10 16
(Pan troglodytes)
Mammalia GDF10 35
  • 98.67 (n)
  • 98.32 (a)
(Rattus norvegicus)
Mammalia Gdf10 35
  • 82.44 (n)
  • 85.56 (a)
(Gallus gallus)
Aves GDF10 35
  • 66.67 (n)
  • 67.41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gdf10 35
  • 56.32 (n)
  • 53.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia xBMP-3b 35
(Danio rerio)
Actinopterygii gdf10a 35
  • 62.41 (n)
  • 60.71 (a)
Species with no ortholog for GDF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDF10 Gene

Gene Tree for GDF10 (if available)
Gene Tree for GDF10 (if available)

Paralogs for GDF10 Gene

Paralogs for GDF10 Gene

(1) SIMAP similar genes for GDF10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDF10: view

Variants for GDF10 Gene

Sequence variations from dbSNP and Humsavar for GDF10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1540253 -- 47,300,362(+) TTCGC(A/G)GCGCG upstream-variant-2KB, utr-variant-5-prime
rs3007 -- 47,313,015(+) GAATT(A/T)GCCCT utr-variant-3-prime
rs9860 -- 47,313,369(+) AGGGC(A/G)TTGAC utr-variant-3-prime
rs1870174 -- 47,311,095(+) GCTCC(C/T)TCCTG intron-variant
rs1870175 -- 47,299,692(-) CATGT(A/G)GCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GDF10 Gene

Variant ID Type Subtype PubMed ID
dgv252e1 CNV Complex 17122850
nsv510991 OTHER Complex 20534489
nsv8636 CNV Gain+Loss 18304495
nsv436102 CNV Deletion 17901297
nsv7203 OTHER Inversion 18451855
esv2736163 CNV Deletion 23290073
nsv467059 CNV Gain 19166990
esv21870 CNV Gain+Loss 19812545
dgv696n71 CNV Gain 21882294
nsv895342 CNV Loss 21882294
nsv895343 CNV Gain 21882294
nsv895344 CNV Loss 21882294
nsv831861 CNV Loss 17160897
essv16333 CNV CNV 17122850
esv1010922 CNV Deletion 20482838

Variation tolerance for GDF10 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GDF10 Gene

Disorders for GDF10 Gene

Relevant External Links for GDF10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GDF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDF10 Gene

Publications for GDF10 Gene

  1. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein- 3. (PMID: 8679252) Cunningham N.S. … Lee S.-J. (Growth Factors 1995) 2 3 4 67
  2. cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). (PMID: 8670277) Hino J. … Kangawa K. (Biochem. Biophys. Res. Commun. 1996) 3 23
  3. GDF10 is a signal for axonal sprouting and functional recovery after stroke. (PMID: 26502261) Li S. … Carmichael S.T. (Nat. Neurosci. 2015) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3

Products for GDF10 Gene

Sources for GDF10 Gene