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GDF10 Gene

protein-coding   GIFtS: 61
GCID: GC10M048425

Growth Differentiation Factor 10

  See GDF10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Growth Differentiation Factor 101 2     BMP-3b2
Bone-Inducing Protein2 3     Bone Morphogenetic Protein 3B2
BIP2 3     BMP-3B3
BMP3B2 3     Growth/Differentiation Factor 103
GDF-102 3     

External Ids:    HGNC: 42151   Entrez Gene: 26622   Ensembl: ENSG000001076237   OMIM: 6013615   UniProtKB: P551073   

Export aliases for GDF10 gene to outside databases

Previous GC identifers: GC10P047501 GC10P047630 GC10M048361 GC10M047820 GC10M048045 GC10M043178


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GDF10 Gene:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta
superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved
to produce a mature protein containing seven conserved cysteine residues. The members of this family are
regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that
the protein encoded by this gene plays a role in skeletal morphogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for GDF10 Gene:
GDF10 (growth differentiation factor 10) is a protein-coding gene. Diseases associated with GDF10 include osteosarcoma. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF15.

Gene Wiki entry for GDF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GDF10 gene promoter:
         RFX1   Egr-1   HNF-4alpha2   NF-kappaB   HNF-4alpha1   AREB6   Nkx6-1   HOXA5   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGDF10 promoter sequence
   Search Chromatin IP Primers for GDF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GDF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.22

GDF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDF10 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M048425:  view genomic region     (about GC identifiers)

Start:
48,425,785 bp from pter      End:
48,439,138 bp from pter
Size:
13,354 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BMP3B_HUMAN, P55107 (See protein sequence)
Recommended Name: Bone morphogenetic protein 3B precursor  
Size: 478 amino acids; 53122 Da
Subunit: Homodimer or heterodimer (Potential)
Secondary accessions: Q5VSQ8 Q9UCX6

Explore the universe of human proteins at neXtProt for GDF10: NX_P55107

Explore proteomics data for GDF10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn118, Asn156, Asn281, Asn469
  • Modification sites at PhosphoSitePlus

  • See GDF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004953.1  
    ENSEMBL proteins: 
     ENSP00000224605  

    GDF10 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GDF10
    GenScript Custom Purified and Recombinant Proteins Services for GDF10
    Novus Biologicals GDF10 Proteins
    Novus Biologicals GDF10 Lysate
    Sino Biological Recombinant Protein for GDF10
    Sino Biological Cell Lysate for GDF10
    ProSpec Recombinant Protein for GDF10
    Cloud-Clone Corp. Proteins for GDF10

     
    Search eBioscience for Proteins for GDF10 

    GDF10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for GDF10

    GDF10 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GDF10
    Cloud-Clone Corp. CLIAs for GDF10
    Search eBioscience for ELISAs for GDF10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR017197 BMP3/GDF10
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P55107

    ProtoNet protein and cluster: P55107

    1 Blocks protein domain: IPB001839 Transforming growth factor beta (TGFb)

    UniProtKB/Swiss-Prot: BMP3B_HUMAN, P55107
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with GDF10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with GDF10           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for GDF10:
     Decreased influenza A/WSN/33 r  Increased Salmonella enterica   Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Gdf10):
     normal 

    Find genes that share phenotypes with GDF10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gdf10tm1Sjl for GDF10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GDF10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GDF10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GDF10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GDF10

    miRNA
    Products:
        
    miRTarBase miRNAs that target GDF10:
    hsa-mir-335-5p (MIRT019185), hsa-mir-26b-5p (MIRT030335), hsa-mir-124-3p (MIRT023151)

    Block miRNA regulation of human, mouse, rat GDF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GDF10 (see all 12):
    hsa-miR-3163 hsa-miR-3152-3p hsa-miR-520d-5p hsa-miR-139-5p hsa-miR-548l hsa-miR-587 hsa-miR-656 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidGDF10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GDF10
    Predesigned siRNA for gene silencing in human, mouse, rat GDF10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GDF10

    Clone
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    OriGene clones in human, mouse for GDF10 (see all 8)
    OriGene ORF clones in mouse, rat for GDF10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GDF10 (NM_004962)
    Sino Biological Human cDNA Clone for GDF10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDF10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDF10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GDF10
    ESI BIO PureStem Progenitors for GDF10: 
    PureStem SK11, NCr-fac & Meso-prx Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMP3B_HUMAN, P55107: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with GDF10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GDF10 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GDF10 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 BioSystems Pathway for GDF10
        Adipogenesis



        Pathway & Disease-focused RT2 Profiler PCR Arrays including GDF10: 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GDF10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for GDF10 (P551073 ENSP000002246054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    SHHENSP000002972614STRING: ENSP00000297261
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8670277
    GO:0007179transforming growth factor beta receptor signaling pathway TAS8679252
    GO:0040007growth IEA--

    Find genes that share ontologies with GDF10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GDF10 (BMP3B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GDF10 gene: 
    NM_004962.3  

    Unigene Cluster for GDF10:

    Growth differentiation factor 10
    Hs.2171  [show with all ESTs]
    Unigene Representative Sequence: NM_004962
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000224605(uc001jfb.3 uc009xnp.3 uc009xnq.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GDF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GDF10 (see all 12):
    hsa-miR-3163 hsa-miR-3152-3p hsa-miR-520d-5p hsa-miR-139-5p hsa-miR-548l hsa-miR-587 hsa-miR-656 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidGDF10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GDF10
    Predesigned siRNA for gene silencing in human, mouse, rat GDF10
    Clone
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    OriGene clones in human, mouse for GDF10 (see all 8)
    OriGene ORF clones in mouse, rat for GDF10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GDF10 (NM_004962)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDF10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDF10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GDF10
    OriGene qSTAR qPCR primer pairs in human, mouse for GDF10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GDF10
      QuantiTect SYBR Green Assays in human, mouse, rat GDF10
      QuantiFast Probe-based Assays in human, mouse, rat GDF10

    Additional mRNA sequence: 

    AK310360.1 AK315322.1 BC028237.1 D49492.1 L42113.1 

    2 DOTS entries:

    DT.445955  DT.121269646 

    Selected AceView cDNA sequences (see all 45):

    H89134 BU678075 T18974 NM_004962 L42113 AA069337 BQ183337 W16549 
    D49492 BU683075 AA018253 BI768895 AA297544 BC028237 AA297489 BV188585 
    W25110 AI185363 AU280015 AA912897 BE673123 N93253 R52633 AA017615 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GDF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATTGAAA
    GDF10 Expression
    About this image


    GDF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Growth Plate
             HyStem+BMP4-induced E15 cells
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    GDF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GDF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2171

    UniProtKB/Swiss-Prot: BMP3B_HUMAN, P55107
    Tissue specificity: Expressed in femur, brain, lung, skeletal muscle, pancreas and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GDF10: 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GDF10
    OriGene qSTAR qPCR primer pairs in human, mouse for GDF10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GDF10
    QuantiTect SYBR Green Assays in human, mouse, rat GDF10
    QuantiFast Probe-based Assays in human, mouse, rat GDF10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GDF10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gdf101 , 5 growth differentiation factor 101, 5 82.81(n)1
    85.33(a)1
      14 (20.80 cM)5
    145601  NM_145741.21  NP_665684.21 
     339235875 
    chicken
    (Gallus gallus)
    Aves GDF101 growth differentiation factor 10 66.67(n)
    67.41(a)
      423776  XM_421648.4  XP_421648.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia xBMP-3b2 xBMP-3b protein 75.51(n)    AB059564.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gdf10a1 growth differentiation factor 10a 62.41(n)
    60.71(a)
      563003  XM_686367.4  XP_691459.3 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1296
    Protein UNC-129 (unc-129) mRNA, complete cds
    20(a)
    1 → many
    IV(9002837-9005410) WBGene00006852


    ENSEMBL Gene Tree for GDF10 (if available)
    TreeFam Gene Tree for GDF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GDF10 gene
    GDF152  GDF92  NODAL2  BMP32  BMP152  
    1 SIMAP similar gene for GDF10 using alignment to 1 protein entry:     BMP3B_HUMAN:
    BMP3

    Find genes that share paralogs with GDF10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GDF10 (see all 351)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404101421,2
    Cuntested148428669(+) CTCCCA/GCGCAG 2 A V mis10--------
    rs732990831,2
    C,F--48425299(+) ATCCTT/GCTACA 1 -- ds50012Minor allele frequency- G:0.14WA 120
    rs1821378411,2
    --48425345(+) TGGCCC/TGTCCA 1 -- ds50010--------
    rs8803131,2
    C,F,A,H--48425463(+) TTTTTA/TAAACA 1 -- ds500111Minor allele frequency- T:0.45NS EA NA WA 646
    rs1496702441,2
    --48425513(+) GGGGAA/TGAGGA 1 -- ds50010--------
    rs1156045031,2
    C,F--48425695(+) CCAGCG/AACCCT 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs22486271,2
    C,F,H--48425714(+) CTGAGT/ACCCCA 1 -- ds500115Minor allele frequency- A:0.11NS EA NA WA CSA 767
    rs98601,2
    C,F,A,H--48425993(-) AGGGCA/GTTGAC 1 -- ut3130Minor allele frequency- N:0.00MN EA NA NS WA CSA 3166
    rs1454387601,2
    --48426002(+) CTCCCG/TTTTTG 1 -- ut310--------
    rs749102961,2
    C,F--48426094(+) CAGTGG/AACTTT 1 -- ut311Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for GDF10 (48425785 - 48439138 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GDF10 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010922CNV Deletion20482838
    nsv436102CNV Deletion17901297
    esv2736163CNV Deletion23290073
    nsv831861CNV Loss17160897
    nsv895342CNV Loss21882294
    nsv895344CNV Loss21882294
    dgv696n71CNV Gain21882294
    nsv895343CNV Gain21882294
    nsv467059CNV Gain19166990
    nsv8636CNV Gain+Loss18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601361    OMIM disorders: --

    1 disease for GDF10:    
    About MalaCards
    osteosarcoma


    Find genes that share disorders with GDF10           About GenesLikeMe

    1 Novoseek inferred disease relationship for GDF10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 44 2 1320380 (1), 8519128 (1)

    Genetic Association Database (GAD): GDF10
    Human Genome Epidemiology (HuGE) Navigator: GDF10 (5 documents)

    Export disorders for GDF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GDF10 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with GDF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein- 3. (PubMed id 8679252)1, 2, 3 Cunningham N.S.... Lee S.-J. (Growth Factors 1995)
    2. cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). (PubMed id 8670277)1, 2, 9 Hino J....Kangawa K. (Biochem. Biophys. Res. Commun. 1996)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    6. The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas. (PubMed id 18949431)1 Kimura K....Date H. (Oncol. Rep. 2008)
    7. Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. (PubMed id 18077449)1 Lafont J.E....Murphy C.L. (J. Biol. Chem. 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. An investigation into the human serum &quot;interactome&quot;. (PubMed id 15174051)1 Zhou M....Conrads T.P. (Electrophoresis 2004)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2662 HGNC: 4215 AceView: GDF10 Ensembl:ENSG00000107623 euGenes: HUgn2662
    ECgene: GDF10 H-InvDB: GDF10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GDF10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GDF10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GDF10 gene:
    Search GeneIP for patents involving GDF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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