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Aliases for GDF10 Gene

Aliases for GDF10 Gene

  • Growth Differentiation Factor 10 2 3
  • Bone-Inducing Protein 3 4
  • BMP-3b 3 4
  • GDF-10 3 4
  • BMP3B 3 4
  • BIP 3 4
  • Growth/Differentiation Factor 10 4
  • Bone Morphogenetic Protein 3B 3

External Ids for GDF10 Gene

Summaries for GDF10 Gene

Entrez Gene Summary for GDF10 Gene

  • The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GDF10 Gene

GDF10 (Growth Differentiation Factor 10) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include cytokine activity and growth factor activity.

Gene Wiki entry for GDF10 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF10 Gene

Genomics for GDF10 Gene

Genomic Location for GDF10 Gene

Start:
47,300,224 bp from pter
End:
47,313,583 bp from pter
Size:
13,360 bases
Orientation:
Plus strand

Genomic View for GDF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GDF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF10 Gene

Regulatory Elements for GDF10 Gene

Proteins for GDF10 Gene

  • Protein details for GDF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55107-BMP3B_HUMAN
    Recommended name:
    Bone morphogenetic protein 3B
    Protein Accession:
    P55107
    Secondary Accessions:
    • Q5VSQ8
    • Q9UCX6

    Protein attributes for GDF10 Gene

    Size:
    478 amino acids
    Molecular mass:
    53122 Da
    Quaternary structure:
    • Homodimer or heterodimer.

neXtProt entry for GDF10 Gene

Proteomics data for GDF10 Gene at MOPED

Post-translational modifications for GDF10 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn118, Asn156, Asn281, and Asn469

Other Protein References for GDF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GDF10 Gene

Domains for GDF10 Gene

Gene Families for GDF10 Gene

HGNC:

UniProtKB/Swiss-Prot:

BMP3B_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • P55107
genes like me logo Genes that share domains with GDF10: view

Function for GDF10 Gene

Gene Ontology (GO) - Molecular Function for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with GDF10: view

Phenotypes for GDF10 Gene

genes like me logo Genes that share phenotypes with GDF10: view

Animal Models for GDF10 Gene

MGI Knock Outs for GDF10:

miRNA for GDF10 Gene

miRTarBase miRNAs that target GDF10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GDF10 Gene

Localization for GDF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GDF10 Gene COMPARTMENTS Subcellular localization image for GDF10 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with GDF10: view

Pathways for GDF10 Gene

genes like me logo Genes that share pathways with GDF10: view

Pathways by source for GDF10 Gene

1 BioSystems pathway for GDF10 Gene

Interacting Proteins for GDF10 Gene

Selected Interacting proteins: P55107-BMP3B_HUMAN for GDF10 Gene via I2D

Symbol External ID(s) Details
IGHA1

Gene Ontology (GO) - Biological Process for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8670277
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8679252
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISS --
GO:0040007 growth IEA --
GO:0042981 regulation of apoptotic process IBA --
genes like me logo Genes that share ontologies with GDF10: view

Transcripts for GDF10 Gene

mRNA/cDNA for GDF10 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF10 Gene

Growth differentiation factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDF10 Gene

No ASD Table

Relevant External Links for GDF10 Gene

GeneLoc Exon Structure for
GDF10
ECgene alternative splicing isoforms for
GDF10

Expression for GDF10 Gene

mRNA expression in normal human tissues for GDF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF10 Gene

This gene is overexpressed in Lung (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GDF10 Gene

SOURCE GeneReport for Unigene cluster for GDF10 Gene Hs.2171

mRNA Expression by UniProt/SwissProt for GDF10 Gene

P55107-BMP3B_HUMAN
Tissue specificity: Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
genes like me logo Genes that share expressions with GDF10: view

Orthologs for GDF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDF10 36
  • 98.67 (n)
  • 98.32 (a)
cow
(Bos Taurus)
Mammalia GDF10 36
  • 85.81 (n)
  • 85.95 (a)
dog
(Canis familiaris)
Mammalia GDF10 36
  • 80.53 (n)
  • 76.2 (a)
mouse
(Mus musculus)
Mammalia Gdf10 36
  • 82.81 (n)
  • 85.33 (a)
Gdf10 16
rat
(Rattus norvegicus)
Mammalia Gdf10 36
  • 82.44 (n)
  • 85.56 (a)
chicken
(Gallus gallus)
Aves GDF10 36
  • 66.67 (n)
  • 67.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia xBMP-3b 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gdf10 36
  • 56.32 (n)
  • 53.69 (a)
zebrafish
(Danio rerio)
Actinopterygii gdf10a 36
  • 62.41 (n)
  • 60.71 (a)
Species with no ortholog for GDF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDF10 Gene

ENSEMBL:
Gene Tree for GDF10 (if available)
TreeFam:
Gene Tree for GDF10 (if available)

Paralogs for GDF10 Gene

Selected SIMAP similar genes for GDF10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDF10: view

No data available for Paralogs for GDF10 Gene

Variants for GDF10 Gene

Sequence variations from dbSNP and Humsavar for GDF10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3007 -- 47,313,015(+) GAATT(A/T)GCCCT utr-variant-3-prime
rs9860 -- 47,313,369(+) AGGGC(A/G)TTGAC utr-variant-3-prime
rs743508 -- 47,312,471(-) GGCAT(A/C)CACCT intron-variant
rs743509 -- 47,312,564(-) AGCTC(C/T)GCCCT intron-variant
rs743510 -- 47,312,696(-) TTCAT(C/T)TTATC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for GDF10 Gene

Variant ID Type Subtype PubMed ID
dgv252e1 CNV Complex 17122850
nsv510991 OTHER Complex 20534489
nsv8636 CNV Gain+Loss 18304495
nsv436102 CNV Deletion 17901297
nsv7203 OTHER Inversion 18451855
esv2736163 CNV Deletion 23290073
nsv467059 CNV Gain 19166990
esv21870 CNV Gain+Loss 19812545
dgv696n71 CNV Gain 21882294
nsv895342 CNV Loss 21882294
nsv895343 CNV Gain 21882294
nsv895344 CNV Loss 21882294
nsv831861 CNV Loss 17160897
essv16333 CNV CNV 17122850
esv1010922 CNV Deletion 20482838

Relevant External Links for GDF10 Gene

HapMap Linkage Disequilibrium report
GDF10

Disorders for GDF10 Gene

(1) Novoseek inferred disease relationships for GDF10 Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 44 2

Relevant External Links for GDF10

Genetic Association Database (GAD)
GDF10
Human Genome Epidemiology (HuGE) Navigator
GDF10
genes like me logo Genes that share disorders with GDF10: view

No data available for UniProtKB/Swiss-Prot for GDF10 Gene

Publications for GDF10 Gene

  1. cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). (PMID: 8670277) Hino J. … Kangawa K. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  2. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein- 3. (PMID: 8679252) Cunningham N.S. … Lee S.-J. (Growth Factors 1995) 2 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 49
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4

Products for GDF10 Gene

Sources for GDF10 Gene

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