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Aliases for GDF10 Gene

Aliases for GDF10 Gene

  • Growth Differentiation Factor 10 2 3 5
  • Bone Morphogenetic Protein 3B 3 4
  • Bone-Inducing Protein 3 4
  • BMP-3b 3 4
  • BMP3B 3 4
  • BIP 3 4
  • Growth/Differentiation Factor 10 3
  • GDF-10 4

External Ids for GDF10 Gene

Previous GeneCards Identifiers for GDF10 Gene

  • GC10P047501
  • GC10P047630
  • GC10M048361
  • GC10M047820
  • GC10M048045
  • GC10M048425
  • GC10M043178

Summaries for GDF10 Gene

Entrez Gene Summary for GDF10 Gene

  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]

GeneCards Summary for GDF10 Gene

GDF10 (Growth Differentiation Factor 10) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is BMP3.

UniProtKB/Swiss-Prot for GDF10 Gene

  • Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Gene Wiki entry for GDF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF10 Gene

Genomics for GDF10 Gene

Regulatory Elements for GDF10 Gene

Enhancers for GDF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G047257 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -40.6 -40591 5.1 HDGF ATF1 TCF12 ZNF766 GATA2 FOS REST ZNF623 TBX21 ZNF592 GDF10 AGAP9 LOC101929216
GH10G047254 1.3 FANTOM5 ENCODE dbSUPER 11.8 -45.1 -45084 0.9 HDGF NFRKB ZSCAN4 MAX CEBPG FOSL1 CTBP1 GATA3 ZNF584 USF2 GDF10 LOC101929216
GH10G047264 1.2 FANTOM5 ENCODE dbSUPER 12.2 -35.2 -35226 0.9 SMARCE1 SOX5 SOX13 PKNOX1 BHLHE40 MAX ZIC2 RARA ZNF274 ZNF766 GDF10 LOC101929216
GH10G047256 1 ENCODE dbSUPER 11.8 -43.3 -43308 0.3 NFRKB CEBPG TCF12 NCOR1 ZSCAN29 FOS RFX1 RNF2 NFYA E2F5 GDF10 LOC101929216
GH10G047276 0.9 ENCODE dbSUPER 11.9 -22.8 -22824 1.7 USF1 MAFG MNT ZIC2 NFIC JUND ZNF316 PBX2 ID3 KDM1A GDF10 LOC101929216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GDF10 on UCSC Golden Path with GeneCards custom track

Promoters for GDF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000027656 76 601 L3MBTL2 SUZ12 RBBP5 EP300 JUND IKZF1 HNF4A ZBTB20 EZH2

Genomic Location for GDF10 Gene

Chromosome:
10
Start:
47,300,224 bp from pter
End:
47,313,583 bp from pter
Size:
13,360 bases
Orientation:
Plus strand

Genomic View for GDF10 Gene

Genes around GDF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF10 Gene

Proteins for GDF10 Gene

  • Protein details for GDF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55107-GDF10_HUMAN
    Recommended name:
    Growth/differentiation factor 10
    Protein Accession:
    P55107
    Secondary Accessions:
    • Q5VSQ8
    • Q9UCX6

    Protein attributes for GDF10 Gene

    Size:
    478 amino acids
    Molecular mass:
    53122 Da
    Quaternary structure:
    • Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.

neXtProt entry for GDF10 Gene

Post-translational modifications for GDF10 Gene

  • Glycosylation at Asn118, isoforms=156, isoforms=281, and isoforms=469
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GDF10 (BMP-3b/GDF-10)
  • Santa Cruz Biotechnology (SCBT) Antibodies for GDF10

Protein Products

No data available for DME Specific Peptides for GDF10 Gene

Domains & Families for GDF10 Gene

Gene Families for GDF10 Gene

Suggested Antigen Peptide Sequences for GDF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55107

UniProtKB/Swiss-Prot:

GDF10_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF10: view

Function for GDF10 Gene

Molecular function for GDF10 Gene

UniProtKB/Swiss-Prot Function:
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Gene Ontology (GO) - Molecular Function for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA,TAS --
genes like me logo Genes that share ontologies with GDF10: view
genes like me logo Genes that share phenotypes with GDF10: view

Animal Models for GDF10 Gene

MGI Knock Outs for GDF10:

Animal Model Products

miRNA for GDF10 Gene

miRTarBase miRNAs that target GDF10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF10 Gene

Localization for GDF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDF10 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IEA --
genes like me logo Genes that share ontologies with GDF10: view

Pathways & Interactions for GDF10 Gene

genes like me logo Genes that share pathways with GDF10: view

Interacting Proteins for GDF10 Gene

Gene Ontology (GO) - Biological Process for GDF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8670277
GO:0001503 ossification IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 8679252
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with GDF10: view

No data available for SIGNOR curated interactions for GDF10 Gene

Drugs & Compounds for GDF10 Gene

No Compound Related Data Available

Transcripts for GDF10 Gene

mRNA/cDNA for GDF10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF10 Gene

Growth differentiation factor 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDF10 Gene

No ASD Table

Relevant External Links for GDF10 Gene

GeneLoc Exon Structure for
GDF10
ECgene alternative splicing isoforms for
GDF10

Expression for GDF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GDF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF10 Gene

This gene is overexpressed in Lung (x4.1).

Protein differential expression in normal tissues from HIPED for GDF10 Gene

This gene is overexpressed in Testis (40.0) and Retina (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GDF10 Gene



Protein tissue co-expression partners for GDF10 Gene

NURSA nuclear receptor signaling pathways regulating expression of GDF10 Gene:

GDF10

SOURCE GeneReport for Unigene cluster for GDF10 Gene:

Hs.2171

mRNA Expression by UniProt/SwissProt for GDF10 Gene:

P55107-GDF10_HUMAN
Tissue specificity: Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.

Evidence on tissue expression from TISSUES for GDF10 Gene

  • Bone(4.3)
genes like me logo Genes that share expression patterns with GDF10: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GDF10 Gene

Orthologs for GDF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDF10 34
  • 98.67 (n)
cow
(Bos Taurus)
Mammalia GDF10 34
  • 85.81 (n)
mouse
(Mus musculus)
Mammalia Gdf10 34 16
  • 82.81 (n)
rat
(Rattus norvegicus)
Mammalia Gdf10 34
  • 82.44 (n)
dog
(Canis familiaris)
Mammalia GDF10 34
  • 80.53 (n)
chicken
(Gallus gallus)
Aves GDF10 34
  • 66.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia gdf10 34
  • 56.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia xBMP-3b 34
zebrafish
(Danio rerio)
Actinopterygii gdf10a 34
  • 62.41 (n)
Species where no ortholog for GDF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDF10 Gene

ENSEMBL:
Gene Tree for GDF10 (if available)
TreeFam:
Gene Tree for GDF10 (if available)

Paralogs for GDF10 Gene

Paralogs for GDF10 Gene

(1) SIMAP similar genes for GDF10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDF10: view

Variants for GDF10 Gene

Sequence variations from dbSNP and Humsavar for GDF10 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs140410142 Uncertain significance 47,310,693(-) CTCCC(A/G)CGCAG reference, missense
rs1000089486 -- 47,305,289(+) AGTGC(A/G)CTCTG intron-variant
rs1000095104 -- 47,311,918(+) GACCC(A/G)GTTGG intron-variant
rs1000479269 -- 47,310,074(+) GCGGC(C/G)TGTGG reference, missense
rs1000930983 -- 47,298,563(+) GGAGA(G/T)ATTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GDF10 Gene

Variant ID Type Subtype PubMed ID
esv1010922 CNV deletion 20482838
nsv831861 CNV loss 17160897

Variation tolerance for GDF10 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GDF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF10 Gene

Disorders for GDF10 Gene

Relevant External Links for GDF10

Genetic Association Database (GAD)
GDF10
Human Genome Epidemiology (HuGE) Navigator
GDF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDF10

No disorders were found for GDF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDF10 Gene

Publications for GDF10 Gene

  1. cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). (PMID: 8670277) Hino J. … Kangawa K. (Biochem. Biophys. Res. Commun. 1996) 3 4 22 64
  2. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein- 3. (PMID: 8679252) Cunningham N.S. … Lee S.-J. (Growth Factors 1995) 2 3 4 64
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma. (PMID: 25728212) Cheng C.W. … Lee A.Y. (Mol. Carcinog. 2016) 3 64

Products for GDF10 Gene

Sources for GDF10 Gene

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