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GDF1 Gene

protein-coding   GIFtS: 53
GCID: GC19M018979

Growth Differentiation Factor 1

  See GDF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Growth Differentiation Factor 11 2
GDF-12 3
DORV2 5
DTGA32 5
RAI2 5
Embryonic Growth/Differentiation Factor 12

External Ids:    HGNC: 42141   Entrez Gene: 26572   Ensembl: ENSG000001302837   OMIM: 6028805   UniProtKB: P275393   

Export aliases for GDF1 gene to outside databases

Previous GC identifers: GC19U990041 GC19M019371 GC19M018824 GC19M018842 GC19M018843 GC19M018543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GDF1 Gene:
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group
of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature
protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth
and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved
in the establishment of left-right asymmetry in early embryogenesis and in neural development in later
embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance
gene. Mutations in this gene are associated with several congenital cardiovascular malformations. (provided by
RefSeq, Mar 2014)

GeneCards Summary for GDF1 Gene:
GDF1 (growth differentiation factor 1) is a protein-coding gene. Diseases associated with GDF1 include transposition of great arteries, dextro-looped 3, and double outlet right ventricle. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: GDF1_HUMAN, P27539
Function: May mediate cell differentiation events during embryonic development

Gene Wiki entry for GDF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the GDF1 gene promoter:
         GR   SRF   SRF (504 AA)   XBP-1   E47   c-Ets-1   FOXJ2 (long isoform)   GR-alpha   ZIC2/Zic2   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GDF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GDF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

GDF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDF1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018979:  view genomic region     (about GC identifiers)

Start:
18,979,361 bp from pter      End:
19,006,953 bp from pter
Size:
27,593 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GDF1_HUMAN, P27539 (See protein sequence)
Recommended Name: Embryonic growth/differentiation factor 1 precursor  
Size: 372 amino acids; 39475 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Miscellaneous: This protein is produced by a bicistronic gene which also produces the CERS1 protein from a
non-overlapping reading frame
Secondary accessions: O43344

Explore the universe of human proteins at neXtProt for GDF1: NX_P27539

Explore proteomics data for GDF1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn206

  • See GDF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001483.3  
    ENSEMBL proteins: 
     ENSP00000247005  
    Reactome Protein details: P27539

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P27539

    ProtoNet protein and cluster: P27539

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: GDF1_HUMAN, P27539
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with GDF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDF1_HUMAN, P27539
    Function: May mediate cell differentiation events during embryonic development

         Genatlas biochemistry entry for GDF1:
    growth/differentiation factor 1,TGFB superfamily,downstream ORF of a bicistronic transcript

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with GDF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GDF1:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gdf1) (see all 17):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     liver/biliary system  mortality/aging  nervous system  normal  renal/urinary system 

    Find genes that share phenotypes with GDF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GDF1: Gdf1tm1.1Dmus Gdf1tm1Sjl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GDF1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GDF1_HUMAN, P27539: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with GDF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GDF1 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway
    2L1CAM interactions
    Developmental Biology0.63
    3Signaling by NODAL
    Signaling by NODAL0.39


    Find genes that share SuperPaths with GDF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for GDF1
        TGF-beta Signaling Pathway

    1 Reactome Pathway for GDF1
        Signaling by NODAL


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GDF1
    Interactions:

        Search GeneGlobe Interaction Network for GDF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for GDF1 (ENSP000002470054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCH1ENSP000003323534STRING: ENSP00000332353
    DHHENSP000002669914STRING: ENSP00000266991
    IHHENSP000002957314STRING: ENSP00000295731
    SHHENSP000002972614STRING: ENSP00000297261
    NANOGENSP000002293074STRING: ENSP00000229307
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0040007growth IEA--

    Find genes that share ontologies with GDF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GDF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GDF1 gene: 
    NM_001492.5  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000247005(uc002nki.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GDF1
      QuantiFast Probe-based Assays in human, mouse, rat GDF1

    Selected AceView cDNA sequences (see all 96):

    AA457570 AI671986 BM503247 BQ876590 NM_198207 AA912332 CR623677 BQ636104 
    AI936592 NM_021267 BM129680 CR614536 BM727671 AI017572 AI671814 BF516540 
    CR594445 BG060020 AL134361 CF541171 BM503409 BX339170 BX419800 BM129393 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GDF1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -     -     -                                             
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for GDF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GDF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GDF1 Expression
    About this image

    GDF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GDF1 Protein Expression

    UniProtKB/Swiss-Prot: GDF1_HUMAN, P27539
    Tissue specificity: Expressed in the brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GDF1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gdf11 , 5 growth differentiation factor 11, 5 74.87(n)1
    72.84(a)1
      8 (34.15 cM)5
    145591  NM_008107.41  NP_032133.21 
     703298175 
    chicken
    (Gallus gallus)
    Aves CVG16
    Gallus gallus growth differentiation factor 3 (GDF...
    36(a)
    1 → many
    28(3514060-3516165)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    23(a)
    many ↔ many
    LGf(3407164-3410255)
    zebrafish
    (Danio rerio)
    Actinopterygii dvr16
    decapentaplegic and Vg-related 1
    34(a)
    1 → many
    17(4016813-4029597) ENSDARG00000037995
    fruit fly
    (Drosophila melanogaster)
    Insecta dpp6
    decapentaplegic
    13(a)
    1 → many
    2L(2428372-2459823)


    ENSEMBL Gene Tree for GDF1 (if available)
    TreeFam Gene Tree for GDF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GDF1 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP22  BMP102  BMP72  BMP8A2  BMP62  
    2 SIMAP similar genes for GDF1 using alignment to 1 protein entry:     GDF1_HUMAN:
    GDF3    GDF3A

    Find genes that share paralogs with GDF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for GDF1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0653354
    Conotruncal heart malformations (CTHM)4--see VAR_0653352 C Y mis40--------
    VAR_0653384
    Transposition of the great arteries dextro-looped 3 (DTGA3)4--see VAR_0653382 A T mis40--------
    VAR_0653374
    Tetralogy of Fallot (TOF)4--see VAR_0653372 P T mis40--------
    VAR_0653364
    Tetralogy of Fallot (TOF)4--see VAR_0653362 S P mis40--------
    VAR_0653334
    Tetralogy of Fallot (TOF)4--see VAR_0653332 G D mis40--------
    VAR_0653324
    ----see VAR_0653322 R H mis40--------
    VAR_0653344
    ----see VAR_0653342 G S mis40--------
    rs48088631,2,4
    ----see VAR_0282742 mis40--------

    HapMap Linkage Disequilibrium report for GDF1 (18979361 - 19006953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GDF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28733CNV Loss19812545
    dgv3787n71CNV Loss21882294
    nsv833777CNV Loss17160897
    nsv470132CNV Loss18288195
    nsv911299CNV Loss21882294
    dgv3786n71CNV Loss21882294
    dgv3788n71CNV Loss21882294
    nsv828473CNV Gain20364138

    Human Gene Mutation Database (HGMD): GDF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GDF1
    DNA2.0 Custom Variant and Variant Library Synthesis for GDF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602880   
    OMIM disorders: 217095  187500  613854  208530  
    UniProtKB/Swiss-Prot: GDF1_HUMAN, P27539
  • Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the
    outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of
    great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate
    aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and
    the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery
    and aorta arise from the right ventricle. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Transposition of the great arteries dextro-looped 3 (DTGA3) [MIM:613854]: A congenital heart defect
    consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right
    ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate
    pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or
    absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients
    with transposition of the great arteries. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis,
    ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and
    hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor)
    is pumped into the body often causing cyanosis. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Right atrial isomerism (RAI) [MIM:208530]: A severe complex congenital heart defect resulting from
    embryonic disruption of proper left-right axis determination. RAI is usually characterized by complete
    atrioventricular septal defect with a common atrium and univentricular AV connection, total anomalous pulmonary
    drainage, and transposition or malposition of the great arteries. Affected individuals present at birth with
    severe cardiac failure. Other associated abnormalities include bilateral trilobed lungs, midline liver, and
    asplenia, as well as situs inversus affecting other organs. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 13 diseases for GDF1:    
    About MalaCards
    transposition of great arteries, dextro-looped 3    double outlet right ventricle    right atrial isomerism    transposition of the great arteries
    tetralogy of fallot    conotruncal heart malformations    ventricular septal defect    transposition of the great arteries, dextro-looped 1
    conotruncal heart malformations, variable    tetrology of fallot    persistent truncus arteriosus    klippel-feil syndrome
    velocardiofacial syndrome

    4 diseases from the University of Copenhagen DISEASES database for GDF1:
    Situs inversus     Klippel-Feil syndrome     Tetralogy of Fallot     Ventricular septal defect

    Find genes that share disorders with GDF1           About GenesLikeMe

    Genetic Association Database (GAD): GDF1
    Human Genome Epidemiology (HuGE) Navigator: GDF1 (3 documents)

    Export disorders for GDF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GDF1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with GDF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. (PubMed id 2034669)1, 2, 3, 9 Lee S.-J. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans. (PubMed id 17924340)1, 2, 9 Karkera J.D.... Muenke M. (Am. J. Hum. Genet. 2007)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1). (PubMed id 20413652)1, 2 Kaasinen E....Lehtonen R. (Hum. Mol. Genet. 2010)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Association of growth/differentiation factor 1 gene polymorphisms with the risk of congenital heart disease in the Chinese Han population. (PubMed id 23076529)1 Sun X....Xie X. (Mol. Biol. Rep. 2013)
    8. New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle. (PubMed id 20807224)1 De Luca A....Dallapiccola B. (Clin. Genet. 2011)
    9. Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma. (PubMed id 19359031)1 Li J....Hu L. (Gynecol. Oncol. 2009)
    10. Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. (PubMed id 19553149)1 Roessler E....Muenke M. (Mol. Genet. Metab. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2657 HGNC: 4214 AceView: GDF1 Ensembl:ENSG00000130283 euGenes: HUgn2657
    ECgene: GDF1 H-InvDB: GDF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GDF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GDF1 gene:
    Search GeneIP for patents involving GDF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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