GDAP2 Gene
protein-coding GIFtS: 47
GCID: GC01M118406
|
|
ganglioside induced differentiation associated protein 2
| |
Aliases
for GDAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ganglioside Induced Differentiation Associated Protein 21 2 | | MACROD31 2 | | DJ776P7.11 | | FLJ201421 | | Ganglioside-Induced Differentiation-Associated Protein 22 |
Export aliases for GDAP2 gene to outside databasesPrevious GC identifers: GC01M118870 GC01M117249 GC01M117559 GC01M117758 GC01M118124 GC01M118213 GC01M116262 |
Summaries
for GDAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for GDAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GDAP2 gene promoter:
Max1 AML1a FOXD3 HNF-4alpha1 Roaz GATA-1 HEN1 Pax-3 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for GDAP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GDAP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p12 Ensembl cytogenetic band: 1p12 HGNC cytogenetic band: 1q11GDAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M118406: view genomic region
(about GC identifiers)
Start:
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118,406,107 bp from pter |
End:
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118,472,302 bp from pter |
Size:
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66,196 bases |
Orientation:
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minus strand |
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Proteins
for GDAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GDAP2_HUMAN, Q9NXN4 (See
protein sequence)Recommended Name: Ganglioside-induced differentiation-associated protein 2 Size: 497 amino acids; 56225 Da
Secondary accessions: Q96DZ0Alternative splicing: 2 isoforms: Q9NXN4-1 Q9NXN4-2 Explore the universe of human proteins at neXtProt for GDAP2: NX_Q9NXN4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXN4
GDAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001129061.1 NP_060156.1
ENSEMBL proteins: ENSP00000358451 ENSP00000358450
Human Recombinant Protein Products:
GDAP2 Antibody Products:
Assay Products for GDAP2: |
Protein
Domains /
Families
for GDAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GDAP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NXN4ProtoNet protein and cluster: Q9NXN4 1 Blocks protein family: IPB002589 Protein of unknown function Appr-1
UniProtKB/Swiss-Prot: GDAP2_HUMAN, Q9NXN4Similarity: Belongs to the GDAP2 familySimilarity: Contains 1 CRAL-TRIO domainSimilarity: Contains 1 Macro domain |
Function
for GDAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GDAP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GDAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for GDAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDAP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDAP2 |
|
Pathways & Interactions
for GDAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GDAP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/20 Interacting proteins for GDAP2 (Q9NXN43 ENSP000003584514) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032526 | response to retinoic acid |
IEA | -- |
GDAP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for GDAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GDAP2
Search CenterWatch for drugs/clinical trials and news about GDAP2
|
Transcripts
for GDAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GDAP2 gene (2 alternative transcripts): NM_001135589.1 NM_017686.3 Unigene Cluster for GDAP2: Ganglioside induced differentiation associated protein 2 Hs.594430 [show with all ESTs]Unigene Representative Sequence: NM_0176866 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369443(uc001ehf.3) ENST00000491626 ENST00000369442(uc001ehg.3)
ENST00000464026 ENST00000493555 ENST00000494224
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GDAP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GDAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): GDAP2 (NM_001135589) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GDAP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDAP2 |
Additional cDNA sequence: AK000149.1 BC013132.1 BC013324.1 BX647355.1 15 DOTS entries: DT.302646 DT.405566 DT.95204507 DT.108555 DT.75163720 DT.100060953 DT.100728323 DT.121463810 DT.206491 DT.40216038 DT.97776638 DT.97840091 DT.100807858 DT.100856937 DT.91915546 24/77 AceView cDNA sequences (see all 77): BX097755 BU172470 AI093725 CB215945 BM974974 BE552139 AI189593 CR608212 BC013132 CN481299 CN479023 AI589069 AA281184 CR601966 AI373061 BM462998 AA788854 AI125031 BM459136 BG252723 AA281062 BP351406 BX362126 BP380501
GeneLoc Exon Structure
|
Expression
for GDAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GDAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGATTGTG
About this image
See GDAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GDAP2
SOURCE GeneReport for Unigene cluster: Hs.594430
SABiosciences Custom PCR Arrays for GDAP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GDAP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GDAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GDAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GDAP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDAP2 |
Orthologs
for GDAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GDAP2 gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GDAP21 |
ganglioside induced differentiation associated protein more |
77.8(n)
86.12(a) |
|
425913 XM_423602.3 XP_423602.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GDAP26 |
-- |
80(a) |
1 ↔ 1 |
GL343218.1(915916-933332) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.257462 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.59(n) |
|
48027994 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.44182 |
Transcribed sequence with weak similarity to protein more |
73.12(n) |
|
CK028217.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG188121 , 3 |
CG188121 |
43(a)
(best of 2)3
50.03(n)1
43.61(a)1 |
|
591731 NM_165552.31 NP_724597.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G693401 |
appr-1-p processing enzyme-like protein |
46.67(n)
37.92(a) |
|
843266 NM_105601.3 NP_564960.1 |
rice
(Oryza sativa) |
Liliopsida |
Os10g04444001 |
hypothetical protein |
47.32(n)
38.78(a) |
|
4348739 NM_001071241.1 NP_001064706.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ymdB6 |
O-acetyl-ADP-ribose deacetylase; RNase III inhibit... |
30(a) |
possible ortholog |
Chromosome(1105043-1105576) |
ENSEMBL Gene Tree for GDAP2 (if available)
TreeFam Gene Tree for GDAP2 (if available) |
Paralogs
for GDAP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GDAP2 gene
- MACROD22 MACROD12
GDAP2 for paralogs About GeneDecksing
|
Genomic Variants
for GDAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GDAP2 (118406107 - 118472302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GDAP2
2 CNVs: 97481 47888 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GDAP2 |
|
Disorders
/ Diseases
for GDAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GDAP2 for disorders About GeneDecksing
2  diseases for GDAP2: About MalaCardstuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: GDAP2 (1 document)
Export disorders for GDAP2 gene to outside databases
|
Publications
for GDAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GDAP2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with GDAP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for GDAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GDAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GDAP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GDAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for GDAP2 gene:
Search GeneIP for patents involving GDAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GDAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GDAP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GDAP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GDAP2 | | | OriGene Protein Over-expression Lysate for GDAP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GDAP2 | | OriGene 3'-UTR Clone for GDAP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GDAP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GDAP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GDAP2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GDAP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GDAP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GDAP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GDAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GDAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GDAP2 |
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 | | | GDAP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDAP2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDAP2 |
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