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Aliases for GDAP1L1 Gene

Aliases for GDAP1L1 Gene

  • Ganglioside Induced Differentiation Associated Protein 1-Like 1 2 3
  • GDAP1-L1 3 4
  • DJ995J12.1.1 3
  • DJ881L22.1 3

External Ids for GDAP1L1 Gene

Previous GeneCards Identifiers for GDAP1L1 Gene

  • GC20P042604
  • GC20P043514
  • GC20P043561
  • GC20P042309
  • GC20P042875
  • GC20P039613

Summaries for GDAP1L1 Gene

Entrez Gene Summary for GDAP1L1 Gene

  • The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for GDAP1L1 Gene

GDAP1L1 (Ganglioside Induced Differentiation Associated Protein 1-Like 1) is a Protein Coding gene. Diseases associated with GDAP1L1 include charcot-marie-tooth disease. An important paralog of this gene is GDAP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDAP1L1 Gene

Genomics for GDAP1L1 Gene

Regulatory Elements for GDAP1L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GDAP1L1 Gene

Chromosome:
20
Start:
44,247,099 bp from pter
End:
44,280,917 bp from pter
Size:
33,819 bases
Orientation:
Plus strand

Genomic View for GDAP1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GDAP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDAP1L1 Gene

Proteins for GDAP1L1 Gene

  • Protein details for GDAP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MZ0-GD1L1_HUMAN
    Recommended name:
    Ganglioside-induced differentiation-associated protein 1-like 1
    Protein Accession:
    Q96MZ0
    Secondary Accessions:
    • B7Z621
    • Q5TE60
    • Q68CW7
    • Q9BQJ7
    • Q9BQV4
    • Q9BWJ4
    • Q9H3Y2
    • Q9H4G5

    Protein attributes for GDAP1L1 Gene

    Size:
    367 amino acids
    Molecular mass:
    41973 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GDAP1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GDAP1L1 Gene

Proteomics data for GDAP1L1 Gene at MOPED

Post-translational modifications for GDAP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GDAP1L1 Gene

Domains & Families for GDAP1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MZ0

UniProtKB/Swiss-Prot:

GD1L1_HUMAN :
  • Contains 1 GST C-terminal domain.
  • Belongs to the GST superfamily.
Domain:
  • Contains 1 GST C-terminal domain.
  • Contains 1 GST N-terminal domain.
Family:
  • Belongs to the GST superfamily.
genes like me logo Genes that share domains with GDAP1L1: view

No data available for Gene Families for GDAP1L1 Gene

Function for GDAP1L1 Gene

Gene Ontology (GO) - Molecular Function for GDAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with GDAP1L1: view

Phenotypes for GDAP1L1 Gene

GenomeRNAi human phenotypes for GDAP1L1:
genes like me logo Genes that share phenotypes with GDAP1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDAP1L1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GDAP1L1 Gene

Localization for GDAP1L1 Gene

Gene Ontology (GO) - Cellular Components for GDAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GDAP1L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GDAP1L1 Gene

Pathways & Interactions for GDAP1L1 Gene

SuperPathways for GDAP1L1 Gene

No Data Available

Interacting Proteins for GDAP1L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341782%0d%0a9606.ENSP00000249396%0d%0a
Selected Interacting proteins: Q96MZ0-GD1L1_HUMAN ENSP00000341782 for GDAP1L1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for GDAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
genes like me logo Genes that share ontologies with GDAP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for GDAP1L1 Gene

Drugs & Compounds for GDAP1L1 Gene

No Compound Related Data Available

Transcripts for GDAP1L1 Gene

Unigene Clusters for GDAP1L1 Gene

Ganglioside induced differentiation associated protein 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDAP1L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDAP1L1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for GDAP1L1 Gene

GeneLoc Exon Structure for
GDAP1L1
ECgene alternative splicing isoforms for
GDAP1L1

Expression for GDAP1L1 Gene

mRNA expression in normal human tissues for GDAP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDAP1L1 Gene

This gene is overexpressed in Brain - Cortex (x6.7), Brain - Frontal Cortex (BA9) (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Cerebellum (x4.3), Brain - Amygdala (x4.3), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for GDAP1L1 Gene

This gene is overexpressed in Fetal Brain (33.0), Brain (20.7), and Frontal cortex (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GDAP1L1 Gene



SOURCE GeneReport for Unigene cluster for GDAP1L1 Gene Hs.517059

genes like me logo Genes that share expression patterns with GDAP1L1: view

Protein tissue co-expression partners for GDAP1L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GDAP1L1 Gene

Orthologs for GDAP1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GDAP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GDAP1L1 35
  • 93.91 (n)
  • 98.37 (a)
GDAP1L1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GDAP1L1 35
  • 93.91 (n)
  • 97.55 (a)
GDAP1L1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdap1l1 35
  • 92.19 (n)
  • 97.82 (a)
Gdap1l1 16
Gdap1l1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GDAP1L1 35
  • 99.73 (n)
  • 100 (a)
GDAP1L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdap1l1 35
  • 91.07 (n)
  • 97.81 (a)
oppossum
(Monodelphis domestica)
Mammalia GDAP1L1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GDAP1L1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves GDAP1L1 35
  • 81.93 (n)
  • 86.1 (a)
GDAP1L1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gdap1l1 35
  • 74.18 (n)
  • 82.42 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19824 35
gdap1l1 35
  • 75.71 (n)
  • 80.27 (a)
gdap1l1 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4623 36
  • 26 (a)
OneToMany
Species with no ortholog for GDAP1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDAP1L1 Gene

ENSEMBL:
Gene Tree for GDAP1L1 (if available)
TreeFam:
Gene Tree for GDAP1L1 (if available)

Paralogs for GDAP1L1 Gene

Paralogs for GDAP1L1 Gene

(1) SIMAP similar genes for GDAP1L1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GDAP1L1: view

Variants for GDAP1L1 Gene

Sequence variations from dbSNP and Humsavar for GDAP1L1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2293 -- 44,263,169(-) CACCT(C/G)CCTTA intron-variant
rs761331 -- 44,264,990(-) TGTGA(C/G)ATGCT intron-variant
rs1884607 -- 44,278,902(+) GAAGC(A/G)AGTGT intron-variant
rs2017384 -- 44,256,438(-) GCCAC(C/T)TCAGC intron-variant
rs2073133 -- 44,258,857(-) AAGTC(A/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDAP1L1 Gene

Variant ID Type Subtype PubMed ID
esv28837 CNV Loss 19812545
nsv3388 CNV Insertion 18451855

Variation tolerance for GDAP1L1 Gene

Residual Variation Intolerance Score: 57.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDAP1L1 Gene

HapMap Linkage Disequilibrium report
GDAP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDAP1L1 Gene

Disorders for GDAP1L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GDAP1L1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease
  • dejerine-sottas disease
- elite association

Relevant External Links for GDAP1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDAP1L1
genes like me logo Genes that share disorders with GDAP1L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GDAP1L1 Gene

Publications for GDAP1L1 Gene

  1. Functional characterisation of ganglioside-induced differentiation- associated protein 1 as a glutathione transferase. (PMID: 16857173) Shield A.J. … Board P.G. (Biochem. Biophys. Res. Commun. 2006) 23 67
  2. Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. (PMID: 14595091) Marco A. … MarA-n I. (Mol. Biol. Evol. 2004) 23 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67

Products for GDAP1L1 Gene

Sources for GDAP1L1 Gene

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