Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GDA Gene

Aliases for GDA Gene

  • Guanine Deaminase 2 3 5
  • Guanine Aminohydrolase 3 4
  • Guanine Aminase 3 4
  • P51-Nedasin 3 4
  • EC 3.5.4.3 4 61
  • GUANASE 3 4
  • GAH 3 4
  • Cytoplasmic PSD95 Interactor 3
  • KIAA1258 4
  • NEDASIN 3
  • CYPIN 3

External Ids for GDA Gene

Previous GeneCards Identifiers for GDA Gene

  • GC09P065808
  • GC09P066620
  • GC09P068299
  • GC09P070221
  • GC09P071993
  • GC09P073954
  • GC09P074764
  • GC09P044586
  • GC09P074729

Summaries for GDA Gene

Entrez Gene Summary for GDA Gene

  • This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for GDA Gene

GDA (Guanine Deaminase) is a Protein Coding gene. Among its related pathways are Purine metabolism (REACTOME) and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include hydrolase activity and guanine deaminase activity.

UniProtKB/Swiss-Prot for GDA Gene

  • Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDA Gene

Genomics for GDA Gene

Regulatory Elements for GDA Gene

Enhancers for GDA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G072144 1.4 Ensembl ENCODE dbSUPER 19.7 +33.9 33947 8.1 TBP FOXA2 ARID4B SIN3A ZNF48 RAD21 YY1 SCRT2 FOS MXD4 GDA LINC01504 GC09M072151
GH09G072140 0.9 ENCODE dbSUPER 12.4 +26.2 26150 1.1 ELF3 TBP STAT1 JUN MAX CEBPB MNT EP300 JUND STAT3 GDA GC09M072151
GH09G072119 1.2 ENCODE dbSUPER 8.9 +6.4 6362 3.0 ELF3 FOXA2 ATF1 MLX ARID4B DMAP1 ZSCAN9 RAD21 RARA GATA4 GDA GC09M072151
GH09G072126 1.2 ENCODE dbSUPER 8.8 +16.3 16255 8.3 ELF3 HNRNPUL1 FOXA2 ARID4B THRB RAD21 RARA YY1 GATA4 CREM GDA GC09M072151
GH09G072139 0.8 ENCODE dbSUPER 12.5 +24.8 24845 0.2 JUND TAF1 JUN STAT3 EP300 BRCA1 GDA GC09M072151
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GDA on UCSC Golden Path with GeneCards custom track

Genomic Location for GDA Gene

Chromosome:
9
Start:
72,114,595 bp from pter
End:
72,259,059 bp from pter
Size:
144,465 bases
Orientation:
Plus strand

Genomic View for GDA Gene

Genes around GDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDA Gene

Proteins for GDA Gene

  • Protein details for GDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T3-GUAD_HUMAN
    Recommended name:
    Guanine deaminase
    Protein Accession:
    Q9Y2T3
    Secondary Accessions:
    • B4DTY5
    • Q5SZC7
    • Q9H335
    • Q9ULG2

    Protein attributes for GDA Gene

    Size:
    454 amino acids
    Molecular mass:
    51003 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAA86572.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GDA Gene

    Alternative splice isoforms for GDA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GDA Gene

Selected DME Specific Peptides for GDA Gene

Q9Y2T3:
  • LTLKEVFRLATLGGSQALGLD
  • VTPRFSLS
  • EIGNFEVGK

Post-translational modifications for GDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GDA Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2T3

UniProtKB/Swiss-Prot:

GUAD_HUMAN :
  • Belongs to the ATZ/TRZ family.
Family:
  • Belongs to the ATZ/TRZ family.
genes like me logo Genes that share domains with GDA: view

No data available for Gene Families for GDA Gene

Function for GDA Gene

Molecular function for GDA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Guanine + H(2)O = xanthine + NH(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

Enzyme Numbers (IUBMB) for GDA Gene

Gene Ontology (GO) - Molecular Function for GDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding TAS,IEA --
GO:0008892 guanine deaminase activity EXP,TAS 10075721
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GDA: view
genes like me logo Genes that share phenotypes with GDA: view

Animal Model Products

miRNA for GDA Gene

miRTarBase miRNAs that target GDA

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GDA Gene

Localization for GDA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDA gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 2
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10542258
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GDA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GDA Gene

Pathways & Interactions for GDA Gene

genes like me logo Genes that share pathways with GDA: view

Pathways by source for GDA Gene

UniProtKB/Swiss-Prot Q9Y2T3-GUAD_HUMAN

  • Pathway: Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.

Gene Ontology (GO) - Biological Process for GDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 10075721
GO:0006147 guanine catabolic process IEA --
GO:0006195 purine nucleotide catabolic process TAS --
GO:0007399 nervous system development TAS 10542258
genes like me logo Genes that share ontologies with GDA: view

No data available for SIGNOR curated interactions for GDA Gene

Drugs & Compounds for GDA Gene

(9) Drugs for GDA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Guanine Experimental Pharma 0
Xanthine Experimental Pharma 0

(8) Additional Compounds for GDA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with GDA: view

Transcripts for GDA Gene

Unigene Clusters for GDA Gene

Guanine deaminase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for GDA Gene

GeneLoc Exon Structure for
GDA
ECgene alternative splicing isoforms for
GDA

Expression for GDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDA Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x8.7), Brain - Frontal Cortex (BA9) (x6.9), Brain - Cortex (x5.7), Brain - Hippocampus (x4.3), Liver (x4.3), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GDA Gene

This gene is overexpressed in Ovary (48.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GDA Gene



NURSA nuclear receptor signaling pathways regulating expression of GDA Gene:

GDA

SOURCE GeneReport for Unigene cluster for GDA Gene:

Hs.494163

Evidence on tissue expression from TISSUES for GDA Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Liver(4.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GDA: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDA Gene

Orthologs for GDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDA 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia GDA 34 35
  • 90.9 (n)
dog
(Canis familiaris)
Mammalia GDA 34 35
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia Gda 34 16 35
  • 88.25 (n)
rat
(Rattus norvegicus)
Mammalia Gda 34
  • 87.67 (n)
oppossum
(Monodelphis domestica)
Mammalia GDA 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GDA 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GDA 34 35
  • 70.74 (n)
lizard
(Anolis carolinensis)
Reptilia GDA 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gda 34
  • 62.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398728 34
zebrafish
(Danio rerio)
Actinopterygii gda 34 35
  • 63.04 (n)
Dr.23036 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005282 34
  • 51.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta DhpD 34 35
  • 51.4 (n)
CG18143 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUD1 34 35 37
  • 51.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19492g 34
  • 48.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1672.03c 34
  • 50.66 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07309 34
  • 46.95 (n)
Species where no ortholog for GDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDA Gene

ENSEMBL:
Gene Tree for GDA (if available)
TreeFam:
Gene Tree for GDA (if available)

Paralogs for GDA Gene

(7) SIMAP similar genes for GDA Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GDA Gene

genes like me logo Genes that share paralogs with GDA: view

No data available for Paralogs for GDA Gene

Variants for GDA Gene

Sequence variations from dbSNP and Humsavar for GDA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000005537 -- 72,237,072(+) ACCAC(A/G)CCTGG intron-variant
rs1000054402 -- 72,234,657(+) GGTAA(A/G)TCTTT intron-variant
rs1000083680 -- 72,234,291(+) ATGAG(A/G)GAATT intron-variant
rs1000086604 -- 72,175,476(+) TTGGA(A/C)CTGTT intron-variant
rs1000099774 -- 72,236,698(+) TGTCT(C/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GDA Gene

Variant ID Type Subtype PubMed ID
esv2634959 CNV deletion 19546169
esv2666473 CNV deletion 23128226
esv2738549 CNV deletion 23290073
esv3573260 CNV loss 25503493
esv3620628 CNV loss 21293372
nsv1042680 CNV loss 25217958
nsv466420 CNV loss 19166990
nsv614610 CNV loss 21841781
nsv831618 CNV loss 17160897

Variation tolerance for GDA Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDA Gene

Disorders for GDA Gene

Relevant External Links for GDA

Genetic Association Database (GAD)
GDA
Human Genome Epidemiology (HuGE) Navigator
GDA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDA

No disorders were found for GDA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDA Gene

Publications for GDA Gene

  1. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. (PMID: 10075721) Yuan G. … Snyder F.F. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. (PMID: 10542258) Kuwahara H. … Saya H. (J. Biol. Chem. 1999) 3 4 22 64
  3. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PMID: 20877300) Perroud N. … McGuffin P. (Pharmacogenomics J. 2012) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Alteration of enzyme specificity by computational loop remodeling and design. (PMID: 19470646) Murphy P.M. … Baker D. (Proc. Natl. Acad. Sci. U.S.A. 2009) 4 22 64

Products for GDA Gene

Sources for GDA Gene

Content
Loading form....