GDA Gene

Aliases
for GDA gene

Previous GC identifers: GC09P065808 GC09P066620 GC09P068299 GC09P070221 GC09P071993 GC09P073954 GC09P074764 GC09P044586

Summaries
for GDA gene

Genomic Views
for GDA gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmid: GDA promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GDA

GDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P074729:  view genomic region     (about GC identifiers)

Proteins
for GDA gene

3 PDB 3D structures from and Proteopedia for GDA:

2UZ9 (3D)        3E0L (3D)        4AQL (3D)    

Explore the universe of human proteins at neXtProt for GDA: NX_Q9Y2T3

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GDA OriGene Protein Over-expression Lysate: GDA OriGene Custom Protein Services for GDA
	GenScript Custom Purified and Recombinant Proteins Services for GDA
	Novus Biologicals GDA Protein Novus Biologicals GDA Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for GDA

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for GDA
	GenScript Custom Superior Antibodies Services for GDA
	Novus Biologicals GDA Antibodies
	Search for Antibodies for GDA at Abcam
	Uscn Antibodies for GDA
	ThermoFisher Antibodies for GDA

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GDA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GDA

Protein Domains /
Families
for GDA gene

ProtoNet protein and cluster: Q9Y2T3

Function
for GDA gene

Enzyme Number (IUBMB): EC 3.5.4.3^{1 2}

miRNA Products:		OriGene 3'-UTR Clone: GDA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GDA
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate GDA (see all 56):
		hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-548k hsa-miR-301a hsa-miR-624 hsa-miR-30d hsa-miR-342-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GDA (see all 7) OriGene shRNA RFP: GDA OriGene siRNA: GDA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GDA

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GDA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GDA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GDA OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GDA (NM_004293)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GDA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GDA
		Search LifeMap BioReagents cell lines for GDA

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDA

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for GDA gene

	Super-pathway	contained gene-specific pathways
1	Purine metabolism	Purine metabolism 1.00 Purine catabolism 0.30 Metabolism of nucleotides 0.42
2	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
3	Purine metabolism	Purine metabolism 1.00
4	purine nucleotides degradation II (aerobic)	purine nucleotides degradation II (aerobic) 1.00
5	adenine and adenosine salvage III	guanosine nucleotides degradation III 0.17

2 BioSystems Pathways for GDA

	purine nucleotides degradation II (aerobic)
	guanosine nucleotides degradation III

4        Reactome Pathways for GDA

	Metabolism of nucleotides
	Metabolism
	Purine catabolism
	Purine metabolism

2         Kegg Pathways  (Kegg details for GDA)

	Purine metabolism
	Metabolic pathways

GDA for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GDA

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/27 Interacting proteins for GDA (Q9Y2T3^{2, 3} ENSP00000351170⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for GDA gene

Transcripts
for GDA gene

Expression
for GDA gene

GDA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTATTCA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Cardiomyocyte-like cells (Spontaneous differen...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GDA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GDA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GDA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GDA

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDA

Orthologs
for GDA gene

Paralogs
for GDA gene

Genomic Variants
for GDA gene

10/2229 NCBI SNPs in GDA are shown (see all 2229)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs727419521,2	C,F,	--	44550040(+)	CAGCTG/ACTTAC	1	--	us2k1		1		NA	120
rs70244301,2	C,F,H,	--	44550057(+)	CATCTT/CGGTGA	1	--	us2k1		5		NS EA WA	538
rs769338101,2	C,	--	44550585(+)	AATAAA/GTCATT	1	--	us2k1		5		NA CSA WA	242
rs557880731,2	C,	--	44551543(+)	CTGCTC/TTCTAC	1	--	int1		2		WA	120
rs2020551521,2	C	--	44551686(+)	CAGGAA/CCTGCC	1	--	int1		0	--	--	--	--
rs123478341,2	F,H,	--	44551757(+)	GAGGAG/TCAGGG	1	--	int1		8		NS EA CSA WA NA	648
rs123491931,2	C,	--	44552864(+)	gttgcC/Ggtgag	1	--	int1		2		NA CSA	3
rs1131854441,2		--	44553159(+)	AATCTT/CGGCTC	1	--	int1		1		CSA	1
rs123493151,2		--	44553234(+)	tacagT/Gtgtgc	1	--	int1		1		CSA	1
rs43959551,2	C,A,	--	44553574(+)	ggtgtT/Gctgca	1	--	int1		2		CSA	2

HapMap Linkage Disequilibrium report for GDA (74729511 - 74872109 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GDA
     1 CNV: 100663

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GDA

DNA2.0 Custom Variant and Variant Library Synthesis for GDA

Disorders / Diseases
for GDA gene

8 diseases for GDA

2 Novoseek disease relationships for GDA gene    About this table

Publications
for GDA gene

PubMed articles for GDA gene, integrated from 9 sources (see all 68): (articles sorted by number of sources associating them with GDA)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. (PubMed id 10075721)^{1, 2, 3, 9} Yuan G.... Snyder F.F. (1999)
2. A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. (PubMed id 10542258)^{1, 2, 9} Kuwahara H.... Saya H. (1999)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
6. Isolation and characterization of human liver guanine deaminase. (PubMed id 3966794)^{1, 3} Gupta N.K. and Glantz M.D. (1985)
7. A histochemical and immunohistochemical investigation of guanase and nedasin in rat and human tissues. (PubMed id 16953061)^{1, 9} Sannomiya K....Ito S. (2006)
8. Histochemical and immunohistochemical investigation of guanase and nedasin in human tissues. (PubMed id 16953063)^{1, 9} Kubo K....Ito S. (2006)
9. Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. (PubMed id 10595517)^{1, 9} Firestein B.L....Bredt D.S. (1999)
10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

External Searches for GDA gene

Genome Databases showing GDA gene

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Specialized Databases showing GDA gene

Products
for GDA gene