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GDA Gene

protein-coding   GIFtS: 63
GCID: GC09P074729

Guanine Deaminase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Guanine Deaminase1 2     CYPIN2 5
Guanine Aminase2 3     GUANASE2
Guanine Aminohydrolase2 3     NEDASIN2
GAH2 3     Cytoplasmic PSD95 Interactor2
p51-nedasin2 3     Guanase3
EC 3.5.4.33 8     KIAA12583

External Ids:    HGNC: 42121   Entrez Gene: 96152   Ensembl: ENSG000001191257   OMIM: 1392605   UniProtKB: Q9Y2T33   

Export aliases for GDA gene to outside databases

Previous GC identifers: GC09P065808 GC09P066620 GC09P068299 GC09P070221 GC09P071993 GC09P073954 GC09P074764 GC09P044586


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GDA Gene:
This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest
this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for GDA Gene:
GDA (guanine deaminase) is a protein-coding gene.

UniProtKB/Swiss-Prot: GUAD_HUMAN, Q9Y2T3
Function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GDA gene promoter:
         p53   AREB6   IRF-2   S8   PPAR-gamma1   Nkx6-1   STAT3   PPAR-gamma2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGDA promoter sequence
   Search Chromatin IP Primers for GDA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GDA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

GDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GDA gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P074729:  view genomic region     (about GC identifiers)

Start:
74,729,511 bp from pter      End:
74,872,109 bp from pter
Size:
142,599 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GUAD_HUMAN, Q9Y2T3 (See protein sequence)
Recommended Name: Guanine deaminase  
Size: 454 amino acids; 51003 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homodimer
Sequence caution: Sequence=BAA86572.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for GDA:
2UZ9 (3D)        3E0L (3D)        4AQL (3D)    
Secondary accessions: B4DTY5 Q5SZC7 Q9H335 Q9ULG2
Alternative splicing: 3 isoforms:  Q9Y2T3-1   Q9Y2T3-2   Q9Y2T3-3   

Explore the universe of human proteins at neXtProt for GDA: NX_Q9Y2T3

Explore proteomics data for GDA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for GDA (Q9Y2T3)
     VTPRFSLS  EIGNFEVGK  LTLKEVFRLATLGGSQALGLD 


    See GDA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229434.1  NP_001229435.1  NP_001229436.1  NP_004284.1  

    ENSEMBL proteins: 
     ENSP00000366185   ENSP00000351170   ENSP00000436619   ENSP00000403897   ENSP00000434682  
     ENSP00000400857   ENSP00000238018   ENSP00000366188   ENSP00000437972  
    Reactome Protein details: Q9Y2T3

    GDA Human Recombinant Protein Products:

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    Novus Biologicals GDA Proteins
    Novus Biologicals GDA Lysate
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    ProSpec Recombinant Protein for GDA
    Cloud-Clone Corp. Proteins for GDA

     
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    antibodies-online proteins for GDA (4 products) 

     
    antibodies-online peptides for GDA

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    GDA Assay Products:

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    Cloud-Clone Corp. ELISAs for GDA
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    antibodies-online kits for GDA (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR014311 Guanine_deaminase
     IPR006680 Amidohydro_1

    Graphical View of Domain Structure for InterPro Entry Q9Y2T3

    ProtoNet protein and cluster: Q9Y2T3

    1 Blocks protein domain: IPB011550 Amidohydrolase-like

    UniProtKB/Swiss-Prot: GUAD_HUMAN, Q9Y2T3
    Similarity: Belongs to the ATZ/TRZ family


    Find genes that share domains with GDA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GUAD_HUMAN, Q9Y2T3
    Function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity)
    Catalytic activity: Guanine + H(2)O = xanthine + NH(3)

         Enzyme Number (IUBMB): EC 3.5.4.31 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0008892guanine deaminase activity EXP--
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with GDA           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GDA

    miRNA
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    miRTarBase miRNAs that target GDA:
    hsa-mir-124-3p (MIRT022762)

    Block miRNA regulation of human, mouse, rat GDA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GDA (see all 56):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-548k hsa-miR-301a hsa-miR-624 hsa-miR-30d hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GDA

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    cytoskeleton1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS10542258
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GDA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GDA About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (REACTOME)
    Purine metabolism0.42
    Purine catabolism0.00
    Metabolism of nucleotides0.42
    guanosine nucleotides degradation0.00
    purine nucleotides degradation0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Purine metabolism (KEGG)
    Purine metabolism0.38


    Find genes that share SuperPaths with GDA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GDA
        guanosine nucleotides degradation
    purine nucleotides degradation

    1 Reactome Pathway for GDA
        Purine catabolism


    2 Kegg Pathways  (Kegg details for GDA):
        Purine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: GUAD_HUMAN, Q9Y2T3
    Pathway: Purine metabolism; guanine degradation; xanthine from guanine: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GDA
    Interactions:

        GeneGlobe Interaction Network for GDA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for GDA (Q9Y2T32, 3 ENSP000003511704) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG3Q927962, 3, ENSP000003634804MINT-72657 MINT-72689 MINT-72705 MINT-72686 MINT-72690 MINT-72685 I2D: score=3 STRING: ENSP00000363480
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    MAPRE1Q156913, ENSP000003647214I2D: score=1 STRING: ENSP00000364721
    NME1-NME2P223923I2D: score=1 
    NME2P223923I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS10075721
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006147guanine catabolic process IEA--
    GO:0006195purine nucleotide catabolic process TAS--
    GO:0007399nervous system development TAS10542258

    Find genes that share ontologies with GDA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GDA (GUAD)

    4 HMDB Compounds for GDA    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    GuanineGUN (see all 26)73-40-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Xanthine1H-Purine-2,6-diol (see all 16)69-89-6--

    Selected Novoseek inferred chemical compound relationships for GDA gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azepinomycin 93.8 3 16920357 (2)
    guanine 82.9 113 11784697 (8), 20023034 (8), 10913105 (4), 19221682 (4) (see all 23)
    purine nucleoside 81.6 10 20481216 (1), 10629441 (1), 8770661 (1), 1367430 (1) (see all 8)
    xanthine 76.5 20 9171854 (1), 14725335 (1), 20481216 (1), 10629441 (1) (see all 10)
    purine 70.9 12 10629441 (1), 10913105 (1), 19221682 (1), 8064675 (1) (see all 5)
    guanosine 66.5 7 14725335 (1), 20481216 (1), 14690689 (1), 10845757 (1)
    hypoxanthine 59.6 1 10629441 (1)
    inosine 52.9 2 10629441 (1)
    adenine 44.1 2 10629441 (1), 10576552 (1)
    cytidine 39.8 3 8076377 (2), 8750586 (1)



    Find genes that share compounds with GDA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GDA gene (4 alternative transcripts): 
    NM_001242505.2  NM_001242506.2  NM_001242507.2  NM_004293.4  

    Unigene Cluster for GDA:

    Guanine deaminase
    Hs.494163  [show with all ESTs]
    Unigene Representative Sequence: NM_001242506
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376986(uc004ais.3) ENST00000358399(uc011lse.2 uc004air.3 uc011lsf.2 uc004aiq.3 uc010mow.2)
    ENST00000475764 ENST00000477618(uc004ait.1) ENST00000414671 ENST00000489618
    ENST00000436438 ENST00000238018 ENST00000376989 ENST00000545168
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GDA (see all 56):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-548k hsa-miR-301a hsa-miR-624 hsa-miR-30d hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat GDA
      QuantiFast Probe-based Assays in human, mouse, rat GDA

    Additional mRNA sequence: 

    AB033084.1 AF095286.1 AJ420441.1 AK023729.1 AK295716.1 AK300418.1 AK315988.1 BC012859.1 
    BC033310.1 BC053584.1 

    11 DOTS entries:

    DT.214359  DT.101981394  DT.121144658  DT.91892823  DT.100783690  DT.100714922  DT.92040232  DT.92055452 
    DT.92055933  DT.95069169  DT.99931219 

    Selected AceView cDNA sequences (see all 126):

    BX481222 CB132690 Z39653 AI245652 AF095286 AL119901 AU139957 AL578895 
    F01627 C00343 CR620032 BU618985 CA420062 AB033084 F09372 BC012859 
    F10466 F11714 Z43587 Z45564 AK023729 F04421 BM977202 BC053584 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GDA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:              -           -                                   -                       -                                   -               
    SP2:              -           -                                   -                       -                                                   
    SP3:                                                              -                                                                           
    SP4:              -           -                                                                                                               
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for GDA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GDA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATTCA
    GDA Expression
    About this image


    GDA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    GDA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GDA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.494163
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GDA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GDA gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gda1 , 5 guanine deaminase1, 5 88.25(n)1
    90.75(a)1
      19 (14.32 cM)5
    145441  NM_010266.21  NP_034396.11 
     213913075 
    chicken
    (Gallus gallus)
    Aves GDA1 guanine deaminase 70.74(n)
    72.22(a)
      427253  XM_424835.4  XP_424835.3 
    lizard
    (Anolis carolinensis)
    Reptilia GDA6
    guanine deaminase
    72(a)
    1 ↔ 1
    2(48198026-48242144)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987282 hypothetical protein LOC398728 72.3(n)    BC058200.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.230362 Transcribed sequence with weak similarity to protein more 75.55(n)    CK127454.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG181433
    DhpD1
    guanine deaminase3
    Dihydropterin deaminase1
    43(a)3
    51.4(n)1
    46.03(a)1
      82A13
    405281  NM_141182.31  NP_649439.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GUD1(YDL238C)4
    GUD11
    Guanine deaminase, a catabolic enzyme of the guanine more4
    GUD11
    51.96(n)1
    44.65(a)1
      4(30454-28985)4
    8513601, 4  NP_010043.11, 4 


    ENSEMBL Gene Tree for GDA (if available)
    TreeFam Gene Tree for GDA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GDA gene
    7 SIMAP similar genes for GDA using alignment to 6 protein entries:     GUAD_HUMAN (see all proteins):
    AURA2    NF2    FAM175A    EIF3L    DNAPTP3    GLT8D2
    LINC00596

    Find genes that share paralogs with GDA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GDA (see all 2733)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420276971,2
    --44549430(+) ATGGGC/TCAGCT 1 -- us2k10--------
    rs1506130971,2
    --44549520(+) TTAGAC/GTTTTA 1 -- us2k10--------
    rs2008974381,2
    --44549614(+) GCATT-/AAAAAA 1 -- us2k10--------
    rs1397228361,2
    C--44549716(+) TCTTTC/GTCAAC 1 -- us2k10--------
    rs104359661,2
    C,F,A,H--44549784(+) CCTCTC/TAGGGG 1 -- us2k112Minor allele frequency- T:0.43NS EA NA WA 756
    rs1430614151,2
    --44549787(+) CTTAGC/GGGTTC 1 -- us2k10--------
    rs1872584561,2
    --44549805(+) CTGAAC/TCAGCG 1 -- us2k10--------
    rs748881601,2
    --44549810(+) CCAGCG/TGTTGA 1 -- us2k10--------
    rs727419521,2
    C,F--44550040(+) CAGCTG/ACTTAC 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs70244301,2
    C,F,H--44550057(+) CATCTT/CGGTGA 1 -- us2k15Minor allele frequency- C:0.01NS EA WA 538

    HapMap Linkage Disequilibrium report for GDA (74729511 - 74872109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GDA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738549CNV Deletion23290073
    esv2634959CNV Deletion19546169
    esv2666473CNV Deletion23128226
    nsv831618CNV Loss17160897
    nsv466420CNV Loss19166990
    nsv893446CNV Gain21882294
    nsv893445CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GDA
    DNA2.0 Custom Variant and Variant Library Synthesis for GDA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139260    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GDA:
    Hepatitis

    Find genes that share disorders with GDA           About GenesLikeMe

    2 Novoseek inferred disease relationships for GDA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 20.2 2 12630570 (1), 14690689 (1)
    liver diseases 14.5 1 14690689 (1)

    Genetic Association Database (GAD): GDA
    Human Genome Epidemiology (HuGE) Navigator: GDA (4 documents)

    Export disorders for GDA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GDA gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with GDA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. (PubMed id 10075721)1, 2, 3, 9 Yuan G.... Snyder F.F. (J. Biol. Chem. 1999)
    2. A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. (PubMed id 10542258)1, 2, 9 Kuwahara H.... Saya H. (J. Biol. Chem. 1999)
    3. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PubMed id 20877300)1, 4 Perroud N....McGuffin P. (Pharmacogenomics J. 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    8. Isolation and characterization of human liver guanine deaminase. (PubMed id 3966794)1, 3 Gupta N.K. and Glantz M.D. (Arch. Biochem. Biophys. 1985)
    9. A histochemical and immunohistochemical investigation of guanase and nedasin in rat and human tissues. (PubMed id 16953061)1, 9 Sannomiya K....Ito S. (J. Med. Invest. 2006)
    10. Histochemical and immunohistochemical investigation of guanase and nedasin in human tissues. (PubMed id 16953063)1, 9 Kubo K....Ito S. (J. Med. Invest. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9615 HGNC: 4212 AceView: GDA Ensembl:ENSG00000119125 euGenes: HUgn9615
    ECgene: GDA Kegg: 9615 H-InvDB: GDA

    (According to HUGE)
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    HUGE: KIAA1258

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GDA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GDA gene:
    Search GeneIP for patents involving GDA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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