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Aliases for GDA Gene

Aliases for GDA Gene

  • Guanine Deaminase 2 3
  • Guanine Aminohydrolase 3 4
  • Guanine Aminase 3 4
  • P51-Nedasin 3 4
  • EC 4 63
  • GUANASE 3 4
  • CYPIN 3 6
  • GAH 3 4
  • Cytoplasmic PSD95 Interactor 3
  • KIAA1258 4

External Ids for GDA Gene

Previous GeneCards Identifiers for GDA Gene

  • GC09P065808
  • GC09P066620
  • GC09P068299
  • GC09P070221
  • GC09P071993
  • GC09P073954
  • GC09P074764
  • GC09P044586
  • GC09P074729

Summaries for GDA Gene

Entrez Gene Summary for GDA Gene

  • This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for GDA Gene

GDA (Guanine Deaminase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for GDA Gene

  • Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDA Gene

Genomics for GDA Gene

Regulatory Elements for GDA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GDA Gene

72,114,595 bp from pter
72,257,193 bp from pter
142,599 bases
Plus strand

Genomic View for GDA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDA Gene

Proteins for GDA Gene

  • Protein details for GDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanine deaminase
    Protein Accession:
    Secondary Accessions:
    • B4DTY5
    • Q5SZC7
    • Q9H335
    • Q9ULG2

    Protein attributes for GDA Gene

    454 amino acids
    Molecular mass:
    51003 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer.
    • Sequence=BAA86572.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GDA Gene

    Alternative splice isoforms for GDA Gene


neXtProt entry for GDA Gene

Proteomics data for GDA Gene at MOPED

Selected DME Specific Peptides for GDA Gene

Post-translational modifications for GDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for GDA Gene

Protein Domains for GDA Gene

Suggested Antigen Peptide Sequences for GDA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATZ/TRZ family.
  • Belongs to the ATZ/TRZ family.
genes like me logo Genes that share domains with GDA: view

No data available for Gene Families for GDA Gene

Function for GDA Gene

Molecular function for GDA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Guanine + H(2)O = xanthine + NH(3)
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

Enzyme Numbers (IUBMB) for GDA Gene

Gene Ontology (GO) - Molecular Function for GDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0008892 guanine deaminase activity EXP --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with GDA: view

miRNA for GDA Gene

miRTarBase miRNAs that target GDA

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDA

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for GDA Gene

Localization for GDA Gene

Subcellular locations from

Jensen Localization Image for GDA Gene COMPARTMENTS Subcellular localization image for GDA gene
Compartment Confidence
cytosol 4
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 10542258
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with GDA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GDA Gene

Pathways for GDA Gene

genes like me logo Genes that share pathways with GDA: view

Pathways by source for GDA Gene

UniProtKB/Swiss-Prot Q9Y2T3-GUAD_HUMAN

  • Pathway: Purine metabolism; guanine degradation; xanthine from guanine: step 1/1

Gene Ontology (GO) - Biological Process for GDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 10075721
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006147 guanine catabolic process IEA --
GO:0006195 purine nucleotide catabolic process TAS --
GO:0007399 nervous system development TAS 10542258
genes like me logo Genes that share ontologies with GDA: view

Drugs for GDA Gene

(4) HMDB Compounds for GDA Gene

Compound Synonyms Cas Number PubMed IDs
  • Ammonia anhydrous
  • 2-Amino-1,7-dihydro-6H-Purin-6-one
  • Dihydrogen oxide
  • 1H-Purine-2,6-diol

(15) Novoseek inferred chemical compound relationships for GDA Gene

Compound -log(P) Hits PubMed IDs
azepinomycin 93.8 2
guanine 82.9 51
purine nucleoside 81.6 8
xanthine 76.5 10
purine 70.9 5
genes like me logo Genes that share compounds with GDA: view

Transcripts for GDA Gene

Unigene Clusters for GDA Gene

Guanine deaminase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GDA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -

Relevant External Links for GDA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GDA Gene

mRNA expression in normal human tissues for GDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDA Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (8.7), Brain - Frontal Cortex (BA9) (6.9), Brain - Cortex (5.7), Brain - Hippocampus (4.3), Liver (4.3), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Protein differential expression in normal tissues for GDA Gene

This gene is overexpressed in Ovary (48.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GDA Gene

SOURCE GeneReport for Unigene cluster for GDA Gene Hs.494163

genes like me logo Genes that share expressions with GDA: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for GDA Gene

Orthologs for GDA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GDA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GDA 35
  • 90.9 (n)
  • 89.65 (a)
GDA 36
  • 90 (a)
(Canis familiaris)
Mammalia GDA 35
  • 89.5 (n)
  • 87.89 (a)
GDA 36
  • 86 (a)
(Mus musculus)
Mammalia Gda 35
  • 88.25 (n)
  • 90.75 (a)
Gda 16
Gda 36
  • 91 (a)
(Pan troglodytes)
Mammalia GDA 35
  • 99.5 (n)
  • 99.58 (a)
GDA 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gda 35
  • 87.67 (n)
  • 90.53 (a)
(Monodelphis domestica)
Mammalia GDA 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia GDA 36
  • 81 (a)
(Gallus gallus)
Aves GDA 35
  • 70.74 (n)
  • 72.22 (a)
GDA 36
  • 72 (a)
(Anolis carolinensis)
Reptilia GDA 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gda 35
  • 62.69 (n)
  • 61.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398728 35
(Danio rerio)
Actinopterygii Dr.23036 35
gda 35
  • 63.04 (n)
  • 59.86 (a)
gda 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18143 37
  • 43 (a)
DhpD 35
  • 51.4 (n)
  • 46.03 (a)
DhpD 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005282 35
  • 51.74 (n)
  • 45.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19492g 35
  • 48.81 (n)
  • 42.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUD1 35
  • 51.96 (n)
  • 44.65 (a)
GUD1 36
  • 37 (a)
GUD1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07309 35
  • 46.95 (n)
  • 41.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1672.03c 35
  • 50.66 (n)
  • 42.69 (a)
Species with no ortholog for GDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDA Gene

Gene Tree for GDA (if available)
Gene Tree for GDA (if available)

Paralogs for GDA Gene

(7) SIMAP similar genes for GDA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GDA: view

No data available for Paralogs for GDA Gene

Variants for GDA Gene

Sequence variations from dbSNP and Humsavar for GDA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1123 -- 72,248,971(-) TCATC(C/G)CCAAA intron-variant, utr-variant-3-prime
rs2208744 -- 72,250,161(-) TTGAG(G/T)GATAA intron-variant, utr-variant-3-prime
rs2295902 -- 72,247,721(-) GATAC(C/T)GAATG intron-variant
rs3802506 -- 72,149,711(+) CACTC(C/G)GACGG intron-variant
rs3830994 -- 72,248,534(-) GAACC(-/C)TCTCA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GDA Gene

Variant ID Type Subtype PubMed ID
nsv831618 CNV Loss 17160897
nsv893445 CNV Gain 21882294
nsv893446 CNV Gain 21882294
esv2738549 CNV Deletion 23290073
nsv466420 CNV Loss 19166990
esv2634959 CNV Deletion 19546169
esv2666473 CNV Deletion 23128226

Relevant External Links for GDA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDA Gene

Disorders for GDA Gene

(1) University of Copenhagen DISEASES for GDA Gene

(2) Novoseek inferred disease relationships for GDA Gene

Disease -log(P) Hits PubMed IDs
hepatitis c 20.2 2
liver diseases 14.5 1

Relevant External Links for GDA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GDA: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for GDA Gene

Publications for GDA Gene

  1. Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. (PMID: 10075721) Yuan G. … Snyder F.F. (J. Biol. Chem. 1999) 2 3 4 23
  2. A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. (PMID: 10542258) Kuwahara H. … Saya H. (J. Biol. Chem. 1999) 3 4 23
  3. Isolation and characterization of human liver guanine deaminase. (PMID: 3966794) Gupta N.K. … Glantz M.D. (Arch. Biochem. Biophys. 1985) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for GDA Gene

Sources for GDA Gene

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