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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GCSH Gene

protein-coding GIFtS: 61
GCID: GC16M081115

glycine cleavage system protein H (aminomethyl carrier)

Explore 10 diseases affiliated with
GCSH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glycine Cleavage System Protein H (Aminomethyl Carrier)¹ ²
NKH² ⁵
GCE²
Glycine Cleavage System H Protein, Mitochondrial²
Lipoic Acid-Containing Protein²
Mitochondrial Glycine Cleavage System H-Protein²

External Ids:	HGNC: 4208¹	Entrez Gene: 2653²	Ensembl: ENSG00000140905⁷	OMIM: 238330⁵	UniProtKB: P23434³

ORGUL members:
	NONCODE:n409114

Export aliases for GCSH gene to outside databases

Previous GC identifers: GC16M072048 GC16M082076 GC16M080854 GC01M165211 GC16M080896 GC16M079673 GC16M066872

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GCSH:

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein

components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing

protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein

encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T

protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one

protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and

non-transcribed pseudogenes of this gene exist throughout the genome.(provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: GCSH_HUMAN, P23434

Function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine

group of glycine from the P protein to the T protein

Gene Wiki entry for GCSH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GCSH gene promoter:
AML1a ATF-2 FOXD1 CBF-C S8 CBF-A CBF-B NF-kappaB1 MRF-2 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GCSH promoter sequence

Search SABiosciences Chromatin IP Primers for GCSH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCSH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.2 Ensembl cytogenetic band: 16q23.2 HGNC cytogenetic band: 16q23.2

GCSH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCSH gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M081115: view genomic region (about GC identifiers)

Start:	81,115,552 bp from pter	End:	81,130,008 bp from pter
Size:	14,457 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GCSH_HUMAN, P23434 (See protein sequence)

Recommended Name: Glycine cleavage system H protein, mitochondrial precursor

Size: 173 amino acids; 18885 Da

Cofactor: Binds 1 lipoyl cofactor covalently

Subunit: The glycine cleavage system is composed of four proteins: P, T, L and H

Subcellular location: Mitochondrion

Secondary accessions: Q9H1E9

Explore the universe of human proteins at neXtProt for GCSH: NX_P23434

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23434

GCSH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004474.2

ENSEMBL proteins:

ENSP00000319531 ENSP00000457630 ENSP00000455579 ENSP00000457645 ENSP00000455287

ENSP00000455019

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005960	glycine cleavage complex	IEA	--

GCSH for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GCSH for domains About GeneDecksing

4 InterPro domains/families:

IPR003016 2-oxoA_DH_lipoyl-BS

IPR017453 GCV_H_sub

IPR011053 Single_hybrid_motif

IPR002930 GCV_H

Graphical View of Domain Structure for InterPro Entry P23434

ProtoNet protein and cluster: P23434

2 Blocks protein families:

IPB002930 Glycine cleavage H-protein

IPB003016 2-oxo acid dehydrogenase

UniProtKB/Swiss-Prot: GCSH_HUMAN, P23434

Similarity: Belongs to the GcvH family

Similarity: Contains 1 lipoyl-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GCSH_HUMAN, P23434

Function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine

group of glycine from the P protein to the T protein

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004047	aminomethyltransferase activity	IEA	--
GO:0019899	enzyme binding	IEA	--

GCSH for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for GCSH

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		SwitchGear 3'UTR luciferase reporter plasmid: GCSH 3' UTR sequence

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GCSH

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/37 Interacting proteins for GCSH (P23434^{2, 3} ENSP00000319531⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBTB16	Q05516²^,³	MINT-63604 I2D: score=5
NMI	Q13287³, ENSP00000243346⁴	I2D: score=4 STRING: ENSP00000243346
AMT	P48728³, ENSP00000273588⁴	I2D: score=2 STRING: ENSP00000273588
FH	P07954³, ENSP00000355518⁴	I2D: score=1 STRING: ENSP00000355518
LIPT1	Q9Y234³, ENSP00000342071⁴	I2D: score=1 STRING: ENSP00000342071

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006546	glycine catabolic process	TAS	1671321
GO:0019464	glycine decarboxylation via glycine cleavage system	IEA	--

GCSH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GCSH

2 HMDB Compounds for GCSH About this table

Compound	Synonyms	CAS #	PubMed Ids
Glycine	2-Aminoacetate (see all 15)	56-40-6	--
Lipoic acid	(+)-alpha-Lipoate (see all 92)	1077-28-7	--

3 DrugBank Compounds for GCSH About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid	--	--	target	--	17139284 17016423 10592235
Dihydrolipoic Acid	--	462-20-4	target	--	10592235
Glycine	2-Aminoacetic acid (see all 4)	56-40-6	target	--	17361008

Search CenterWatch for drugs/clinical trials and news about GCSH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GCSH gene:

NM_004483.4

Unigene Cluster for GCSH:

Glycine cleavage system protein H (aminomethyl carrier)

Hs.546256 [show with all ESTs]

Unigene Representative Sequence: BM474983

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000315467(uc002fgd.3 uc002fge.3) ENST00000564386 ENST00000569885

ENST00000561801 ENST00000564477 ENST00000566566

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		hsa-miR-3163 hsa-miR-1226 hsa-miR-634 hsa-miR-29c hsa-miR-29a hsa-miR-545 hsa-miR-183* hsa-miR-518a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: GCSH 3' UTR sequence

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Additional cDNA sequence:

AK311978.1 AY533031.1 BC000790.1 BC009065.1 BC020922.1 BT009827.1 CR457072.1 D00723.1

M69175.1 NR_033249.1

8 DOTS entries:

DT.447456 DT.100779940 DT.100779942 DT.75184737 DT.100000731 DT.121423899 DT.95272855 DT.92444931

24/237 AceView cDNA sequences (see all 237):

AI650884 AY533031 BX111930 BI094355 BF448093 CR606547 CA777840 AI432670

BG528603 CR603013 AW194585 BI093591 BC000790 CR603107 N72768 BG576993

N63246 NM_004483 BI091245 CR601763 AA905107 AA307978 AI952820 AA304964

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GCSH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCCATACC

About this image

GCSH expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GCSH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GCSH

SOURCE GeneReport for Unigene cluster: Hs.546256

SABiosciences Custom PCR Arrays for GCSH

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for GCSH gene from 10/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gcsh^{1 , 5}	glycine cleavage system protein H (aminomethyl carrier)^{1, 5}	83.73(n)¹ 81.76(a)¹		8 (63.43 cM)⁵ 68133¹ NM_026572.3¹ NP_080848.1¹ 116981810⁵
chicken (Gallus gallus)	Aves	GCSH¹	glycine cleavage system protein H (aminomethyl carrier)	76.89(n) 75.46(a)		415803 NM_001004372.1 NP_001004372.1
lizard (Anolis carolinensis)	Reptilia	GCSH⁶	--	90(a)	1 ↔ 1	LGc(5731084-5736379)
zebrafish (Danio rerio)	Actinopterygii	gcsha¹	glycine cleavage system protein H (aminomethyl carrier), more	68.4(n) 71.11(a)		541329 NM_001013457.1 NP_001013475.1
fruit fly (Drosophila melanogaster)	Insecta	ppl^{1 , 3}	pumpless¹	53(a)³ 55.07(n)¹ 53.62(a)¹		78C4³ 40349¹ NM_079473.3¹ NP_524197.1¹
worm (Caenorhabditis elegans)	Secernentea	F52A8.5^{1 , 3}	glycine cleavage system H protein like³ Protein F52A8.5¹	52(a)³ 55.88(n)¹ 52.94(a)¹		I(7354137-7354785)³ 172486¹ NM_059674.5¹ NP_492075.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GCV3(YAL044C)⁴ GCV3¹	H subunit of the mitochondrial glycine decarboxylase more⁴ Gcv3p¹	51.59(n)¹ 48.7(a)¹		1(58462-57950)⁴ 851254^{1, 4} NP_009355.3¹ NP_009355.2⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	GDCH¹	glycine cleavage system H protein 1	57.18(n) 50.86(a)		818104 NM_129089.1 NP_181080.1
rice (Oryza sativa)	Liliopsida	Os10g0516100¹	hypothetical protein	53.45(n) 50(a)		4349114 NM_001071595.1 NP_001065060.1
E. coli (Escherichia coli)	Gamma proteobacteria	gcvH⁶	glycine cleavage complex lipoylprotein	40(a)	1 ↔ 1	Chromosome(3047182-3047571)

ENSEMBL Gene Tree for GCSH (if available)
TreeFam Gene Tree for GCSH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GCSH gene

GCSH for paralogs About GeneDecksing

5/12 Pseudogenes.org Pseudogenes for GCSH (see all 12)
PGOHUM00000262180 PGOHUM00000239314 PGOHUM00000248274 PGOHUM00000245131 PGOHUM00000240498

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8177934^1,2	C,F	--	66876325(-)	`gccgcC/Tgttcc`	1	--	int¹		1	NS	174
rs8177933^1,2	C,F	--	66876327(-)	`gagccG/Accgtt`	1	--	int¹		1	NS	174
rs8177932^1,2	C,F	--	66876334(-)	`caggcA/Gtgagc`	1	--	int¹		1	NS	174
rs8177930^1,2	C,F	--	66876388(-)	`aactcG/Ctgacc`	1	--	int¹		1	NS	174
rs8177929^1,2	C,F	--	66876443(-)	`tatttC/Tgaggt`	1	--	int¹		2	NS WA	292
rs8177928^1,2	C,F	--	66876465(-)	`tttttA/Taatta`	1	--	int¹		3	NS WA EA	412
rs8177927^1,2	C,F	--	66876493(-)	`caggcA/Gtgcac`	1	--	int¹		1	NS	174
rs8177926^1,2	C,F	--	66876501(-)	`tgggaG/Ctacag`	1	--	int¹		1	NS	174
rs8177925^1,2	C,F	--	66876505(-)	`tagctG/Aggagt`	1	--	int¹		1	NS	174
rs8177924^1,2	C,F	--	66876506(-)	`gtagcT/Cgggag`	1	--	int¹		1	NS	174

HapMap Linkage Disequilibrium report for GCSH (81115552 - 81130008 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for GCSH
3 CNVs: 8830 102344 5331
4 Indels: 45468 25688 61542 40154
Human Gene Mutation Database (HGMD): GCSH

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GCSH

DNA2.0 Custom Variant and Variant Library Synthesis for GCSH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GCSH for disorders           About GeneDecksing

OMIM gene information: 238330
OMIM disorders: 605899
UniProtKB/Swiss-Prot: GCSH_HUMAN, P23434

Defects in GCSH are a cause of non-ketotic hyperglycinemia (NKH) [MIM:605899]; also known as glycine

encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine

in body fluid and by severe neurological symptoms

10 diseases for GCSH: About MalaCards

desquamative interstitial pneumonia glycine encephalopathy autosomal recessive disease hepatocellular carcinoma

pneumonia cholesterol tuberculosis carcinoma

malaria mycobacterium tuberculosis

2 diseases from the University of Copenhagen DISEASES database for GCSH:

Glycine encephalopathy Desquamative interstitial pneumonia

1 Novoseek disease relationship for GCSH gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperglycinemia nonketotic	95.6	2	11450847 (1), 16450403 (1)

GeneTests: GCSH

Glycine Encephalopathy

Human Genome Epidemiology (HuGE) Navigator: GCSH (3 documents)

Export disorders for GCSH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GCSH gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with GCSH)

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The glycine cleavage system: structure of a cDNA encoding human H- protein, and partial characterization of its gene in patients with hyperglycinemias. (PubMed id 1671321)^{1, 2, 3} Koyata H. and Hiraga K. (1991)
The primary structure of human H-protein of the glycine cleavage system deduced by cDNA cloning. (PubMed id 2025283)^{1, 2, 3} Fujiwara K.... Motokawa Y. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Chromosomal localization, structure, single-nucleotide polymorphisms, and expression of the human H-protein gene of the glycine cleavage system (GCSH), a candidate gene for nonketotic hyperglycinemia. (PubMed id 11450847)^{1, 9} Kure S....Matsubara Y. (2001)
Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia. (PubMed id 16450403)^{1, 9} Kure S....Matsubara Y. (2006)
Heterozygous GLDC and GCSH gene mutations in transient neonatal hyperglycinemia. (PubMed id 12402263)^{1, 9} Kure S....Matsubara Y. (2002)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Glycine cleavage enzyme complex: molecular cloning an d expression of the H-protein cDNA from cultured human skin fibroblasts. (PubMed id 21539457)¹ Zay A....Sinclair G. (2011)
Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)¹ Dastani Z....Genest J. (2010)
Atypical glycine encephalopathy in an extremely low b irth weight infant: description of a new mutation and clinical and electroencep halographic analysis. (PubMed id 19299230)¹ Pardal-FernA!ndez J.M....MartA-nez-GutiAcrrez A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2653	HGNC: 4208	AceView: GCSHandFLJ32702	Ensembl:ENSG00000140905	euGenes: HUgn2653
ECgene: GCSH	H-InvDB: GCSH

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GCSH	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GCSH
NIEHS-SNPs	http://egp.gs.washington.edu/data/gcsh/

Intellectual Property for GCSH gene
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Patent Information for GCSH gene:
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glycine cleavage system protein H (aminomethyl carrier)

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glycine cleavage system protein H (aminomethyl carrier)

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