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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GCOM1 Gene

protein-coding   GIFtS: 43
GCID: GC15P057884

GRINL1A complex locus 1
 Explore 2 diseases affiliated with
GCOM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GCOM1    

Aliases
for GCOM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
GRINL1A Complex Locus 11 2     GRINL1A Combined Protein Gcom122
GRINL1A1 2     GRINL1A Complex Locus Protein 12
MYZAP-POLR2M1 2     Myocardial Zonula Adherens Protein2
FLJ309731     MYZAP-POLR2M Protein2
Gcom22     MYZAP-POLR2M Readthrough2
MYZAP2     NMDAR1 Subunit-Interacting Protein2
Gcom1     Gup3
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Like 1A Combined Protein2     MYOZAP3
GRINL1A Combined Protein2     GRINL1A Upstream Protein3

External Ids:    HGNC: 264241   Entrez Gene: 1457812   Ensembl: ENSG000001378787   UniProtKB: P0CAP13   

Export aliases for GCOM1 gene to outside databases

Previous GC identifer: GC15P055675


Summaries
for GCOM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GCOM1:
This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula
adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternate
splicing results in two readthrough transcript variants that encode different isoforms. One of the readthrough
variants encodes a fusion protein that shares sequence identity with each individual gene product. The other variant
encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct
due to frameshifts relative to the downstream gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: MYZAP_HUMAN, P0CAP1
Function: Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of
transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in
glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity)




Genomic Views
for GCOM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GCOM1 gene promoter:
         PPAR-alpha   AREB6   TBP   p53   AML1a   FOXJ2 (long isoform)   FOXJ2   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GCOM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCOM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

GCOM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCOM1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P057884:  view genomic region     (about GC identifiers)

Start:
 57,884,102 bp from pter      End:
 58,009,753 bp from pter
Size:
 125,652 bases      Orientation:
 plus strand

1 alternative location:
Chr15+ 57,884,139-57,977,562     

Proteins
for GCOM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MYZAP_HUMAN, P0CAP1 (See protein sequence)
Recommended Name: Myocardial zonula adherens protein precursor  
Size: 466 amino acids; 54206 Da
Subunit: Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor
SRF (By similarity). Interacts with GRIN1. Interacts with DYNLL1
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic
side (By similarity). Cytoplasm, myofibril, sarcomere, I band (By similarity). Cytoplasm, myofibril, sarcomere, Z line
(By similarity). Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low
levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity)
Miscellaneous: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts
derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of
MYZAP use exons of the downstream POLR2M gene
1 PDB 3D structure from and Proteopedia for GCOM1:
2KXS (3D)    
Secondary accessions: D2E9U7 Q6EER8 Q6EES2 Q6EEV3 Q6EF00 Q6EF01 Q6EF02 Q6EF46 Q6EFN8 Q6EM48 Q6K046
Q6K050 Q6K051 Q6ZQZ3 Q8NC58 Q8NCF3 Q96DI5 Q96JB7 Q96NF5
Alternative splicing: 11 isoforms:  P0CAP1-1   P0CAP1-2   P0CAP1-3   P0CAP1-4   P0CAP1-5   P0CAP1-6   P0CAP1-7   P0CAP1-8   
P0CAP1-9   P0CAP1-10   P0CAP1-11   (Based on a naturally occurring readthrough transcript which produces a MYZAP-POLR2M fusion protein)

Explore the universe of human proteins at neXtProt for GCOM1: NX_P0CAP1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0CAP1

    • GCOM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018100.1  NP_001018101.1  

    ENSEMBL proteins: 
     ENSP00000369943   ENSP00000465231   ENSP00000434588   ENSP00000432563   ENSP00000432066  
     ENSP00000433702   ENSP00000436614   ENSP00000435774   ENSP00000369942   ENSP00000435028  
     ENSP00000436922   ENSP00000434505   ENSP00000369935   ENSP00000461898   ENSP00000459294  
     ENSP00000379483   ENSP00000369933  

    Human Recombinant Protein Products: 
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    Novus Biologicals GCOM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GCOM1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030018Z disc ----
    GO:0030054cell junction ----
    GO:0030864cortical actin cytoskeleton ----
    GO:0031234extrinsic to internal side of plasma membrane ----
    GO:0031674I band ----


    GCOM1 for ontologies           About GeneDecksing



    GCOM1 Antibody Products: 
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    Uscn Antibodies for GCOM1
    ThermoFisher Antibodies for GCOM1

    Assay Products for GCOM1: 
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    Uscn ELISAs and CLIAs for GCOM1

    Protein Domains /
    Families
    for GCOM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P0CAP1

    UniProtKB/Swiss-Prot: MYZAP_HUMAN, P0CAP1
    Similarity: Belongs to the MYZAP family


    Function
    for GCOM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MYZAP_HUMAN, P0CAP1
    Function: Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of
    transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in
    glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GCOM1
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate GCOM1 (see all 30):
    hsa-miR-582-3p hsa-miR-3910 hsa-miR-579 hsa-miR-495 hsa-miR-361-5p hsa-miR-607 hsa-miR-539 hsa-miR-429
    SwitchGear 3'UTR luciferase reporter plasmid: GCOM1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GCOM1 (see all 4)
    OriGene shRNA RFP: GCOM1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GCOM1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for GCOM1

    In Situ Assay
    Products:       
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    Pathways & Interactions
    for GCOM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GCOM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/32 Interacting proteins for GCOM1 (P0CAP12, 3 ENSP000003699434) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEBPGP535672, 3, ENSP000002840004MINT-67959 I2D: score=4 STRING: ENSP00000284000
    AHSPQ9NZD42, 3MINT-65214 I2D: score=4 
    APODP050902, 3MINT-65205 I2D: score=4 
    HIGD1BQ9P2982, 3MINT-65215 I2D: score=4 
    KIAA1377Q9P2H02, 3MINT-65216 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction ----


    GCOM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GCOM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GCOM1
    Search CenterWatch for drugs/clinical trials and news about GCOM1 / MYZAP 

    Transcripts
    for GCOM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GCOM1 gene (10 alternative transcripts): 
    NM_001018092.1  NM_001018093.1  NM_001018094.1  NM_001018095.1  NM_001018096.1  NM_001018097.1  NM_001018098.1  NM_001018099.1  
    NM_001018090.4  NM_001018091.4  

    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000380569 ENST00000587652 ENST00000496101(uc002aek.3) ENST00000471563(uc002ael.3 uc002aer.1)
    ENST00000488175 ENST00000468886 ENST00000496627 ENST00000460962 ENST00000380568
    ENST00000463717 ENST00000482814 ENST00000477282 ENST00000484300 ENST00000569945
    ENST00000380561 ENST00000574161(uc002aei.3) ENST00000572390(uc002aej.3)
    ENST00000396180

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GCOM1
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate GCOM1 (see all 30):
    hsa-miR-582-3p hsa-miR-3910 hsa-miR-579 hsa-miR-495 hsa-miR-361-5p hsa-miR-607 hsa-miR-539 hsa-miR-429
    SwitchGear 3'UTR luciferase reporter plasmid: GCOM1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GCOM1 (see all 4)
    OriGene shRNA RFP: GCOM1
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    Clone
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    24/384 AceView cDNA sequences (see all 384):

    AY353056 AI862730 AI493108 CA447169 CR610275 AI801462 AY237639 BX343902 
    BF725893 AI375286 AF326773 AY333779 AA810422 AY331564 AW302560 AI873504 
    AI332865 BM714319 AI370941 AI263471 AI632774 BX508828 BC050322 AL050091 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GCOM1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18
    SP1:              -     -                                                                                                                           
    SP2:              -     -                                                                 -                                                         
    SP3:                                                                                                                                                
    SP4:                                                                                            -     -                                             
    SP5:                                                                                                                          -                     


    ECgene alternative splicing isoforms for GCOM1

    Expression
    for GCOM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GCOM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GCOM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GCOM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GCOM1

    UniProtKB/Swiss-Prot: MYZAP_HUMAN, P0CAP1
    Tissue specificity: Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis

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    In Situ
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    Orthologs
    for GCOM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GCOM1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GCOM11 GRINL1A complex locus 70.07(n)
    69.39(a)    		   415404  XM_413789.3  XP_413789.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GCOM16
    		 --
    		 43(a)
    		 1 → many
    		 GL343573.1(316082-338829)
    zebrafish
    (Danio rerio)    		 Actinopterygii polr2m1 polymerase (RNA) II (DNA directed) polypeptide M 56.09(n)
    44.19(a)    		   555796  XM_678415.5  XP_683507.4 


    ENSEMBL Gene Tree for GCOM1 (if available)
    TreeFam Gene Tree for GCOM1 (if available) 

    Paralogs
    for GCOM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GCOM1 gene
    TUFT12  CCDC682  
    5 SIMAP similar genes for GCOM1 using alignment to 3 protein entries:     H0YCD3_HUMAN (see all proteins):
    MYZAP    GCOM2    POLR2M    CCDC68    TUFT1

    GCOM1 for paralogs           About GeneDecksing



    Genomic Variants
    for GCOM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2391 NCBI SNPs in GCOM1 are shown (see all 2391)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1832593361,2
    		--57882250(+) ACATTG/TACTTG 4 -- us2k10--------
    rs19082021,2
    		C,F,O,A,H,--57882297(+) ACAGGC/GAGAGA 4 -- us2k1 tfbs321Minor allele frequency- G:0.38NS EA NA WA CSA 1352
    rs793613521,2
    		--57882323(+) GCTTCC/TACACA 4 -- us2k10--------
    rs24511821,2
    		C,F,A,H,--57882349(+) TGAGCT/CGTCTG 4 -- us2k112Minor allele frequency- C:0.42NA WA CSA EA 374
    rs16903271,2
    		C,F,A,H,--57882546(+) GGGTTA/CGAAGA 4 -- us2k119Minor allele frequency- C:0.35NS EA NA WA CSA 2045
    rs1877321721,2
    		--57882585(+) ATTAAC/TCTAAT 4 -- us2k10--------
    rs1913080091,2
    		--57882597(+) TCTCTA/GGCCTC 4 -- us2k10--------
    rs1834559281,2
    		--57882629(+) GGGGCA/GATAAC 4 -- us2k10--------
    rs19082031,2
    		C,F,A,--57882729(+) CGATGA/GGGATG 4 -- us2k112Minor allele frequency- G:0.43NA WA CSA EA 374
    rs133804061,2
    		C,F,--57882733(+) GAGGAT/CGGTGA 4 -- us2k12Minor allele frequency- C:0.09WA NA 238

    HapMap Linkage Disequilibrium report for GCOM1 (57884102 - 58009753 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GCOM1
         1 CNV: 5784
         1 Indel: 40100

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    Disorders / Diseases
    for GCOM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GCOM1 for disorders           About GeneDecksing

    2 diseases for GCOM1:    About MalaCards
    glaucoma    neuronitis


    Export disorders for GCOM1 gene to outside databases

    Publications
    for GCOM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GCOM1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with GCOM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity. (PubMed id 18849881)1, 2, 3 Roginski R.S....Yang J. (2008)
    2. The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. (PubMed id 15233991)1, 2, 3 Roginski R.S.... Rowen L. (2004)
    3. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac f unction in vivo. (PubMed id 20093627)1, 2 Seeger T.S....Frey N. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1 Lettre G....Boerwinkle E. (2011)
    7. Cdc42-dependent formation of the ZO-1/MRCKI^ complex a t the leading edge controls cell migration. (PubMed id 21240187)2 Huo L....Zhang M. (2011)
    8. Structural basis for the interaction between dynein l ight chain 1 and the glutamate channel homolog GRINL1A. (PubMed id 20412299)2 GarcA-a-Mayoral M.F....Bruix M. (2010)
    9. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    External Searches for GCOM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing GCOM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145781 HGNC: 26424 AceView: GRINL1AandGup1 Ensembl:ENSG00000137878 euGenes: HUgn145781
    ECgene: GCOM1 H-InvDB: GCOM1

    Other Databases showing GCOM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GCOM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GCOM1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GCOM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GCOM1 gene:
    Search GeneIP for patents involving GCOM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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