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Aliases for GCOM1 Gene

Aliases for GCOM1 Gene

  • GRINL1A Complex Locus 1 2 3 5
  • MYZAP-POLR2M Readthrough 2 3
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Like 1A Combined Protein 3
  • NMDAR1 Subunit-Interacting Protein 3
  • Myocardial Zonula Adherens Protein 3
  • GRINL1A Combined Protein Gcom12 3
  • GRINL1A Combined Protein 3
  • MYZAP-POLR2M Protein 3
  • MYZAP-POLR2M 3
  • GRINL1A 3
  • Gcom2 3
  • MYZAP 3
  • Gcom 3

External Ids for GCOM1 Gene

Previous GeneCards Identifiers for GCOM1 Gene

  • GC15P055675
  • GC15P057884

Summaries for GCOM1 Gene

Entrez Gene Summary for GCOM1 Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternative splicing results in multiple readthrough transcript variants. Readthrough variants may encode proteins that share sequence identity with the upstream gene product or with both the upstream and downstream gene products. Some readthrough transcript variants are also expected to be candidates for nonsense-mediated decay (NMD). [provided by RefSeq, Oct 2013]

GeneCards Summary for GCOM1 Gene

GCOM1 (GRINL1A Complex Locus 1) is a Protein Coding gene. An important paralog of this gene is MYZAP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCOM1 Gene

Genomics for GCOM1 Gene

Regulatory Elements for GCOM1 Gene

Enhancers for GCOM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GCOM1 on UCSC Golden Path with GeneCards custom track

Promoters for GCOM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for GCOM1 Gene

Chromosome:
15
Start:
57,591,904 bp from pter
End:
57,717,557 bp from pter
Size:
125,654 bases
Orientation:
Plus strand

Genomic View for GCOM1 Gene

Genes around GCOM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCOM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCOM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCOM1 Gene

Proteins for GCOM1 Gene

  • Protein details for GCOM1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H8Y6P7
    Recommended name:
    GRINL1A combined protein 15
    Protein Accession:
    H8Y6P7

    Protein attributes for GCOM1 Gene

    Size:
    765 amino acids
    Molecular mass:
    87807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCOM1 Gene

Post-translational modifications for GCOM1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GCOM1 Gene

Domains & Families for GCOM1 Gene

Protein Domains for GCOM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GCOM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GCOM1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GCOM1 Gene

Function for GCOM1 Gene

genes like me logo Genes that share phenotypes with GCOM1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GCOM1 Gene

Localization for GCOM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GCOM1 Gene COMPARTMENTS Subcellular localization image for GCOM1 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GCOM1 Gene

Pathways & Interactions for GCOM1 Gene

SuperPathways for GCOM1 Gene

No Data Available

Interacting Proteins for GCOM1 Gene

Gene Ontology (GO) - Biological Process for GCOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with GCOM1: view

No data available for Pathways by source and SIGNOR curated interactions for GCOM1 Gene

Drugs & Compounds for GCOM1 Gene

No Compound Related Data Available

Transcripts for GCOM1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCOM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18
SP1: - -
SP2: - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for GCOM1 Gene

GeneLoc Exon Structure for
GCOM1
ECgene alternative splicing isoforms for
GCOM1

Expression for GCOM1 Gene

mRNA expression in normal human tissues for GCOM1 Gene

mRNA differential expression in normal tissues according to GTEx for GCOM1 Gene

This gene is overexpressed in Heart - Left Ventricle (x7.8), Heart - Atrial Appendage (x6.2), and Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for GCOM1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for GCOM1 Gene



Protein tissue co-expression partners for GCOM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GCOM1 Gene:

GCOM1
genes like me logo Genes that share expression patterns with GCOM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GCOM1 Gene

Orthologs for GCOM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GCOM1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GCOM1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves GCOM1 34
  • 63.38 (n)
  • 60 (a)
-- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia myzap 34
  • 63.77 (n)
  • 57.75 (a)
zebrafish
(Danio rerio)
Actinopterygii polr2m 34
  • 58.08 (n)
  • 45.43 (a)
polr2m 35
  • 30 (a)
OneToMany
Species where no ortholog for GCOM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GCOM1 Gene

ENSEMBL:
Gene Tree for GCOM1 (if available)
TreeFam:
Gene Tree for GCOM1 (if available)

Paralogs for GCOM1 Gene

Paralogs for GCOM1 Gene

(5) SIMAP similar genes for GCOM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GCOM1: view

Variants for GCOM1 Gene

Sequence variations from dbSNP and Humsavar for GCOM1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2733615 -- 57,693,078(+) AAAAA(A/C)ACAAA intron-variant
rs2733616 -- 57,697,319(+) ATATA(G/T)CCAGA intron-variant
rs2733617 -- 57,698,711(+) aaaac(C/T)gtatg intron-variant
rs4357879 -- 57,700,477(+) GCTAC(G/T)TGGGA intron-variant
rs4774282 -- 57,685,989(+) TTGCT(C/G)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GCOM1 Gene

Variant ID Type Subtype PubMed ID
dgv1219n106 CNV deletion 24896259
dgv150n21 CNV loss 19592680
esv2034597 CNV deletion 18987734
esv2749736 CNV deletion 23290073
esv3307804 CNV mobile element insertion 20981092
esv3346438 CNV insertion 20981092
esv3636613 CNV loss 21293372
nsv1045611 CNV gain 25217958
nsv1054547 CNV gain 25217958
nsv1071212 CNV deletion 25765185
nsv1116765 CNV tandem duplication 24896259
nsv1127435 CNV deletion 24896259
nsv1129179 CNV insertion 24896259
nsv1130353 CNV deletion 24896259
nsv1134451 CNV deletion 24896259
nsv1138376 CNV deletion 24896259
nsv1140003 CNV deletion 24896259
nsv1141769 CNV insertion 24896259
nsv1142690 CNV deletion 24896259
nsv473762 CNV novel sequence insertion 20440878
nsv476074 CNV novel sequence insertion 20440878
nsv7266 OTHER inversion 18451855
nsv94840 CNV deletion 16902084
nsv957989 CNV deletion 24416366
nsv984076 CNV duplication 23825009

Variation tolerance for GCOM1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GCOM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCOM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCOM1 Gene

Disorders for GCOM1 Gene

Relevant External Links for GCOM1

Genetic Association Database (GAD)
GCOM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCOM1

No disorders were found for GCOM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GCOM1 Gene

Publications for GCOM1 Gene

  1. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 3 46 65
  2. GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity. (PMID: 18849881) Roginski R.S. … Yang J. (NeuroReport 2008) 2 3 65
  3. The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. (PMID: 15233991) Roginski R.S. … Rowen L. (Genomics 2004) 2 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 65

Products for GCOM1 Gene

Sources for GCOM1 Gene

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