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Aliases for GCNT3 Gene

Aliases for GCNT3 Gene

  • Glucosaminyl (N-Acetyl) Transferase 3, Mucin Type 2 3 5
  • Core 2/Core 4 Beta-1,6-N-Acetylglucosaminyltransferase 3 4
  • C2GnT-Mucin Type 3 4
  • HC2GnT-M 3 4
  • C2/4GnT 3 4
  • Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 3 3
  • Mucus-Type Core 2 Beta-1,6-N-Acetylglucosaminyltransferase 3
  • Beta1,6-N-Acetylglucosaminyltransferase-M 3
  • Beta1,6GlcNAc-Transferase 3
  • EC 2.4.1.102 4
  • EC 2.4.1.150 4
  • C2GnT-M 4
  • C24GNT 3
  • C2GNT2 3
  • C2GNTM 3
  • GNTM 3

External Ids for GCNT3 Gene

Previous GeneCards Identifiers for GCNT3 Gene

  • GC15P055467
  • GC15P052952
  • GC15P057483
  • GC15P057620
  • GC15P057691
  • GC15P059903
  • GC15P036725

Summaries for GCNT3 Gene

Entrez Gene Summary for GCNT3 Gene

  • This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]

GeneCards Summary for GCNT3 Gene

GCNT3 (Glucosaminyl (N-Acetyl) Transferase 3, Mucin Type) is a Protein Coding gene. Diseases associated with GCNT3 include Colorectal Cancer. Among its related pathways are terminal O-glycans residues modification and O-linked glycosylation. GO annotations related to this gene include acetylglucosaminyltransferase activity and N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. An important paralog of this gene is GCNT1.

UniProtKB/Swiss-Prot for GCNT3 Gene

  • Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCNT3 Gene

Genomics for GCNT3 Gene

Regulatory Elements for GCNT3 Gene

Enhancers for GCNT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G059553 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -39.4 -39407 3.5 FOXA2 ATF1 MLX ZNF48 TCF12 GTF3C2 FOS SP5 MXD4 NFYC PIGHP1 RPS3AP6 GCNT3 RPL21P117 RNA5SP396 GC15M059576
GH15G059270 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -315.9 -315940 16.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS DEK MYO1E FAM81A PIGHP1 RPS3AP6 MIR2116 ENSG00000259250 GCNT3 GC15M059271 GC15M059344
GH15G059593 1.5 Ensembl ENCODE dbSUPER 0.7 +0.6 555 3.2 PKNOX1 FEZF1 ZNF2 FOS KLF7 ZNF263 ZNF488 TSHZ1 SREBF1 ZNF610 GC15M059584 GCNT3
GH15G059590 0.6 ENCODE dbSUPER 0.7 -3.4 -3413 0.9 IKZF1 GCNT3 GC15M059575
GH15G059586 0.8 ENCODE 0.4 -7.3 -7298 1.3 JUN SALL2 CTBP1 ZNF316 GATA3 ZNF366 SCRT2 ZNF169 ZNF26 FOS ICE2 MINDY2 RPS3AP6 GCNT3 GC15M059575
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GCNT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GCNT3 Gene

Chromosome:
15
Start:
59,594,875 bp from pter
End:
59,640,239 bp from pter
Size:
45,365 bases
Orientation:
Plus strand

Genomic View for GCNT3 Gene

Genes around GCNT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCNT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCNT3 Gene

Proteins for GCNT3 Gene

  • Protein details for GCNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95395-GCNT3_HUMAN
    Recommended name:
    Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
    Protein Accession:
    O95395

    Protein attributes for GCNT3 Gene

    Size:
    438 amino acids
    Molecular mass:
    50864 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCNT3 Gene

Post-translational modifications for GCNT3 Gene

Other Protein References for GCNT3 Gene

No data available for DME Specific Peptides for GCNT3 Gene

Domains & Families for GCNT3 Gene

Protein Domains for GCNT3 Gene

Suggested Antigen Peptide Sequences for GCNT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95395

UniProtKB/Swiss-Prot:

GCNT3_HUMAN :
  • Belongs to the glycosyltransferase 14 family.
Family:
  • Belongs to the glycosyltransferase 14 family.
genes like me logo Genes that share domains with GCNT3: view

Function for GCNT3 Gene

Molecular function for GCNT3 Gene

GENATLAS Biochemistry:
beta 1,6-N-acetyl-glucosaminyl transferase 3,transmembrane protein,mucin type,core 2/core 4 branching enzyme in O-glycans,expressed in colon,small intestine,trachea,stomach,kidney,pancreas
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA), TNF and IL13/interleukin-13. Strongly down-regulated in colorectal cancer.

Enzyme Numbers (IUBMB) for GCNT3 Gene

Gene Ontology (GO) - Molecular Function for GCNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity TAS --
GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity IEA,TAS --
GO:0008375 acetylglucosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with GCNT3: view
genes like me logo Genes that share phenotypes with GCNT3: view

Animal Models for GCNT3 Gene

MGI Knock Outs for GCNT3:

Animal Model Products

CRISPR Products

miRNA for GCNT3 Gene

miRTarBase miRNAs that target GCNT3

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GCNT3 Gene

Localization for GCNT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCNT3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCNT3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GCNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,TAS 9988682
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with GCNT3: view

Pathways & Interactions for GCNT3 Gene

genes like me logo Genes that share pathways with GCNT3: view

UniProtKB/Swiss-Prot O95395-GCNT3_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for GCNT3 Gene

Gene Ontology (GO) - Biological Process for GCNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002426 immunoglobulin production in mucosal tissue IEA --
GO:0005975 carbohydrate metabolic process NAS 9988682
GO:0006486 protein glycosylation IEA --
GO:0006493 protein O-linked glycosylation TAS 9988682
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with GCNT3: view

No data available for SIGNOR curated interactions for GCNT3 Gene

Drugs & Compounds for GCNT3 Gene

(1) Drugs for GCNT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0

(1) Additional Compounds for GCNT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
528-04-1
genes like me logo Genes that share compounds with GCNT3: view

Transcripts for GCNT3 Gene

Unigene Clusters for GCNT3 Gene

Glucosaminyl (N-acetyl) transferase 3, mucin type:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCNT3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for GCNT3 Gene

GeneLoc Exon Structure for
GCNT3
ECgene alternative splicing isoforms for
GCNT3

Expression for GCNT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GCNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GCNT3 Gene

This gene is overexpressed in Colon - Transverse (x18.2), Small Intestine - Terminal Ileum (x8.6), Minor Salivary Gland (x7.8), and Vagina (x4.7).

Protein differential expression in normal tissues from HIPED for GCNT3 Gene

This gene is overexpressed in Islet of Langerhans (45.3) and Stomach (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GCNT3 Gene



Protein tissue co-expression partners for GCNT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GCNT3 Gene:

GCNT3

SOURCE GeneReport for Unigene cluster for GCNT3 Gene:

Hs.194710

mRNA Expression by UniProt/SwissProt for GCNT3 Gene:

O95395-GCNT3_HUMAN
Tissue specificity: Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.

Evidence on tissue expression from TISSUES for GCNT3 Gene

  • Intestine(4.8)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with GCNT3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GCNT3 Gene

Orthologs for GCNT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCNT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCNT3 34 35
  • 98.93 (n)
dog
(Canis familiaris)
Mammalia GCNT3 34 35
  • 85.05 (n)
cow
(Bos Taurus)
Mammalia GCNT3 34 35
  • 84.74 (n)
rat
(Rattus norvegicus)
Mammalia Gcnt3 34
  • 79.56 (n)
mouse
(Mus musculus)
Mammalia Gcnt3 34 16 35
  • 78.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GCNT3 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GCNT3 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GCNT3 34 35
  • 62.21 (n)
lizard
(Anolis carolinensis)
Reptilia GCNT3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486342 34
  • 61.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24450 34
zebrafish
(Danio rerio)
Actinopterygii gcnt3 34 35
  • 62.4 (n)
worm
(Caenorhabditis elegans)
Secernentea gly-15 34
  • 44.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for GCNT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GCNT3 Gene

ENSEMBL:
Gene Tree for GCNT3 (if available)
TreeFam:
Gene Tree for GCNT3 (if available)

Paralogs for GCNT3 Gene

Paralogs for GCNT3 Gene

(8) SIMAP similar genes for GCNT3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GCNT3: view

Variants for GCNT3 Gene

Sequence variations from dbSNP and Humsavar for GCNT3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000017134 -- 59,609,895(+) ATAGA(A/G)CAAGC upstream-variant-2KB
rs1000068130 -- 59,610,028(+) CCTTT(A/T)CAATT upstream-variant-2KB
rs1000121636 -- 59,610,156(+) CTGCC(G/T)GCCTG upstream-variant-2KB
rs1000368320 -- 59,619,367(+) AGGGT(G/T)CTCCT reference, missense
rs1000641083 -- 59,614,871(+) CCTAC(A/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GCNT3 Gene

Variant ID Type Subtype PubMed ID
esv23994 CNV gain 19812545
esv2668729 CNV deletion 23128226
esv3636644 CNV loss 21293372
nsv527307 CNV gain 19592680
nsv569605 CNV loss 21841781
nsv7266 OTHER inversion 18451855

Variation tolerance for GCNT3 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GCNT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCNT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCNT3 Gene

Disorders for GCNT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCNT3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GCNT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GCNT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCNT3
genes like me logo Genes that share disorders with GCNT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCNT3 Gene

Publications for GCNT3 Gene

  1. Molecular cloning and expression of a novel beta-1, 6-N- acetylglucosaminyltransferase that forms core 2, core 4, and I branches. (PMID: 9915862) Yeh J.-C. … Fukuda M. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Mucin biosynthesis: identification of the cis-regulatory elements of human C2GnT-M gene. (PMID: 17303715) Tan S. … Cheng P.-W. (Am. J. Respir. Cell Mol. Biol. 2007) 3 4 22 64
  3. C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. (PMID: 16418723) Huang M.-C. … Hsu S.-M. (Oncogene 2006) 3 4 22 64
  4. Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4. (PMID: 9988682) Schwientek T. … Clausen H. (J. Biol. Chem. 1999) 2 3 4 64
  5. Clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer. (PMID: 25466507) GonzA!lez-Vallinas M. … RamA-rez de Molina A. (Eur. J. Cancer 2015) 3 64

Products for GCNT3 Gene

Sources for GCNT3 Gene

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