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Aliases for GCNA Gene

Aliases for GCNA Gene

  • Germ Cell Nuclear Acidic Peptidase 2 3
  • Acidic Repeat Containing 2 3 5
  • ACRC 3 4 5
  • Acidic Repeat-Containing Protein 3
  • Putative Nuclear Protein 3
  • NAAR1 3

External Ids for GCNA Gene

Previous HGNC Symbols for GCNA Gene

  • ACRC

Summaries for GCNA Gene

GeneCards Summary for GCNA Gene

GCNA (Germ Cell Nuclear Acidic Peptidase) is a Protein Coding gene. Diseases associated with GCNA include Appendix Adenocarcinoma.

Gene Wiki entry for GCNA Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCNA Gene

Genomics for GCNA Gene

Regulatory Elements for GCNA Gene

Enhancers for GCNA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF071605 1.1 FANTOM5 Ensembl ENCODE 13.4 +28.8 28791 2.2 ZNF316 NR2F1 MAFG NR2F6 NFE2 EMSY MAFK GCNA CXCR3 IL2RG TAF1
GH0XF071579 0.6 ENCODE 0.8 +1.8 1802 0.2 ZFHX2 KLF16 SP2 TRIM24 REST EGR2 GCNA CXCR3
GH0XF071539 1.1 Ensembl ENCODE 0.3 -36.2 -36189 5.3 CTCF ZNF146 MXI1 PKNOX1 JUN INSM2 CEBPG HIC1 ZNF121 FOS OGT GCNA
GH0XF071615 1.4 FANTOM5 Ensembl ENCODE 0.2 +40.2 40182 5.9 CTCF TBP PKNOX1 MXI1 TBL1XR1 WRNIP1 MAX BMI1 RAD21 RELA CXCR3 OGT TAF1 GCNA
GH0XF071530 1.2 ENCODE 0.2 -44.8 -44755 4.8 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SNX12 TAF1 LOC100420758 ERCC6L RGAG4 RPS23P8 OGT GCNA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GCNA on UCSC Golden Path with GeneCards custom track

Genomic Location for GCNA Gene

Chromosome:
X
Start:
71,578,024 bp from pter
End:
71,613,583 bp from pter
Size:
35,560 bases
Orientation:
Plus strand

Genomic View for GCNA Gene

Genes around GCNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCNA Gene

Proteins for GCNA Gene

  • Protein details for GCNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QF7-ACRC_HUMAN
    Recommended name:
    Acidic repeat-containing protein
    Protein Accession:
    Q96QF7
    Secondary Accessions:
    • B9EG62

    Protein attributes for GCNA Gene

    Size:
    691 amino acids
    Molecular mass:
    76112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCNA Gene

Post-translational modifications for GCNA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCNA Gene

No data available for DME Specific Peptides for GCNA Gene

Domains & Families for GCNA Gene

Protein Domains for GCNA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GCNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QF7

UniProtKB/Swiss-Prot:

ACRC_HUMAN :
  • Contains 1 SprT-like domain.
  • Belongs to the serine-aspartate repeat-containing protein (SDr) family.
Domain:
  • Contains 1 SprT-like domain.
Family:
  • Belongs to the serine-aspartate repeat-containing protein (SDr) family.
genes like me logo Genes that share domains with GCNA: view

No data available for Gene Families for GCNA Gene

Function for GCNA Gene

genes like me logo Genes that share phenotypes with GCNA: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GCNA Gene

Localization for GCNA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCNA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCNA gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for GCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with GCNA: view

Pathways & Interactions for GCNA Gene

No Data Available

Interacting Proteins for GCNA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362799%0d%0a9606.ENSP00000354497%0d%0a
Selected Interacting proteins: ENSP00000362799 for GCNA Gene via STRING

Symbol External ID(s) Details
FAN1

Gene Ontology (GO) - Biological Process for GCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080111 DNA demethylation IBA --
genes like me logo Genes that share ontologies with GCNA: view

No data available for Pathways by source and SIGNOR curated interactions for GCNA Gene

Transcripts for GCNA Gene

mRNA/cDNA for GCNA Gene

Unigene Clusters for GCNA Gene

Acidic repeat containing:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCNA Gene

No ASD Table

Relevant External Links for GCNA Gene

GeneLoc Exon Structure for
GCNA
ECgene alternative splicing isoforms for
GCNA

Expression for GCNA Gene

NURSA nuclear receptor signaling pathways regulating expression of GCNA Gene:

GCNA

SOURCE GeneReport for Unigene cluster for GCNA Gene:

Hs.135167

mRNA Expression by UniProt/SwissProt for GCNA Gene:

Q96QF7-ACRC_HUMAN
Tissue specificity: Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GCNA Gene

Orthologs for GCNA Gene

This gene was present in the common ancestor of animals.

Orthologs for GCNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACRC 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACRC 35
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACRC 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACRC 35
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACRC 35
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii acrc 35
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14814 35
  • 14 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK328.4 35
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5183 35
  • 31 (a)
OneToOne
Species where no ortholog for GCNA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GCNA Gene

ENSEMBL:
Gene Tree for GCNA (if available)
TreeFam:
Gene Tree for GCNA (if available)

Paralogs for GCNA Gene

Pseudogenes.org Pseudogenes for GCNA Gene

genes like me logo Genes that share paralogs with GCNA: view

No data available for Paralogs for GCNA Gene

Variants for GCNA Gene

Sequence variations from dbSNP and Humsavar for GCNA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10217999 -- 71,605,675(+) GAAGC(A/G)TGGGC reference, missense
rs10678786 -- 71,585,870(+) AATCA(-/CT)CTTTG intron-variant
rs10706633 -- 71,588,889(+) TTTTT(-/T)AAGTT intron-variant
rs111319528 -- 71,585,679(+) CGAAG(A/T)TAAGA intron-variant
rs111364651 -- 71,600,254(+) CTAAT(C/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GCNA Gene

Variant ID Type Subtype PubMed ID
nsv6954 CNV insertion 18451855
esv33082 CNV loss 17666407
esv2740214 CNV deletion 23290073
esv27144 CNV gain 19812545
esv1584074 OTHER inversion 17803354

Variation tolerance for GCNA Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GCNA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCNA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCNA Gene

Disorders for GCNA Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCNA Gene - From: DISEASES

Disorder Aliases PubMed IDs
appendix adenocarcinoma
  • adenocarcinoma of appendix
- elite association - COSMIC cancer census association via MalaCards
Search GCNA in MalaCards View complete list of genes associated with diseases

Relevant External Links for GCNA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCNA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCNA
genes like me logo Genes that share disorders with GCNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCNA Gene

Publications for GCNA Gene

  1. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. (PMID: 27718356) Carmell M.A. … Page D.C. (Elife 2016) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1. (PMID: 11714101) Nolte D. … Mueller U. (Neurogenetics 2001) 3 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for GCNA Gene

Sources for GCNA Gene

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