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Aliases for GCN1L1 Gene

Aliases for GCN1L1 Gene

  • GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast) 2 3
  • GCN1 (General Control Of Amino-Acid Synthesis 1, Yeast)-Like 1 2 3
  • GCN1-Like Protein 1 3 4
  • HsGCN1 3 4
  • Peroxisome Proliferator Activated Receptor Interacting Complex Protein 3
  • Translational Activator GCN1 3
  • KIAA0219 4
  • PRIC295 3
  • GCN1L 3
  • GCN1 3

External Ids for GCN1L1 Gene

Previous GeneCards Identifiers for GCN1L1 Gene

  • GC12M119438
  • GC12M120091
  • GC12M120347
  • GC12M118976
  • GC12M119027
  • GC12M120565
  • GC12M117574

Summaries for GCN1L1 Gene

GeneCards Summary for GCN1L1 Gene

GCN1L1 (GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast)) is a Protein Coding gene. GO annotations related to this gene include translation factor activity, RNA binding.

UniProtKB/Swiss-Prot for GCN1L1 Gene

  • Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.

Gene Wiki entry for GCN1L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCN1L1 Gene

Genomics for GCN1L1 Gene

Regulatory Elements for GCN1L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GCN1L1 Gene

Start:
120,127,203 bp from pter
End:
120,194,710 bp from pter
Size:
67,508 bases
Orientation:
Minus strand

Genomic View for GCN1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GCN1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCN1L1 Gene

Proteins for GCN1L1 Gene

  • Protein details for GCN1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92616-GCN1L_HUMAN
    Recommended name:
    Translational activator GCN1
    Protein Accession:
    Q92616
    Secondary Accessions:
    • A8KAY1
    • O95001
    • O95651
    • Q6P2S3
    • Q86X65
    • Q8N5I5
    • Q8WU80
    • Q99736
    • Q9UE60

    Protein attributes for GCN1L1 Gene

    Size:
    2671 amino acids
    Molecular mass:
    292758 Da
    Quaternary structure:
    • Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4).
    SequenceCaution:
    • Sequence=AAC51648.1; Type=Frameshift; Positions=2657; Evidence={ECO:0000305}; Sequence=AAC83183.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA13209.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GCN1L1 Gene

Proteomics data for GCN1L1 Gene at MOPED

Post-translational modifications for GCN1L1 Gene

  • Ubiquitination at Lys12, Lys101, Lys268, Lys616, Lys695, Lys802, Lys965, Lys1208, Lys1390, Lys1556, Lys1663, Lys2083, Lys2237, Lys2285, Lys2550, Lys2572, and Lys2591
  • Modification sites at PhosphoSitePlus

Other Protein References for GCN1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCN1L1 Gene

Domains for GCN1L1 Gene

Suggested Antigen Peptide Sequences for GCN1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92616

UniProtKB/Swiss-Prot:

GCN1L_HUMAN :
  • Q92616
Family:
  • Belongs to the GCN1 family.
Similarity:
  • Contains 24 HEAT repeats.
genes like me logo Genes that share domains with GCN1L1: view

No data available for Gene Families for GCN1L1 Gene

Function for GCN1L1 Gene

Molecular function for GCN1L1 Gene

GENATLAS Biochemistry: translational regulator of the activator GCN4,potentially functioning on elongating ribosomes in activation of EIF2 alpha kinase GCN2,yeast GCN1 general control of amino-acid synthesis,homolog-like 1
UniProtKB/Swiss-Prot Function: Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.

Gene Ontology (GO) - Molecular Function for GCN1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0008135 translation factor activity, RNA binding NAS 9234705
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with GCN1L1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GCN1L1 Gene

Localization for GCN1L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GCN1L1 Gene COMPARTMENTS Subcellular localization image for GCN1L1 gene
Compartment Confidence
cytosol 4
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GCN1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9234705
GO:0005840 ribosome NAS 9234705
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GCN1L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GCN1L1 Gene

Pathways for GCN1L1 Gene

SuperPathways for GCN1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GCN1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 9234705
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with GCN1L1: view

No data available for Pathways by source for GCN1L1 Gene

Transcripts for GCN1L1 Gene

mRNA/cDNA for GCN1L1 Gene

(10) Selected AceView cDNA sequences:
(13) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GCN1L1 Gene

GCN1 general control of amino-acid synthesis 1-like 1 (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GCN1L1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GCN1L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCN1L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GCN1L1 Gene

GeneLoc Exon Structure for
GCN1L1
ECgene alternative splicing isoforms for
GCN1L1

Expression for GCN1L1 Gene

mRNA expression in normal human tissues for GCN1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GCN1L1 Gene

SOURCE GeneReport for Unigene cluster for GCN1L1 Gene Hs.298716

mRNA Expression by UniProt/SwissProt for GCN1L1 Gene

Q92616-GCN1L_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with GCN1L1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GCN1L1 Gene

Orthologs for GCN1L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GCN1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCN1L1 35
  • 99.54 (n)
  • 99.74 (a)
GCN1L1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GCN1L1 35
  • 90.57 (n)
  • 96.14 (a)
GCN1L1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GCN1L1 35
  • 90.96 (n)
  • 96.82 (a)
GCN1L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcn1l1 35
  • 87.42 (n)
  • 94.01 (a)
Gcn1l1 16
Gcn1l1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GCN1L1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCN1L1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcn1l1 35
  • 87.76 (n)
  • 94.27 (a)
chicken
(Gallus gallus)
Aves GCN1L1 35
  • 76.18 (n)
  • 85.74 (a)
GCN1L1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GCN1L1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6112 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gcn1l1 35
  • 72.35 (n)
  • 85.19 (a)
zebrafish
(Danio rerio)
Actinopterygii gcn1l1 35
  • 69.2 (n)
  • 72.69 (a)
gcn1l1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001700 35
  • 54.89 (n)
  • 48.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17514 35
  • 47.39 (n)
  • 44.59 (a)
CG17514 36
  • 44 (a)
OneToOne
CG17514 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea gcn-1 35
  • 46.62 (n)
  • 38.96 (a)
gcn-1 36
  • 32 (a)
OneToOne
Y48G9A.1 37
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR169W 35
  • 44.37 (n)
  • 33.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN1 35
  • 45.09 (n)
  • 36.62 (a)
GCN1 36
  • 27 (a)
OneToOne
GCN1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12430g 35
  • 44.6 (n)
  • 35.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ILA 35
  • 44.83 (n)
  • 37.12 (a)
rice
(Oryza sativa)
Liliopsida Os.15153 35
Os03g0721200 35
  • 49.62 (n)
  • 45.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05803 35
  • 48.36 (n)
  • 34.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC18G6.05c 35
  • 42.69 (n)
  • 34.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for GCN1L1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GCN1L1 Gene

ENSEMBL:
Gene Tree for GCN1L1 (if available)
TreeFam:
Gene Tree for GCN1L1 (if available)

Paralogs for GCN1L1 Gene

Selected SIMAP similar genes for GCN1L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GCN1L1: view

No data available for Paralogs for GCN1L1 Gene

Variants for GCN1L1 Gene

Sequence variations from dbSNP and Humsavar for GCN1L1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2422 -- 120,127,384(-) TCTGA(C/T)CCCTG utr-variant-3-prime
rs1005260 -- 120,130,148(+) AAAAT(A/G)CACCC intron-variant
rs1049516 -- 120,161,980(-) TCACT(G/T)CCTCC reference, missense
rs1166547 -- 120,172,521(+) ttttt(A/C)ttttt intron-variant
rs1179253 -- 120,152,697(+) atata(C/T)ataca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GCN1L1 Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv519657 CNV Loss 19592680
nsv832530 CNV Loss 17160897
nsv904 CNV Insertion 18451855

Relevant External Links for GCN1L1 Gene

HapMap Linkage Disequilibrium report
GCN1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCN1L1 Gene

Disorders for GCN1L1 Gene

(1) University of Copenhagen DISEASES for GCN1L1 Gene

Relevant External Links for GCN1L1

Genetic Association Database (GAD)
GCN1L1
genes like me logo Genes that share disorders with GCN1L1: view

No data available for UniProtKB/Swiss-Prot for GCN1L1 Gene

Publications for GCN1L1 Gene

  1. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. (PMID: 9234705) Marton M.J. … Hinnebusch A.G. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4

Products for GCN1L1 Gene

Sources for GCN1L1 Gene

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