Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GCN1L1 Gene

protein-coding   GIFtS: 56
GCID: GC12M120565

GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast)

(Previous names: GCN1 (general control of amino-acid synthesis 1, yeast)-like...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast)1 2     hsGCN12
GCN1 (General Control Of Amino-Acid Synthesis 1, Yeast)-Like 11 2     Peroxisome Proliferator Activated Receptor Interacting Complex Protein2
GCN1-Like Protein 12 3     Translational Activator GCN12
GCN12     HsGCN13
GCN1L2     KIAA02193
PRIC2952     

External Ids:    HGNC: 41991   Entrez Gene: 109852   Ensembl: ENSG000000891547   OMIM: 6056145   UniProtKB: Q926163   

Export aliases for GCN1L1 gene to outside databases

Previous GC identifers: GC12M119438 GC12M120091 GC12M120347 GC12M118976 GC12M119027 GC12M117574


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GCN1L1 Gene: 
GCN1L1 (GCN1 general control of amino-acid synthesis 1-like 1 (yeast)) is a protein-coding gene. Diseases associated with GCN1L1 include progressive multifocal leukoencephalopathy. GO annotations related to this gene include translation factor activity, nucleic acid binding.

UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
Function: Acts as a translation activator that mediates translational control and perform an EF3-related function
on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity (By similarity)

Gene Wiki entry for GCN1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GCN1L1 gene promoter:
         ER-alpha   GR   AML1a   GR-beta   AP-2gamma   HSF2   GR-alpha   Pax-4a   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GCN1L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCN1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.2

GCN1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCN1L1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120565:  view genomic region     (about GC identifiers)

Start:
120,565,007 bp from pter      End:
120,632,513 bp from pter
Size:
67,507 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616 (See protein sequence)
Recommended Name: Translational activator GCN1  
Size: 2671 amino acids; 292758 Da
Subunit: Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) (By similarity)
Sequence caution: Sequence=AAC51648.1; Type=Frameshift; Positions=2657; Sequence=AAC83183.1; Type=Erroneous gene
model prediction; Sequence=BAA13209.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8KAY1 O95001 O95651 Q6P2S3 Q86X65 Q8N5I5 Q8WU80 Q99736 Q9UE60

Explore the universe of human proteins at neXtProt for GCN1L1: NX_Q92616

Explore proteomics data for GCN1L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92616

  • GCN1L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GCN1L1 Protein Expression
    REFSEQ proteins: NP_006827.1  
    ENSEMBL proteins: 
     ENSP00000300648  

    Human Recombinant Protein Products for GCN1L1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GCN1L1
    GenScript Custom Purified and Recombinant Proteins Services for GCN1L1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GCN1L1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS9234705
    GO:0005840ribosome NAS9234705

    GCN1L1 for ontologies           About GeneDecksing



    GCN1L1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GCN1L1
    GenScript Custom Superior Antibodies Services for GCN1L1
    Novus Biologicals GCN1L1 Antibodies
    Abcam antibodies for GCN1L1
    Cloud-Clone Corp. Antibodies for GCN1L1 
    Search ThermoFisher Antibodies for GCN1L1
    Search LSBio for Antibodies for GCN1L1 

    Assay Products for GCN1L1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GCN1L1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GCN1L1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GCN1L1 
    Cloud-Clone Corp. CLIAs for GCN1L1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR011989 ARM-like
     IPR022716 DUF3554
     IPR000225 Armadillo
     IPR021133 HEAT_type_2
     IPR026827 ECM29/GCN1

    Graphical View of Domain Structure for InterPro Entry Q92616

    ProtoNet protein and cluster: Q92616

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB000847 Bacterial regulatory protein LysR


    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Similarity: Belongs to the GCN1 family
    Similarity: Contains 24 HEAT repeats


    GCN1L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCN1L_HUMAN, Q92616
    Function: Acts as a translation activator that mediates translational control and perform an EF3-related function
    on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity (By similarity)

         Genatlas biochemistry entry for GCN1L1:
    translational regulator of the activator GCN4,potentially functioning on elongating ribosomes in activation of
    EIF2 alpha kinase GCN2,yeast GCN1 general control of amino-acid synthesis,homolog-like 1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008135translation factor activity, nucleic acid binding NAS9234705
         
    GCN1L1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GCN1L1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GCN1L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GCN1L1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GCN1L1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GCN1L1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate GCN1L1 (see all 9):
    hsa-miR-607 hsa-miR-765 hsa-miR-551b* hsa-miR-1305 hsa-miR-570 hsa-miR-4314 hsa-miR-3613-3p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidGCN1L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GCN1L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GCN1L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GCN1L1


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GCN1L1 (see all 5)
    OriGene ORF clones in mouse, rat for GCN1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCN1L1 (NM_006836)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCN1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCN1L1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GCN1L1
    Search LifeMap BioReagents cell lines for GCN1L1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCN1L1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GCN1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1106 Interacting proteins for GCN1L1 (Q926162, 3 ENSP000003006484) via UniProtKB, MINT, STRING, and/or I2D (see all 1106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS9234705
    GO:0006417regulation of translation IEA--

    GCN1L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GCN1L1 (GCN1L)

    Search CenterWatch for drugs/clinical trials and news about GCN1L1 / GCN1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GCN1L1 gene: 
    NM_006836.1  

    Unigene Cluster for GCN1L1:

    GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
    Hs.298716  [show with all ESTs]
    Unigene Representative Sequence: NM_006836
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300648(uc001txo.3) ENST00000549815 ENST00000547263 ENST00000548132
    ENST00000551920 ENST00000547369 ENST00000550471 ENST00000551549 ENST00000548821

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GCN1L1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate GCN1L1 (see all 9):
    hsa-miR-607 hsa-miR-765 hsa-miR-551b* hsa-miR-1305 hsa-miR-570 hsa-miR-4314 hsa-miR-3613-3p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidGCN1L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GCN1L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GCN1L1
    Clone
    Products:
         
    OriGene clones in human, mouse for GCN1L1 (see all 5)
    OriGene ORF clones in mouse, rat for GCN1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCN1L1 (NM_006836)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCN1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCN1L1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GCN1L1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GCN1L1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GCN1L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GCN1L1

    Additional mRNA sequence: 

    AK297271.1 BC021129.1 BC032335.1 BC040172.1 BC046177.1 BC064346.1 BC113083.1 BC113084.1 
    BC153881.1 D86973.2 U77700.1 U88836.1 U88837.1 

    24 DOTS entries:

    DT.95338247  DT.101969584  DT.40115774  DT.121112656  DT.92442294  DT.121113274  DT.102826929  DT.95343278 
    DT.121112917  DT.40223302  DT.75131390  DT.92044142  DT.95326127  DT.97798165  DT.100030746  DT.100650231 
    DT.100825974  DT.121113344  DT.75172344  DT.95075247  DT.99965505  DT.121112667  DT.65286828  DT.75150986 

    10 AceView cDNA sequences:

    BC021129 BC040172 BC064346 BC046177 U88837 CR607697 BC032335 D86973 
    U88836 U77700 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GCN1L1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^
    SP1:                                                                                      -                                         -                 -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^
    SP1:                          -                                                                                         -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57
    SP1:        -                             -                                                               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for GCN1L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GCN1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAGGTCTG
    GCN1L1 Expression
    About this image


    See GCN1L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GCN1L1

    SOURCE GeneReport for Unigene cluster: Hs.298716

    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for GCN1L1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GCN1L1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GCN1L1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GCN1L1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GCN1L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCN1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GCN1L1 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gcn1l11 , 5 GCN1 general control of amino-acid synthesis 1-like more1, 5 87.42(n)1
    94.01(a)1
      5 (56.10 cM)5
    2316591  NM_172719.21  NP_766307.21 
     1155652545 
    chicken
    (Gallus gallus)
    Aves GCN1L11 GCN1 general control of amino-acid synthesis 1-like more 76.21(n)
    85.74(a)
      416982  XM_003642223.1  XP_003642271.1 
    lizard
    (Anolis carolinensis)
    Reptilia GCN1L16
    Uncharacterized protein
    83(a)
    1 ↔ 1
    GL343338.1(456686-488905)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61122 Xenopus laevis transcribed sequence with weak similarity more 73.79(n)    BX850198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570523922   -- 75.01(n)    57052392 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175141 , 3 translation activator3
    CG175141
    46(a)3
    47.36(n)1
    44.41(a)1
      33550401  NM_001015316.21  NP_001015316.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G9A.13
    gcn-11
    Protein GCN-11 41(a)3
    44.13(n)1
    34.68(a)1
      III(2246490-2269511)3
    1900511  NM_065105.41  NP_497506.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCN1(YGL195W)4
    GCN11
    Positive regulator of the Gcn2p kinase activity, forms more4
    Gcn1p1
    44.88(n)1
    36.37(a)1
      7(131525-139543)4
    8526801, 4  NP_011320.31  NP_011320.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ILA1 protein ILITYHIA 44.27(n)
    36.27(a)
      842787  NM_105153.7  NP_176659.6 
    rice
    (Oryza sativa)
    Liliopsida Os.151532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.18(n)    AK065408.1 


    ENSEMBL Gene Tree for GCN1L1 (if available)
    TreeFam Gene Tree for GCN1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GCN1L1 gene
    1 SIMAP similar gene for GCN1L1 using alignment to 2 protein entries:     GCN1L_HUMAN (see all proteins):
    PRIC295

    GCN1L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1571 SNPs in GCN1L1 are shown (see all 1571)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0622284
    ----see VAR_0622282 Y D mis40--------
    rs1816114791,2
    --120564655(+) GGAGGA/GAGGAA 1 -- ds50010--------
    rs1480480761,2
    C--120564887(+) CACAC-/CTCTCAA 1 -- ds50010--------
    rs47678781,2
    C,F,H--120564999(+) CAGGTG/ACAAAC 1 -- ds500118Minor allele frequency- A:0.01NS EA NA WA CSA 1075
    rs1859716271,2
    --120565057(+) TTTTTA/TAAAAT 1 -- ut310--------
    rs1917705921,2
    --120565072(+) TTATAC/TCAAGA 1 -- ut310--------
    rs24221,2
    C,F,O,A,H--120565188(-) TCTGAC/TCCCTG 1 -- ut31 ese326Minor allele frequency- T:0.50MN EA NS NA WA CSA 3806
    rs1814335661,2
    --120565429(+) GCATGC/TGTGTG 1 -- ut310--------
    rs115547381,2
    C--120565473(-) CTCCTC/ACATCT 1 -- ut31 ese32Minor allele frequency- A:0.00NA 4
    rs1426109261,2
    C--120565499(+) GTGTGG/TGTTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GCN1L1 (120565007 - 120632513 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GCN1L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904CNV Insertion18451855
    nsv832530CNV Loss17160897
    nsv899555CNV Loss21882294
    nsv519657CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GCN1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for GCN1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605614    OMIM disorders: --

    2 diseases for GCN1L1:    About MalaCards
    progressive multifocal leukoencephalopathy    

    1 disease from the University of Copenhagen DISEASES database for GCN1L1:
    Progressive multifocal leukoencephalopathy

    GCN1L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GCN1L1

    Export disorders for GCN1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GCN1L1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with GCN1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. (PubMed id 9234705)1, 2, 3, 9 Marton M.J....Hinnebusch A.G. (1997)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    6. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (2013)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    10. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10985 HGNC: 4199 AceView: GCN1L1 Ensembl:ENSG00000089154 euGenes: HUgn10985
    ECgene: GCN1L1 H-InvDB: GCN1L1

    (According to HUGE)
    About This Section
    HUGE: KIAA0219

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GCN1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GCN1L1 gene:
    Search GeneIP for patents involving GCN1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GCN1L1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GCN1L1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GCN1L1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GCN1L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GCN1L1   OriGene Custom Protein Services for GCN1L1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GCN1L1
     QIAGEN SeqTarget long-range PCR primers for resequencing GCN1L1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCN1L1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GCN1L1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GCN1L1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GCN1L1
     GenScript Custom Purified and Recombinant Proteins Services for GCN1L1 GenScript cDNA clones with any tag delivered in your preferred vector for GCN1L1
     GenScript Custom Assay Services for GCN1L1 GenScript Custom Superior Antibodies Services for GCN1L1
     GenScript Custom overexpressing Cell Line Services for GCN1L1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GCN1L1 promoter
     Search Chromatin IP Primers for GCN1L1
     RT2 qPCR Primer Assay in human, mouse, rat GCN1L1
     GNC Network for GCN1L1
     SABiosciences Custom PCR Arrays for GCN1L1
     Search Tocris compounds for GCN1L1 (GCN1L)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GCN1L1 antibodies
     Antibodies for GCN1L1
     See all of Abcam's Antibodies, Kits and Proteins for GCN1L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GCN1L1
     Antibodies for GCN1L1
     ELISAs for GCN1L1
     CLIAs for GCN1L1
     Search LifeMap BioReagents cell lines for GCN1L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCN1L1
     SwitchGear 3'UTR luciferase reporter plasmids for GCN1L1
     Browse SwitchGear Promoter luciferase reporter plasmids for GCN1L1
     Search ThermoFisher Antibodies for GCN1L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCN1L1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GCN1L1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GCN1L1
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression
     Search LSBio for Antibodies for GCN1L1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GCN1L1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4