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GCN1L1 Gene

protein-coding   GIFtS: 57
GCID: GC12M120565

GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast)

(Previous names: GCN1 (general control of amino-acid synthesis 1, yeast)-like...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast)1 2     hsGCN12
GCN1 (General Control Of Amino-Acid Synthesis 1, Yeast)-Like 11 2     Peroxisome Proliferator Activated Receptor Interacting Complex Protein2
GCN1-Like Protein 12 3     Translational Activator GCN12
GCN12     HsGCN13
GCN1L2     KIAA02193
PRIC2952     

External Ids:    HGNC: 41991   Entrez Gene: 109852   Ensembl: ENSG000000891547   OMIM: 6056145   UniProtKB: Q926163   

Export aliases for GCN1L1 gene to outside databases

Previous GC identifers: GC12M119438 GC12M120091 GC12M120347 GC12M118976 GC12M119027 GC12M117574


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GCN1L1 Gene:
GCN1L1 (GCN1 general control of amino-acid synthesis 1-like 1 (yeast)) is a protein-coding gene. GO annotations related to this gene include translation factor activity, nucleic acid binding.

UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
Function: Acts as a translation activator that mediates translational control and perform an EF3-related function
on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity (By similarity)

Gene Wiki entry for GCN1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the GCN1L1 gene promoter:
         ER-alpha   GR   AML1a   GR-beta   AP-2gamma   HSF2   GR-alpha   Pax-4a   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GCN1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GCN1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.2

GCN1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCN1L1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120565:  view genomic region     (about GC identifiers)

Start:
120,565,007 bp from pter      End:
120,632,513 bp from pter
Size:
67,507 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616 (See protein sequence)
Recommended Name: Translational activator GCN1  
Size: 2671 amino acids; 292758 Da
Subunit: Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) (By similarity)
Sequence caution: Sequence=AAC51648.1; Type=Frameshift; Positions=2657; Sequence=AAC83183.1; Type=Erroneous gene
model prediction; Sequence=BAA13209.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8KAY1 O95001 O95651 Q6P2S3 Q86X65 Q8N5I5 Q8WU80 Q99736 Q9UE60

Explore the universe of human proteins at neXtProt for GCN1L1: NX_Q92616

Explore proteomics data for GCN1L1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys101, Lys268, Lys616, Lys695, Lys802, Lys965, Lys1208, Lys1390, Lys1556,
                                 Lys1663, Lys2083, Lys2237, Lys2285, Lys2550, Lys2572, Lys2591
  • Modification sites at PhosphoSitePlus

  • See GCN1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006827.1  
    ENSEMBL proteins: 
     ENSP00000300648  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR011989 ARM-like
     IPR022716 DUF3554
     IPR000225 Armadillo
     IPR021133 HEAT_type_2
     IPR026827 ECM29/GCN1

    Graphical View of Domain Structure for InterPro Entry Q92616

    ProtoNet protein and cluster: Q92616

    2 Blocks protein domains:
    IPB000225 Armadillo repeat
    IPB000847 Bacterial regulatory protein LysR


    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Similarity: Belongs to the GCN1 family
    Similarity: Contains 24 HEAT repeats


    Find genes that share domains with GCN1L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCN1L_HUMAN, Q92616
    Function: Acts as a translation activator that mediates translational control and perform an EF3-related function
    on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity (By similarity)

         Genatlas biochemistry entry for GCN1L1:
    translational regulator of the activator GCN4,potentially functioning on elongating ribosomes in activation of
    EIF2 alpha kinase GCN2,yeast GCN1 general control of amino-acid synthesis,homolog-like 1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008135translation factor activity, nucleic acid binding NAS9234705
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with GCN1L1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GCN1L1

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    miRTarBase miRNAs that target GCN1L1:
    hsa-mir-221-3p (MIRT046958), hsa-mir-18a-3p (MIRT040858), hsa-let-7a-5p (MIRT052425), hsa-mir-149-5p (MIRT045622), hsa-mir-328-3p (MIRT043819), hsa-mir-222-3p (MIRT046637), hsa-mir-423-3p (MIRT042534), hsa-mir-425-3p (MIRT042433), hsa-mir-1293 (MIRT035903), hsa-mir-185-5p (MIRT045354), hsa-let-7b-5p (MIRT052324), hsa-mir-484 (MIRT042010), hsa-mir-1226-3p (MIRT036502)

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    SwitchGear 3'UTR luciferase reporter plasmidGCN1L1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS9234705
    GO:0005840ribosome NAS9234705

    Find genes that share ontologies with GCN1L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GCN1L1
    Interactions:

        GeneGlobe Interaction Network for GCN1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GCN1L1 (Q926162, 3 ENSP000003006484) via UniProtKB, MINT, STRING, and/or I2D (see all 1221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS9234705
    GO:0006417regulation of translation IEA--

    Find genes that share ontologies with GCN1L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GCN1L1 (GCN1L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GCN1L1 gene: 
    NM_006836.1  

    Unigene Cluster for GCN1L1:

    GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
    Hs.298716  [show with all ESTs]
    Unigene Representative Sequence: NM_006836
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300648(uc001txo.3) ENST00000549815 ENST00000547263 ENST00000548132
    ENST00000551920 ENST00000547369 ENST00000550471 ENST00000551549 ENST00000548821

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    Selected qRT-PCR Assays for microRNAs that regulate GCN1L1 (see all 9):
    hsa-miR-607 hsa-miR-765 hsa-miR-551b* hsa-miR-1305 hsa-miR-570 hsa-miR-4314 hsa-miR-3613-3p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidGCN1L1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GCN1L1

    Additional mRNA sequence: 

    AK297271.1 BC021129.1 BC032335.1 BC040172.1 BC046177.1 BC064346.1 BC113083.1 BC113084.1 
    BC153881.1 D86973.2 U77700.1 U88836.1 U88837.1 

    24 DOTS entries:

    DT.95338247  DT.101969584  DT.40115774  DT.121112656  DT.92442294  DT.121113274  DT.102826929  DT.95343278 
    DT.121112917  DT.40223302  DT.75131390  DT.92044142  DT.95326127  DT.97798165  DT.100030746  DT.100650231 
    DT.100825974  DT.121113344  DT.75172344  DT.95075247  DT.99965505  DT.121112667  DT.65286828  DT.75150986 

    10 AceView cDNA sequences:

    BC064346 BC040172 BC032335 U88837 BC021129 BC046177 D86973 CR607697 
    U88836 U77700 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GCN1L1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^
    SP1:                                                                                      -                                         -                 -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43 ^
    SP1:                          -                                                                                         -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57
    SP1:        -                             -                                                               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for GCN1L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GCN1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAGGTCTG
    GCN1L1 Expression
    About this image


    GCN1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    GCN1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GCN1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.298716

    UniProtKB/Swiss-Prot: GCN1L_HUMAN, Q92616
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GCN1L1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gcn1l11 , 5 GCN1 general control of amino-acid synthesis 1-like more1, 5 87.42(n)1
    94.01(a)1
      5 (56.10 cM)5
    2316591  NM_172719.21  NP_766307.21 
     1155652545 
    chicken
    (Gallus gallus)
    Aves GCN1L11 GCN1 general control of amino-acid synthesis 1-like more 76.18(n)
    85.74(a)
      416982  XM_003642223.2  XP_003642271.2 
    lizard
    (Anolis carolinensis)
    Reptilia GCN1L16
    GCN1 general control of amino-acid synthesis 1-lik...
    83(a)
    1 ↔ 1
    GL343338.1(456686-488905)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61122 Xenopus laevis transcribed sequence with weak similarity more 73.79(n)    BX850198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570523922   -- 75.01(n)    57052392 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175141 , 3 translation activator3
    CG175141
    46(a)3
    47.39(n)1
    44.59(a)1
      33550401  NM_001015316.31  NP_001015316.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G9A.13
    gcn-11
    gcn-11 41(a)3
    46.62(n)1
    38.96(a)1
      III(2246490-2269511)3
    1900511  NM_065105.51  NP_497506.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCN1(YGL195W)4
    GCN11
    Positive regulator of the Gcn2p kinase activity, forms more4
    GCN11
    45.09(n)1
    36.62(a)1
      7(131525-139543)4
    8526801, 4  NP_011320.31  NP_011320.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ILA1 ILA 44.83(n)
    37.12(a)
      842787  NM_105153.7  NP_176659.6 
    rice
    (Oryza sativa)
    Liliopsida Os.151532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.18(n)    AK065408.1 


    ENSEMBL Gene Tree for GCN1L1 (if available)
    TreeFam Gene Tree for GCN1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GCN1L1 gene
    1 SIMAP similar gene for GCN1L1 using alignment to 2 protein entries:     GCN1L_HUMAN (see all proteins):
    PRIC295

    Find genes that share paralogs with GCN1L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for GCN1L1 (see all 1571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816114791,2
    --120564655(+) GGAGGA/GAGGAA 1 -- ds50010--------
    rs1480480761,2
    C--120564887(+) CACAC-/CTCTCAA 1 -- ds50010--------
    rs47678781,2
    C,F,H--120564999(+) CAGGTG/ACAAAC 1 -- ds500118Minor allele frequency- A:0.01NS EA NA WA CSA 1075
    rs1859716271,2
    --120565057(+) TTTTTA/TAAAAT 1 -- ut310--------
    rs1917705921,2
    --120565072(+) TTATAC/TCAAGA 1 -- ut310--------
    rs24221,2
    C,F,O,A,H--120565188(-) TCTGAC/TCCCTG 1 -- ut31 ese326Minor allele frequency- T:0.50MN EA NS NA WA CSA 3806
    rs1814335661,2
    --120565429(+) GCATGC/TGTGTG 1 -- ut310--------
    rs115547381,2
    C--120565473(-) CTCCTC/ACATCT 1 -- ut31 ese32Minor allele frequency- A:0.00NA 4
    rs1426109261,2
    C--120565499(+) GTGTGG/TGTTTG 1 -- ut310--------
    rs1505563201,2
    --120565554(+) GGGAAC/TGCCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GCN1L1 (120565007 - 120632513 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for GCN1L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904CNV Insertion18451855
    nsv832530CNV Loss17160897
    nsv899555CNV Loss21882294
    nsv519657CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GCN1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for GCN1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605614    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GCN1L1:
    Progressive multifocal leukoencephalopathy

    Find genes that share disorders with GCN1L1           About GenesLikeMe

    Genetic Association Database (GAD): GCN1L1

    Export disorders for GCN1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GCN1L1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with GCN1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. (PubMed id 9234705)1, 2, 3, 9 Marton M.J....Hinnebusch A.G. (Mol. Cell. Biol. 1997)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10985 HGNC: 4199 AceView: GCN1L1 Ensembl:ENSG00000089154 euGenes: HUgn10985
    ECgene: GCN1L1 H-InvDB: GCN1L1

    (According to HUGE)
    About This Section

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    HUGE: KIAA0219

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GCN1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for GCN1L1 gene:
    Search GeneIP for patents involving GCN1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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