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Aliases for GCN1 Gene

Aliases for GCN1 Gene

  • GCN1 EIF2 Alpha Kinase Activator Homolog 2 3
  • GCN1 (General Control Of Amino-Acid Synthesis 1, Yeast)-Like 1 2 3
  • GCN1-Like Protein 1 3 4
  • HsGCN1 3 4
  • GCN1L1 3 4
  • Peroxisome Proliferator Activated Receptor Interacting Complex Protein 3
  • GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast) 2
  • GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 3
  • KIAA0219 4
  • PRIC295 3
  • GCN1L 3

External Ids for GCN1 Gene

Previous HGNC Symbols for GCN1 Gene

  • GCN1L1

Summaries for GCN1 Gene

GeneCards Summary for GCN1 Gene

GCN1 (GCN1 EIF2 Alpha Kinase Activator Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GCN1 Gene

  • Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.

Gene Wiki entry for GCN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCN1 Gene

Genomics for GCN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GCN1 Gene

Chromosome:
12
Start:
120,127,203 bp from pter
End:
120,194,710 bp from pter
Size:
67,508 bases
Orientation:
Minus strand

Genomic View for GCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCN1 Gene

No data available for Regulatory Elements for GCN1 Gene

Proteins for GCN1 Gene

  • Protein details for GCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92616-GCN1L_HUMAN
    Recommended name:
    Translational activator GCN1
    Protein Accession:
    Q92616
    Secondary Accessions:
    • A8KAY1
    • O95001
    • O95651
    • Q6P2S3
    • Q86X65
    • Q8N5I5
    • Q8WU80
    • Q99736
    • Q9UE60

    Protein attributes for GCN1 Gene

    Size:
    2671 amino acids
    Molecular mass:
    292758 Da
    Quaternary structure:
    • Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4).
    SequenceCaution:
    • Sequence=AAC51648.1; Type=Frameshift; Positions=2657; Evidence={ECO:0000305}; Sequence=AAC83183.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA13209.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GCN1 Gene

Proteomics data for GCN1 Gene at MOPED

Post-translational modifications for GCN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCN1 Gene

Domains & Families for GCN1 Gene

Suggested Antigen Peptide Sequences for GCN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92616

UniProtKB/Swiss-Prot:

GCN1L_HUMAN :
  • Belongs to the GCN1 family.
  • Contains 24 HEAT repeats.
Family:
  • Belongs to the GCN1 family.
Similarity:
  • Contains 24 HEAT repeats.
genes like me logo Genes that share domains with GCN1: view

No data available for Gene Families for GCN1 Gene

Function for GCN1 Gene

Molecular function for GCN1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a translation activator that mediates translational control and perform an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.

Gene Ontology (GO) - Molecular Function for GCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0008135 translation factor activity, RNA binding NAS 9234705
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with GCN1: view
genes like me logo Genes that share phenotypes with GCN1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GCN1 Gene

Localization for GCN1 Gene

Gene Ontology (GO) - Cellular Components for GCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9234705
GO:0005840 ribosome NAS 9234705
GO:0005844 polysome ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GCN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GCN1 Gene

Pathways & Interactions for GCN1 Gene

SuperPathways for GCN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 9234705
GO:0006417 regulation of translation IEA --
GO:0034198 cellular response to amino acid starvation ISS --
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress ISS --
GO:1990253 cellular response to leucine starvation ISS --
genes like me logo Genes that share ontologies with GCN1: view

No data available for Pathways by source and SIGNOR curated interactions for GCN1 Gene

Drugs & Compounds for GCN1 Gene

No Compound Related Data Available

Transcripts for GCN1 Gene

mRNA/cDNA for GCN1 Gene

(1) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GCN1 Gene

No ASD Table

Relevant External Links for GCN1 Gene

GeneLoc Exon Structure for
GCN1
ECgene alternative splicing isoforms for
GCN1

Expression for GCN1 Gene

mRNA Expression by UniProt/SwissProt for GCN1 Gene

Q92616-GCN1L_HUMAN
Tissue specificity: Ubiquitously expressed.

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GCN1 Gene

Orthologs for GCN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GCN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GCN1L1 35
  • 90.57 (n)
  • 96.14 (a)
GCN1L1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GCN1L1 35
  • 90.96 (n)
  • 96.82 (a)
GCN1L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcn1l1 35
  • 87.42 (n)
  • 94.01 (a)
Gcn1l1 16
Gcn1l1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GCN1L1 35
  • 99.54 (n)
  • 99.74 (a)
GCN1L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcn1l1 35
  • 87.76 (n)
  • 94.27 (a)
oppossum
(Monodelphis domestica)
Mammalia GCN1L1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCN1L1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GCN1L1 35
  • 76.18 (n)
  • 85.74 (a)
GCN1L1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GCN1L1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gcn1l1 35
  • 72.35 (n)
  • 85.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6112 35
zebrafish
(Danio rerio)
Actinopterygii gcn1l1 35
  • 69.2 (n)
  • 72.69 (a)
gcn1l1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001700 35
  • 54.89 (n)
  • 48.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17514 35
  • 47.39 (n)
  • 44.59 (a)
CG17514 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gcn-1 35
  • 46.62 (n)
  • 38.96 (a)
gcn-1 36
  • 32 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR169W 35
  • 44.37 (n)
  • 33.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12430g 35
  • 44.6 (n)
  • 35.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN1 35
  • 45.09 (n)
  • 36.62 (a)
GCN1 36
  • 27 (a)
OneToOne
GCN1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ILA 35
  • 44.83 (n)
  • 37.12 (a)
rice
(Oryza sativa)
Liliopsida Os.15153 35
Os03g0721200 35
  • 49.62 (n)
  • 45.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05803 35
  • 48.36 (n)
  • 34.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC18G6.05c 35
  • 42.69 (n)
  • 34.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for GCN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GCN1 Gene

ENSEMBL:
Gene Tree for GCN1 (if available)
TreeFam:
Gene Tree for GCN1 (if available)

Paralogs for GCN1 Gene

No data available for Paralogs for GCN1 Gene

Variants for GCN1 Gene

Sequence variations from dbSNP and Humsavar for GCN1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2422 -- 120,127,384(-) TCTGA(C/T)CCCTG utr-variant-3-prime
rs1005260 -- 120,130,148(+) AAAAT(A/G)CACCC intron-variant
rs1049516 -- 120,161,980(-) TCACT(G/T)CCTCC reference, missense
rs1166547 -- 120,172,521(+) ttttt(A/C)ttttt intron-variant
rs1179253 -- 120,152,697(+) atata(C/T)ataca intron-variant

Variation tolerance for GCN1 Gene

Residual Variation Intolerance Score: .27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GCN1 Gene

HapMap Linkage Disequilibrium report
GCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GCN1 Gene

Disorders for GCN1 Gene

Relevant External Links for GCN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCN1
genes like me logo Genes that share disorders with GCN1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GCN1 Gene

Publications for GCN1 Gene

  1. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. (PMID: 9234705) Marton M.J. … Hinnebusch A.G. (Mol. Cell. Biol. 1997) 2 23 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for GCN1 Gene

Sources for GCN1 Gene

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