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Aliases for GCN1 Gene

Aliases for GCN1 Gene

  • GCN1, EIF2 Alpha Kinase Activator Homolog 2 3 5
  • GCN1 (General Control Of Amino-Acid Synthesis 1, Yeast)-Like 1 2 3
  • General Control Of Amino-Acid Synthesis 1-Like Protein 1 3 4
  • GCN1 EIF-2-Alpha Kinase Activator Homolog 3 4
  • Translational Activator GCN1 3 4
  • GCN1-Like Protein 1 3 4
  • HsGCN1 3 4
  • GCN1L1 3 4
  • Peroxisome Proliferator Activated Receptor Interacting Complex Protein 3
  • GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 (Yeast) 2
  • GCN1 General Control Of Amino-Acid Synthesis 1-Like 1 3
  • GCN1 EIF2 Alpha Kinase Activator Homolog 3
  • KIAA0219 4
  • PRIC295 3
  • GCN1L 3

External Ids for GCN1 Gene

Previous HGNC Symbols for GCN1 Gene

  • GCN1L1

Summaries for GCN1 Gene

GeneCards Summary for GCN1 Gene

GCN1 (GCN1, EIF2 Alpha Kinase Activator Homolog) is a Protein Coding gene. Diseases associated with GCN1 include neuroblastoma.

UniProtKB/Swiss-Prot for GCN1 Gene

  • Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on Ser-52, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.

Gene Wiki entry for GCN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCN1 Gene

Genomics for GCN1 Gene

Regulatory Elements for GCN1 Gene

Promoters for GCN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GCN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GCN1 Gene

Chromosome:
12
Start:
120,127,203 bp from pter
End:
120,194,710 bp from pter
Size:
67,508 bases
Orientation:
Minus strand

Genomic View for GCN1 Gene

Genes around GCN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCN1 Gene

Proteins for GCN1 Gene

  • Protein details for GCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92616-GCN1_HUMAN
    Recommended name:
    eIF-2-alpha kinase activator GCN1
    Protein Accession:
    Q92616
    Secondary Accessions:
    • A8KAY1
    • O95001
    • O95651
    • Q6P2S3
    • Q86X65
    • Q8N5I5
    • Q8WU80
    • Q99736
    • Q9UE60

    Protein attributes for GCN1 Gene

    Size:
    2671 amino acids
    Molecular mass:
    292758 Da
    Quaternary structure:
    • Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity.
    SequenceCaution:
    • Sequence=AAC51648.1; Type=Frameshift; Positions=2657; Evidence={ECO:0000305}; Sequence=AAC83183.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA13209.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GCN1 Gene

Proteomics data for GCN1 Gene at MOPED

Post-translational modifications for GCN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCN1 Gene

Domains & Families for GCN1 Gene

Suggested Antigen Peptide Sequences for GCN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92616

UniProtKB/Swiss-Prot:

GCN1_HUMAN :
  • Belongs to the GCN1 family.
  • Contains 47 HEAT repeats.
Family:
  • Belongs to the GCN1 family.
Similarity:
  • Contains 47 HEAT repeats.
genes like me logo Genes that share domains with GCN1: view

No data available for Gene Families for GCN1 Gene

Function for GCN1 Gene

Molecular function for GCN1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on Ser-52, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.

Gene Ontology (GO) - Molecular Function for GCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0019901 protein kinase binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with GCN1: view
genes like me logo Genes that share phenotypes with GCN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GCN1 Gene

Localization for GCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCN1 Gene

Cytoplasm. Note=Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation. {ECO:0000250 UniProtKB:E9PVA8}.

Gene Ontology (GO) - Cellular Components for GCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS,IDA 9234705
genes like me logo Genes that share ontologies with GCN1: view

No data available for Subcellular locations from COMPARTMENTS for GCN1 Gene

Pathways & Interactions for GCN1 Gene

SuperPathways for GCN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 9234705
GO:0033674 positive regulation of kinase activity IEA --
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress IEA,ISS --
GO:0045859 regulation of protein kinase activity IEA --
GO:1990253 cellular response to leucine starvation IEA,ISS --
genes like me logo Genes that share ontologies with GCN1: view

No data available for Pathways by source and SIGNOR curated interactions for GCN1 Gene

Drugs & Compounds for GCN1 Gene

No Compound Related Data Available

Transcripts for GCN1 Gene

mRNA/cDNA for GCN1 Gene

(1) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GCN1 Gene

No ASD Table

Relevant External Links for GCN1 Gene

GeneLoc Exon Structure for
GCN1
ECgene alternative splicing isoforms for
GCN1

Expression for GCN1 Gene

mRNA Expression by UniProt/SwissProt for GCN1 Gene

Q92616-GCN1_HUMAN
Tissue specificity: Ubiquitously expressed (PubMed:9039502). Expressed in skeletal muscules, ovary and testis (PubMed:9234705).

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GCN1 Gene

Orthologs for GCN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCN1L1 36
  • 100 (a)
OneToOne
GCN1L1 35
  • 99.54 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia GCN1L1 36
  • 96 (a)
OneToOne
GCN1L1 35
  • 90.57 (n)
  • 96.14 (a)
dog
(Canis familiaris)
Mammalia GCN1L1 35
  • 90.96 (n)
  • 96.82 (a)
GCN1L1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcn1l1 36
  • 94 (a)
OneToOne
Gcn1l1 35
  • 87.42 (n)
  • 94.01 (a)
Gcn1l1 16
oppossum
(Monodelphis domestica)
Mammalia GCN1L1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCN1L1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcn1l1 35
  • 87.76 (n)
  • 94.27 (a)
chicken
(Gallus gallus)
Aves GCN1L1 35
  • 76.18 (n)
  • 85.74 (a)
GCN1L1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GCN1L1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6112 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gcn1l1 35
  • 72.35 (n)
  • 85.19 (a)
zebrafish
(Danio rerio)
Actinopterygii gcn1l1 35
  • 69.2 (n)
  • 72.69 (a)
gcn1l1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001700 35
  • 54.89 (n)
  • 48.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17514 35
  • 47.39 (n)
  • 44.59 (a)
CG17514 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gcn-1 36
  • 32 (a)
OneToOne
gcn-1 35
  • 46.62 (n)
  • 38.96 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR169W 35
  • 44.37 (n)
  • 33.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN1 35
  • 45.09 (n)
  • 36.62 (a)
GCN1 36
  • 27 (a)
OneToOne
GCN1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12430g 35
  • 44.6 (n)
  • 35.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ILA 35
  • 44.83 (n)
  • 37.12 (a)
rice
(Oryza sativa)
Liliopsida Os.15153 35
Os03g0721200 35
  • 49.62 (n)
  • 45.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05803 35
  • 48.36 (n)
  • 34.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC18G6.05c 35
  • 42.69 (n)
  • 34.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for GCN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GCN1 Gene

ENSEMBL:
Gene Tree for GCN1 (if available)
TreeFam:
Gene Tree for GCN1 (if available)

Paralogs for GCN1 Gene

No data available for Paralogs for GCN1 Gene

Variants for GCN1 Gene

Sequence variations from dbSNP and Humsavar for GCN1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3864938 - 120,137,745(+) CAGAT(A/C)CTCGA reference, missense
rs1166547 -- 120,172,521(+) ttttt(A/C)ttttt intron-variant
rs1005260 -- 120,130,148(+) AAAAT(A/G)CACCC intron-variant
rs1179263 -- 120,181,847(+) aaaaa(A/T)aaaaa intron-variant
rs1183769 -- 120,181,788(+) gagcc(A/G)agatc intron-variant

Variation tolerance for GCN1 Gene

Residual Variation Intolerance Score: 0.271% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GCN1 Gene

HapMap Linkage Disequilibrium report
GCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GCN1 Gene

Disorders for GCN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCN1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search GCN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GCN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCN1
genes like me logo Genes that share disorders with GCN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCN1 Gene

Publications for GCN1 Gene

  1. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. (PMID: 9234705) Marton M.J. … Hinnebusch A.G. (Mol. Cell. Biol. 1997) 2 3 4 23 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for GCN1 Gene

Sources for GCN1 Gene

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