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GCM1 Gene

protein-coding   GIFtS: 52
GCID: GC06M052991

Glial Cells Missing Homolog 1 (Drosophila)

(Previous name: glial cells missing (Drosophila) homolog a)
(Previous symbol: GCMA)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glial Cells Missing Homolog 1 (Drosophila)1 2     Glial Cells Missing (Drosophila) Homolog A1
GCMA1 2 3     Chorion-Specific Transcription Factor GCMa2
GCM Motif Protein 12 3     Glial Cells Missing Homolog 13
hGCMa2 3     

External Ids:    HGNC: 41971   Entrez Gene: 85212   Ensembl: ENSG000001372707   OMIM: 6037155   UniProtKB: Q9NP623   

Export aliases for GCM1 gene to outside databases

Previous GC identifers: GC06M052993 GC06M053039 GC06M053099 GC06M052823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GCM1 Gene:
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a
homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a
novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique
DNA-binding activity of this protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for GCM1 Gene:
GCM1 (glial cells missing homolog 1 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GCM2.

UniProtKB/Swiss-Prot: GCM1_HUMAN, Q9NP62
Function: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific
element 2 (TSE2) of the aromatase gene enhancer

Gene Wiki entry for GCM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the GCM1 gene promoter:
         Pbx1a   AML1a   GATA-1   MEF-2A   RORalpha1   AREB6   ZID   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGCM1 promoter sequence
   Search Chromatin IP Primers for GCM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GCM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p21-p12

GCM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCM1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052991:  view genomic region     (about GC identifiers)

Start:
52,991,759 bp from pter      End:
53,013,627 bp from pter
Size:
21,869 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GCM1_HUMAN, Q9NP62 (See protein sequence)
Recommended Name: Chorion-specific transcription factor GCMa  
Size: 436 amino acids; 49268 Da
Secondary accessions: Q4VAQ7 Q5T0X0 Q99468 Q9P1X3

Explore the universe of human proteins at neXtProt for GCM1: NX_Q9NP62

Explore proteomics data for GCM1 at MOPED

Post-translational modifications: 

  • Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GCM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003634.2  
    ENSEMBL proteins: 
     ENSP00000259803  

    GCM1 Human Recombinant Protein Products:

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    antibodies-online proteins for GCM1 (2 products) 

     
    antibodies-online peptides for GCM1

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    antibodies-online antibodies for GCM1 (32 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003902 Tscrpt_reg_GCM_motif

    Graphical View of Domain Structure for InterPro Entry Q9NP62

    ProtoNet protein and cluster: Q9NP62

    UniProtKB/Swiss-Prot: GCM1_HUMAN, Q9NP62
    Similarity: Contains 1 GCM DNA-binding domain


    Find genes that share domains with GCM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCM1_HUMAN, Q9NP62
    Function: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific
    element 2 (TSE2) of the aromatase gene enhancer

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA15385555
    GO:0005515protein binding ----
    GO:0008134transcription factor binding IPI15385555
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with GCM1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GCM1:
     Synthetic lethal with c-Myc af 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Gcm1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     nervous system  normal  other 

    Find genes that share phenotypes with GCM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gcm1tm1Hoso for GCM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GCM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GCM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GCM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GCM1

    miRNA
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    miRTarBase miRNAs that target GCM1:
    hsa-mir-19b-3p (MIRT007272)

    Block miRNA regulation of human, mouse, rat GCM1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate GCM1:
    hsa-miR-548k hsa-miR-1236 hsa-miR-545 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidGCM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GCM1
    Predesigned siRNA for gene silencing in human, mouse, rat GCM1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: GCM1 (NM_003643)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCM1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCM1_HUMAN, Q9NP62: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IDA15385555

    Find genes that share ontologies with GCM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GCM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Human Early Embryo Development
    Human Early Embryo Development

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for GCM1
        Human Early Embryo Development


        Pathway & Disease-focused RT2 Profiler PCR Array including GCM1: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GCM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for GCM1 (Q9NP623 ENSP000002598034) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    HDAC4P565243, ENSP000002646064I2D: score=2 STRING: ENSP00000264606
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA15385555
    GO:0009653anatomical structure morphogenesis TAS8962155
    GO:0060018astrocyte fate commitment IEA--
    GO:0060143positive regulation of syncytium formation by plasma membrane fusion IEA--

    Find genes that share ontologies with GCM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GCM1

    1 Novoseek inferred chemical compound relationship for GCM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 42.1 1 16528103 (1)



    Find genes that share compounds with GCM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GCM1 gene: 
    NM_003643.3  

    Unigene Cluster for GCM1:

    Glial cells missing homolog 1 (Drosophila)
    Hs.28346  [show with all ESTs]
    Unigene Representative Sequence: NM_003643
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259803(uc003pbp.3 uc010jzr.2)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate GCM1:
    hsa-miR-548k hsa-miR-1236 hsa-miR-545 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidGCM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GCM1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCM1
      QuantiTect SYBR Green Assays in human, mouse, rat GCM1
      QuantiFast Probe-based Assays in human, mouse, rat GCM1

    Additional mRNA sequence: 

    AB026493.1 AB041714.1 BC096288.1 BC096289.1 D88613.1 

    2 DOTS entries:

    DT.425005  DT.424053 

    Selected AceView cDNA sequences (see all 26):

    AB026493 AI800327 AB041714 AI219562 AA330932 NM_003643 AI192428 AI288224 
    C16723 BG434356 BF109347 D88613 C16815 R82262 BQ367968 BF988772 
    T46962 R79118 R82207 R62687 R79119 BQ367427 R62635 BF998746 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GCM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAACAA
    GCM1 Expression
    About this image


    GCM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     NULL (Uncategorized)
             Trophoblast-like cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    GCM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GCM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.28346

    UniProtKB/Swiss-Prot: GCM1_HUMAN, Q9NP62
    Tissue specificity: Placenta specific

        Pathway & Disease-focused RT2 Profiler PCR Array including GCM1: 
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GCM1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gcm11 , 5 glial cells missing homolog 1 (Drosophila)1, 5 78.9(n)1
    73.62(a)1
      9 (43.49 cM)5
    145311  NM_008103.31  NP_032129.21 
     780519585 
    chicken
    (Gallus gallus)
    Aves GCM11 glial cells missing homolog 1 (Drosophila) 59.29(n)
    54.55(a)
      404300  NM_206980.1  NP_996863.1 
    lizard
    (Anolis carolinensis)
    Reptilia GCM16
    glial cells missing homolog 1 (Drosophila)
    65(a)
    1 ↔ 1
    1(151588795-151593682)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165622 Xenopus laevis transcribed sequence with weak similarity more 76.5(n)    BJ063134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gcm6
    gcm26
    gcm2
    23(a)
    19(a)
    many ↔ many
    many ↔ many
    2L(9579449-9581742)
    2L(9608479-9612706)


    ENSEMBL Gene Tree for GCM1 (if available)
    TreeFam Gene Tree for GCM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GCM1 gene
    GCM22  
    1 SIMAP similar gene for GCM1 using alignment to 1 protein entry:     GCM1_HUMAN:
    GCM2

    Find genes that share paralogs with GCM1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GCM1
    PGOHUM00000234280


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GCM1 (see all 599)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178167321,2
    C,F,H--52991298(+) TCTTGT/CCACTT 1 -- ds50016Minor allele frequency- C:0.02NA NS EA 500
    rs1810397271,2
    --52991335(+) CAAATA/CTAAAT 1 -- ds50010--------
    rs69333221,2
    C,F,A,H--52991358(+) GGACTA/GTTTAA 1 -- ds500117Minor allele frequency- G:0.08NS EA NA WA 2338
    rs1839825181,2
    --52991361(+) CTATTA/TAATTA 1 -- ds50010--------
    rs1449925851,2
    C--52991519(+) TCTCT-/TATATAT 1 -- ds50010--------
    rs2020713881,2
    --52991520(+) CTCTT-/ATATATAT 1 -- ds50010--------
    rs1886568881,2
    --52991547(+) TATATA/GTAAAA 1 -- ds50010--------
    rs1814866301,2
    --52991614(+) TGCAGA/GGAACA 1 -- ds50010--------
    rs94743961,2
    C,F,A,H--52991621(+) AACATT/CTCTAA 1 -- ds500117Minor allele frequency- C:0.12NS EA NA WA CSA 2222
    rs351144681,2
    C--52991624(+) ATTTCC/TAATAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for GCM1 (52991759 - 53013627 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GCM1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GCM1
    DNA2.0 Custom Variant and Variant Library Synthesis for GCM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603715    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GCM1:
    pre-eclampsia

    Find genes that share disorders with GCM1           About GenesLikeMe

    Genetic Association Database (GAD): GCM1
    Human Genome Epidemiology (HuGE) Navigator: GCM1 (2 documents)

    Export disorders for GCM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GCM1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with GCM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals. (PubMed id 8962155)1, 2, 3 Akiyama Y.... Hotta Y. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PubMed id 18703417)1, 2, 9 Chiang M.H.... Chen H. (Biol. Reprod. 2008)
    3. Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. (PubMed id 19890582)1, 4, 9 Woo K.T....Chan C.M. (Ann. Acad. Med. Singap. 2009)
    4. Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene. (PubMed id 11071865)1, 2, 9 Yamada K.... Okazaki T. (Biochem. Biophys. Res. Commun. 2000)
    5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. A GCM motif protein is involved in placenta-specific expression of human aromatase gene. (PubMed id 10542267)1, 2 Yamada K.... Okazaki T. (J. Biol. Chem. 1999)
    9. FBW2 targets GCMa to the ubiquitin-proteasome degradation system. (PubMed id 15640526)1, 9 Yang C.S....Chen H. (J. Biol. Chem. 2005)
    10. Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. (PubMed id 16166624)1, 9 Chang C.W....Chen H. (Mol. Cell. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8521 HGNC: 4197 AceView: GCM1 Ensembl:ENSG00000137270 euGenes: HUgn8521
    ECgene: GCM1 H-InvDB: GCM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GCM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GCM1 gene:
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    GeneCards and IP:
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