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Aliases for GCM1 Gene

Aliases for GCM1 Gene

  • Glial Cells Missing Homolog 1 (Drosophila) 2 3
  • GCM Motif Protein 1 3 4
  • HGCMa 3 4
  • GCMA 3 4
  • Glial Cells Missing (Drosophila) Homolog A 2
  • Chorion-Specific Transcription Factor GCMa 3
  • Glial Cells Missing Homolog 1 4

External Ids for GCM1 Gene

Previous Symbols for GCM1 Gene

  • GCMA

Summaries for GCM1 Gene

Entrez Gene Summary for GCM1 Gene

  • This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCM1 Gene

GCM1 (Glial Cells Missing Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are Human Early Embryo Development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is GCM2.

UniProtKB/Swiss-Prot for GCM1 Gene

  • Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer

Gene Wiki entry for GCM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCM1 Gene

Genomics for GCM1 Gene

Genomic Location for GCM1 Gene

Start:
53,126,961 bp from pter
End:
53,148,829 bp from pter
Size:
21,869 bases
Orientation:
Minus strand

Genomic View for GCM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GCM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCM1 Gene

Regulatory Elements for GCM1 Gene

Proteins for GCM1 Gene

  • Protein details for GCM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP62-GCM1_HUMAN
    Recommended name:
    Chorion-specific transcription factor GCMa
    Protein Accession:
    Q9NP62
    Secondary Accessions:
    • Q4VAQ7
    • Q5T0X0
    • Q99468
    • Q9P1X3

    Protein attributes for GCM1 Gene

    Size:
    436 amino acids
    Molecular mass:
    49268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCM1 Gene

Proteomics data for GCM1 Gene at MOPED

Post-translational modifications for GCM1 Gene

  • Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCM1 Gene

Domains for GCM1 Gene

Protein Domains for GCM1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GCM1_HUMAN
Domain:
  • Contains 1 GCM DNA-binding domain.:
    • Q9NP62
genes like me logo Genes that share domains with GCM1: view

No data available for Gene Families for GCM1 Gene

Function for GCM1 Gene

Molecular function for GCM1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer

Gene Ontology (GO) - Molecular Function for GCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 15385555
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IDA 23867755
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 15385555
GO:0003677 DNA binding TAS 8962155
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 15385555
genes like me logo Genes that share ontologies with GCM1: view
genes like me logo Genes that share phenotypes with GCM1: view

Animal Models for GCM1 Gene

MGI Knock Outs for GCM1:

miRNA for GCM1 Gene

miRTarBase miRNAs that target GCM1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GCM1 Gene

Localization for GCM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GCM1 Gene COMPARTMENTS Subcellular localization image for GCM1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for GCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23867755
GO:0005667 transcription factor complex IDA 15385555
genes like me logo Genes that share ontologies with GCM1: view

Pathways for GCM1 Gene

genes like me logo Genes that share pathways with GCM1: view

Pathways by source for GCM1 Gene

1 Qiagen pathway for GCM1 Gene

Gene Ontology (GO) - Biological Process for GCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IDA 15385555
GO:0006366 transcription from RNA polymerase II promoter IDA 23867755
GO:0009653 anatomical structure morphogenesis TAS 8962155
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 15385555
genes like me logo Genes that share ontologies with GCM1: view

Compounds for GCM1 Gene

(1) Novoseek inferred chemical compound relationships for GCM1 Gene

Compound -log(P) Hits PubMed IDs
forskolin 42.1 1
genes like me logo Genes that share compounds with GCM1: view

Transcripts for GCM1 Gene

mRNA/cDNA for GCM1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GCM1 Gene

Glial cells missing homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GCM1 Gene

No ASD Table

Relevant External Links for GCM1 Gene

GeneLoc Exon Structure for
GCM1
ECgene alternative splicing isoforms for
GCM1

Expression for GCM1 Gene

mRNA expression in normal human tissues for GCM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GCM1 Gene

This gene is overexpressed in Whole Blood (20.6), Testis (6.3), and Kidney - Cortex (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GCM1 Gene

SOURCE GeneReport for Unigene cluster for GCM1 Gene Hs.28346

mRNA Expression by UniProt/SwissProt for GCM1 Gene

Q9NP62-GCM1_HUMAN
Tissue specificity: Placenta specific
genes like me logo Genes that share expressions with GCM1: view

Orthologs for GCM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCM1 36
  • 99.77 (n)
  • 99.54 (a)
GCM1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GCM-1 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GCM1 36
  • 86.05 (n)
  • 82.07 (a)
GCM1 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcm1 36
  • 78.9 (n)
  • 73.62 (a)
Gcm1 16
Gcm1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GCM1 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCM1 37
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcm1 36
  • 77.91 (n)
  • 74.31 (a)
chicken
(Gallus gallus)
Aves GCM1 36
  • 59.29 (n)
  • 54.55 (a)
GCM1 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GCM1 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16562 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gcm1 36
  • 56.23 (n)
  • 48.28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007782 36
  • 61.31 (n)
  • 58.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta gcm 37
  • 23 (a)
ManyToMany
gcm2 37
  • 19 (a)
ManyToMany
Species with no ortholog for GCM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GCM1 Gene

ENSEMBL:
Gene Tree for GCM1 (if available)
TreeFam:
Gene Tree for GCM1 (if available)

Paralogs for GCM1 Gene

Paralogs for GCM1 Gene

Selected SIMAP similar genes for GCM1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GCM1 Gene

genes like me logo Genes that share paralogs with GCM1: view

Variants for GCM1 Gene

Sequence variations from dbSNP and Humsavar for GCM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1129069 -- 53,128,360(-) TCAAG(A/G)AGACC reference, missense
rs1129070 -- 53,145,616(-) CGACT(C/T)TGATT missense, reference
rs2427838 -- 53,146,218(-) AAAAA(A/T)ATATA intron-variant
rs2518572 -- 53,138,821(-) AAATC(C/T)GTTAG intron-variant
rs2518573 -- 53,134,058(-) AGCTT(A/C)GTGGC intron-variant

Relevant External Links for GCM1 Gene

HapMap Linkage Disequilibrium report
GCM1

No data available for Structural Variations from Database of Genomic Variants (DGV) for GCM1 Gene

Disorders for GCM1 Gene

(1) University of Copenhagen DISEASES for GCM1 Gene

Relevant External Links for GCM1

Genetic Association Database (GAD)
GCM1
Human Genome Epidemiology (HuGE) Navigator
GCM1
genes like me logo Genes that share disorders with GCM1: view

No data available for UniProtKB/Swiss-Prot for GCM1 Gene

Publications for GCM1 Gene

  1. Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene. (PMID: 11071865) Yamada K. … Okazaki T. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. (PMID: 19890582) Woo K.T. … Chan C.M. (Ann. Acad. Med. Singap. 2009) 3 23 49
  3. The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals. (PMID: 8962155) Akiyama Y. … Hotta Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  4. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang M.H. … Chen H. (Biol. Reprod. 2008) 3 4 23
  5. Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsia. (PMID: 19416964) Chiang M.H. … Chen H. (J. Biol. Chem. 2009) 3 23

Products for GCM1 Gene

Sources for GCM1 Gene

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