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Aliases for GCM1 Gene

Aliases for GCM1 Gene

  • Glial Cells Missing Homolog 1 2 3 4
  • Glial Cells Missing Homolog 1 (Drosophila) 2 5
  • GCM Motif Protein 1 3 4
  • HGCMa 3 4
  • GCMA 3 4
  • Glial Cells Missing (Drosophila) Homolog A 2

External Ids for GCM1 Gene

Previous HGNC Symbols for GCM1 Gene

  • GCMA

Previous GeneCards Identifiers for GCM1 Gene

  • GC06M052993
  • GC06M053039
  • GC06M052991
  • GC06M052823

Summaries for GCM1 Gene

Entrez Gene Summary for GCM1 Gene

  • This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCM1 Gene

GCM1 (Glial Cells Missing Homolog 1) is a Protein Coding gene. Diseases associated with GCM1 include Pre-Eclampsia. Among its related pathways are Human Early Embryo Development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is GCM2.

UniProtKB/Swiss-Prot for GCM1 Gene

  • Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.

Gene Wiki entry for GCM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCM1 Gene

Genomics for GCM1 Gene

Regulatory Elements for GCM1 Gene

Enhancers for GCM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GCM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GCM1 Gene

Chromosome:
6
Start:
53,126,961 bp from pter
End:
53,148,829 bp from pter
Size:
21,869 bases
Orientation:
Minus strand

Genomic View for GCM1 Gene

Genes around GCM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCM1 Gene

Proteins for GCM1 Gene

  • Protein details for GCM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP62-GCM1_HUMAN
    Recommended name:
    Chorion-specific transcription factor GCMa
    Protein Accession:
    Q9NP62
    Secondary Accessions:
    • Q4VAQ7
    • Q5T0X0
    • Q99468
    • Q9P1X3

    Protein attributes for GCM1 Gene

    Size:
    436 amino acids
    Molecular mass:
    49268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCM1 Gene

Proteomics data for GCM1 Gene at MOPED

Post-translational modifications for GCM1 Gene

  • Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCM1 Gene

Domains & Families for GCM1 Gene

Protein Domains for GCM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GCM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NP62

UniProtKB/Swiss-Prot:

GCM1_HUMAN :
  • Contains 1 GCM DNA-binding domain.
Domain:
  • Contains 1 GCM DNA-binding domain.
genes like me logo Genes that share domains with GCM1: view

No data available for Gene Families for GCM1 Gene

Function for GCM1 Gene

Molecular function for GCM1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.

Gene Ontology (GO) - Molecular Function for GCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 23867755
GO:0008134 transcription factor binding IPI 15385555
GO:0042826 histone deacetylase binding IPI 23867755
genes like me logo Genes that share ontologies with GCM1: view
genes like me logo Genes that share phenotypes with GCM1: view

Animal Models for GCM1 Gene

MGI Knock Outs for GCM1:

Animal Model Products

miRNA for GCM1 Gene

miRTarBase miRNAs that target GCM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GCM1 Gene

Localization for GCM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GCM1 Gene COMPARTMENTS Subcellular localization image for GCM1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for GCM1 Gene

Pathways & Interactions for GCM1 Gene

genes like me logo Genes that share pathways with GCM1: view

Pathways by source for GCM1 Gene

1 Qiagen pathway for GCM1 Gene

Gene Ontology (GO) - Biological Process for GCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060670 branching involved in labyrinthine layer morphogenesis IEA --
genes like me logo Genes that share ontologies with GCM1: view

No data available for SIGNOR curated interactions for GCM1 Gene

Drugs & Compounds for GCM1 Gene

(1) Drugs for GCM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GCM1: view

Transcripts for GCM1 Gene

mRNA/cDNA for GCM1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GCM1 Gene

Glial cells missing homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GCM1 Gene

No ASD Table

Relevant External Links for GCM1 Gene

GeneLoc Exon Structure for
GCM1
ECgene alternative splicing isoforms for
GCM1

Expression for GCM1 Gene

mRNA expression in normal human tissues for GCM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GCM1 Gene

This gene is overexpressed in Whole Blood (x20.6), Testis (x6.3), and Kidney - Cortex (x5.6).

Protein differential expression in normal tissues from HIPED for GCM1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GCM1 Gene



SOURCE GeneReport for Unigene cluster for GCM1 Gene Hs.28346

mRNA Expression by UniProt/SwissProt for GCM1 Gene

Q9NP62-GCM1_HUMAN
Tissue specificity: Placenta specific.
genes like me logo Genes that share expression patterns with GCM1: view

Protein tissue co-expression partners for GCM1 Gene

Primer Products

Orthologs for GCM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCM1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GCM1 35
  • 86.05 (n)
  • 82.07 (a)
GCM1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcm1 35
  • 78.9 (n)
  • 73.62 (a)
Gcm1 16
Gcm1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GCM1 35
  • 99.77 (n)
  • 99.54 (a)
GCM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcm1 35
  • 77.91 (n)
  • 74.31 (a)
cow
(Bos Taurus)
Mammalia GCM-1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GCM1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCM1 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves GCM1 35
  • 59.29 (n)
  • 54.55 (a)
GCM1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GCM1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gcm1 35
  • 56.23 (n)
  • 48.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16562 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007782 35
  • 61.31 (n)
  • 58.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta gcm 36
  • 23 (a)
ManyToMany
gcm2 36
  • 19 (a)
ManyToMany
Species with no ortholog for GCM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GCM1 Gene

ENSEMBL:
Gene Tree for GCM1 (if available)
TreeFam:
Gene Tree for GCM1 (if available)

Paralogs for GCM1 Gene

Paralogs for GCM1 Gene

(1) SIMAP similar genes for GCM1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GCM1 Gene

genes like me logo Genes that share paralogs with GCM1: view

Variants for GCM1 Gene

Sequence variations from dbSNP and Humsavar for GCM1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1129069 -- 53,128,360(-) TCAAG(A/G)AGACC reference, missense
rs1129070 -- 53,145,616(-) CGACT(C/T)TGATT reference, missense
rs5876306 -- 53,133,331(+) GCAAA(-/TG/TGTG)TGTGT intron-variant
rs5876307 -- 53,150,307(+) TTTTT(-/T/TTT)GAAAC upstream-variant-2KB
rs6903756 -- 53,149,494(+) gaaac(A/C)ccgtc upstream-variant-2KB

Variation tolerance for GCM1 Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for GCM1 Gene

Disorders for GCM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pre-eclampsia
  • preeclampsia
- elite association - COSMIC cancer census association via MalaCards
Search GCM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GCM1

Genetic Association Database (GAD)
GCM1
Human Genome Epidemiology (HuGE) Navigator
GCM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCM1
genes like me logo Genes that share disorders with GCM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCM1 Gene

Publications for GCM1 Gene

  1. The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals. (PMID: 8962155) Akiyama Y. … Hotta Y. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 67
  2. CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway. (PMID: 19692500) Muroi Y. … Imakawa K. (Reproduction 2009) 3 23
  3. Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. (PMID: 19890582) Woo K.T. … Chan C.M. (Ann. Acad. Med. Singap. 2009) 3 23
  4. Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast. (PMID: 18160678) Chang M. … Torry D.S. (Biol. Reprod. 2008) 3 23
  5. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang M.H. … Chen H. (Biol. Reprod. 2008) 3 23

Products for GCM1 Gene

Sources for GCM1 Gene

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