Aliases for GCLM Gene
External Ids for GCLM Gene
Previous HGNC Symbols for GCLM Gene
Previous GeneCards Identifiers for GCLM Gene
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
GeneCards Summary for GCLM Gene
GCLM (Glutamate-Cysteine Ligase, Modifier Subunit) is a Protein Coding gene. Diseases associated with GCLM include gamma-glutamylcysteine synthetase deficiency and ancylostomiasis. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include protein heterodimerization activity and glutamate-cysteine ligase activity.