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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GCKR Gene

protein-coding   GIFtS: 59
GCID: GC02P027720

Glucokinase (Hexokinase 4) Regulator

(Previous name: glucokinase (hexokinase 4) regulatory protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glucokinase (Hexokinase 4) Regulator1 2
FGQTL52 5
GKRP2 5
Glucokinase (Hexokinase 4) Regulatory Protein1
Glucokinase Regulatory Protein2
Glucokinase Regulator3

External Ids:    HGNC: 41961   Entrez Gene: 26462   Ensembl: ENSG000000847347   OMIM: 6008425   UniProtKB: Q143973   

Export aliases for GCKR gene to outside databases

Previous GC identifers: GC02P027641 GC02P027812 GC02P027694 GC02P027631 GC02P027573 GC02P027461


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GCKR Gene:
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The
gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding
non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene
candidate for a form of maturity-onset diabetes of the young (MODY). (provided by RefSeq, Jul 2008)

GeneCards Summary for GCKR Gene: 
GCKR (glucokinase (hexokinase 4) regulator) is a protein-coding gene. Diseases associated with GCKR include fasting plasma glucose level qtl 5, and maturity-onset diabetes of the young, and among its related super-pathways are Glucose transport and Transmembrane transport of small molecules. GO annotations related to this gene include carbohydrate binding and enzyme binding.

UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
Function: Inhibits glucokinase by forming an inactive complex with this enzyme




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GCKR gene promoter:
         CREB   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGCKR promoter sequence
   Search SABiosciences Chromatin IP Primers for GCKR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCKR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

GCKR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCKR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027720:  view genomic region     (about GC identifiers)

Start:
27,719,706 bp from pter      End:
27,746,554 bp from pter
Size:
26,849 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397 (See protein sequence)
Recommended Name: Glucokinase regulatory protein  
Size: 625 amino acids; 68685 Da
2 PDB 3D structures from and Proteopedia for GCKR:
4BB9 (3D)        4BBA (3D)    
Secondary accessions: A1L4C2 Q53RY6 Q99522

Explore the universe of human proteins at neXtProt for GCKR: NX_Q14397

Explore proteomics data for GCKR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14397

  • GCKR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GCKR Protein Expression
    REFSEQ proteins: NP_001477.2  
    ENSEMBL proteins: 
     ENSP00000264717   ENSP00000398303   ENSP00000399463   ENSP00000416917   ENSP00000409109  
    Reactome Protein details: Q14397
    Human Recombinant Protein Products for GCKR: 
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    Novus Biologicals GCKR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    GCKR for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001347 SIS
     IPR005486 Glucokinase_regulatory_CS

    Graphical View of Domain Structure for InterPro Entry Q14397

    ProtoNet protein and cluster: Q14397

    3 Blocks protein domains:
    IPB001347 Sugar isomerase (SIS)
    IPB005486 Glucokinase regulatory protein
    IPB005487 Glucokinase regulatory protein


    UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
    Similarity: Belongs to the GCKR family
    Similarity: Contains 2 SIS domains


    GCKR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCKR_HUMAN, Q14397
    Function: Inhibits glucokinase by forming an inactive complex with this enzyme

         Genatlas biochemistry entry for GCKR:
    glucokinase regulatory protein 69kDa,,interacting non-covalently with GCR and inhibiting it in presence of
    fructose-6-phosphate

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI11522786
    GO:0016301kinase activity ----
    GO:0019899enzyme binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    GCKR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GCKR:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Gckr):
     homeostasis/metabolism 

    GCKR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GCKR: Gckrtm1Bms Gckrtm1Jfg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GCKR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GCKR

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCKR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GCKR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Hexose transport0.87
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    3MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    4Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/7        Reactome Pathways for GCKR (see all 7)
        Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of carbohydrates
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Hexose transport



    GCKR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GCKR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for GCKR (Q143971, 3 ENSP000002647174) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCKP355571, 3, ENSP000002233664EBI-709948,EBI-709928 I2D: score=4 STRING: ENSP00000223366
    TRAF2Q129333, ENSP000002476684I2D: score=2 STRING: ENSP00000247668
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    GLUD1P003673I2D: score=1 
    HCKENSP000003650124STRING: ENSP00000365012
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation ISS--
    GO:0001678cellular glucose homeostasis IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0009750response to fructose stimulus IDA14627435

    GCKR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GCKR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GCKR

    4 HMDB Compounds for GCKR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    Beta-D-Glucoseb-D-Glucopyranose (see all 8)492-61-5--
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    Glucose 6-phosphateD(+)-Glucopyranose 6-phosphate (see all 11)56-73-5--

    10/11 Novoseek inferred chemical compound relationships for GCKR gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 1-phosphate 90.1 11 9230355 (1), 18199594 (1), 8662230 (1), 14988235 (1) (see all 6)
    fructose-6-phosphate 80.8 14 14627435 (2), 10620331 (2), 9230355 (1), 12739015 (1) (see all 7)
    mannitol-1-phosphate 71.9 3 14627435 (2)
    mannoheptulose 65.6 1 14988235 (1)
    leptomycin b 62.3 1 10622744 (1)
    glucose 61.9 82 18199594 (4), 10744755 (4), 19073768 (3), 10620331 (3) (see all 27)
    n-acetylglucosamine 26.4 1 14988235 (1)
    glycogen 24.8 8 10744755 (4), 7508874 (1), 14988235 (1)
    uric acid 23.8 3 19861489 (3), 20162742 (1), 19503597 (1), 20090896 (1) (see all 5)
    mannitol 22.9 3 18199594 (1), 14988235 (1), 10744755 (1)

    Search CenterWatch for drugs/clinical trials and news about GCKR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GCKR gene: 
    NM_001486.3  

    Unigene Cluster for GCKR:

    Glucokinase (hexokinase 4) regulator
    Hs.89771  [show with all ESTs]
    Unigene Representative Sequence: NM_001486
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264717(uc002rky.3 uc010ezd.3 uc010ylu.2) ENST00000417872
    ENST00000472290 ENST00000453813 ENST00000411584 ENST00000478147 ENST00000424318

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    Inhib. RNA
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    Additional mRNA sequence: 

    AK291846.1 AK309599.1 BC130481.1 BC130483.1 Z48475.1 

    3 DOTS entries:

    DT.411646  DT.100688188  DT.70101443 

    24/25 AceView cDNA sequences (see all 25):

    CD368313 AI633729 AV660423 NM_001486 CD368544 Z48475 CB163787 CB157064 
    BX101812 AI125712 BX509066 AV718702 AV696845 AA700791 AV684281 C20978 
    W86849 H47348 T67006 T67007 H47437 R01023 R06977 R06976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GCKR expression in normal human tissues (normalized intensities)      GCKR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAGGAAG
    GCKR Expression
    About this image


    GCKR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/midbrain/lateral wall   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Neural Tube (Nervous System)
             brain/midbrain/lateral wall   
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer

    See GCKR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GCKR

    SOURCE GeneReport for Unigene cluster: Hs.89771

    UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
    Tissue specificity: Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus,
    adipose tissue, kidney, adrenal, lung or spleen

        SABiosciences Expression via Pathway-Focused PCR Array including GCKR: 
              Drug Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCKR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GCKR gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gckr1 , 5 glucokinase regulatory protein1, 5 86.14(n)1
    88.73(a)1
      5 (17.27 cM)5
    2311031  NM_144909.11  NP_659158.11 
     312975815 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685832 hypothetical protein MGC68583 73.75(n)    BC060011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003330441 glucokinase regulatory protein-like 50.25(n)
    42.54(a)
      100333044  XM_002665145.2  XP_002665191.2 


    ENSEMBL Gene Tree for GCKR (if available)
    TreeFam Gene Tree for GCKR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
    Polymorphism: Genetic variations in GCKR define the fasting plasma glucose levels quantitative trait locus 5
    (FGQTL5) [MIM:613463]. The normal fasting plasma glucose level is defined as less than 100 mg glucose per
    deciliter plasma (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young
    adults and increases the risk of mortality


    10/680 SNPs in GCKR are shown (see all 680)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12603261,2,4
    C,F,A,Hother127654090(+) CTTGCC/TGGTGA 2 P L mis147Minor allele frequency- A:0.00EA NA MN NS WA CSA EU 11119
    rs1845078971,2
    --27640857(+) GCCCGG/TGCGGC 1 -- us2k10--------
    rs1889197991,2
    --27640889(+) CCCACA/CCCCAC 1 -- us2k10--------
    rs1453450571,2
    --27641050(+) GGCGCA/GGGTCT 1 -- us2k10--------
    rs1921738951,2
    --27641541(+) GCTAAC/TAGGAG 1 -- us2k10--------
    rs1444546641,2
    C--27641585(+) AACAA-/TCCCTT 1 -- us2k10--------
    rs7800901,2
    C,F,H--27641624(+) TCTTTC/TCCATT 1 -- us2k1 trp328Minor allele frequency- T:0.04MN NS EA NA WA CSA 2750
    rs1116469811,2
    C,F--27641673(+) CTTTCA/TTTTAT 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1840576611,2
    --27641677(+) CATTTA/GTTCAC 1 -- us2k10--------
    rs1899124391,2
    C--27641730(+) AAAACC/TTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GCKR (27719706 - 27746554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GCKR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv817684CNV Gain17921354


    Human Gene Mutation Database (HGMD): GCKR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600842   
    OMIM disorders: 613463  
    20/26 diseases for GCKR (see all 26):    About MalaCards
    fasting plasma glucose level qtl 5    maturity-onset diabetes of the young    cardiovascular disease risk factor )    ischemic heart disease
    hyperinsulinism    gout    hyperglycemia    fatty liver disease
    ankylosing spondylitis    hypertriglyceridemia    pancreatitis    spondylitis
    hypoglycemia    crohn's disease    liver disease    coronary heart disease
    obesity    ulcerative colitis    insulin resistance    kidney disease

    2 diseases from the University of Copenhagen DISEASES database for GCKR:
    maturity-onset diabetes of the young     Diabetes mellitus

    GCKR for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for GCKR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 56.3 4 16731834 (1), 18439548 (1), 8662230 (1), 10744755 (1)
    hyperglycemia 55.5 2 16731834 (1), 15677479 (1)
    hypoglycemia 34.7 2 17082186 (2)
    obesity 33.5 5 12739015 (3), 9054940 (1)

    Genetic Association Database (GAD): GCKR
    Human Genome Epidemiology (HuGE) Navigator: GCKR (79 documents)

    Export disorders for GCKR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GCKR gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with GCKR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. (PubMed id 18678614)1, 2, 4, 9 Orho-Melander M....Kathiresan S. (2008)
    2. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general french population. (PubMed id 18556336)1, 2, 4, 9 Vaxillaire M....Froguel P. (2008)
    3. Organization of the human glucokinase regulator gene GCKR. (PubMed id 9570959)1, 2, 3, 9 Hayward B.E.... Bonthron D.T. (1998)
    4. Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23. (PubMed id 8662230)1, 3, 9 Hayward B.E....Bonthron D.T. (1996)
    5. Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents. (PubMed id 19073768)1, 4, 9 Tam C.H....Ng M.C. (2009)
    6. Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians. (PubMed id 12739015)1, 4, 9 Veiga-da-Cunha M....Froguel P. (2003)
    7. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. (PubMed id 8589523)1, 2, 9 Warner J.P.... Bonthron D.T. (1995)
    8. The P446L variant in GCKR associated with fasting pla sma glucose and triglyceride levels exerts its effect through increased glucoki nase activity in liver. (PubMed id 19643913)1, 2, 9 Beer N.L....Gloyn A.L. (2009)
    9. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. (PubMed id 19056598)1, 4, 9 Perez-Martinez P....Ordovas J.M. (2009)
    10. Combined effects of single-nucleotide polymorphisms i n GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes ris k. (PubMed id 19533084)1, 4, 9 Reiling E....'t Hart L.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2646 HGNC: 4196 AceView: GCKR Ensembl:ENSG00000084734 euGenes: HUgn2646
    ECgene: GCKR H-InvDB: GCKR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GCKR Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gckr/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GCKR gene:
    Search GeneIP for patents involving GCKR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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