Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GCKR Gene

protein-coding   GIFtS: 58
GCID: GC02P027720

Glucokinase (Hexokinase 4) Regulator

(Previous name: glucokinase (hexokinase 4) regulatory protein)
  See GCKR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glucokinase (Hexokinase 4) Regulator1 2
GKRP2 3 5
FGQTL52 5
Glucokinase (Hexokinase 4) Regulatory Protein1
Glucokinase Regulatory Protein2
Glucokinase Regulator3

External Ids:    HGNC: 41961   Entrez Gene: 26462   Ensembl: ENSG000000847347   OMIM: 6008425   UniProtKB: Q143973   

Export aliases for GCKR gene to outside databases

Previous GC identifers: GC02P027641 GC02P027812 GC02P027694 GC02P027631 GC02P027573 GC02P027461


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GCKR Gene:
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The
gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding
non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene
candidate for a form of maturity-onset diabetes of the young (MODY). (provided by RefSeq, Jul 2008)

GeneCards Summary for GCKR Gene:
GCKR (glucokinase (hexokinase 4) regulator) is a protein-coding gene. Diseases associated with GCKR include maturity-onset diabetes of the young, and cardiovascular disease risk factor. GO annotations related to this gene include carbohydrate binding and enzyme binding.

UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
Function: Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK
is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while
GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GCKR gene promoter:
         CREB   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGCKR promoter sequence
   Search Chromatin IP Primers for GCKR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GCKR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

GCKR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCKR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027720:  view genomic region     (about GC identifiers)

Start:
27,719,706 bp from pter      End:
27,746,554 bp from pter
Size:
26,849 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397 (See protein sequence)
Recommended Name: Glucokinase regulatory protein  
Size: 625 amino acids; 68685 Da
Subunit: Interacts (fructose 6-phosphate bound form) with GCK
3 PDB 3D structures from and Proteopedia for GCKR:
4BB9 (3D)        4BBA (3D)        4LY9 (3D)    
Secondary accessions: A1L4C2 Q53RY6 Q99522

Explore the universe of human proteins at neXtProt for GCKR: NX_Q14397

Explore proteomics data for GCKR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GCKR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001477.2  
    ENSEMBL proteins: 
     ENSP00000264717   ENSP00000398303   ENSP00000399463   ENSP00000416917   ENSP00000409109  
    Reactome Protein details: Q14397

    GCKR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GCKR
    OriGene Protein Over-expression Lysate for GCKR
    OriGene MassSpec for GCKR
    OriGene Custom Protein Services for GCKR
    GenScript Custom Purified and Recombinant Proteins Services for GCKR
    Novus Biologicals GCKR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GCKR 

    GCKR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GCKR
    OriGene Custom Antibody Services for GCKR
    Novus Biologicals GCKR Antibodies
    Abcam antibodies for GCKR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for GCKR
    LSBio Antibodies in human, mouse, rat for GCKR

    GCKR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GCKR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GCKR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GCKR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR001347 SIS
     IPR005486 Glucokinase_regulatory_CS
     IPR028832 Glucokinase_regulator

    Graphical View of Domain Structure for InterPro Entry Q14397

    ProtoNet protein and cluster: Q14397

    3 Blocks protein domains:
    IPB001347 Sugar isomerase (SIS)
    IPB005486 Glucokinase regulatory protein
    IPB005487 Glucokinase regulatory protein


    UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
    Domain: Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site
    Similarity: Belongs to the GCKR family
    Similarity: Contains 2 SIS domains


    Find genes that share domains with GCKR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCKR_HUMAN, Q14397
    Function: Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK
    is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while
    GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity

         Genatlas biochemistry entry for GCKR:
    glucokinase regulatory protein 69kDa,,interacting non-covalently with GCR and inhibiting it in presence of
    fructose-6-phosphate

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI11522786
    GO:0016301kinase activity ----
    GO:0019899enzyme binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with GCKR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GCKR:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Gckr):
     homeostasis/metabolism 

    Find genes that share phenotypes with GCKR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GCKR: Gckrtm1Bms Gckrtm1Jfg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GCKR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GCKR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GCKR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GCKR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GCKR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GCKR
    SwitchGear 3'UTR luciferase reporter plasmidGCKR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GCKR
    Predesigned siRNA for gene silencing in human, mouse, rat GCKR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GCKR

    Clone
    Products:
         
    OriGene clones in human, mouse for GCKR (see all 7)
    OriGene ORF clones in mouse, rat for GCKR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCKR (NM_001486)
    Sino Biological Human cDNA Clone for GCKR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCKR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCKR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GCKR
    Browse ESI BIO Cell Lines and PureStem Progenitors for GCKR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCKR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GCKR_HUMAN, Q14397: Nucleus (By similarity). Cytoplasm (By similarity). Note=Nuclear and cytoplasmic by itself;
    predominantly nuclear when together with GCK (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion2
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with GCKR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GCKR About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Hexose transport0.87
    Glucose transport0.87
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    3MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    4Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with GCKR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for GCKR
        Regulation of Glucokinase by Glucokinase Regulatory Protein


        Pathway & Disease-focused RT2 Profiler PCR Array including GCKR: 
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GCKR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for GCKR (Q143971, 3 ENSP000002647174) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCKP355571, 3, ENSP000002233664EBI-709948,EBI-709928 I2D: score=4 STRING: ENSP00000223366
    TRAF2Q129333, ENSP000002476684I2D: score=2 STRING: ENSP00000247668
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    GLUD1P003673I2D: score=1 
    HCKENSP000003650124STRING: ENSP00000365012
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation ISS--
    GO:0001678cellular glucose homeostasis IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0009750response to fructose IDA14627435

    Find genes that share ontologies with GCKR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GCKR

    4 HMDB Compounds for GCKR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    Beta-D-Glucoseb-D-Glucopyranose (see all 8)492-61-5--
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    Glucose 6-phosphateD(+)-Glucopyranose 6-phosphate (see all 11)56-73-5--

    Selected Novoseek inferred chemical compound relationships for GCKR gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 1-phosphate 90.1 11 9230355 (1), 18199594 (1), 8662230 (1), 14988235 (1) (see all 6)
    fructose-6-phosphate 80.8 14 14627435 (2), 10620331 (2), 9230355 (1), 12739015 (1) (see all 7)
    mannitol-1-phosphate 71.9 3 14627435 (2)
    mannoheptulose 65.6 1 14988235 (1)
    leptomycin b 62.3 1 10622744 (1)
    glucose 61.9 82 18199594 (4), 10744755 (4), 19073768 (3), 10620331 (3) (see all 27)
    n-acetylglucosamine 26.4 1 14988235 (1)
    glycogen 24.8 8 10744755 (4), 7508874 (1), 14988235 (1)
    uric acid 23.8 3 19861489 (3), 20162742 (1), 19503597 (1), 20090896 (1) (see all 5)
    mannitol 22.9 3 18199594 (1), 14988235 (1), 10744755 (1)



    Find genes that share compounds with GCKR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GCKR gene: 
    NM_001486.3  

    Unigene Cluster for GCKR:

    Glucokinase (hexokinase 4) regulator
    Hs.89771  [show with all ESTs]
    Unigene Representative Sequence: NM_001486
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264717(uc002rky.3 uc010ezd.3 uc010ylu.2) ENST00000417872
    ENST00000472290 ENST00000453813 ENST00000411584 ENST00000478147 ENST00000424318

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GCKR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GCKR
    SwitchGear 3'UTR luciferase reporter plasmidGCKR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GCKR
    Predesigned siRNA for gene silencing in human, mouse, rat GCKR
    Clone
    Products:
         
    OriGene clones in human, mouse for GCKR (see all 7)
    OriGene ORF clones in mouse, rat for GCKR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCKR (NM_001486)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCKR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCKR
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GCKR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCKR
      QuantiTect SYBR Green Assays in human, mouse, rat GCKR
      QuantiFast Probe-based Assays in human, mouse, rat GCKR

    Additional mRNA sequence: 

    AK291846.1 AK309599.1 BC130481.1 BC130483.1 Z48475.1 

    3 DOTS entries:

    DT.411646  DT.100688188  DT.70101443 

    Selected AceView cDNA sequences (see all 25):

    CD368313 CD368544 AI633729 NM_001486 AV660423 AV718702 AI125712 BX101812 
    BX509066 Z48475 CB163787 CB157064 AV684281 AA700791 AV696845 C20978 
    T67006 H47437 T67007 H47348 W86849 R01023 R06977 R06976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GCKR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAGGAAG
    GCKR Expression
    About this image


    GCKR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
    GCKR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GCKR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89771

    UniProtKB/Swiss-Prot: GCKR_HUMAN, Q14397
    Tissue specificity: Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus,
    adipose tissue, kidney, adrenal, lung or spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including GCKR: 
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GCKR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCKR
    QuantiTect SYBR Green Assays in human, mouse, rat GCKR
    QuantiFast Probe-based Assays in human, mouse, rat GCKR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCKR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for GCKR gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gckr1 , 5 glucokinase regulatory protein1, 5 85.94(n)1
    88.47(a)1
      5 (17.27 cM)5
    2311031  NM_144909.11  NP_659158.11 
     312975815 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685832 hypothetical protein MGC68583 73.75(n)    BC060011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003330441 glucokinase regulatory protein-like 48.97(n)
    41.59(a)
      100333044  XM_002665145.3  XP_002665191.3 


    ENSEMBL Gene Tree for GCKR (if available)
    TreeFam Gene Tree for GCKR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    GCKR_HUMAN, Q14397: Genetic variations in GCKR define the fasting plasma glucose levels quantitative trait locus 5
    (FGQTL5) [MIM:613463]. The normal fasting plasma glucose level is defined as less than 100 mg glucose per
    deciliter plasma (5.55 mmol per liter). Higher fasting plasma glucose levels predict type 2 diabetes in young
    adults and increases the risk of mortality


    Selected SNPs for GCKR (see all 680)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12603261,2,,4
    C,F,A,Hother127654090(+) CTTGCC/TGGTGA 2 P L mis147Minor allele frequency- A:0.00EA NA MN NS WA CSA EU 11119
    rs1845078971,2
    --27640857(+) GCCCGG/TGCGGC 1 -- us2k10--------
    rs1889197991,2
    --27640889(+) CCCACA/CCCCAC 1 -- us2k10--------
    rs1453450571,2
    --27641050(+) GGCGCA/GGGTCT 1 -- us2k10--------
    rs1921738951,2
    --27641541(+) GCTAAC/TAGGAG 1 -- us2k10--------
    rs1444546641,2
    C--27641585(+) AACAA-/TCCCTT 1 -- us2k10--------
    rs7800901,2
    C,F,H--27641624(+) TCTTTC/TCCATT 1 -- us2k1 trp328Minor allele frequency- T:0.04MN NS EA NA WA CSA 2750
    rs1116469811,2
    C,F--27641673(+) CTTTCA/TTTTAT 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1840576611,2
    --27641677(+) CATTTA/GTTCAC 1 -- us2k10--------
    rs1899124391,2
    C--27641730(+) AAAACC/TTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GCKR (27719706 - 27746554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GCKR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv817684CNV Gain17921354

    Human Gene Mutation Database (HGMD): GCKR
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GCKR
    DNA2.0 Custom Variant and Variant Library Synthesis for GCKR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600842   
    OMIM disorders: 613463  
    2 diseases for GCKR:    
    About MalaCards
    maturity-onset diabetes of the young    cardiovascular disease risk factor

    2 diseases from the University of Copenhagen DISEASES database for GCKR:
    maturity-onset diabetes of the young     Diabetes mellitus

    Find genes that share disorders with GCKR           About GenesLikeMe

    4 Novoseek inferred disease relationships for GCKR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 56.3 4 16731834 (1), 18439548 (1), 8662230 (1), 10744755 (1)
    hyperglycemia 55.5 2 16731834 (1), 15677479 (1)
    hypoglycemia 34.7 2 17082186 (2)
    obesity 33.5 5 12739015 (3), 9054940 (1)

    Genetic Association Database (GAD): GCKR
    Human Genome Epidemiology (HuGE) Navigator: GCKR (79 documents)

    Export disorders for GCKR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GCKR gene, integrated from 10 sources (see all 178):
    (articles sorted by number of sources associating them with GCKR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. (PubMed id 18678614)1, 2, 4, 9 Orho-Melander M.... Kathiresan S. (Diabetes 2008)
    2. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. (PubMed id 18556336)1, 2, 4, 9 Vaxillaire M.... Froguel P. (Diabetes 2008)
    3. Organization of the human glucokinase regulator gene GCKR. (PubMed id 9570959)1, 2, 3, 9 Hayward B.E.... Bonthron D.T. (Genomics 1998)
    4. Co-localization of the ketohexokinase and glucokinase regulator genes to a 500-kb region of chromosome 2p23. (PubMed id 8662230)1, 3, 9 Hayward B.E....Bonthron D.T. (Mamm. Genome 1996)
    5. Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents. (PubMed id 19073768)1, 4, 9 Tam C.H....Ng M.C. (Diabetes 2009)
    6. Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians. (PubMed id 12739015)1, 4, 9 Veiga-da-Cunha M....Froguel P. (Diabetologia 2003)
    7. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. (PubMed id 8589523)1, 2, 9 Warner J.P.... Bonthron D.T. (Mamm. Genome 1995)
    8. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. (PubMed id 19643913)1, 2, 9 Beer N.L.... Gloyn A.L. (Hum. Mol. Genet. 2009)
    9. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. (PubMed id 19056598)1, 4, 9 Perez-Martinez P....Ordovas J.M. (Am. J. Clin. Nutr. 2009)
    10. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. (PubMed id 19533084)1, 4, 9 Reiling E....'t Hart L.M. (Diabetologia 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2646 HGNC: 4196 AceView: GCKR Ensembl:ENSG00000084734 euGenes: HUgn2646
    ECgene: GCKR H-InvDB: GCKR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GCKR Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/gckr/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GCKR gene:
    Search GeneIP for patents involving GCKR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GCKR   OriGene RNAi products in human, mouse, rat for GCKR  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GCKR  
     OriGene MassSpec something-or-other for GCKR   OriGene clones in human, mouse for GCKR  
     OriGene qSTAR qPCR primer pairs in human, mouse for GCKR   OriGene Purified Protein for GCKR  
     OriGene ORF clones in mouse, rat for GCKR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GCKR   OriGene Custom Protein Services for GCKR  

     
     
     Block miRNA regulation of human, mouse, rat GCKR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GCKR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GCKR Predesigned siRNA for gene silencing in human, mouse, rat GCKR
     QuantiFast Probe-based Assays in human, mouse, rat GCKR QuantiTect SYBR Green Assays in human, mouse, rat GCKR
     PCR Arrays including human, mouse, rat GCKR Search Chromatin IP Primers for GCKR
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCKR  GeneGlobe Interaction Network for GCKR
     Regulatory tfbs in GCKR promoter
     GenScript Custom Purified and Recombinant Proteins Services for GCKR GenScript cDNA clones with any tag delivered in your preferred vector for GCKR
     GenScript Custom Assay Services for GCKR GenScript Custom overexpressing Cell Line Services for GCKR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GCKR
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GCKR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GCKR antibodies
     GCKR lysates
     Antibodies for GCKR
     See all of Abcam's Antibodies, Kits and Proteins for GCKR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GCKR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCKR
     SwitchGear 3'UTR luciferase reporter plasmids for GCKR
     SwitchGear Promoter luciferase reporter plasmids for GCKR
     ThermoFisher Antibodies for GCKR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCKR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GCKR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GCKR
     LSBio Antibodies in human, mouse, rat for GCKR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GCKR
      Search eBioscience for proteins for GCKR
      Search eBioscience for elisas for GCKR
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GCKR gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4