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GCGR Gene

protein-coding   GIFtS: 67
GCID: GC17P079763

Glucagon Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Glucagon Receptor1 2
GL-R2 3
GGR2

External Ids:    HGNC: 41921   Entrez Gene: 26422   Ensembl: ENSG000002156447   OMIM: 1380335   UniProtKB: P478713   
ORGUL members:         

Export aliases for GCGR gene to outside databases

Previous GC identifers: GC17P079285 GC17P9I0091 GC17M9K0029 GC17P9P0057 GC17P8B0057 GC17P075168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GCGR Gene:
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels.
Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).(provided by RefSeq, Jan
2010)

GeneCards Summary for GCGR Gene:
GCGR (glucagon receptor) is a protein-coding gene. Diseases associated with GCGR include diabetes mellitus, noninsulin-dependent, and hyperglycemia. GO annotations related to this gene include glucagon receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: GLR_HUMAN, P47871
Function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose
levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis
and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a
conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates
the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase.
Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system

summary for GCGR Gene:
Glucagon receptors are members of the glucagon receptor family that also includes GLP-1, GLP-2, secretin,
GHRH and GIP receptors. Glucagon receptors regulate blood glucose levels via control of hepatic
glycogenolysis and gluconeogenesis and via regulation of insulin release from the beta-cells of the
pancreatic islets. Glucagon receptors are predominantly expressed in the pancreas, liver and kidneys, but
are also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human
glucagon receptor gene is localized on chromosome 17q25.

Gene Wiki entry for GCGR (Glucagon receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010663.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for GCGR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GCGR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GCGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

GCGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCGR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079763:  view genomic region     (about GC identifiers)

Start:
79,762,008 bp from pter      End:
79,771,889 bp from pter
Size:
9,882 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GLR_HUMAN, P47871 (See protein sequence)
Recommended Name: Glucagon receptor precursor  
Size: 477 amino acids; 54009 Da
4 PDB 3D structures from and Proteopedia for GCGR:
3CZF (3D)        4ERS (3D)        4L6R (3D)        4LF3 (3D)    
Secondary accessions: Q2M3M5

Explore the universe of human proteins at neXtProt for GCGR: NX_P47871

Explore proteomics data for GCGR at MOPED

Post-translational modifications: 

  • Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation
    is important for receptor endocytosis after ligand-binding1
  • Glycosylation2 at Asn46, Asn59, Asn74, Asn78
  • Modification sites at PhosphoSitePlus

  • See GCGR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000151.1  
    ENSEMBL proteins: 
     ENSP00000383558   ENSP00000460976   ENSP00000458930  
    Reactome Protein details: P47871

    GCGR Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant GCGR Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GCGR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GCGR
    GenScript Custom Purified and Recombinant Proteins Services for GCGR
    Novus Biologicals GCGR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GCGR

    GCGR Antibody Products:

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    Novus Biologicals GCGR Antibodies
    Abcam antibodies for GCGR
    Cloud-Clone Corp. Antibodies for GCGR
    ThermoFisher Antibodies for GCGR
    LSBio Antibodies in human, mouse, rat for GCGR

    GCGR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GCGR
    Browse R&D Systems for biochemical assays
    GenScript GCGR-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GCGR
    Cloud-Clone Corp. CLIAs for GCGR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GCGR: GPCR / Class B : Glucagon receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: glucagon receptor
    Glucagon receptor family

    Selected InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003290 GPCR_2_GLP1/glucagon_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P47871

    ProtoNet protein and cluster: P47871

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003290 Glucagon family receptor signature
    IPB003291 Glucagon receptor signature


    UniProtKB/Swiss-Prot: GLR_HUMAN, P47871
    Similarity: Belongs to the G-protein coupled receptor 2 family


    GCGR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GLR_HUMAN, P47871
    Function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose
    levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis
    and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a
    conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates
    the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase.
    Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for GCGR:
    glucagon receptor,G protein coupled,receptor

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004967glucagon receptor activity IDA9287038
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0017046peptide hormone binding IEA--
         
    GCGR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GCGR:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gcgr):
     adipose tissue  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  mortality/aging 
     normal  reproductive system 

    GCGR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GCGR: Gcgrtm1Jcp Gcgrtm1Mjch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GCGR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GCGR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GCGR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GCGR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat GCGR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate GCGR
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GCGR
    Predesigned siRNA for gene silencing in human, mouse, rat GCGR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GCGR

    Clone
    Products:
         
    OriGene clones in human, mouse for GCGR (see all 7)
    OriGene ORF clones in mouse, rat for GCGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCGR (NM_000160)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCGR

    Cell Line
    Products:
         
    GenScript GCGR-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for GCGR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCGR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLR_HUMAN, P47871: Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after
    ligand-binding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA9287038
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS8144028

    GCGR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GCGR About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5ADP signalling through P2Y purinoceptor 12
    Glucagon-type ligand receptors0.61
    Class B/2 (Secretin family receptors)0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GCGR
        Activation of PKA through GPCR
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 BioSystems Pathway for GCGR
        GPCRs, Class B Secretin-like

    4 Reactome Pathways for GCGR
        Glucagon-type ligand receptors
    Glucagon signaling in metabolic regulation
    G alpha (q) signalling events
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for GCGR):
        Neuroactive ligand-receptor interaction


    GCGR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GCGR: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GCGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GCGR (P478713 ENSP000003835584) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    GCGP012753, ENSP000003876624I2D: score=1 STRING: ENSP00000387662
    BMPR2Q138733, ENSP000003637084I2D: score=1 STRING: ENSP00000363708
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS7773293
    GO:0006112energy reserve metabolic process TAS--
    GO:0006887exocytosis IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----

    GCGR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GCGR
      Browse compounds at ApexBio 

    Compounds for GCGR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    OxyntomodulinEndogenous gut peptide; modulates feeding and metabolism[62340-29-8]
    des-His1-[Glu9]-Glucagon (1-29) amideGlucagon receptor antagonist[110084-95-2]
    L-168,049 Potent, orally active human glucagon receptor antagonist [191034-25-0]

    1 HMDB Compound for GCGR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for GCGR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glucagon recombinant-- 9007-92-5targetagonist17534934 17462598 8020989 11752352 17623014 17620721 12529935 17479245 8144028

    6 IUPHAR Ligands for GCGR (glucagon receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    glucagon
    AgonistFull agonist94305077
    L-168,049
    AntagonistAntagonist8.410085108
    N-[3-cyano-6-(1,1-dimethylpropyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]-2-ethylbutanamide
    AntagonistAntagonist7.115561959
    NNC 92-1687
    AntagonistAntagonist59857085
    [125I]glucagon (human, mouse, rat)
    AgonistFull agonist5--
    BAY27-9955
    AntagonistAntagonist511719833

    Selected Novoseek inferred chemical compound relationships for GCGR gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    des-his 1-[glu9]glucagon amide 93.7 2 10965931 (1), 8383321 (1)
    adenylate 59.4 11 11118010 (2), 9611120 (1), 9673441 (1), 11853547 (1) (see all 9)
    glucose 57.1 34 15173883 (3), 10990079 (2), 11719833 (1), 17983555 (1) (see all 22)
    glycogen 45 11 12808881 (2), 8712800 (1), 17983555 (1), 15544551 (1) (see all 8)
    cyclic amp 36.9 3 11033435 (1), 7592863 (1), 10660533 (1)
    incretin 34.3 1 10990079 (1)
    gtp 24.7 1 8383321 (1)
    fructose 18 3 12570714 (1), 15544551 (1), 18054737 (1)
    epinephrine 6.48 1 15952078 (1)
    lead 0 1 12477359 (1)



    GCGR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for GCGR gene: 
    NM_000160.3  

    Unigene Cluster for GCGR:

    Glucagon receptor
    Hs.208  [show with all ESTs]
    Unigene Representative Sequence: NM_000160
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572185(uc010wuv.2) ENST00000400723(uc010wuw.2 uc010wux.2)
    ENST00000570996 ENST00000573428 ENST00000574283 ENST00000571425
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat GCGR
    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for GCGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCGR (NM_000160)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCGR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GCGR
    OriGene qSTAR qPCR primer pairs in human, mouse for GCGR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCGR
      QuantiTect SYBR Green Assays in human, mouse, rat GCGR
      QuantiFast Probe-based Assays in human, mouse, rat GCGR

    Additional mRNA sequence: 

    AK307234.1 AK314247.1 BC104854.1 BC112041.1 L20316.1 U03469.1 

    2 DOTS entries:

    DT.207258  DT.121644116 

    14 AceView cDNA sequences:

    L20316 BV198997 U03469 NM_000160 BV198996 AI261290 BF516595 AU100536 
    CB142724 BX114160 BM129254 BM129241 BV198994 AA676734 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GCGR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGTCCT
    GCGR Expression
    About this image

    GCGR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GCGR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.208
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GCGR: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GCGR
    OriGene qSTAR qPCR primer pairs in human, mouse for GCGR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCGR
    QuantiTect SYBR Green Assays in human, mouse, rat GCGR
    QuantiFast Probe-based Assays in human, mouse, rat GCGR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCGR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GCGR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gcgr1 , 5 glucagon receptor1, 5 82.5(n)1
    83.01(a)1
      11 (84.24 cM)5
    145271  NM_008101.21  NP_032127.21 
     1205306995 
    chicken
    (Gallus gallus)
    Aves GIPR1 gastric inhibitory polypeptide receptor 77.31(n)
    71.1(a)
      425670  NM_001101035.1  NP_001094505.1 
    lizard
    (Anolis carolinensis)
    Reptilia GCGR6
    glucagon receptor
    63(a)
    1 ↔ 1
    2(118685374-118730383)
    African clawed frog
    (Xenopus laevis)
    Amphibia gcgrp-A2 glucagon receptor precursor 72.67(n)    AF318178.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5629731 glucagon receptor-like 62.63(n)
    56.82(a)
      562973  XM_686342.5  XP_691434.5 


    ENSEMBL Gene Tree for GCGR (if available)
    TreeFam Gene Tree for GCGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for GCGR gene
    GLP1R2  GHRHR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    13 SIMAP similar genes for GCGR using alignment to 3 protein entries:     GLR_HUMAN (see all proteins):
    GLP2R    GLP1R    GHRHR    GIPR    PTH1R    VIPR1
    PTH2R    SCTR    VIPR2    CALCRL    CRHR2    PTHR2
    CALCR

    GCGR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GCGR (see all 251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18014831,2,,4
    Cpathogenic179767715(+) TCTACA/GGTGAC 2 S G mis10--------
    rs1466959781,2
    --79760090(+) CGGTGC/TGCCGT 1 -- us2k10--------
    rs1392486001,2
    C--79760197(+) CCATCA/GCCGCC 1 -- us2k10--------
    rs1440365381,2
    --79760323(+) GAGAGA/GGGAGA 1 -- us2k10--------
    rs1468575791,2
    --79760367(+) GAGACA/CAACTT 1 -- us2k10--------
    rs1895951751,2
    C--79760488(+) AGTGTA/GGCTAT 1 -- us2k10--------
    rs1489748541,2
    --79760689(+) CTCCAC/TGGGCA 1 -- us2k10--------
    rs1818169041,2
    --79760703(+) GGTGTA/CCCAGG 1 -- us2k10--------
    rs1438289181,2
    --79760809(+) GAGACA/GGGCAC 1 -- us2k10--------
    rs1511064681,2
    C--79760832(+) TCAGCA/GGGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GCGR (79762008 - 79771889 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GCGR:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3333n71CNV Loss21882294
    nsv909134CNV Loss21882294
    nsv909052CNV Loss21882294
    nsv470620CNV Loss18288195
    dgv3332n71CNV Loss21882294
    dgv3330n71CNV Loss21882294
    nsv428351CNV Gain18775914

    Human Gene Mutation Database (HGMD): GCGR
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GCGR
    DNA2.0 Custom Variant and Variant Library Synthesis for GCGR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138033   
    OMIM disorders: 125853  
    15 diseases for GCGR:    
    About MalaCards
    diabetes mellitus, noninsulin-dependent    hyperglycemia    islet cell tumor    pheochromocytoma
    essential hypertension    diabetes mellitus    hypoglycemia    hepatitis
    liposarcoma    pancreatitis    xeroderma pigmentosum    hypertension
    insulin resistance    obesity    kidney disease

    3 diseases from the University of Copenhagen DISEASES database for GCGR:
    Diabetes mellitus     Hyperglycemia     Hypoglycemia

    GCGR for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for GCGR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperglucagonemia 86.1 4 19657311 (2), 19720878 (1), 9186298 (1)
    hyperglycemia 52.2 8 19720878 (1), 18707090 (1), 11118010 (1), 15948676 (1) (see all 6)
    niddm 47.8 13 9285210 (2), 8712800 (1), 8732726 (1), 12536714 (1) (see all 6)
    impaired glucose tolerance 35.9 1 8931690 (1)
    hypoglycemia 32.7 2 9186298 (1), 16174875 (1)
    essential hypertension 18.3 1 9673441 (1)
    pheochromocytoma 14.2 7 15952078 (4), 19897672 (1), 11311729 (1)
    insulin resistance 8.26 1 18028036 (1)
    tumors 0.993 5 19897672 (2), 15952078 (2), 8396602 (1)
    obesity 0 2 9673441 (1), 9690058 (1)

    Genetic Association Database (GAD): GCGR
    Human Genome Epidemiology (HuGE) Navigator: GCGR (5 documents)

    Export disorders for GCGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GCGR gene, integrated from 10 sources (see all 172):
    (articles sorted by number of sources associating them with GCGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the glucagon receptor gene to human chromosome band 17q25. (PubMed id 8020989)1, 2, 3, 7 Menzel S....Bell G.I. (Genomics 1994)
    2. The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization. (PubMed id 8144028)1, 2, 7, 9 Lok S.... Rosenberg G.B. (Gene 1994)
    3. A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. (PubMed id 7589886)1, 2, 4 Fujisawa T.... Ogihara T. (Diabetologia 1995)
    4. Cloning and expression of a human glucagon receptor. (PubMed id 7507321)1, 2, 9 Macneil D.J.... Graziano M.P. (Biochem. Biophys. Res. Commun. 1994)
    5. [Gly40Ser mutation of glucagon receptor gene and NIDDM in Han nationality]. (PubMed id 12536714)1, 4, 9 Deng H....Pan Q. (Hunan Yi Ke Da Xue Xue Bao 2001)
    6. Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. (PubMed id 11692154)1, 4, 9 Strazzullo P....Cappuccio F.P. (J. Mol. Med. 2001)
    7. Structure of the human glucagon class B G-protein-coupled receptor. (PubMed id 23863937)1, 2 Siu F.Y....Stevens R.C. (Nature 2013)
    8. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Gly40Ser polymorphism of the glucagon receptor gene is associated with central adiposity in men. (PubMed id 11707539)1, 4 Siani A....Strazzullo P. (Obes. Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2642 HGNC: 4192 AceView: GCGR Ensembl:ENSG00000215644 euGenes: HUgn2642
    ECgene: GCGR Kegg: 2642 H-InvDB: GCGR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GCGR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GCGR gene:
    Search GeneIP for patents involving GCGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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