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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GCGR Gene

protein-coding   GIFtS: 65
GCID: GC17P079763

glucagon receptor

 Explore 16 diseases affiliated with
GCGR via our new
 Human Malady Compendium 
Biological research products
for GCGR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Glucagon Receptor1 2
GGR1 2
GL-R2 3

External Ids:    HGNC: 41921   Entrez Gene: 26422   Ensembl: ENSG000002156447   OMIM: 1380335   UniProtKB: P478713   

Export aliases for GCGR gene to outside databases

Previous GC identifers: GC17P079285 GC17P9I0091 GC17M9K0029 GC17P9P0057 GC17P8B0057 GC17P075168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GCGR:
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects
in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).(provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: GLR_HUMAN, P47871
Function: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by
controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by
G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

summary for GCGR:
Glucagon receptors are members of the glucagon receptor family that also includes GLP-1, GLP-2, secretin,
GHRH and GIP receptors. Glucagon receptors regulate blood glucose levels via control of hepatic
glycogenolysis and gluconeogenesis and via regulation of insulin release from the beta-cells of the
pancreatic islets. Glucagon receptors are predominantly expressed in the pancreas, liver and kidneys, but
are also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human
glucagon receptor gene is localized on chromosome 17q25.

Gene Wiki entry for GCGR (Glucagon receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GCGR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for GCGR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

GCGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCGR gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079763:  view genomic region     (about GC identifiers)

Start:
79,762,008 bp from pter      End:
79,771,889 bp from pter
Size:
9,882 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GLR_HUMAN, P47871 (See protein sequence)
Recommended Name: Glucagon receptor precursor  
Size: 477 amino acids; 54009 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for GCGR:
3CZF (3D)        4ERS (3D)    
Secondary accessions: Q2M3M5

Explore the universe of human proteins at neXtProt for GCGR: NX_P47871

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P47871

  • GCGR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000151.1  
    ENSEMBL proteins: 
     ENSP00000383558   ENSP00000460976   ENSP00000458930  
    Reactome Protein details: P47871
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant GCGR Protein
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    OriGene Protein Over-expression Lysate: GCGR
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    Novus Biologicals GCGR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GCGR

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    GCGR for ontologies           About GeneDecksing



    GCGR Antibody Products: 
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    Uscn ELISAs and CLIAs for GCGR


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GCGR for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003290 GPCR_2_GLP1/glucagon_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P47871

    ProtoNet protein and cluster: P47871

    3 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003290 Glucagon family receptor signature
    IPB003291 Glucagon receptor signature


    UniProtKB/Swiss-Prot: GLR_HUMAN, P47871
    Similarity: Belongs to the G-protein coupled receptor 2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: GLR_HUMAN, P47871
    Function: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by
    controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by
    G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for GCGR:
    glucagon receptor,G protein coupled,receptor

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: GCGR
    OriGene siRNA: GCGR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GCGR

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCGR

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004967glucagon receptor activity IEA--
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0017046peptide hormone binding IEA--


    GCGR for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for GCGR:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for GCGR: Gcgrtm1Jcp Gcgrtm1Mjch
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Gcgr):
     adipose tissue  endocrine/exocrine gland  growth/size  homeostasis/metabolism  mortality/aging 
     normal  reproductive system 

    GCGR for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA1.00
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3G beta:gamma signalling through PLC beta
    Glucagon-type ligand receptors0.52
    G alpha (s) signalling events0.14
    Class B/2 (Secretin family receptors)0.20
    4G alpha (q) signalling events
    G alpha (q) signalling events1.00
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    5Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.75
    Neuroactive ligand-receptor interaction0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GCGR
        Adenylate cyclase-activating neuropeptides

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GCGR
        Activation of PKA through GPCR
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 BioSystems Pathway for GCGR 
        GPCRs, Class B Secretin-like

    5/12        Reactome Pathways for GCGR (see all 12)
        GPCR downstream signaling
    Glucagon-type ligand receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Metabolism
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for GCGR):
        Neuroactive ligand-receptor interaction


    GCGR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GCGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/196 Interacting proteins for GCGR (P478713 ENSP000003835584) via UniProtKB, MINT, STRING, and/or I2D (see all 196)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    GCGP012753, ENSP000003876624I2D: score=1 STRING: ENSP00000387662
    BMPR2Q138733, ENSP000003637084I2D: score=1 STRING: ENSP00000363708
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS7773293
    GO:0006112energy reserve metabolic process TAS--
    GO:0006887exocytosis IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS8144028


    GCGR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GCGR for compounds           About GeneDecksing

    EMD Millipore small molecules for GCGR:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for GCGR

    Compounds for GCGR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    des-His1-[Glu9]-Glucagon (1-29) amideGlucagon receptor antagonist[110084-95-2]
    L-168,049 Potent, orally active human glucagon receptor antagonist [191034-25-0]

    1 HMDB Compound for GCGR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for GCGR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glucagon recombinant-- 9007-92-5targetagonist17534934 17462598 8020989 11752352 17623014 17620721 12529935 17479245 8144028

    10/15 Novoseek chemical compound relationships for GCGR gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    des-his 1-[glu9]glucagon amide 93.7 2 10965931 (1), 8383321 (1)
    adenylate 59.4 11 11118010 (2), 9611120 (1), 9673441 (1), 11853547 (1) (see all 9)
    glucose 57.1 34 15173883 (3), 10990079 (2), 11719833 (1), 17983555 (1) (see all 22)
    glycogen 45 11 12808881 (2), 8712800 (1), 17983555 (1), 15544551 (1) (see all 8)
    cyclic amp 36.9 3 11033435 (1), 7592863 (1), 10660533 (1)
    incretin 34.3 1 10990079 (1)
    gtp 24.7 1 8383321 (1)
    fructose 18 3 12570714 (1), 15544551 (1), 18054737 (1)
    epinephrine 6.48 1 15952078 (1)
    lead 0 1 12477359 (1)

    Search CenterWatch for drugs/clinical trials and news about GCGR / GLR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GCGR gene: 
    NM_000160.3  

    Unigene Cluster for GCGR:

    Glucagon receptor
    Hs.208  [show with all ESTs]
    Unigene Representative Sequence: NM_000160
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572185(uc010wuv.2) ENST00000400723(uc010wuw.2 uc010wux.2)
    ENST00000570996 ENST00000573428 ENST00000574283 ENST00000571425

    miRNA
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    Additional cDNA sequence: 

    AK307234.1 AK314247.1 BC104854.1 BC112041.1 L20316.1 U03469.1 

    2 DOTS entries:

    DT.207258  DT.121644116 

    14 AceView cDNA sequences:

    AI261290 BX114160 BF516595 U03469 AU100536 BV198997 L20316 BV198996 
    NM_000160 CB142724 BM129254 BM129241 BV198994 AA676734 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GCGR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAATGTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GCGR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GCGR

    SOURCE GeneReport for Unigene cluster: Hs.208
        SABiosciences Expression via Pathway-Focused PCR Arrays including GCGR: 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat
              Diabetes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCGR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GCGR gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GIPR1 gastric inhibitory polypeptide receptor 76.99(n)
    71.3(a)
      425670  NM_001101035.1  NP_001094505.1 
    lizard
    (Anolis carolinensis)
    Reptilia GCGR6
    --
    62(a)
    1 ↔ 1
    2(118688385-118700020)
    African clawed frog
    (Xenopus laevis)
    Amphibia gcgrp-A2 glucagon receptor precursor 72.67(n)    AF318178.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5629731 glucagon receptor-like 62.01(n)
    56.37(a)
      562973  XM_686342.4  XP_691434.4 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    (see all 4)
    --
    5(a)
    26(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    Group9.2(517685-519657)
    GroupUn.2891(6917-15037)


    ENSEMBL Gene Tree for GCGR (if available)
    TreeFam Gene Tree for GCGR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GCGR gene
    GLP1R2  GHRHR2  CALCR2  CRHR22  PTH1R2  VIPR12  CRHR12  PTH2R2  
    CALCRL2  ADCYAP1R12  SCTR2  GLP2R2  VIPR22  GIPR2  
    13 SIMAP similar genes for GCGR using alignment to 3 protein entries:     GLR_HUMAN (see all proteins):
    GLP1R    GLP2R    GIPR    GHRHR    PTH1R    VIPR1
    PTH2R    SCTR    VIPR2    CALCRL    CRHR2    PTHR2
    CALCR

    GCGR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/151 NCBI SNPs in GCGR are shown (see all 151    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18014831,2
    C,pathogenic79767715(+) TCTACA/GGTGAC 2 S G mis10--------
    rs1466959781,2
    --79760090(+) CGGTGC/TGCCGT 1 -- us2k10--------
    rs1392486001,2
    --79760197(+) CCATCA/GCCGCC 1 -- us2k10--------
    rs1440365381,2
    --79760323(+) GAGAGA/GGGAGA 1 -- us2k10--------
    rs1468575791,2
    --79760367(+) GAGACA/CAACTT 1 -- us2k10--------
    rs1895951751,2
    --79760488(+) AGTGTA/GGCTAT 1 -- us2k10--------
    rs1489748541,2
    --79760689(+) CTCCAC/TGGGCA 1 -- us2k10--------
    rs1818169041,2
    --79760703(+) GGTGTA/CCCAGG 1 -- us2k10--------
    rs1438289181,2
    --79760809(+) GAGACA/GGGCAC 1 -- us2k10--------
    rs1511064681,2
    --79760832(+) TCAGCA/GGGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GCGR (79762008 - 79771889 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GCGR
         1 CNV: 30036
    Human Gene Mutation Database (HGMD): GCGR

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GCGR for disorders           About GeneDecksing

    OMIM gene information: 138033   
    OMIM disorders: 125853  
    16 diseases for GCGR:    About MalaCards
    diabetes mellitus    diabetes mellitus, noninsulin-dependent    hepatitis    pancreatitis
    type 2 diabetes mellitus    xeroderma pigmentosum    islet cell tumor    insulin resistance
    essential hypertension    cockayne syndrome    hypoglycemia    pheochromocytoma
    hyperglycemia    liposarcoma    hypertension    obesity

    10 Novoseek disease relationships for GCGR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperglucagonemia 86.1 4 19657311 (2), 19720878 (1), 9186298 (1)
    hyperglycemia 52.2 8 19720878 (1), 18707090 (1), 11118010 (1), 15948676 (1) (see all 6)
    niddm 47.8 13 9285210 (2), 8712800 (1), 8732726 (1), 12536714 (1) (see all 6)
    impaired glucose tolerance 35.9 1 8931690 (1)
    hypoglycemia 32.7 2 9186298 (1), 16174875 (1)
    essential hypertension 18.3 1 9673441 (1)
    pheochromocytoma 14.2 7 15952078 (4), 19897672 (1), 11311729 (1)
    insulin resistance 8.26 1 18028036 (1)
    tumors 0.993 5 19897672 (2), 15952078 (2), 8396602 (1)
    obesity 0 2 9673441 (1), 9690058 (1)

    Genetic Association Database (GAD): GCGR
    Human Genome Epidemiology (HuGE) Navigator: GCGR (5 documents)

    Export disorders for GCGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GCGR gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with GCGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the glucagon receptor gene to human chromosome band 17q25. (PubMed id 8020989)1, 2, 3, 7 Menzel S....Bell G.I. (1994)
    2. The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization. (PubMed id 8144028)1, 2, 7, 9 Lok S.... Rosenberg G.B. (1994)
    3. A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. (PubMed id 7589886)1, 2, 4 Fujisawa T.... Ogihara T. (1995)
    4. Cloning and expression of a human glucagon receptor. (PubMed id 7507321)1, 2, 9 Macneil D.J.... Graziano M.P. (1994)
    5. [Gly40Ser mutation of glucagon receptor gene and NIDDM in Han nationality] (PubMed id 12536714)1, 4, 9 Deng H....Pan Q. (2001)
    6. Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. (PubMed id 11692154)1, 4, 9 Strazzullo P....Cappuccio F.P. (2001)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Gly40Ser polymorphism of the glucagon receptor gene is associated with central adiposity in men. (PubMed id 11707539)1, 4 Siani A....Strazzullo P. (2001)
    9. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. (PubMed id 7773293)1, 4 Hager J....Julier C. (1995)
    10. Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus. (PubMed id 12724331)1, 9 Runge S....Wulff B.S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2642 HGNC: 4192 AceView: GCGR Ensembl:ENSG00000215644 euGenes: HUgn2642
    ECgene: GCGR Kegg: 2642 H-InvDB: GCGR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GCGR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GCGR gene:
    Search GeneIP for patents involving GCGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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