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GCC2 Gene

protein-coding   GIFtS: 53
GCID: GC02P109065

GRIP And Coiled-Coil Domain Containing 2

(Previous name: GRIP and coiled-coil domain-containing 2)
  See GCC2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
GRIP And Coiled-Coil Domain Containing 21 2     KIAA03363 5
GCC1852 3 5     GRIP And Coiled-Coil Domain-Containing 21
Renal Carcinoma Antigen NY-REN-532 3     REN532
185 KDa Golgi Coiled-Coil Protein2 3     GCC Protein, 185-KD2
RANBP2L42 3     Golgi Coiled-Coil Protein GCC1852
CLL-Associated Antigen KW-112 3     GRIP And Coiled-Coil Domain-Containing Protein 22
CTCL Tumor Antigen Se1-12 3     RanBP2L43
Ran-Binding Protein 2-Like 42 3     

External Ids:    HGNC: 232181   Entrez Gene: 96482   Ensembl: ENSG000001359687   OMIM: 6127115   UniProtKB: Q8IWJ23   

Export aliases for GCC2 gene to outside databases

Previous GC identifers: GC02P108687 GC02P108524 GC02P108432 GC02P102664


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GCC2 Gene:
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is
sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2009)

GeneCards Summary for GCC2 Gene:
GCC2 (GRIP and coiled-coil domain containing 2) is a protein-coding gene. Diseases associated with GCC2 include secretory diarrhea. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot: GCC2_HUMAN, Q8IWJ2
Function: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates
vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the
mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the
recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the
biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2

Gene Wiki entry for GCC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GCC2 gene promoter:
         Nkx3-1   Elk-1   Nkx3-1 v4   FOXD3   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   SRY   NRF-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGCC2 promoter sequence
   Search Chromatin IP Primers for GCC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GCC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q12.3

GCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCC2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P109065:  view genomic region     (about GC identifiers)

Start:
109,065,017 bp from pter      End:
109,125,871 bp from pter
Size:
60,855 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GCC2_HUMAN, Q8IWJ2 (See protein sequence)
Recommended Name: GRIP and coiled-coil domain-containing protein 2  
Size: 1684 amino acids; 195910 Da
Subunit: Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact
(RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi
localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in
its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts
with STX16
Sequence caution: Sequence=AAG34902.1; Type=Frameshift; Positions=694, 700, 937, 940; Sequence=AAH37774.1;
Type=Miscellaneous discrepancy; Note=Wrong choice of CDS; Sequence=AAI46790.1; Type=Miscellaneous discrepancy;
Note=Wrong choice of CDS; Sequence=AAL99918.1; Type=Erroneous initiation; Note=Translation N-terminally
shortened; Sequence=AAX88838.1; Type=Erroneous gene model prediction; Sequence=BAA20794.2; Type=Miscellaneous
discrepancy; Note=Wrong choice of CDS; Sequence=EAW53882.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for GCC2:
3BBP (3D)    
Secondary accessions: A6H8X8 O15045 Q4ZG46 Q8TDH3 Q9H2G8
Alternative splicing: 2 isoforms:  Q8IWJ2-1   Q8IWJ2-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for GCC2: NX_Q8IWJ2

Explore proteomics data for GCC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys72
  • Modification sites at PhosphoSitePlus

  • See GCC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_852118.1  
    ENSEMBL proteins: 
     ENSP00000307939   ENSP00000387350   ENSP00000419969   ENSP00000386997   ENSP00000475234  
     ENSP00000475798   ENSP00000392470   ENSP00000376996  

    GCC2 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for GCC2
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GCC2

     
    Search eBioscience for Proteins for GCC2 

    GCC2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GCC2
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    Abcam antibodies for GCC2
    Cloud-Clone Corp. Antibodies for GCC2
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    LSBio Antibodies in human, mouse, rat for GCC2

    GCC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for GCC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GCC2
    Cloud-Clone Corp. CLIAs for GCC2
    Search eBioscience for ELISAs for GCC2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000237 GRIP

    Graphical View of Domain Structure for InterPro Entry Q8IWJ2

    ProtoNet protein and cluster: Q8IWJ2

    UniProtKB/Swiss-Prot: GCC2_HUMAN, Q8IWJ2
    Domain: Extended rod-like protein with coiled-coil domains
    Similarity: Contains 1 GRIP domain


    Find genes that share domains with GCC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCC2_HUMAN, Q8IWJ2
    Function: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates
    vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the
    mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the
    recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the
    biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI16885419
    GO:0042802identical protein binding IPI18243103
         
    Find genes that share ontologies with GCC2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GCC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GCC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GCC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GCC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target GCC2:
    hsa-mir-193b-3p (MIRT041322), hsa-mir-128-3p (MIRT021983)

    Block miRNA regulation of human, mouse, rat GCC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GCC2 (see all 73):
    hsa-miR-548j hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidGCC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GCC2
    Predesigned siRNA for gene silencing in human, mouse, rat GCC2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for GCC2 (see all 6)
    OriGene ORF clones in mouse, rat for GCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCC2 (NM_181453)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCC2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for GCC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for GCC2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCC2_HUMAN, Q8IWJ2: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network IDA16885419
    GO:0016020membrane IEA--

    Find genes that share ontologies with GCC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GCC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    2Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for GCC2
        Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for GCC2
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GCC2
    Interactions:

        Search GeneGlobe Interaction Network for GCC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for GCC2 (Q8IWJ21, 3 ENSP000003079394) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB6AP203401, 3, ENSP000003114494EBI-1645320,EBI-1052826 I2D: score=1 STRING: ENSP00000311449
    ARL1P406163, ENSP000002616364I2D: score=2 STRING: ENSP00000261636
    ZRANB1Q9UGI03, ENSP000003526764I2D: score=2 STRING: ENSP00000352676
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    CDC42P609533I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000042protein targeting to Golgi IEA--
    GO:0006622protein targeting to lysosome IMP16885419
    GO:0031023microtubule organizing center organization IMP17543864
    GO:0034067protein localization to Golgi apparatus IMP16885419
    GO:0034453microtubule anchoring IMP17543864

    Find genes that share ontologies with GCC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GCC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GCC2 gene: 
    NM_181453.3  

    Unigene Cluster for GCC2:

    GRIP and coiled-coil domain containing 2
    Hs.436505  [show with all ESTs]
    Unigene Representative Sequence: NM_181453
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309863 ENST00000467566 ENST00000478207 ENST00000409821 ENST00000482325(uc002tec.3 uc002ted.3)
    ENST00000409896 ENST00000485546 ENST00000462897 ENST00000492785 ENST00000447558
    ENST00000393321 ENST00000481729 ENST00000480863
    miRNA
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    Block miRNA regulation of human, mouse, rat GCC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GCC2 (see all 73):
    hsa-miR-548j hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidGCC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GCC2
    Predesigned siRNA for gene silencing in human, mouse, rat GCC2
    Clone
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    OriGene clones in human, mouse for GCC2 (see all 6)
    OriGene ORF clones in mouse, rat for GCC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GCC2 (NM_181453)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GCC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GCC2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GCC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GCC2
      QuantiTect SYBR Green Assays in human, mouse, rat GCC2
      QuantiFast Probe-based Assays in human, mouse, rat GCC2

    Additional mRNA sequence: 

    AB002334.1 AF273042.1 AF432211.1 AK090813.1 AK308707.1 BC020645.1 BC037774.2 BC146789.1 
    NR_028063.1 

    24 DOTS entries:

    DT.86858214  DT.100790281  DT.100019251  DT.105553  DT.70104053  DT.91900581  DT.92409447  DT.95274706 
    DT.118021  DT.95274716  DT.100790280  DT.100790282  DT.118019  DT.120996976  DT.449837  DT.91842999 
    DT.91923516  DT.92453561  DT.100028501  DT.120933557  DT.120933580  DT.120933586  DT.120968053  DT.120992108 

    Selected AceView cDNA sequences (see all 205):

    BM676829 AI470828 NM_181453 AL603129 AA377363 AV685687 CK430688 CB529073 
    AI084646 AA844489 AW339579 AA495873 AK090813 CA391119 AA766460 BU074558 
    CA396284 AA904344 AW026932 AI077322 BC037774 AA570644 BU625872 AI445892 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GCC2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                    -           -                 -                                                                                                   
    SP2:                                -                 -                                                                                                   
    SP3:                    -           -     -           -                                                                                                   
    SP4:                    -           -                                                                                                                     
    SP5:                                -     -           -                                                                                                   


    ECgene alternative splicing isoforms for GCC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GCC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GCC2 Expression
    About this image

    GCC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GCC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436505

    UniProtKB/Swiss-Prot: GCC2_HUMAN, Q8IWJ2
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for GCC2
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    QuantiFast Probe-based Assays in human, mouse, rat GCC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GCC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GCC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gcc21 , 5 GRIP and coiled-coil domain containing 21, 5 83.28(n)1
    78.6(a)1
      10 (29.30 cM)5
    702971  NM_027375.21  NP_081651.21 
     582554975 
    chicken
    (Gallus gallus)
    Aves GCC21 GRIP and coiled-coil domain containing 2 68.69(n)
    63.03(a)
      428014  XM_425585.4  XP_425585.3 
    lizard
    (Anolis carolinensis)
    Reptilia GCC26
    GRIP and coiled-coil domain containing 2
    61(a)
    1 ↔ 1
    3(107596631-107629827)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL852536.22   -- 73.2(n)    AL852536.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35326
    --
    24(a)
    1 ↔ 1
    3R(7836504-7840784)
    worm
    (Caenorhabditis elegans)
    Secernentea T05G5.96
    Protein T05G5.9, isoform b (T05G5.9) mRNA, complet...
    27(a)
    1 ↔ 1
    III(9757621-9762143) WBGene00011503


    ENSEMBL Gene Tree for GCC2 (if available)
    TreeFam Gene Tree for GCC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GCC2 gene

    Find genes that share paralogs with GCC2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for GCC2 (see all 7)
    PGOHUM00000240136 PGOHUM00000240236 PGOHUM00000240253 PGOHUM00000240261 PGOHUM00000240713


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GCC2 (see all 2003)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101826351,2
    C--102662299(+) cctgtC/Ttgaaa 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1116647641,2
    C,F--102662340(+) AAAAAA/CAATAC 2 -- us2k12Minor allele frequency- C:0.04WA 120
    rs773845751,2
    --102662353(+) TGTAAA/GTGTAG 2 -- us2k10--------
    rs728331271,2
    C,F--102662459(+) AGATCA/GGGTGT 2 -- us2k11Minor allele frequency- G:0.00NA 120
    rs1908310171,2
    C--102662470(+) CTCTCC/TGGACC 2 -- us2k10--------
    rs1829652021,2
    --102662471(+) TCTCCA/GGACCA 2 -- us2k10--------
    rs126164111,2
    H--102662480(+) CATCCC/TTAAGC 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1489213901,2
    --102662553(+) GTAAAA/GAAGCT 2 -- us2k10--------
    rs1456395301,2
    --102662554(+) TAAAGA/CAGCTA 2 -- us2k10--------
    rs102064591,2
    C,F--102662627(+) AACATA/GCAGCA 2 -- us2k11Minor allele frequency- G:0.08WA 118

    HapMap Linkage Disequilibrium report for GCC2 (109065017 - 109125871 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GCC2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989899CNV Deletion20482838
    esv2720498CNV Deletion23290073
    dgv724e199CNV Deletion23128226
    nsv527491CNV Loss19592680
    nsv874770CNV Loss21882294
    nsv819058CNV Loss19587683
    nsv10113CNV Loss18304495
    nsv2871CNV Loss18451855
    nsv874772CNV Gain21882294
    nsv527686CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GCC2
    DNA2.0 Custom Variant and Variant Library Synthesis for GCC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612711    OMIM disorders: --

    1 disease for GCC2:    
    About MalaCards
    secretory diarrhea

    1 disease from the University of Copenhagen DISEASES database for GCC2:
    Secretory diarrhea

    Find genes that share disorders with GCC2           About GenesLikeMe


    Export disorders for GCC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GCC2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with GCC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. (PubMed id 12446665)1, 2, 3, 9 Luke M.R.... Gleeson P.A. (J. Biol. Chem. 2003)
    2. The trans-Golgi network golgin, GCC185, is required for endosome-to- Golgi transport and maintenance of Golgi structure. (PubMed id 17488291)1, 2, 9 Derby M.C.... Gleeson P.A. (Traffic 2007)
    3. The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1. (PubMed id 19703403)1, 2 Houghton F.J.... Gleeson P.A. (Cell 2009)
    4. Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185. (PubMed id 18243103)1, 2 Burguete A.S.... Pfeffer S.R. (Cell 2008)
    5. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. (PubMed id 17543864)1, 2 Efimov A.... Kaverina I. (Dev. Cell 2007)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling. (PubMed id 16885419)1, 2 Reddy J.V....Pfeffer S.R. (Mol. Biol. Cell 2006)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. (PubMed id 12200376)1, 2 Krackhardt A.M.... Gribben J.G. (Blood 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9648 HGNC: 23218 AceView: GCC2 Ensembl:ENSG00000135968 euGenes: HUgn9648
    ECgene: GCC2 H-InvDB: GCC2

    (According to HUGE)
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    HUGE: KIAA0336

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GCC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GCC2 gene:
    Search GeneIP for patents involving GCC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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