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Aliases for GCC2 Gene

Aliases for GCC2 Gene

  • GRIP And Coiled-Coil Domain Containing 2 2 3
  • GCC185 3 4 6
  • Renal Carcinoma Antigen NY-REN-53 3 4
  • 185 KDa Golgi Coiled-Coil Protein 3 4
  • CLL-Associated Antigen KW-11 3 4
  • Ran-Binding Protein 2-Like 4 3 4
  • CTCL Tumor Antigen Se1-1 3 4
  • RANBP2L4 3 4
  • KIAA0336 4 6
  • GRIP And Coiled-Coil Domain-Containing Protein 2 3
  • GRIP And Coiled-Coil Domain-Containing 2 2
  • Golgi Coiled-Coil Protein GCC185 3
  • GCC Protein, 185-KD 3
  • REN53 3

External Ids for GCC2 Gene

Summaries for GCC2 Gene

Entrez Gene Summary for GCC2 Gene

  • The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for GCC2 Gene

GCC2 (GRIP And Coiled-Coil Domain Containing 2) is a Protein Coding gene. Diseases associated with GCC2 include secretory diarrhea. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for GCC2 Gene

  • Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.

Gene Wiki entry for GCC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCC2 Gene

Genomics for GCC2 Gene

Genomic Location for GCC2 Gene

Start:
108,448,561 bp from pter
End:
108,509,415 bp from pter
Size:
60,855 bases
Orientation:
Plus strand

Genomic View for GCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCC2 Gene

Regulatory Elements for GCC2 Gene

Proteins for GCC2 Gene

  • Protein details for GCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWJ2-GCC2_HUMAN
    Recommended name:
    GRIP and coiled-coil domain-containing protein 2
    Protein Accession:
    Q8IWJ2
    Secondary Accessions:
    • A6H8X8
    • O15045
    • Q4ZG46
    • Q8TDH3
    • Q9H2G8

    Protein attributes for GCC2 Gene

    Size:
    1684 amino acids
    Molecular mass:
    195910 Da
    Quaternary structure:
    • Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16.
    SequenceCaution:
    • Sequence=AAG34902.1; Type=Frameshift; Positions=694, 700, 937, 940; Evidence={ECO:0000305}; Sequence=AAH37774.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI46790.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL99918.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAX88838.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA20794.2; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW53882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GCC2 Gene

    Alternative splice isoforms for GCC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GCC2 Gene

Proteomics data for GCC2 Gene at MOPED

Post-translational modifications for GCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys72

No data available for DME Specific Peptides for GCC2 Gene

Domains for GCC2 Gene

Protein Domains for GCC2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

GCC2_HUMAN
Domain:
  • Extended rod-like protein with coiled-coil domains:
    • Q8IWJ2
  • Contains 1 GRIP domain.:
    • Q8IWJ2
genes like me logo Genes that share domains with GCC2: view

No data available for Gene Families for GCC2 Gene

Function for GCC2 Gene

Molecular function for GCC2 Gene

UniProtKB/Swiss-Prot Function: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.

Gene Ontology (GO) - Molecular Function for GCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 16885419
GO:0042802 identical protein binding IPI 18243103
genes like me logo Genes that share ontologies with GCC2: view

miRNA for GCC2 Gene

miRTarBase miRNAs that target GCC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GCC2 Gene

Localization for GCC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCC2 Gene

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GCC2 Gene COMPARTMENTS Subcellular localization image for GCC2 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for GCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005802 trans-Golgi network IDA 16885419
genes like me logo Genes that share ontologies with GCC2: view

Pathways for GCC2 Gene

genes like me logo Genes that share pathways with GCC2: view

Pathways by source for GCC2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for GCC2 Gene

Gene Ontology (GO) - Biological Process for GCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0006622 protein targeting to lysosome IMP 16885419
GO:0031023 microtubule organizing center organization IMP 17543864
GO:0034067 protein localization to Golgi apparatus IMP 16885419
GO:0034453 microtubule anchoring IMP 17543864
genes like me logo Genes that share ontologies with GCC2: view

Transcripts for GCC2 Gene

Unigene Clusters for GCC2 Gene

GRIP and coiled-coil domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GCC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: -
SP8: - - - - -
SP9:
SP10:

Relevant External Links for GCC2 Gene

GeneLoc Exon Structure for
GCC2
ECgene alternative splicing isoforms for
GCC2

Expression for GCC2 Gene

mRNA expression in normal human tissues for GCC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GCC2 Gene

SOURCE GeneReport for Unigene cluster for GCC2 Gene Hs.436505

mRNA Expression by UniProt/SwissProt for GCC2 Gene

Q8IWJ2-GCC2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with GCC2: view

Orthologs for GCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCC2 36
  • 99.31 (n)
  • 98.81 (a)
GCC2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GCC2 36
  • 81.61 (n)
  • 78.81 (a)
GCC2 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GCC2 36
  • 87.28 (n)
  • 83.72 (a)
GCC2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gcc2 36
  • 83.28 (n)
  • 78.6 (a)
Gcc2 16
Gcc2 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GCC2 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCC2 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcc2 36
  • 83.35 (n)
  • 78.11 (a)
chicken
(Gallus gallus)
Aves GCC2 36
  • 68.69 (n)
  • 63.03 (a)
GCC2 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GCC2 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gcc2 36
  • 64.15 (n)
  • 58.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3532 37
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T05G5.9 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8814 37
  • 23 (a)
OneToOne
Species with no ortholog for GCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for GCC2 Gene

ENSEMBL:
Gene Tree for GCC2 (if available)
TreeFam:
Gene Tree for GCC2 (if available)

Paralogs for GCC2 Gene

genes like me logo Genes that share paralogs with GCC2: view

No data available for Paralogs for GCC2 Gene

Variants for GCC2 Gene

Sequence variations from dbSNP and Humsavar for GCC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1025695 -- 108,479,180(-) CTGGC(C/T)TATTT intron-variant
rs1053027 -- 108,475,099(+) TTACA(C/G)GTTTC intron-variant, utr-variant-3-prime
rs1061202 - 108,486,610(+) AGCAG(A/G)GAGTG reference, missense, nc-transcript-variant
rs1138405 -- 108,487,717(+) CTGTA(A/G)CCTCT reference, missense, nc-transcript-variant
rs1474220 -- 108,450,343(-) ATTTA(A/C)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GCC2 Gene

Variant ID Type Subtype PubMed ID
esv2720498 CNV Deletion 23290073
dgv1234e1 CNV Complex 17122850
dgv724e199 CNV Deletion 23128226
nsv874770 CNV Loss 21882294
nsv527686 CNV Gain 19592680
dgv153e55 CNV Gain 17911159
nsv527491 CNV Loss 19592680
nsv469774 CNV Complex 16826518
nsv874772 CNV Gain 21882294
nsv2871 CNV Loss 18451855
nsv834328 CNV Gain 17160897
esv989899 CNV Deletion 20482838
nsv819058 CNV Loss 19587683
nsv10113 CNV Loss 18304495

Relevant External Links for GCC2 Gene

HapMap Linkage Disequilibrium report
GCC2

Disorders for GCC2 Gene

(1) MalaCards Diseases for GCC2 Gene

Search for GCC2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for GCC2 Gene

genes like me logo Genes that share disorders with GCC2: view

No data available for UniProtKB/Swiss-Prot for GCC2 Gene

Publications for GCC2 Gene

  1. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. (PMID: 12446665) Luke M.R. … Gleeson P.A. (J. Biol. Chem. 2003) 2 3 4 23
  2. The trans-Golgi network golgin, GCC185, is required for endosome-to- Golgi transport and maintenance of Golgi structure. (PMID: 17488291) Derby M.C. … Gleeson P.A. (Traffic 2007) 3 4 23
  3. Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. (PMID: 15522892) Derby M.C. … Gleeson P.A. (J. Cell. Sci. 2004) 3 23
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  5. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4

Products for GCC2 Gene

Sources for GCC2 Gene

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