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Aliases for GCC1 Gene

Aliases for GCC1 Gene

  • GRIP And Coiled-Coil Domain Containing 1 2 3 5
  • Golgi Coiled-Coil Protein 1 3 4
  • Golgi Coiled-Coil 1 2 3
  • Peripheral Membrane Golgi Protein 3
  • GCC1P 3
  • GCC88 3

External Ids for GCC1 Gene

Previous GeneCards Identifiers for GCC1 Gene

  • GC07M125698
  • GC07M126761
  • GC07M126775
  • GC07M126814
  • GC07M127008
  • GC07M127220
  • GC07M121581

Summaries for GCC1 Gene

Entrez Gene Summary for GCC1 Gene

  • The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCC1 Gene

GCC1 (GRIP And Coiled-Coil Domain Containing 1) is a Protein Coding gene. Diseases associated with GCC1 include Phencyclidine Abuse. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for GCC1 Gene

  • Probably involved in maintaining Golgi structure.

Gene Wiki entry for GCC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCC1 Gene

Genomics for GCC1 Gene

Regulatory Elements for GCC1 Gene

Enhancers for GCC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GCC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GCC1 Gene

127,580,618 bp from pter
127,593,611 bp from pter
12,994 bases
Minus strand

Genomic View for GCC1 Gene

Genes around GCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCC1 Gene

Proteins for GCC1 Gene

  • Protein details for GCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRIP and coiled-coil domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9H6N7

    Protein attributes for GCC1 Gene

    775 amino acids
    Molecular mass:
    87811 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH08902.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAB15218.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GCC1 Gene

Proteomics data for GCC1 Gene at MOPED

Post-translational modifications for GCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCC1 Gene

Domains & Families for GCC1 Gene

Protein Domains for GCC1 Gene


Suggested Antigen Peptide Sequences for GCC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Extended rod-like protein with coiled-coil domains.
  • Extended rod-like protein with coiled-coil domains.
  • Contains 1 GRIP domain.
genes like me logo Genes that share domains with GCC1: view

No data available for Gene Families for GCC1 Gene

Function for GCC1 Gene

Molecular function for GCC1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in maintaining Golgi structure.

Phenotypes for GCC1 Gene

GenomeRNAi human phenotypes for GCC1:
genes like me logo Genes that share phenotypes with GCC1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GCC1 Gene

Localization for GCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCC1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for GCC1 Gene COMPARTMENTS Subcellular localization image for GCC1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for GCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with GCC1: view

Pathways & Interactions for GCC1 Gene

genes like me logo Genes that share pathways with GCC1: view

Gene Ontology (GO) - Biological Process for GCC1 Gene


No data available for SIGNOR curated interactions for GCC1 Gene

Drugs & Compounds for GCC1 Gene

No Compound Related Data Available

Transcripts for GCC1 Gene

mRNA/cDNA for GCC1 Gene

Unigene Clusters for GCC1 Gene

GRIP and coiled-coil domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GCC1 Gene

No ASD Table

Relevant External Links for GCC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GCC1 Gene

mRNA expression in normal human tissues for GCC1 Gene

Protein differential expression in normal tissues from HIPED for GCC1 Gene

This gene is overexpressed in Lymph node (19.1), Salivary gland (10.2), and Stomach (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GCC1 Gene

SOURCE GeneReport for Unigene cluster for GCC1 Gene Hs.521168

genes like me logo Genes that share expression patterns with GCC1: view

Protein tissue co-expression partners for GCC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GCC1 Gene

Orthologs for GCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GCC1 35
  • 89.08 (n)
  • 92.9 (a)
GCC1 36
  • 93 (a)
(Canis familiaris)
Mammalia GCC1 35
  • 89.55 (n)
  • 94.32 (a)
GCC1 36
  • 94 (a)
(Mus musculus)
Mammalia Gcc1 35
  • 88.09 (n)
  • 93.55 (a)
Gcc1 16
Gcc1 36
  • 93 (a)
(Pan troglodytes)
Mammalia GCC1 35
  • 99.57 (n)
  • 99.61 (a)
GCC1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gcc1 35
  • 87.57 (n)
  • 93.03 (a)
(Monodelphis domestica)
Mammalia GCC1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia GCC1 36
  • 80 (a)
(Gallus gallus)
Aves GCC1 35
  • 72.13 (n)
  • 72.65 (a)
GCC1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia GCC1 36
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19283 35
(Danio rerio)
Actinopterygii gcc1 35
  • 60.63 (n)
  • 59.77 (a)
gcc1 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012521 35
  • 39.76 (n)
  • 28.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10703 35
  • 47.81 (n)
  • 35.86 (a)
CG10703 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
-- 36
  • 36 (a)
Species with no ortholog for GCC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GCC1 Gene

Gene Tree for GCC1 (if available)
Gene Tree for GCC1 (if available)

Paralogs for GCC1 Gene

No data available for Paralogs for GCC1 Gene

Variants for GCC1 Gene

Sequence variations from dbSNP and Humsavar for GCC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_020157 -
VAR_021902 -
VAR_049259 -
VAR_049260 -
VAR_049261 -

Structural Variations from Database of Genomic Variants (DGV) for GCC1 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV Gain 17160897

Variation tolerance for GCC1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GCC1 Gene

Disorders for GCC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards
Search GCC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GCC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GCC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCC1 Gene

Publications for GCC1 Gene

  1. A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. (PMID: 10209125) Kjer-Nielsen L. … Gleeson P.A. (Curr. Biol. 1999) 2 3 4 67
  2. The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. (PMID: 17914056) Lieu Z.Z. … Gleeson P.A. (Mol. Biol. Cell 2007) 3 23
  3. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. (PMID: 12446665) Luke M.R. … Gleeson P.A. (J. Biol. Chem. 2003) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for GCC1 Gene

Sources for GCC1 Gene