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Aliases for GCC1 Gene

Aliases for GCC1 Gene

  • GRIP And Coiled-Coil Domain Containing 1 2 3 5
  • Golgi Coiled-Coil Protein 1 3 4
  • Golgi Coiled-Coil 1 2 3
  • GRIP And Coiled-Coil Domain-Containing Protein 1 3
  • Peripheral Membrane Golgi Protein 3
  • GCC1P 3
  • GCC88 3

External Ids for GCC1 Gene

Previous GeneCards Identifiers for GCC1 Gene

  • GC07M125698
  • GC07M126761
  • GC07M126775
  • GC07M126814
  • GC07M127008
  • GC07M127220
  • GC07M121581

Summaries for GCC1 Gene

Entrez Gene Summary for GCC1 Gene

  • The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCC1 Gene

GCC1 (GRIP And Coiled-Coil Domain Containing 1) is a Protein Coding gene. Diseases associated with GCC1 include Phencyclidine Abuse. Among its related pathways are Vesicle-mediated transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for GCC1 Gene

  • Probably involved in maintaining Golgi structure.

Gene Wiki entry for GCC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCC1 Gene

Genomics for GCC1 Gene

Regulatory Elements for GCC1 Gene

Enhancers for GCC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G128010 1.4 ENCODE dbSUPER 13 -417.8 -417756 1.2 HDGF PKNOX1 CREB3L1 AGO1 SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 SND1 ZNF800 GCC1 LRRC4 ENSG00000243679 ENSG00000230715 ENSG00000243302 RBM28 ENSG00000242588 ENSG00000224138
GH07G128012 1.1 dbSUPER 13 -420.6 -420592 4.3 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF800 RBM28 ENSG00000224138 ENSG00000242588 ENSG00000243679 ENSG00000243302 ENSG00000230715 GCC1 SND1 RPS10P15
GH07G127650 1.2 ENCODE 11.8 -59.0 -58977 3.7 CREB3L1 AGO1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 SND1 ZNF800 GCC1 ENSG00000243302 RPS10P15 RBM28 ENSG00000224138 ENSG00000242588 GC07P127653 GC07P127654
GH07G128341 1.2 ENCODE 11.6 -749.6 -749631 2.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ZNF800 ENSG00000243679 IMPDH1 ENSG00000230715 ENSG00000243302 GCC1 RPS10P15 ENSG00000224138 LEP ENSG00000242588
GH07G127347 1.2 Ensembl ENCODE 11.2 +245.6 245649 0.9 HDAC1 RB1 ARNT AGO1 SIN3A ZNF2 RAD21 GLIS2 CBX5 ZNF143 ZNF800 ENSG00000224138 GCC1 SND1 GC07M127329
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GCC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GCC1 Gene

Chromosome:
7
Start:
127,580,618 bp from pter
End:
127,593,611 bp from pter
Size:
12,994 bases
Orientation:
Minus strand

Genomic View for GCC1 Gene

Genes around GCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCC1 Gene

Proteins for GCC1 Gene

  • Protein details for GCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CN9-GCC1_HUMAN
    Recommended name:
    GRIP and coiled-coil domain-containing protein 1
    Protein Accession:
    Q96CN9
    Secondary Accessions:
    • Q9H6N7

    Protein attributes for GCC1 Gene

    Size:
    775 amino acids
    Molecular mass:
    87811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08902.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAB15218.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GCC1 Gene

Post-translational modifications for GCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCC1 Gene

Domains & Families for GCC1 Gene

Protein Domains for GCC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GCC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CN9

UniProtKB/Swiss-Prot:

GCC1_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
Domain:
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GCC1: view

No data available for Gene Families for GCC1 Gene

Function for GCC1 Gene

Molecular function for GCC1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in maintaining Golgi structure.

Gene Ontology (GO) - Molecular Function for GCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GCC1: view

Phenotypes for GCC1 Gene

GenomeRNAi human phenotypes for GCC1:
genes like me logo Genes that share phenotypes with GCC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GCC1 Gene

Localization for GCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCC1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCC1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for GCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with GCC1: view

Pathways & Interactions for GCC1 Gene

genes like me logo Genes that share pathways with GCC1: view

Gene Ontology (GO) - Biological Process for GCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
genes like me logo Genes that share ontologies with GCC1: view

No data available for SIGNOR curated interactions for GCC1 Gene

Drugs & Compounds for GCC1 Gene

No Compound Related Data Available

Transcripts for GCC1 Gene

mRNA/cDNA for GCC1 Gene

Unigene Clusters for GCC1 Gene

GRIP and coiled-coil domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCC1 Gene

No ASD Table

Relevant External Links for GCC1 Gene

GeneLoc Exon Structure for
GCC1
ECgene alternative splicing isoforms for
GCC1

Expression for GCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GCC1 Gene

Protein differential expression in normal tissues from HIPED for GCC1 Gene

This gene is overexpressed in Lymph node (19.1), Salivary gland (10.2), and Stomach (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GCC1 Gene



Protein tissue co-expression partners for GCC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GCC1 Gene:

GCC1

SOURCE GeneReport for Unigene cluster for GCC1 Gene:

Hs.521168

Evidence on tissue expression from TISSUES for GCC1 Gene

  • Gall bladder(5)
  • Intestine(5)
  • Pancreas(5)
  • Nervous system(5)
  • Skin(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with GCC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCC1 Gene

Orthologs for GCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCC1 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia GCC1 35 34
  • 89.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GCC1 35 34
  • 89.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gcc1 34 16 35
  • 88.09 (n)
rat
(Rattus norvegicus)
Mammalia Gcc1 34
  • 87.57 (n)
oppossum
(Monodelphis domestica)
Mammalia GCC1 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GCC1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GCC1 34 35
  • 72.13 (n)
lizard
(Anolis carolinensis)
Reptilia GCC1 35
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19283 34
zebrafish
(Danio rerio)
Actinopterygii gcc1 34 35
  • 60.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10703 34 35
  • 47.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012521 34
  • 39.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
Species where no ortholog for GCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GCC1 Gene

ENSEMBL:
Gene Tree for GCC1 (if available)
TreeFam:
Gene Tree for GCC1 (if available)

Paralogs for GCC1 Gene

No data available for Paralogs for GCC1 Gene

Variants for GCC1 Gene

Sequence variations from dbSNP and Humsavar for GCC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000402305 -- 127,584,548(+) CTCCC(C/T)CCAGG reference, missense
rs1001030731 -- 127,585,638(+) GCGCC(A/G)CAGGC upstream-variant-2KB
rs1001082739 -- 127,585,779(+) ACACC(A/C/T)GAGTG upstream-variant-2KB
rs1001203478 -- 127,580,975(+) CTACT(A/T)ATGCC utr-variant-3-prime
rs1001426199 -- 127,587,445(+) CACCT(A/C)CCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GCC1 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV gain 17160897

Variation tolerance for GCC1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCC1 Gene

Disorders for GCC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards
Search GCC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GCC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GCC1
genes like me logo Genes that share disorders with GCC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCC1 Gene

Publications for GCC1 Gene

  1. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. (PMID: 12446665) Luke M.R. … Gleeson P.A. (J. Biol. Chem. 2003) 3 4 22 64
  2. A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. (PMID: 10209125) Kjer-Nielsen L. … Gleeson P.A. (Curr. Biol. 1999) 2 3 4 64
  3. The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. (PMID: 17914056) Lieu Z.Z. … Gleeson P.A. (Mol. Biol. Cell 2007) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GCC1 Gene

Sources for GCC1 Gene

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