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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GCAT Gene

protein-coding   GIFtS: 59
GCID: GC22P038203

glycine C-acetyltransferase

(Previous name: glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme...)
  Search for GCAT
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Biological research products
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Aliases
for GCAT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glycine C-Acetyltransferase1 2     EC 2.3.1.293 8
KBL1 2 3 5     Glycine C-Acetyltransferase (2-Amino-3-Ketobutyrate Coenzyme A Ligase)1
Aminoacetone Synthase2 3     2-Amino-3-Ketobutyrate Coenzyme A Ligase, Mitochondrial2
Glycine Acetyltransferase2 3     2-Amino-3-Ketobutyrate-CoA Ligase2
AKB Ligase2 3     EC 2.3.18

External Ids:    HGNC: 41881   Entrez Gene: 234642   Ensembl: ENSG000001001167   OMIM: 6074225   UniProtKB: O756003   

Export aliases for GCAT gene to outside databases

Previous GC identifers: GC22P034818 GC22P036446 GC22P036528 GC22P021170


Summaries
for GCAT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GCAT:
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine
dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate
by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction
between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class
II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A
pseudogene of this gene is found on chromosome 14. (provided by RefSeq, Jan 2010)




Genomic Views
for GCAT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GCAT gene promoter:
         Pax-5   Pax-6   Lmo2   GATA-2   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GCAT promoter sequence
   Search SABiosciences Chromatin IP Primers for GCAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GCAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

GCAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GCAT gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038203:  view genomic region     (about GC identifiers)

Start:
 38,203,912 bp from pter      End:
 38,213,183 bp from pter
Size:
 9,272 bases      Orientation:
 plus strand

Proteins
for GCAT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KBL_HUMAN, O75600 (See protein sequence)
Recommended Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor  
Size: 419 amino acids; 45285 Da
Cofactor: Pyridoxal phosphate (By similarity)
Subcellular location: Mitochondrion (By similarity). Nucleus. Note=Translocates to the nucleus upon cold and osmotic
stress
Sequence caution: Sequence=BAC85552.1; Type=Frameshift; Positions=232;
Secondary accessions: E2QC23 Q6ZWF1 Q96CA9
Alternative splicing: 2 isoforms:  O75600-1   O75600-2   (Ref.2 (BAC85552) sequence is in conflict in position: 77:L->S. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GCAT: NX_O75600

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75600

    • 4/7 DME Specific Peptides for GCAT (O75600) (see all 7)
     YPVVPKG  PVMLGDA  SDELNHAS  LNHASIIDG 

    GCAT Protein expression data from MOPED and PaxDb:    About this image 
    GCAT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165161.1  NP_055106.1  

    ENSEMBL proteins: 
     ENSP00000371110   ENSP00000248924   ENSP00000406719   ENSP00000414995   ENSP00000402213  
     ENSP00000388151  

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    Uscn Proteins for GCAT

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion NAS--

    GCAT for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GCAT

    Protein Domains /
    Families
    for GCAT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GCAT for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011282 2am3keto_CoA_ligase
     IPR001917 Aminotrans_II_pyridoxalP_BS
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR004839 Aminotransferase_I/II
     IPR015424 PyrdxlP-dep_Trfase

    Graphical View of Domain Structure for InterPro Entry O75600

    ProtoNet protein and cluster: O75600

    1 Blocks protein family: IPB001917 Aminotransferase

    UniProtKB/Swiss-Prot: KBL_HUMAN, O75600
    Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family


    Function
    for GCAT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KBL_HUMAN, O75600
    Catalytic activity: Acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate

         Genatlas biochemistry entry for GCAT:
    glycine C-acetyltransferase,mitochondrial

         Enzyme Numbers (IUBMB): EC 2.3.1.291 2 EC 2.3.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008890glycine C-acetyltransferase activity NAS10712613
    GO:0016740transferase activity ----
    GO:0016874ligase activity ----
    GO:0030170pyridoxal phosphate binding IEA--
         
    GCAT for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    In Situ Assay
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    Pathways & Interactions
    for GCAT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycine, serine and threonine metabolism
    		Glycine, serine and threonine metabolism1.00
    2threonine degradation II
    		threonine degradation II1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for GCAT 
        threonine degradation II


    1         Kegg Pathway  (Kegg details for GCAT):
        Glycine, serine and threonine metabolism

    UniProtKB/Swiss-Prot: KBL_HUMAN, O75600
    Pathway: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step
    2/2


    GCAT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GCAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/21 Interacting proteins for GCAT (O756003 ENSP000002489244) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BECN1Q144573I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    SQSTM1Q135013I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process NAS10712613
    GO:0009058biosynthetic process IEA--
    GO:0019518L-threonine catabolic process to glycine IEA--

    GCAT for ontologies           About GeneDecksing



    Drugs & Compounds
    for GCAT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GCAT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GCAT

    5 HMDB Compounds for GCAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Glycine2-Aminoacetate (see all 15)56-40-6--
    L-2-Amino-3-oxobutanoic acid(2S)-2-amino-3-oxobutanoate (see all 10)----
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    2 DrugBank Compounds for GCAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17146529
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11318637

    7 Novoseek chemical compound relationships for GCAT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-amino-3-ketobutyrate 98.3 10 10712613 (2), 17688197 (2), 11318637 (1), 17146529 (1) (see all 5)
    7-keto-8-aminopelargonic acid 95.4 3 8468290 (1), 8112347 (1)
    pyridoxal 73.3 2 10712613 (1), 7880831 (1)
    5-aminolevulinic acid 67.9 1 8112347 (1)
    pyridoxal 5-phosphate 60.2 6 11318637 (3)
    threonine 45.9 6 10712613 (1), 11318637 (1)
    serine 20.3 1 12781953 (1)

    Search CenterWatch for drugs/clinical trials and news about GCAT / KBL 

    Transcripts
    for GCAT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GCAT gene (2 alternative transcripts): 
    NM_001171690.1  NM_014291.3  

    Unigene Cluster for GCAT:

    Glycine C-acetyltransferase
    Hs.54609  [show with all ESTs]
    Unigene Representative Sequence: NM_001171690
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323205(uc003aua.2) ENST00000248924(uc003atz.3) ENST00000445195
    ENST00000415371 ENST00000478203 ENST00000426858 ENST00000451984

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF077740.1 AK123190.1 AK290093.1 BC014457.1 

    5 DOTS entries:

    DT.111891  DT.99943555  DT.312356  DT.100777986  DT.100777988 

    24/131 AceView cDNA sequences (see all 131):

    AA541628 BM715489 CR603831 AI763375 BX101962 BM018723 AU105308 AU099328 
    BU526482 BI251895 NM_014291 BU145158 CB137500 BP369347 AI610987 BM016700 
    AI935359 BG720482 AW196667 BX331419 BG762288 BF062892 BM750839 CA778022 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GCAT (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                            -     -                             -                             -         
    SP2:                          -                 -     -                             -                                       
    SP3:                          -                 -     -                                                                     
    SP4:                          -     -           -     -                                                                     
    SP5:                          -     -           -                                                                           


    ECgene alternative splicing isoforms for GCAT

    Expression
    for GCAT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GCAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAAGAGAG
    GCAT Expression
    About this image

    GCAT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb

    See GCAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GCAT

    SOURCE GeneReport for Unigene cluster: Hs.54609

    UniProtKB/Swiss-Prot: KBL_HUMAN, O75600
    Tissue specificity: Strongly expressed in heart, brain, liver and pancreas. Also found in lung

        SABiosciences Expression via Pathway-Focused PCR Array including GCAT: 
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    In Situ
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    Orthologs
    for GCAT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GCAT gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GCAT1 glycine C-acetyltransferase 76.77(n)
    84.25(a)    		   427905  XM_425478.3  XP_425478.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GCAT6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 5(24004756-24018574)
    African clawed frog
    (Xenopus laevis)    		 Amphibia gcat-prov2 glycine C-acetyltransferase (2-amino-3-ketobutyrate more 75.17(n)    BC047258.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.23012 Danio rerio cDNA clone IMAGE6789719, partial cds 73.56(n)    BC056328.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG103611 , 3 glycine C-acetyltransferase3
    CG103611    		 68(a)3
    64.03(n)1
    66.91(a)1    		   68E13
    393331  NM_140252.11  NP_648509.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea T25B9.11 , 3 glycine C-acetyltransferase3
    Protein T25B9.11    		 54(a)3
    57.48(n)1
    64.83(a)1    		   IV(10748587-10750328)3
    1779681  NM_069590.31  NP_501991.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons BIOF1 8-amino-7-oxononanoate synthase 43.44(n)
    35.44(a)    		   830339  NM_203002.3  NP_974731.1 
    rice
    (Oryza sativa)    		 Liliopsida Os10g05609001 hypothetical protein 46.15(n)
    37.54(a)    		   4349380  NM_001071913.1  NP_001065381.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria kbl6
    		 glycine C-acetyltransferase
    		 54(a)
    		 1 ↔ 1
    		 Chromosome(3789378-3790574)


    ENSEMBL Gene Tree for GCAT (if available)
    TreeFam Gene Tree for GCAT (if available) 

    Paralogs
    for GCAT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GCAT gene
    ALAS22  ALAS12  
    2 SIMAP similar genes for GCAT using alignment to 4 protein entries:     KBL_HUMAN (see all proteins):
    ALAS2    SPTLC3

    GCAT for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GCAT
    PGOHUM00000247826


    Genomic Variants
    for GCAT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 NCBI SNPs in GCAT are shown (see all 230)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2012412231,2
    		--38203952(+) GCAGGA/CGCGCT 2 -- ut510--------
    rs2003364031,2
    		--38203958(+) GCGCTC/TGGGCG 2 -- ut510--------
    rs1394289151,2
    		--38203975(+) GAGCGA/GTGTGG 4 M V mis10--------
    rs2021836021,2
    		C--38203979(+) GATGTA/GGCCTG 4 * W stg10--------
    rs786103321,2
    		C,F--38204029(+) GCCGCC/TGCGCA 4 R C mis11Minor allele frequency- T:0.03WA 118
    rs1995954021,2
    		--38204033(+) CCGCGC/TACAGT 4 A V mis10--------
    rs1888589871,2
    		--38204072(+) GGAGGA/GGGAGC 4 E G mis10--------
    rs798495711,2
    		C,F--38204089(+) GCATCT/CGCGGA 4 /R /C mis111Minor allele frequency- C:0.42NA WA CSA EA EU 3593
    rs1380253661,2
    		C,F--38204130(+) ACGTCC/TCGTCA 4 S syn11Minor allele frequency- T:0.00NA 3414
    rs751825671,2
    		C,F--38204180(+) CGCTCC/G/TGTTCC 2 -- int12WA NA 238

    HapMap Linkage Disequilibrium report for GCAT (38203912 - 38213183 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for GCAT
         1 CNV: 4128

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GCAT
    DNA2.0 Custom Variant and Variant Library Synthesis for GCAT

    Disorders / Diseases
    for GCAT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GCAT for disorders           About MalaCards

    GCAT for disorders           About GeneDecksing

    OMIM gene information: 607422    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: GCAT (3 documents)

    Export disorders for GCAT gene to outside databases

    Publications
    for GCAT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GCAT gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with GCAT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs. (PubMed id 10712613)1, 2, 9 Edgar A.J. and Polak J.M. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    4. Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism. (PubMed id 11318637)7, 9 Schmidt A....Cygler M. (2001)
    5. Nuclear translocation of 2-amino-3-ketobutyrate coenzyme A ligase by cold and osmotic stress. (PubMed id 17688197)2, 9 Hoshino A. and Fujii H. (2007)
    6. Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes. (PubMed id 17146529)7, 9 Bashir Q....Akhtar M. (2006)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    External Searches for GCAT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GCAT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23464 HGNC: 4188 AceView: GCAT Ensembl:ENSG00000100116 euGenes: HUgn23464
    ECgene: GCAT Kegg: 23464 H-InvDB: GCAT

    Other Databases showing GCAT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GCAT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GCAT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GCAT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GCAT gene:
    Search GeneIP for patents involving GCAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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